NO20052968L - Fremgangsmate for pavisning av nukleinsyrer med en bestemt sekvenssammensetning. - Google Patents
Fremgangsmate for pavisning av nukleinsyrer med en bestemt sekvenssammensetning.Info
- Publication number
- NO20052968L NO20052968L NO20052968A NO20052968A NO20052968L NO 20052968 L NO20052968 L NO 20052968L NO 20052968 A NO20052968 A NO 20052968A NO 20052968 A NO20052968 A NO 20052968A NO 20052968 L NO20052968 L NO 20052968L
- Authority
- NO
- Norway
- Prior art keywords
- nucleic acid
- nucleic acids
- detection
- acids
- specific
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 9
- 102000039446 nucleic acids Human genes 0.000 title abstract 8
- 108020004707 nucleic acids Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000001514 detection method Methods 0.000 abstract 3
- 230000027455 binding Effects 0.000 abstract 2
- 230000004807 localization Effects 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 230000035508 accumulation Effects 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Foreliggende oppfinnelse er en ny fremgangsmåte for påvisning og lokalisering av spesifikke nukleinsyresekvenser i en prøve med høy grad av sensitivitet og spesifisitet. Fremgangsmåten og de nye preparater som benyttes i fremgangsmåten, omfatter anvendelse av probenukleinsyrer, fremstilling av bindingsområder i nukleinsyren og anvendelse av målbindingsansamlinger i nukleinsyren for påvisning og lokalisering av spesifikke målnukleinsyrer. Påvisning og lokalisering av målnukleinsyren oppnås selv i nærvær av nukleinsyrer med lignende sekvenser. Fremgangsmåten tilveiebringer en høy grad av amplifisering av signalet som dannes ved hver spesifikke bindingsbegivenhet. Nærmere bestemt presenteres fremgangsmåter og preparater for påvisning av HIV- og HPV-nukleinsyre i prøver. Disse fremgangsmåter og preparater kan anvendes ved diagnose av sykdom, genetiske undersøkelser, retts~ medisinske formål og analyse av nukleinsyreblandinger. Noen av de nye preparater som benyttes i påvisningsfremgangsmåten, er anvendbare for forebyggelse eller behandling av patogene tilstander.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/353,476 US5871902A (en) | 1994-12-09 | 1994-12-09 | Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids |
PCT/US1995/015944 WO1996017956A2 (en) | 1994-12-09 | 1995-12-07 | Method of detection of nucleic acids with a specific sequence composition |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20052968L true NO20052968L (no) | 1997-08-11 |
NO20052968D0 NO20052968D0 (no) | 2005-06-17 |
Family
ID=23389290
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19972611A NO321557B1 (no) | 1994-12-09 | 1997-06-06 | Fremgangsmate for pavisning av nukleinsyrer med en bestemt sekvenssammensetning |
NO20052968A NO20052968D0 (no) | 1994-12-09 | 2005-06-17 | Fremgangsmate for pavisning av nukleinsyrer med en bestemt sekvenssammensetning. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19972611A NO321557B1 (no) | 1994-12-09 | 1997-06-06 | Fremgangsmate for pavisning av nukleinsyrer med en bestemt sekvenssammensetning |
Country Status (15)
Country | Link |
---|---|
US (1) | US5871902A (no) |
EP (2) | EP0796344B1 (no) |
JP (2) | JPH10510157A (no) |
CN (2) | CN1936020A (no) |
AT (1) | ATE353372T1 (no) |
BR (1) | BR9509977A (no) |
CA (1) | CA2206127A1 (no) |
DE (1) | DE69535384T2 (no) |
DK (1) | DK0796344T3 (no) |
ES (1) | ES2279516T3 (no) |
IL (2) | IL116321A (no) |
MX (1) | MX9704281A (no) |
NO (2) | NO321557B1 (no) |
PT (1) | PT796344E (no) |
WO (1) | WO1996017956A2 (no) |
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EP0823486A3 (en) * | 1991-06-27 | 2004-02-11 | Genelabs Technologies, Inc. | Method for inhibiting the binding of a dna-binding protein to duplex dna |
EP0672177B1 (en) * | 1992-01-28 | 2006-07-19 | President And Fellows of Harvard College | Method for nucleic acid hybridization using single-stranded dna binding protein |
AU3919293A (en) * | 1992-03-27 | 1993-11-08 | University Of Maryland At Baltimore | Detection of gene mutations with mismatch repair enzymes |
JPH05308999A (ja) * | 1992-05-08 | 1993-11-22 | Sumitomo Metal Ind Ltd | B型肝炎ウイルスpre−C変異の判定法 |
AU682340B2 (en) * | 1993-01-28 | 1997-10-02 | Regents Of The University Of California, The | TATA-binding protein associated factors, nucleic acids encoding TAFs, and methods of use |
US5593834A (en) * | 1993-06-17 | 1997-01-14 | The Research Foundation Of State University Of New York | Method of preparing DNA sequences with known ligand binding characteristics |
US5871902A (en) * | 1994-12-09 | 1999-02-16 | The Gene Pool, Inc. | Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids |
-
1994
- 1994-12-09 US US08/353,476 patent/US5871902A/en not_active Expired - Lifetime
-
1995
- 1995-12-07 DE DE69535384T patent/DE69535384T2/de not_active Expired - Lifetime
- 1995-12-07 DK DK95943035T patent/DK0796344T3/da active
- 1995-12-07 ES ES95943035T patent/ES2279516T3/es not_active Expired - Lifetime
- 1995-12-07 CA CA002206127A patent/CA2206127A1/en not_active Abandoned
- 1995-12-07 CN CN200610071545.7A patent/CN1936020A/zh active Pending
- 1995-12-07 CN CN95197558.7A patent/CN1255551C/zh not_active Expired - Fee Related
- 1995-12-07 PT PT95943035T patent/PT796344E/pt unknown
- 1995-12-07 EP EP95943035A patent/EP0796344B1/en not_active Expired - Lifetime
- 1995-12-07 EP EP07002519A patent/EP1820864A3/en not_active Withdrawn
- 1995-12-07 JP JP8517797A patent/JPH10510157A/ja not_active Withdrawn
- 1995-12-07 BR BR9509977A patent/BR9509977A/pt not_active Application Discontinuation
- 1995-12-07 AT AT95943035T patent/ATE353372T1/de active
- 1995-12-07 WO PCT/US1995/015944 patent/WO1996017956A2/en active IP Right Grant
- 1995-12-10 IL IL11632195A patent/IL116321A/en not_active IP Right Cessation
- 1995-12-10 IL IL150713A patent/IL150713A/en not_active IP Right Cessation
-
1997
- 1997-06-06 NO NO19972611A patent/NO321557B1/no not_active IP Right Cessation
- 1997-06-06 MX MX9704281A patent/MX9704281A/es not_active IP Right Cessation
-
2005
- 2005-06-17 NO NO20052968A patent/NO20052968D0/no not_active Application Discontinuation
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2006
- 2006-06-13 JP JP2006163414A patent/JP4598722B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0796344A1 (en) | 1997-09-24 |
PT796344E (pt) | 2007-05-31 |
DK0796344T3 (da) | 2007-06-04 |
JP4598722B2 (ja) | 2010-12-15 |
WO1996017956A3 (en) | 1997-07-24 |
DE69535384D1 (de) | 2007-03-22 |
US5871902A (en) | 1999-02-16 |
IL116321A0 (en) | 1996-03-31 |
MX9704281A (es) | 1998-07-31 |
IL150713A0 (en) | 2003-02-12 |
CA2206127A1 (en) | 1996-06-13 |
CN1255551C (zh) | 2006-05-10 |
ES2279516T3 (es) | 2007-08-16 |
IL150713A (en) | 2011-02-28 |
CN1176663A (zh) | 1998-03-18 |
NO20052968D0 (no) | 2005-06-17 |
EP1820864A3 (en) | 2008-01-23 |
JP2006320326A (ja) | 2006-11-30 |
IL116321A (en) | 2004-09-27 |
WO1996017956A2 (en) | 1996-06-13 |
CN1936020A (zh) | 2007-03-28 |
EP1820864A2 (en) | 2007-08-22 |
NO972611L (no) | 1997-08-11 |
ATE353372T1 (de) | 2007-02-15 |
DE69535384T2 (de) | 2007-09-13 |
EP0796344B1 (en) | 2007-02-07 |
NO321557B1 (no) | 2006-05-29 |
BR9509977A (pt) | 1998-06-09 |
NO972611D0 (no) | 1997-06-06 |
JPH10510157A (ja) | 1998-10-06 |
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