MX9704281A - Metodo de deteccion de acidos nucleicos con una composicion de secuencia especifica. - Google Patents

Metodo de deteccion de acidos nucleicos con una composicion de secuencia especifica.

Info

Publication number
MX9704281A
MX9704281A MX9704281A MX9704281A MX9704281A MX 9704281 A MX9704281 A MX 9704281A MX 9704281 A MX9704281 A MX 9704281A MX 9704281 A MX9704281 A MX 9704281A MX 9704281 A MX9704281 A MX 9704281A
Authority
MX
Mexico
Prior art keywords
nucleic acid
detection
nucleic acids
specific
novel
Prior art date
Application number
MX9704281A
Other languages
English (en)
Inventor
Susan Weininger
Arthur M Weininger
Original Assignee
Gene Pool Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Pool Inc filed Critical Gene Pool Inc
Publication of MX9704281A publication Critical patent/MX9704281A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Esta invencion es un método novedoso para detectar y localizar secuencias específicas de ácido nucleico en un muestra con un alto grado de sensibilidad y especificidad. El método y las composiciones novedosas utilizados en el método entrañan el uso de ácido nucleicos de sonda, la produccion de regiones de ácido nucleico y el uso ensambles de union de objetivo de ácido nucleico para detectar y localizar ácidos nucleicos objetivos específicos. La deteccion y localizacion del ácido nucleico de objetivo se logra incluso en presencia de ácidos nucleicos los cuales tiene secuencias similares. El método provee un alto grado de amplificacion de la señal producida por cada evento de union específico. En particular, se presentan métodos y composiciones para la deteccion, en muestras, de ácido nucleico de VIH y HPV. Esto métodos y composiciones encuentran uso en el diagnostico de enfermedades, monitoreo genético, medicina forense y análisis de mezclas de ácido nucleico. Algunas de las composiciones novedosas utilizadas en el método de deteccion son utiles para prevenir o tratar condiciones patogénicas.
MX9704281A 1994-12-09 1997-06-06 Metodo de deteccion de acidos nucleicos con una composicion de secuencia especifica. MX9704281A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/353,476 US5871902A (en) 1994-12-09 1994-12-09 Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids

Publications (1)

Publication Number Publication Date
MX9704281A true MX9704281A (es) 1998-07-31

Family

ID=23389290

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704281A MX9704281A (es) 1994-12-09 1997-06-06 Metodo de deteccion de acidos nucleicos con una composicion de secuencia especifica.

Country Status (15)

Country Link
US (1) US5871902A (es)
EP (2) EP1820864A3 (es)
JP (2) JPH10510157A (es)
CN (2) CN1936020A (es)
AT (1) ATE353372T1 (es)
BR (1) BR9509977A (es)
CA (1) CA2206127A1 (es)
DE (1) DE69535384T2 (es)
DK (1) DK0796344T3 (es)
ES (1) ES2279516T3 (es)
IL (2) IL116321A (es)
MX (1) MX9704281A (es)
NO (2) NO321557B1 (es)
PT (1) PT796344E (es)
WO (1) WO1996017956A2 (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084885A1 (en) * 1994-01-18 2005-04-21 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
USRE45795E1 (en) 1994-08-20 2015-11-10 Gendaq, Ltd. Binding proteins for recognition of DNA
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
US20030104361A1 (en) * 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US5853990A (en) 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
ATE243761T1 (de) * 1996-10-04 2003-07-15 Dako As Sonden zur detektion von mycobakterien
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
AU746454B2 (en) * 1998-03-02 2002-05-02 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6335162B1 (en) 1998-03-13 2002-01-01 Promega Corporation Nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
JP2002506640A (ja) 1998-03-17 2002-03-05 ジェンダック・リミテッド 核酸結合タンパク質
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
US6664045B1 (en) 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
US6599692B1 (en) * 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6534261B1 (en) * 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) * 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7013219B2 (en) * 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7030215B2 (en) * 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
CA2381750A1 (en) * 1999-08-13 2001-02-22 Nanogen, Inc. Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
ATE309536T1 (de) 1999-12-06 2005-11-15 Sangamo Biosciences Inc Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
CA2398155C (en) * 2000-01-24 2011-07-19 Sangamo Biosciences, Inc. Methods and compositions for linking binding domains in nucleic acid binding proteins
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
DE60141205D1 (de) * 2000-04-03 2010-03-18 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
WO2002016644A1 (en) * 2000-08-18 2002-02-28 Massachusetts Institute Of Technology Inhibition of protein-protein interaction
AU2002225623A8 (en) * 2000-11-17 2009-07-30 John G Wise Creation and identification of proteins having new dna binding specificities
US7067317B2 (en) * 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7026462B2 (en) * 2000-12-07 2006-04-11 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
EP1288292A1 (en) * 2001-08-31 2003-03-05 Leids Universitair Medisch Centrum Long peptides of 22-40 amino acid residues that induce and/or enhance antigen specific immune responses.
EP1353941B1 (en) * 2001-01-22 2013-03-13 Sangamo BioSciences, Inc. Modified zinc finger binding proteins
US20040161753A1 (en) * 2001-11-16 2004-08-19 Wise John G. Creation and identification of proteins having new dna binding specificities
US7262054B2 (en) * 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
CN100507564C (zh) * 2002-04-09 2009-07-01 唐舜荣 改进的通过颗粒结合来检测靶分子的方法
US7361635B2 (en) * 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
JP2005304489A (ja) * 2004-03-24 2005-11-04 Sysmex Corp 標的物質検出用プローブセット及び標的物質検出方法。
US20070253950A1 (en) * 2006-03-21 2007-11-01 Wyeth Methods for Preventing and Treating Amyloidogenic Diseases
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
WO2007136834A2 (en) * 2006-05-19 2007-11-29 Codon Devices, Inc. Combined extension and ligation for nucleic acid assembly
EP2038651B1 (en) * 2006-06-29 2017-03-29 Koninklijke Philips N.V. An in vitro method of detecting and/or diagnosing cancer using uv light based dna image cytometry
WO2008027558A2 (en) * 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US8227590B2 (en) * 2006-11-21 2012-07-24 Jawaharlal Nehru Centre For Advanced Scientific Research High sensitivity assay for molecular typing of biological sample, probes and a kit thereof
EP2664677B1 (en) * 2008-06-30 2018-05-30 BioNano Genomics, Inc. Methods for single-molecule whole genome analysis
JP2013505016A (ja) * 2009-09-16 2013-02-14 マッシー ユニヴァーシティー 融合ポリペプチドおよびその使用
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
ES2548400T3 (es) 2010-11-12 2015-10-16 Gen9, Inc. Métodos y dispositivos para la síntesis de ácidos nucleicos
EP2944693B1 (en) 2011-08-26 2019-04-24 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP4001427A1 (en) 2012-04-24 2022-05-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
JP6509727B2 (ja) 2012-06-25 2019-05-15 ギンゴー バイオワークス， インコーポレイテッド 核酸アセンブリおよび高処理シークエンシングのための方法
RU2015122794A (ru) * 2012-11-15 2017-01-10 Молекуляр Детекшн Израиль Лтд. Реакционные смеси для пцр и способы применения
CN105039587A (zh) * 2015-04-20 2015-11-11 广东温氏食品集团股份有限公司 用于检测鸭腺病毒2型的引物对及试剂盒
CN105039586A (zh) * 2015-04-20 2015-11-11 广东温氏食品集团股份有限公司 检测鸭2型腺病毒的引物及试剂盒
EP3899029A1 (en) * 2018-12-21 2021-10-27 Illumina, Inc. Nuclease-based rna depletion
CN114592022A (zh) * 2022-03-30 2022-06-07 南京大学 一种基于dna模板的长链tna合成方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556643A (en) * 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4623627A (en) * 1983-08-19 1986-11-18 Cetus Corporation Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same
US4724202A (en) * 1983-12-12 1988-02-09 Molecular Diagnostics, Inc. Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization
US4777129A (en) * 1983-12-12 1988-10-11 Molecular Diagnostics, Inc. Nucleic acid probe detectable by specific nucleic acid binding protein
EP0146039A3 (en) * 1983-12-12 1986-08-27 Miles Inc. Hybridization assay with immobilization of hybrids by antihybrid binding
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4794075A (en) * 1985-08-29 1988-12-27 Lifecodes Corporation Method for locating and purifying DNA containing single base mismatches
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US5306614A (en) * 1986-01-22 1994-04-26 Institut Pasteur Methods and kits for diagnosing human immunodeficiency virus type 2(HIV-2)
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
US5310650A (en) * 1986-09-29 1994-05-10 Abbott Laboratoires Method and device for improved reaction kinetics in nucleic acid hybridizations
WO1988006601A1 (en) * 1987-03-02 1988-09-07 Genex Corporation Gene repressors
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
JP2739068B2 (ja) * 1988-09-24 1998-04-08 春馬 川口 Ｄｎａ固定ミクロスフェア及びそれを用いるｄｎａ転写制御因子精製法
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5556750A (en) * 1989-05-12 1996-09-17 Duke University Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
WO1991006679A1 (en) * 1989-10-24 1991-05-16 Stratagene An improved method for hybridizing nucleic acids using single-stranded nucleic acid binding protein
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5215882A (en) * 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
WO1991011534A1 (en) * 1990-01-24 1991-08-08 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce A rapid and sensitive test for detecting hepatitis a virus
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
JPH04222599A (ja) * 1990-04-20 1992-08-12 Syntex Usa Inc 二重受容体ポリヌクレオチド検定方法
AU2028792A (en) * 1991-05-17 1992-12-30 Uab Research Foundation Sequence specific dna binding drugs
DK0519338T3 (da) * 1991-06-20 1996-10-28 Hoffmann La Roche Forbedrede fremgangsmåder til nukleinsyreamplifikation
EP0593618B1 (en) * 1991-06-27 1998-04-22 Genelabs Technologies, Inc. Screening assay for the detection of dna-binding molecules
WO1993015226A1 (en) * 1992-01-28 1993-08-05 President And Fellows Of Harvard College Method for nucleic acid hybridization using single-stranded dna binding protein
WO1993020233A1 (en) * 1992-03-27 1993-10-14 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
JPH05308999A (ja) * 1992-05-08 1993-11-22 Sumitomo Metal Ind Ltd Ｂ型肝炎ウイルスｐｒｅ−Ｃ変異の判定法
WO1994017087A1 (en) * 1993-01-28 1994-08-04 The Regents Of The University Of California Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use
US5593834A (en) * 1993-06-17 1997-01-14 The Research Foundation Of State University Of New York Method of preparing DNA sequences with known ligand binding characteristics
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids

Also Published As

Publication number Publication date
EP0796344A1 (en) 1997-09-24
EP1820864A3 (en) 2008-01-23
IL116321A (en) 2004-09-27
NO20052968D0 (no) 2005-06-17
DE69535384T2 (de) 2007-09-13
CN1176663A (zh) 1998-03-18
CN1255551C (zh) 2006-05-10
DK0796344T3 (da) 2007-06-04
ATE353372T1 (de) 2007-02-15
ES2279516T3 (es) 2007-08-16
PT796344E (pt) 2007-05-31
NO972611L (no) 1997-08-11
EP1820864A2 (en) 2007-08-22
CN1936020A (zh) 2007-03-28
CA2206127A1 (en) 1996-06-13
IL150713A (en) 2011-02-28
NO20052968L (no) 1997-08-11
JP4598722B2 (ja) 2010-12-15
BR9509977A (pt) 1998-06-09
US5871902A (en) 1999-02-16
IL116321A0 (en) 1996-03-31
JP2006320326A (ja) 2006-11-30
EP0796344B1 (en) 2007-02-07
IL150713A0 (en) 2003-02-12
DE69535384D1 (de) 2007-03-22
NO972611D0 (no) 1997-06-06
NO321557B1 (no) 2006-05-29
WO1996017956A3 (en) 1997-07-24
JPH10510157A (ja) 1998-10-06
WO1996017956A2 (en) 1996-06-13

Similar Documents

Publication Publication Date Title
MX9704281A (es) Metodo de deteccion de acidos nucleicos con una composicion de secuencia especifica.
Böhm et al. Real‐time quantitative PCR: DNA determination in isolated spores of the mycorrhizal fungus Glomus mosseae and monitoring of Phytophthora infestans and Phytophthora citricola in their respective host plants
ATE199572T1 (de) Unimolekulare segmentamplifikation und bestimmung
DE69231646T2 (de) Fingerabdruckartige identifikation von bakterienstämmen mittels amplifikation repetitiver dna-sequenzen
ATE161891T1 (de) Verfahren zum nachweis von picornaviren in biologischen flüssigkeiten und geweben
EA199901057A1 (ru) Способ, основанный на применении бактериофагов, для обнаружения биологических молекул в биологических образцах
ATE364722T1 (de) Verfahren zum nachweis und zur lokalisierung von genen in situ durch hybridisierung einer verzweigten dna
Chen et al. Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection
ES2052607T3 (es) Metodos y kits para detectar secuencias de acidos nucleicos.
WO1995033854B1 (en) Use of a specific marker for detection of salmonella with pcr
CN110791551A (zh) 一种无载体氯霉素适配体信号放大传感器的建立方法
CN106033060B (zh) 基于吗啉寡核苷酸功能化磁性微球的高灵敏度dna荧光分析方法
CN113186253B (zh) 一种用于检测路易体病标志物的Cas12a-DNAzyme传感器及其制备方法
KR102435116B1 (ko) CRISPR-Cas 시스템과 멀티플렉스 LAMP 프라이머 세트를 이용한 인플루엔자 바이러스의 검출 방법
CN114480682A (zh) 一种检测结核分枝杆菌的组合物、试剂盒及其应用
WO2005059161A2 (en) Methods for evaluation a bacteriophage preparation
Kawai et al. Development and evaluation of a loop-mediated isothermal amplification method for the rapid detection of Chlamydophila pneumoniae
DE69524199D1 (de) Primer und sonden zur amplifizierung und zum nachweis von cmv nukleinsäure
CN115976245A (zh) 嗜果刀孢菌的特异性检测引物及检测方法
Zhang et al. Development and application of a loop-mediated isothermal amplification method for rapid detection of Haemophilus parasuis
JPH0349698A (ja) 細菌検出のためのオリゴヌクレオチドおよびそれを用いた細菌検出法
KR20190084533A (ko) 리얼타임 피씨알을 이용한 살모넬라 균의 검출 키트 및 방법
JPH03228700A (ja) 細菌検出のためのオリゴヌクレオチドおよびそれを用いた細菌検出法
KR20030047954A (ko) 멀티플렉스 피씨알 방법을 이용한 에이치아이브이-1, 비형간염 바이러스 및 결핵균의 진단방법 및 키트

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees