ES2173476T3 - Procedimiento de produccion de iohexol. - Google Patents

Procedimiento de produccion de iohexol.

Info

Publication number
ES2173476T3
ES2173476T3 ES97939000T ES97939000T ES2173476T3 ES 2173476 T3 ES2173476 T3 ES 2173476T3 ES 97939000 T ES97939000 T ES 97939000T ES 97939000 T ES97939000 T ES 97939000T ES 2173476 T3 ES2173476 T3 ES 2173476T3
Authority
ES
Spain
Prior art keywords
production procedure
iohexol
iohexol production
triiodoftalamide
dihydroxipropilant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97939000T
Other languages
English (en)
Spanish (es)
Inventor
Dick Malthe-Sorenssen
Odd Einar Ingvoldstad
Espen Myrbraten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of ES2173476T3 publication Critical patent/ES2173476T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
ES97939000T 1996-08-29 1997-08-29 Procedimiento de produccion de iohexol. Expired - Lifetime ES2173476T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9618056.7A GB9618056D0 (en) 1996-08-29 1996-08-29 Process

Publications (1)

Publication Number Publication Date
ES2173476T3 true ES2173476T3 (es) 2002-10-16

Family

ID=10799120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97939000T Expired - Lifetime ES2173476T3 (es) 1996-08-29 1997-08-29 Procedimiento de produccion de iohexol.

Country Status (25)

Country Link
US (2) US5948940A (enEXAMPLES)
EP (1) EP0925275B1 (enEXAMPLES)
JP (1) JP3780002B2 (enEXAMPLES)
KR (1) KR100517588B1 (enEXAMPLES)
CN (1) CN1120148C (enEXAMPLES)
AT (1) ATE210631T1 (enEXAMPLES)
AU (1) AU723184B2 (enEXAMPLES)
BG (1) BG63663B1 (enEXAMPLES)
BR (1) BR9711381A (enEXAMPLES)
CA (1) CA2265047A1 (enEXAMPLES)
CZ (1) CZ295058B6 (enEXAMPLES)
DE (1) DE69709127T2 (enEXAMPLES)
EE (1) EE9900082A (enEXAMPLES)
ES (1) ES2173476T3 (enEXAMPLES)
GB (1) GB9618056D0 (enEXAMPLES)
HU (1) HU229253B1 (enEXAMPLES)
IL (1) IL128715A (enEXAMPLES)
IN (1) IN186429B (enEXAMPLES)
NO (1) NO322795B1 (enEXAMPLES)
NZ (1) NZ334817A (enEXAMPLES)
PL (1) PL190151B1 (enEXAMPLES)
PT (1) PT925275E (enEXAMPLES)
SK (1) SK26499A3 (enEXAMPLES)
TR (1) TR199900405T2 (enEXAMPLES)
WO (1) WO1998008804A1 (enEXAMPLES)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US6262303B1 (en) * 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
NO20033058D0 (no) * 2003-07-03 2003-07-03 Amersham Health As Prosess
NO20053676D0 (no) 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
ES2391002T3 (es) 2008-01-14 2012-11-20 Mallinckrodt Llc Proceso para la preparación de iosimenol
RU2711501C2 (ru) 2014-03-04 2020-01-17 Оцука Фармасьютикал Ко., Лтд. Порошок йогексола и способ его применения
CN110054569B (zh) * 2019-05-17 2022-05-17 浙江海洲制药有限公司 一种制备碘海醇的方法
CN116178204A (zh) * 2022-04-21 2023-05-30 安徽普利药业有限公司 一种工业化生产碘海醇精制品的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548594A (en) * 1922-05-27 1925-08-04 Helios Machine Company Motion-converting mechanism
CH608189A5 (enEXAMPLES) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
EP0105752B1 (en) * 1982-10-01 1986-05-07 NYEGAARD & CO. A/S X-ray contrast agents
NO161368C (no) * 1982-11-08 1989-08-09 Nyegaard & Co As Roentgenkontrastmidler samt radiologiske preparater derav.
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process

Also Published As

Publication number Publication date
EP0925275A1 (en) 1999-06-30
GB9618056D0 (en) 1996-10-09
CZ66999A3 (cs) 1999-08-11
BG63663B1 (bg) 2002-08-30
NZ334817A (en) 2000-09-29
US6153796A (en) 2000-11-28
NO990889D0 (no) 1999-02-25
HUP9904325A2 (hu) 2000-04-28
TR199900405T2 (xx) 1999-06-21
IN186429B (enEXAMPLES) 2001-09-01
NO990889L (no) 1999-02-25
PL331706A1 (en) 1999-08-02
US5948940A (en) 1999-09-07
CN1228763A (zh) 1999-09-15
BR9711381A (pt) 1999-08-17
AU4123697A (en) 1998-03-19
CN1120148C (zh) 2003-09-03
JP2000517312A (ja) 2000-12-26
CA2265047A1 (en) 1998-03-05
PT925275E (pt) 2002-05-31
SK26499A3 (en) 1999-08-06
WO1998008804A1 (en) 1998-03-05
HK1020722A1 (en) 2000-05-19
DE69709127D1 (de) 2002-01-24
PL190151B1 (pl) 2005-11-30
DE69709127T2 (de) 2002-08-14
CZ295058B6 (cs) 2005-05-18
EP0925275B1 (en) 2001-12-12
IL128715A0 (en) 2000-01-31
BG103289A (en) 2000-01-31
ATE210631T1 (de) 2001-12-15
NO322795B1 (no) 2006-12-11
HUP9904325A3 (en) 2000-06-28
KR20000035945A (ko) 2000-06-26
KR100517588B1 (ko) 2005-09-29
JP3780002B2 (ja) 2006-05-31
IL128715A (en) 2002-08-14
AU723184B2 (en) 2000-08-17
HU229253B1 (en) 2013-10-28
EE9900082A (et) 1999-10-15

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