ES2162929T3 - Procedimiento para la preparacion de 2-(1-azabiciclo(2.2.2)oct-3-il)-2,4,5,6-tetrahidro-1h-benz(de)isoquinolin-1-ona y producto intermediario. - Google Patents

Procedimiento para la preparacion de 2-(1-azabiciclo(2.2.2)oct-3-il)-2,4,5,6-tetrahidro-1h-benz(de)isoquinolin-1-ona y producto intermediario.

Info

Publication number
ES2162929T3
ES2162929T3 ES95925803T ES95925803T ES2162929T3 ES 2162929 T3 ES2162929 T3 ES 2162929T3 ES 95925803 T ES95925803 T ES 95925803T ES 95925803 T ES95925803 T ES 95925803T ES 2162929 T3 ES2162929 T3 ES 2162929T3
Authority
ES
Spain
Prior art keywords
azabiciclo
tetrahidro
ona
isoquinolin
benz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95925803T
Other languages
English (en)
Inventor
Charles Alois Dvorak
Bruce Andrew Kowalczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23040964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2162929(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2162929T3 publication Critical patent/ES2162929T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

TEXTO
ES95925803T 1994-07-08 1995-07-01 Procedimiento para la preparacion de 2-(1-azabiciclo(2.2.2)oct-3-il)-2,4,5,6-tetrahidro-1h-benz(de)isoquinolin-1-ona y producto intermediario. Expired - Lifetime ES2162929T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/272,715 US5567818A (en) 1994-07-08 1994-07-08 Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein

Publications (1)

Publication Number Publication Date
ES2162929T3 true ES2162929T3 (es) 2002-01-16

Family

ID=23040964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95925803T Expired - Lifetime ES2162929T3 (es) 1994-07-08 1995-07-01 Procedimiento para la preparacion de 2-(1-azabiciclo(2.2.2)oct-3-il)-2,4,5,6-tetrahidro-1h-benz(de)isoquinolin-1-ona y producto intermediario.

Country Status (16)

Country Link
US (1) US5567818A (es)
EP (1) EP0770077B1 (es)
JP (1) JP2898758B2 (es)
CN (1) CN1048727C (es)
AT (1) ATE205845T1 (es)
AU (1) AU2979995A (es)
BR (1) BR9508249A (es)
CL (2) CL2004001244A1 (es)
CY (1) CY2342B1 (es)
DE (1) DE69522808T2 (es)
DK (1) DK0770077T3 (es)
ES (1) ES2162929T3 (es)
FI (1) FI120198B (es)
MX (1) MX9700157A (es)
PT (1) PT770077E (es)
WO (1) WO1996001824A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437525B (zh) 2000-04-20 2013-09-04 梅森奈特公司 木材复合制品和制造反向模制的木材复合制品的方法
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formulations of palonosetron
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
US8614225B2 (en) * 2006-08-30 2013-12-24 Dr. Reddy's Laboratories Limited Process for the purification of palonosetron or its salt
US7737280B2 (en) 2006-10-23 2010-06-15 Sicor Inc. Processes for preparing palonosetron salts
JP2010512333A (ja) * 2006-12-07 2010-04-22 ヘルシン ヘルスケア ソシエテ アノニム 塩酸パロノセトロンの結晶及び非晶質形
WO2008146283A2 (en) * 2007-05-29 2008-12-04 Chemagis Ltd. Novel palonosetron salts and processes for preparation and purification thereof
WO2009010987A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved process for the preparation of pure palonosetron hydrochloride
AR069625A1 (es) * 2007-12-13 2010-02-03 Glenmark Generics Ltd Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) * 2008-01-11 2009-07-16 Natco Pharma Limited Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) * 2008-05-05 2009-11-12 Natco Pharma Limited High purity palonosetron base and its solid state characteristics
EP2364312A4 (en) * 2008-11-11 2012-05-02 Reddys Lab Ltd Dr SYNTHESIS OF CRYSTALLINE PALONOSETRON CHLORHYDRATE
CN101851233B (zh) * 2009-04-03 2013-03-06 四川滇虹医药开发有限公司 盐酸帕洛诺司琼和其前体化合物及制备
WO2011001400A2 (en) 2009-06-30 2011-01-06 Ranbaxy Laboratories Limited Processes for the preparation of form i and form ii of palonosetron hydrochloride
WO2011013095A1 (en) 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Processes for the preparation of palonosetron
JP2014070036A (ja) * 2012-09-28 2014-04-21 Mitsubishi Gas Chemical Co Inc １，８−テトラリンジカルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007191A (en) * 1975-10-14 1977-02-08 E. R. Squibb & Sons, Inc. 2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
CA2030718C (en) * 1989-11-28 1998-05-12 Jacob Berger Tricyclic compounds
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes

Also Published As

Publication number Publication date
AU2979995A (en) 1996-02-09
JPH09508645A (ja) 1997-09-02
CY2342B1 (en) 2004-02-06
CL2004001244A1 (es) 2005-04-15
US5567818A (en) 1996-10-22
EP0770077A1 (en) 1997-05-02
PT770077E (pt) 2002-02-28
BR9508249A (pt) 1998-01-06
JP2898758B2 (ja) 1999-06-02
EP0770077B1 (en) 2001-09-19
DE69522808T2 (de) 2002-04-04
FI970068A7 (fi) 1997-01-07
CN1152313A (zh) 1997-06-18
ATE205845T1 (de) 2001-10-15
CL2007001958A1 (es) 2008-02-22
DK0770077T3 (da) 2002-01-14
MX9700157A (es) 1997-04-30
FI970068A0 (fi) 1997-01-07
DE69522808D1 (de) 2001-10-25
WO1996001824A1 (en) 1996-01-25
FI120198B (fi) 2009-07-31
CN1048727C (zh) 2000-01-26

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