ATE205845T1 - Verfahren zur herstellung von 2- (1-azabicyclo (2.2.2) oct-3-y)) -2,4,5,6-tetrahydro-1 h-benz (de) isochinolin-1-on und zwischenprodukte - Google Patents

Verfahren zur herstellung von 2- (1-azabicyclo (2.2.2) oct-3-y)) -2,4,5,6-tetrahydro-1 h-benz (de) isochinolin-1-on und zwischenprodukte

Info

Publication number
ATE205845T1
ATE205845T1 AT95925803T AT95925803T ATE205845T1 AT E205845 T1 ATE205845 T1 AT E205845T1 AT 95925803 T AT95925803 T AT 95925803T AT 95925803 T AT95925803 T AT 95925803T AT E205845 T1 ATE205845 T1 AT E205845T1
Authority
AT
Austria
Prior art keywords
benz
azabicyclo
tetrahydro
oct
isochinolin
Prior art date
Application number
AT95925803T
Other languages
English (en)
Inventor
Charles Alois Dvorak
Bruce Andrew Kowalczyk
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23040964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE205845(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE205845T1 publication Critical patent/ATE205845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT95925803T 1994-07-08 1995-07-01 Verfahren zur herstellung von 2- (1-azabicyclo (2.2.2) oct-3-y)) -2,4,5,6-tetrahydro-1 h-benz (de) isochinolin-1-on und zwischenprodukte ATE205845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/272,715 US5567818A (en) 1994-07-08 1994-07-08 Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein
PCT/EP1995/002556 WO1996001824A1 (en) 1994-07-08 1995-07-01 Process for the preparation of 2-(1-azabicyclo(2.2.2)oct-3-yl) -2,4,5,6-tetrahydro-1h-benz(de)isoquinolin-1-one and intermediate product

Publications (1)

Publication Number Publication Date
ATE205845T1 true ATE205845T1 (de) 2001-10-15

Family

ID=23040964

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925803T ATE205845T1 (de) 1994-07-08 1995-07-01 Verfahren zur herstellung von 2- (1-azabicyclo (2.2.2) oct-3-y)) -2,4,5,6-tetrahydro-1 h-benz (de) isochinolin-1-on und zwischenprodukte

Country Status (16)

Country Link
US (1) US5567818A (de)
EP (1) EP0770077B1 (de)
JP (1) JP2898758B2 (de)
CN (1) CN1048727C (de)
AT (1) ATE205845T1 (de)
AU (1) AU2979995A (de)
BR (1) BR9508249A (de)
CL (2) CL2004001244A1 (de)
CY (1) CY2342B1 (de)
DE (1) DE69522808T2 (de)
DK (1) DK0770077T3 (de)
ES (1) ES2162929T3 (de)
FI (1) FI120198B (de)
MX (1) MX9700157A (de)
PT (1) PT770077E (de)
WO (1) WO1996001824A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501001A (ja) 2000-04-20 2004-01-15 メイソナイト・コーポレイション 反転成型パネル
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
US8614225B2 (en) * 2006-08-30 2013-12-24 Dr. Reddy's Laboratories Limited Process for the purification of palonosetron or its salt
EP1960397A2 (de) * 2006-10-23 2008-08-27 Sicor Inc. Kristalline formen von palonosetron-hydrochlorid
WO2008073757A1 (en) * 2006-12-07 2008-06-19 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
WO2008146283A2 (en) * 2007-05-29 2008-12-04 Chemagis Ltd. Novel palonosetron salts and processes for preparation and purification thereof
WO2009010987A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved process for the preparation of pure palonosetron hydrochloride
AR069625A1 (es) * 2007-12-13 2010-02-03 Glenmark Generics Ltd Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) * 2008-01-11 2009-07-16 Natco Pharma Limited Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) * 2008-05-05 2009-11-12 Natco Pharma Limited High purity palonosetron base and its solid state characteristics
EP2364312A4 (de) * 2008-11-11 2012-05-02 Reddys Lab Ltd Dr Herstellung von kristallinem palonosetron-hydrochlorid
CN101851233B (zh) * 2009-04-03 2013-03-06 四川滇虹医药开发有限公司 盐酸帕洛诺司琼和其前体化合物及制备
US20120267533A1 (en) 2009-06-30 2012-10-25 Ranbaxy Laboratories Limited Processes for the preparation of form i and form ii of palonosetron hydrochloride
WO2011013095A1 (en) 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Processes for the preparation of palonosetron
JP2014070036A (ja) * 2012-09-28 2014-04-21 Mitsubishi Gas Chemical Co Inc １，８−テトラリンジカルボン酸無水物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007191A (en) * 1975-10-14 1977-02-08 E. R. Squibb & Sons, Inc. 2-(Piperidinyl or tetrahydropyridinyl)-alkyl)-2,3-dihydro-3-hydroxy-1H-benz(DE)isoquinolin-1-ones
IL96486A (en) * 1989-11-28 1995-03-30 Syntex Inc Preparation tricyclic compounds and pharmaceutical preparations containing them
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes

Also Published As

Publication number Publication date
DE69522808D1 (de) 2001-10-25
AU2979995A (en) 1996-02-09
CN1048727C (zh) 2000-01-26
CN1152313A (zh) 1997-06-18
FI120198B (fi) 2009-07-31
CL2004001244A1 (es) 2005-04-15
MX9700157A (es) 1997-04-30
EP0770077B1 (de) 2001-09-19
WO1996001824A1 (en) 1996-01-25
JPH09508645A (ja) 1997-09-02
DK0770077T3 (da) 2002-01-14
CY2342B1 (en) 2004-02-06
FI970068A0 (fi) 1997-01-07
BR9508249A (pt) 1998-01-06
CL2007001958A1 (es) 2008-02-22
DE69522808T2 (de) 2002-04-04
JP2898758B2 (ja) 1999-06-02
ES2162929T3 (es) 2002-01-16
FI970068A (fi) 1997-01-07
EP0770077A1 (de) 1997-05-02
PT770077E (pt) 2002-02-28
US5567818A (en) 1996-10-22

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UEP Publication of translation of european patent specification