DE69616446T2 - Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden - Google Patents
Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxidenInfo
- Publication number
- DE69616446T2 DE69616446T2 DE69616446T DE69616446T DE69616446T2 DE 69616446 T2 DE69616446 T2 DE 69616446T2 DE 69616446 T DE69616446 T DE 69616446T DE 69616446 T DE69616446 T DE 69616446T DE 69616446 T2 DE69616446 T2 DE 69616446T2
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- halohydrines
- epoxides
- haloketones
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3926695 | 1995-02-03 | ||
JP27354795 | 1995-09-26 | ||
PCT/JP1996/000212 WO1996023756A1 (fr) | 1995-02-03 | 1996-02-02 | PROCEDES DE PRODUCTION D'α-HALOCETONES, D'α-HALOHYDRINES ET D'EPOXYDES |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69616446D1 DE69616446D1 (de) | 2001-12-06 |
DE69616446T2 true DE69616446T2 (de) | 2002-05-16 |
Family
ID=26378596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69616446T Expired - Lifetime DE69616446T2 (de) | 1995-02-03 | 1996-02-02 | Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden |
Country Status (9)
Country | Link |
---|---|
US (2) | US5929284A (de) |
EP (1) | EP0754669B1 (de) |
JP (1) | JP3665343B2 (de) |
KR (1) | KR100411856B1 (de) |
CN (1) | CN1091088C (de) |
CA (1) | CA2186483A1 (de) |
DE (1) | DE69616446T2 (de) |
ES (1) | ES2167541T3 (de) |
WO (1) | WO1996023756A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1097919A3 (de) | 1995-11-17 | 2003-08-06 | Ajinomoto Co., Inc. | Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters |
HU228370B1 (en) * | 1996-08-05 | 2013-03-28 | Bayer Ag | Pesticidal phenyl-substituted heterocyclic ketoenol derivatives, intermediates, preparation and use thereof |
US6107511A (en) * | 1998-07-29 | 2000-08-22 | Kaneka Corporation | Process for the purification or isolation of (2S,3R)-1-halo-2-hydroxy-3-(protected amino)4-phenylthiobutanes or optical antipodes thereof |
EP1661893A3 (de) * | 1999-01-29 | 2006-06-07 | Kaneka Corporation | Verfahren zur Herstellung von threo-1,2-epoxy-3-amino-4-phenylbutan-Derivaten |
KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
US6764545B2 (en) * | 2000-12-12 | 2004-07-20 | Ajinomoto Co., Inc. | Production method of epoxide crystal |
US6888012B2 (en) | 2000-12-25 | 2005-05-03 | Ajinomoto Co., Inc. | Process for producing optically active halohydrin compound |
DE10143742A1 (de) * | 2001-09-06 | 2003-03-27 | Consortium Elektrochem Ind | Verfahren zur Herstellung von alpha-Halogenketonen |
JPWO2003040382A1 (ja) * | 2001-11-09 | 2005-03-03 | 株式会社カネカ | 光学活性クロマン誘導体の製造法および中間体 |
US20040030199A1 (en) * | 2002-01-29 | 2004-02-12 | Maughon Robert R. | Process for reducing alpha-haloketones to secondary alpha-haloalcohols |
JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | (3R,3aS,6aR)−ヘキサヒドロフロ〔2,3−b〕フラン−3−イル(1S,1R)−3−〔〔(4−アミノフェニル)スルホニル〕(イソブチル)アミノ〕−1−ベンジル−2−ヒドロキシプロピルカルバマートの製造方法 |
KR101192859B1 (ko) | 2003-12-23 | 2012-10-19 | 얀센 알 앤드 디 아일랜드 | (3r,3as,6ar)-헥사하이드로푸로〔2,3-b〕푸란-3-일(1s,2r)-3-〔〔(4-아미노페닐)설포닐〕(이소부틸)아미노〕-1-벤질-2-하이드록시프로필카바메이트의 제조방법 |
GB0417824D0 (en) * | 2004-08-11 | 2004-09-15 | Phoenix Chemicals Ltd | Process for asymmetric catalytic hydrogenation |
WO2006051723A1 (ja) * | 2004-11-09 | 2006-05-18 | Kaneka Corporation | 1-ハロ-3-アリール-2-プロパノン類の製造法 |
BRPI0718706B8 (pt) | 2006-11-09 | 2021-05-25 | Janssen R & D Ireland | métodos para a preparação de hexa-hidrofuro[2,3- b]furan-3-ol |
ATE498606T1 (de) | 2007-04-27 | 2011-03-15 | Tibotec Pharm Ltd | Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzolsulfonylamidderivate |
AR073248A1 (es) | 2008-09-01 | 2010-10-20 | Tibotec Pharm Ltd | Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. |
CA2744985C (en) | 2008-12-01 | 2014-05-06 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring useful for the prevention or treatment of hyperlipidemia |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
ES2516916T3 (es) | 2010-01-28 | 2014-10-31 | Mapi Pharma Limited | Procedimiento para la preparación de darunavir e intermedios de darunavir |
ITUB20160227A1 (it) * | 2016-01-21 | 2017-07-21 | Menarini Int Operations Luxembourg Sa | Processo per la sintesi di intermedi di Nebivololo |
CN109896942A (zh) * | 2017-12-07 | 2019-06-18 | 孙建 | 一种α-羟基酮光引发剂的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1793243A1 (de) * | 1968-08-21 | 1971-09-02 | Bayer Ag | Verfahren zur Herstellung von halogenierten sekundaeren Alkoholen |
US5101068A (en) * | 1990-02-16 | 1992-03-31 | Prototek Inc. | Magnesium fluoromalonates |
DE4025188A1 (de) * | 1990-08-09 | 1992-02-13 | Bayer Ag | Verfahren zur herstellung von halogenmethylketonen, insbesondere von 1,1,1-trifluoraceton |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
US5475136A (en) * | 1992-12-22 | 1995-12-12 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
DE4321017A1 (de) * | 1993-06-24 | 1995-01-05 | Solvay Fluor & Derivate | Verfahren zur Herstellung von Ketonen unter Umesterung mit Trifluoressigsäure |
US5495054A (en) * | 1994-05-31 | 1996-02-27 | Sepracor, Inc. | Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts |
US5591885A (en) * | 1994-09-23 | 1997-01-07 | Hoffman-La Roche Inc. | Process for the preparation of halogenated α-aminoketone compounds |
US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
CA2137406C (en) * | 1994-12-06 | 2005-09-13 | Pierre Louis Beaulieu | Process for key intermediates for hiv protease inhibitors |
US5481011A (en) * | 1994-12-13 | 1996-01-02 | Bristol-Myers Squibb Company | Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters |
US5693847A (en) * | 1995-04-19 | 1997-12-02 | Vertex Pharmaceuticals Incorporated | Heteroatom functionalized α-methyl ketones |
-
1996
- 1996-02-02 WO PCT/JP1996/000212 patent/WO1996023756A1/ja active IP Right Grant
- 1996-02-02 CA CA002186483A patent/CA2186483A1/en not_active Abandoned
- 1996-02-02 US US08/722,102 patent/US5929284A/en not_active Expired - Lifetime
- 1996-02-02 CN CN96190075A patent/CN1091088C/zh not_active Expired - Fee Related
- 1996-02-02 JP JP52342096A patent/JP3665343B2/ja not_active Expired - Fee Related
- 1996-02-02 DE DE69616446T patent/DE69616446T2/de not_active Expired - Lifetime
- 1996-02-02 KR KR1019960705529A patent/KR100411856B1/ko not_active IP Right Cessation
- 1996-02-02 ES ES96901520T patent/ES2167541T3/es not_active Expired - Lifetime
- 1996-02-02 EP EP96901520A patent/EP0754669B1/de not_active Expired - Lifetime
-
1997
- 1997-08-08 US US08/907,461 patent/US5936104A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR970702234A (ko) | 1997-05-13 |
CA2186483A1 (en) | 1996-08-08 |
US5936104A (en) | 1999-08-10 |
KR100411856B1 (ko) | 2004-05-20 |
ES2167541T3 (es) | 2002-05-16 |
DE69616446D1 (de) | 2001-12-06 |
WO1996023756A1 (fr) | 1996-08-08 |
JP3665343B2 (ja) | 2005-06-29 |
EP0754669B1 (de) | 2001-10-31 |
CN1091088C (zh) | 2002-09-18 |
EP0754669A4 (de) | 1997-12-03 |
US5929284A (en) | 1999-07-27 |
CN1146760A (zh) | 1997-04-02 |
EP0754669A1 (de) | 1997-01-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |