ES2167541T3 - Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos. - Google Patents
Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos.Info
- Publication number
- ES2167541T3 ES2167541T3 ES96901520T ES96901520T ES2167541T3 ES 2167541 T3 ES2167541 T3 ES 2167541T3 ES 96901520 T ES96901520 T ES 96901520T ES 96901520 T ES96901520 T ES 96901520T ES 2167541 T3 ES2167541 T3 ES 2167541T3
- Authority
- ES
- Spain
- Prior art keywords
- production
- alfa
- epoxides
- ketone
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
Abstract
PROCESO PARA LA PRODUCCION EFICIENTE DE AL -HALO CETONAS, {AL}-HALOHIDRINAS Y EPOXIDOS A ESCALA INDUSTRIAL. EL PROCESO INCLUYE UNA FASE PARA LA PRODUCCION DE UNA {AL}-HALO CETONA DE FORMULA GENERAL (3) MEDIANTE LA DECARBOXILACION DE UN PRODUCTO DE LA REACCION ENTRE UN DERIVADO DE ACIDO CARBOXILICO DE FORMULA GENERAL (1) Y UN ENOLATO DE METAL PREPARADO A PARTIR DE UN ACIDO {AL}-HALOACETICO DE FORMULA GENERAL (2) O UNA SAL ACEPTABLE DEL MISMO, UNA FASE PARA LA PRODUCCION DE UNA {AL}-HALO CETONA MEDIANTE LA REDUCCION DE LA {AL}-HALO CETONA (3) Y UN PROCESO PARA LA PRODUCCION DE UN EPOXIDO (13) MEDIANTE LA PRODUCCION DE UNA {AL}-HALOHIDRINA (11) CON UNA BASE QUE EFECTUA UNA CICLIZACION. LOS PROCESOS ANTERIORES SON PARTICULARMENTE ACTIVOS PARA LA PRODUCCION DE {AL}-HALO CETONAS OPTICAMENTE ACTIVAS, {AL}-HALOHIDRINAS Y EPOXIDOS A PARTIR DE LOS DERIVADOS DE {AL}AMINOACIDO CORRESPONDIENTES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3926695 | 1995-02-03 | ||
JP27354795 | 1995-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2167541T3 true ES2167541T3 (es) | 2002-05-16 |
Family
ID=26378596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96901520T Expired - Lifetime ES2167541T3 (es) | 1995-02-03 | 1996-02-02 | Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5929284A (es) |
EP (1) | EP0754669B1 (es) |
JP (1) | JP3665343B2 (es) |
KR (1) | KR100411856B1 (es) |
CN (1) | CN1091088C (es) |
CA (1) | CA2186483A1 (es) |
DE (1) | DE69616446T2 (es) |
ES (1) | ES2167541T3 (es) |
WO (1) | WO1996023756A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0774453B1 (en) | 1995-11-17 | 2002-02-06 | Ajinomoto Co., Inc. | Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
DK0915846T3 (da) * | 1996-08-05 | 2003-08-11 | Bayer Cropscience Ag | 2- og 2,5-substituerede phenylketoenoler |
US6107511A (en) * | 1998-07-29 | 2000-08-22 | Kaneka Corporation | Process for the purification or isolation of (2S,3R)-1-halo-2-hydroxy-3-(protected amino)4-phenylthiobutanes or optical antipodes thereof |
EP1661893A3 (en) * | 1999-01-29 | 2006-06-07 | Kaneka Corporation | Process for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives |
KR100708221B1 (ko) * | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
US6764545B2 (en) * | 2000-12-12 | 2004-07-20 | Ajinomoto Co., Inc. | Production method of epoxide crystal |
JPWO2002051781A1 (ja) * | 2000-12-25 | 2004-04-22 | 味の素株式会社 | 光学活性ハロヒドリン化合物の製造方法 |
DE10143742A1 (de) * | 2001-09-06 | 2003-03-27 | Consortium Elektrochem Ind | Verfahren zur Herstellung von alpha-Halogenketonen |
EP1445324A4 (en) * | 2001-11-09 | 2005-02-16 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE PRODUCT |
US20040030199A1 (en) * | 2002-01-29 | 2004-02-12 | Maughon Robert R. | Process for reducing alpha-haloketones to secondary alpha-haloalcohols |
EP1725566B1 (en) | 2003-12-23 | 2009-06-17 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
ME01059B (me) | 2003-12-23 | 2012-10-20 | Janssen Sciences Ireland Uc | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata |
GB0417824D0 (en) * | 2004-08-11 | 2004-09-15 | Phoenix Chemicals Ltd | Process for asymmetric catalytic hydrogenation |
WO2006051723A1 (ja) * | 2004-11-09 | 2006-05-18 | Kaneka Corporation | 1-ハロ-3-アリール-2-プロパノン類の製造法 |
BRPI0718706B8 (pt) | 2006-11-09 | 2021-05-25 | Janssen R & D Ireland | métodos para a preparação de hexa-hidrofuro[2,3- b]furan-3-ol |
MX2009011574A (es) | 2007-04-27 | 2009-11-09 | Tibotec Pharm Ltd | Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida. |
TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備(3r,3as,6ar)-六氫呋喃并〔2,3-b〕呋喃-3-基(1s,2r)-3-〔〔(4-胺基苯基)磺醯基〕(異丁基)胺基〕-1-苯甲基-2-羥基丙基胺基甲酸酯之方法 |
US8497382B2 (en) | 2008-12-01 | 2013-07-30 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
CN102725295A (zh) | 2010-01-28 | 2012-10-10 | Mapi医药公司 | 制备达芦那韦和达芦那韦中间体的方法 |
ITUB20160227A1 (it) * | 2016-01-21 | 2017-07-21 | Menarini Int Operations Luxembourg Sa | Processo per la sintesi di intermedi di Nebivololo |
CN109896942A (zh) * | 2017-12-07 | 2019-06-18 | 孙建 | 一种α-羟基酮光引发剂的制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1793243A1 (de) * | 1968-08-21 | 1971-09-02 | Bayer Ag | Verfahren zur Herstellung von halogenierten sekundaeren Alkoholen |
US5101068A (en) * | 1990-02-16 | 1992-03-31 | Prototek Inc. | Magnesium fluoromalonates |
DE4025188A1 (de) * | 1990-08-09 | 1992-02-13 | Bayer Ag | Verfahren zur herstellung von halogenmethylketonen, insbesondere von 1,1,1-trifluoraceton |
US5482947A (en) * | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
US5475136A (en) * | 1992-12-22 | 1995-12-12 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
DE4321017A1 (de) * | 1993-06-24 | 1995-01-05 | Solvay Fluor & Derivate | Verfahren zur Herstellung von Ketonen unter Umesterung mit Trifluoressigsäure |
US5495054A (en) * | 1994-05-31 | 1996-02-27 | Sepracor, Inc. | Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts |
US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
US5591885A (en) * | 1994-09-23 | 1997-01-07 | Hoffman-La Roche Inc. | Process for the preparation of halogenated α-aminoketone compounds |
CA2137406C (en) * | 1994-12-06 | 2005-09-13 | Pierre Louis Beaulieu | Process for key intermediates for hiv protease inhibitors |
US5481011A (en) * | 1994-12-13 | 1996-01-02 | Bristol-Myers Squibb Company | Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters |
US5693847A (en) * | 1995-04-19 | 1997-12-02 | Vertex Pharmaceuticals Incorporated | Heteroatom functionalized α-methyl ketones |
-
1996
- 1996-02-02 JP JP52342096A patent/JP3665343B2/ja not_active Expired - Fee Related
- 1996-02-02 ES ES96901520T patent/ES2167541T3/es not_active Expired - Lifetime
- 1996-02-02 US US08/722,102 patent/US5929284A/en not_active Expired - Lifetime
- 1996-02-02 KR KR1019960705529A patent/KR100411856B1/ko not_active IP Right Cessation
- 1996-02-02 CN CN96190075A patent/CN1091088C/zh not_active Expired - Fee Related
- 1996-02-02 WO PCT/JP1996/000212 patent/WO1996023756A1/ja active IP Right Grant
- 1996-02-02 DE DE69616446T patent/DE69616446T2/de not_active Expired - Lifetime
- 1996-02-02 EP EP96901520A patent/EP0754669B1/en not_active Expired - Lifetime
- 1996-02-02 CA CA002186483A patent/CA2186483A1/en not_active Abandoned
-
1997
- 1997-08-08 US US08/907,461 patent/US5936104A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996023756A1 (fr) | 1996-08-08 |
DE69616446D1 (de) | 2001-12-06 |
US5929284A (en) | 1999-07-27 |
EP0754669A1 (en) | 1997-01-22 |
KR970702234A (ko) | 1997-05-13 |
CN1146760A (zh) | 1997-04-02 |
CA2186483A1 (en) | 1996-08-08 |
JP3665343B2 (ja) | 2005-06-29 |
CN1091088C (zh) | 2002-09-18 |
DE69616446T2 (de) | 2002-05-16 |
EP0754669B1 (en) | 2001-10-31 |
US5936104A (en) | 1999-08-10 |
KR100411856B1 (ko) | 2004-05-20 |
EP0754669A4 (en) | 1997-12-03 |
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