ES2147183T3 - Nuevos derivados de acido metilenobisfosfonico. - Google Patents

Nuevos derivados de acido metilenobisfosfonico.

Info

Publication number
ES2147183T3
ES2147183T3 ES92900615T ES92900615T ES2147183T3 ES 2147183 T3 ES2147183 T3 ES 2147183T3 ES 92900615 T ES92900615 T ES 92900615T ES 92900615 T ES92900615 T ES 92900615T ES 2147183 T3 ES2147183 T3 ES 2147183T3
Authority
ES
Spain
Prior art keywords
hydrogen
groups
alkyl
branched
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900615T
Other languages
English (en)
Inventor
Hannu Nikander
Marjaana Heikkila-Hoikka
Esko Pohjala
Hannu Hanhijarvi
Leena Lauren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Oy
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Application granted granted Critical
Publication of ES2147183T3 publication Critical patent/ES2147183T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)

Abstract

NUEVOS METILENOBISFOSFONATOS ACTIVOS FARMACOLOGICAMENTE QUE TIENEN LA FORMULA (I), EN LA QUE R1, R2, R3 Y R4 SON ALQUILO C1C10 OPCIONALMENTE INSATURADOS, ESTIRADOS O RAMIFICADOS DE MODO INDEPENDIENTE, CICLOALQUILO C3-C10 OPCIONALMENTE INSATURADOS, ARILO, ARALQUILO, SILILO, SIR3 O HIDROGENO, PARA LO CUAL EN LA FORMULA (I) POR LO MENOS UNO DE LOS GRUPOS R1, R2, R3 Y R4 ES HIDROGENO Y POR LO MENOS UNO DE LOS GRUPOS ES DIFERENTE DEL HIDROGENO, Q1 ES HIDROGENO, HIDROXILO, HALOGENO, AMINO NH2, U OR'', EN LA QUE R'' ES ALQUILO ACILO C1-C4 INFERIOR, Q2 ES ALQUILO C1-C10 OPCIONALMENTE INSATURADO, ESTIRADO O RAMIFICADO, HIDROXIALQUILO C1-C10 O AMINOALQUILO C1-C10, PARA LO CUAL EL OXIGENO, COMO UN SUSTITUYENTE, PUEDE CONTENER UN GRUPO O EL NITROGENO COMO UN SUSTITUYENTE PUEDE CONTENER UNO O DOS GRUPOS, LOS CUALES SON ALQUILO O ACILO C1-C4 INFERIOR, O LOS DOS SUSTITUYENTES DEL NITROGENO FORMAN JUNTOS CON EL ATOMO DE NITROGENO UN ANILLO SATURADO, PARCIALMENTE SATURADO O UN ANILLO HETEROCICLICO AROMATICO,O Q2 ES CICLOALQUILO C3-C10 OPCIONALMENTE SUSTITUIDO Y OPCIONALMENTE INSATURADO, EL CUAL OPCIONALMENTE ESTA LIGADO A LA MOLECULA POR MEDIO DE UN GRUPO ALQUILENO ESTIRADO O RAMIFICADO QUE CONTIENE 1 A 4 ATOMOS DE C, INCLUYENDO LOS ESTEREOISOMEROS, TALES COMO LOS ISOMEROS GEOMETRICOS Y LOS ISOMEROS ACTIVOS OPTICAMENTE DE LOS COMPUESTOS, ASI COMO LAS SALES ACEPTABLES FARMACOLOGICAMENTE DE ESTOS COMPUESTOS.
ES92900615T 1990-12-20 1991-12-18 Nuevos derivados de acido metilenobisfosfonico. Expired - Lifetime ES2147183T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI906294A FI89364C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (1)

Publication Number Publication Date
ES2147183T3 true ES2147183T3 (es) 2000-09-01

Family

ID=8531619

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900615T Expired - Lifetime ES2147183T3 (es) 1990-12-20 1991-12-18 Nuevos derivados de acido metilenobisfosfonico.

Country Status (25)

Country Link
US (1) US5438048A (es)
EP (1) EP0563096B1 (es)
JP (1) JP3347324B2 (es)
KR (1) KR100233986B1 (es)
CN (1) CN1030609C (es)
AT (1) ATE192451T1 (es)
AU (1) AU665342B2 (es)
CA (1) CA2098732C (es)
CZ (1) CZ287453B6 (es)
DE (1) DE69132163T2 (es)
DK (1) DK0563096T3 (es)
EE (1) EE02948B1 (es)
ES (1) ES2147183T3 (es)
FI (1) FI89364C (es)
HU (1) HUT64546A (es)
IE (1) IE914388A1 (es)
IL (1) IL100338A (es)
NO (1) NO301590B1 (es)
NZ (1) NZ241041A (es)
PL (1) PL169772B1 (es)
RU (1) RU2079504C1 (es)
SK (1) SK281788B6 (es)
TW (1) TW203054B (es)
WO (1) WO1992011267A1 (es)
ZA (1) ZA9110009B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
RU2124881C1 (ru) * 1997-11-26 1999-01-20 Матковская Татьяна Александровна Наружное лечебно-косметическое средство
AU6991400A (en) * 1999-08-03 2001-02-19 Amersham Plc Radiolabelled bisphosphonates and method
PL196485B1 (pl) * 2000-05-11 2008-01-31 Inst Farmaceutyczny Stała doustna kompozycja farmaceutyczna zawierająca aminową pochodną kwasu bisfosfonowego i sposób jej wytwarzania
PT1328277E (pt) * 2000-10-27 2007-05-31 Schering Ag Compostos bisfosfónicos para o fortalecimento do osso cortical.
CA2431515C (en) * 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
CZ20032950A3 (cs) * 2001-05-02 2004-06-16 Novartis Ag Léčiva s obsahem bisfosfonátů pro léčení karcinomu prostaty
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
WO2003008425A1 (fr) * 2001-07-16 2003-01-30 Universite Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
FR2837490B1 (fr) * 2002-03-21 2009-04-17 Univ Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
WO2010035664A1 (ja) * 2008-09-24 2010-04-01 田辺三菱製薬株式会社 ビスホスホン酸誘導体の製法
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用
TWI730039B (zh) * 2016-01-29 2021-06-11 日商富士藥品股份有限公司 新穎雙膦酸化合物
CN121471259A (zh) * 2026-01-08 2026-02-06 浙江工业大学 一种双膦酸及其盐类化合物、其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
DE1202441B (de) * 1963-03-02 1965-10-07 Therachemie Chem Therapeut Mittel zur Verminderung der Schaedigung von Haaren beim Bleichen und Faerben
DE1617118C3 (de) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Verfahren zur Reinigung von etikettierten starren Gegenständen
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
CH555894A (fr) * 1972-08-10 1974-11-15 Oxy Metal Industries Corp Utilisation de derives organophosphores dans les bains sulfitiques pour l'electrodeposition de l'or et des alliages d'or.
US4113861A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Phosphonate pharmaceutical composition
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4634691A (en) * 1980-10-07 1987-01-06 The Procter & Gamble Company Method for inhibiting tumor metastasis
DE3225469A1 (de) * 1982-07-05 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
US4818774A (en) * 1986-03-10 1989-04-04 Occidental Chemical Corporation Organophosphorus compounds
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
KR100233986B1 (ko) 1999-12-15
DK0563096T3 (da) 2000-09-25
SK281788B6 (sk) 2001-07-10
IL100338A (en) 1998-01-04
RU2079504C1 (ru) 1997-05-20
FI89364B (fi) 1993-06-15
KR930703334A (ko) 1993-11-29
IE914388A1 (en) 1992-07-01
NO932254D0 (no) 1993-06-18
CZ287453B6 (cs) 2000-11-15
SK62993A3 (en) 1993-12-08
DE69132163D1 (de) 2000-06-08
AU665342B2 (en) 1996-01-04
CA2098732A1 (en) 1992-06-21
US5438048A (en) 1995-08-01
CA2098732C (en) 2002-03-05
EP0563096B1 (en) 2000-05-03
CN1030609C (zh) 1996-01-03
EE02948B1 (et) 1996-12-16
NO932254L (no) 1993-08-19
JPH06504045A (ja) 1994-05-12
WO1992011267A1 (en) 1992-07-09
DE69132163T2 (de) 2001-01-11
HU9301779D0 (en) 1993-09-28
FI906294A0 (fi) 1990-12-20
NO301590B1 (no) 1997-11-17
TW203054B (es) 1993-04-01
JP3347324B2 (ja) 2002-11-20
ATE192451T1 (de) 2000-05-15
FI906294A7 (fi) 1992-06-21
FI89364C (fi) 1993-09-27
ZA9110009B (en) 1992-09-30
PL169772B1 (pl) 1996-08-30
CZ119893A3 (en) 1994-02-16
IL100338A0 (en) 1992-09-06
AU9074991A (en) 1992-07-22
NZ241041A (en) 1994-09-27
EP0563096A1 (en) 1993-10-06
HUT64546A (en) 1994-01-28
CN1062532A (zh) 1992-07-08

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