ES2010224A6 - Procediniento para la obtencion de nuevas composciones farmaceuticasa base de diclofenac. - Google Patents

Procediniento para la obtencion de nuevas composciones farmaceuticasa base de diclofenac.

Info

Publication number
ES2010224A6
ES2010224A6 ES8701870A ES8701870A ES2010224A6 ES 2010224 A6 ES2010224 A6 ES 2010224A6 ES 8701870 A ES8701870 A ES 8701870A ES 8701870 A ES8701870 A ES 8701870A ES 2010224 A6 ES2010224 A6 ES 2010224A6
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
novel pharmaceutical
topical application
systemic action
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701870A
Other languages
English (en)
Inventor
Peter Fankhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES2010224A6 publication Critical patent/ES2010224A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVAS COMPOSICIONES FARMACEUTICAS A BASE DE DICLOFENAC. COMPRENDE MEZCLAR: A) DICLOFENAC O UNA SAL FARMACEUTICAMENTE EMPLEABLE DEL MISM; B) UN COMPUESTO REFORZADOR DE LA CAPACIDAD DE PERMEACION DEL COMPONENTE (A), DE FORMULA (I): EN LA QUE R1 ES ALQUILO DE 9 A 19 ATOMOS DE CARBONO Y R2 Y R3 SON ACIDO DE 1 A 4 ATOMOS DE CARBONO, O DONDE R1 ESTA ENLAZADO CON UNO DE LOS RESTOS R2 Y R3 Y SON CONJUNTAMENTE ALQUILENO CON 5 A 7 ATOMOS DE CARBONO Y EL OTRO RESTO R2 Y R3 ES ALQUILO CON 10 A 20 ATOMOS DE CARBONO Y, EN CASO DADO, C) PARAFINAS ADECUADAS PARA EMPLEO TOPICO; Y, EN CASO DADO, D) OTROS PRODUCTOS AUXILIARES EMPLEABLES PARA PERCUTANTOPICOS. LAS COMPOSICIONES POSEEN EXCELENTES PROPIEDADES DE PENETRACION EN LA PIEL Y SE PUEDEN EMPLEAR POR LO TANTO EN LOS SISTEMAS TERAPEUTICOS TRANSDERMALES (TTS) COMO RESERVA DE LA SUSTANCIA ACTIVA.
ES8701870A 1986-06-27 1987-06-26 Procediniento para la obtencion de nuevas composciones farmaceuticasa base de diclofenac. Expired ES2010224A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2597/86A CH666621A5 (de) 1986-06-27 1986-06-27 Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung.

Publications (1)

Publication Number Publication Date
ES2010224A6 true ES2010224A6 (es) 1989-11-01

Family

ID=4237351

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701870A Expired ES2010224A6 (es) 1986-06-27 1987-06-26 Procediniento para la obtencion de nuevas composciones farmaceuticasa base de diclofenac.

Country Status (27)

Country Link
US (1) US4999379A (es)
JP (1) JPS638329A (es)
KR (1) KR880000093A (es)
AT (1) AT397199B (es)
AU (1) AU612323B2 (es)
BE (1) BE1000233A4 (es)
CA (1) CA1315692C (es)
CH (1) CH666621A5 (es)
DD (1) DD263448A5 (es)
DE (1) DE3720896A1 (es)
DK (1) DK326587A (es)
ES (1) ES2010224A6 (es)
FI (1) FI872808A (es)
FR (1) FR2601588B1 (es)
GB (1) GB2192539B (es)
GR (1) GR871002B (es)
HU (1) HU197984B (es)
IT (1) IT1216827B (es)
LU (1) LU86929A1 (es)
MY (1) MY101570A (es)
NL (1) NL8701508A (es)
NO (1) NO872685L (es)
NZ (1) NZ220861A (es)
PH (1) PH26781A (es)
PT (1) PT85158B (es)
SE (1) SE8702642L (es)
ZA (1) ZA874621B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902676A (en) * 1986-09-29 1990-02-20 Nelson Research & Development Co. Compositions comprising N,N-dialkylalkanamides
US4808414A (en) * 1986-09-29 1989-02-28 Nelson Research & Development Co. Amide penetration enhancers for transdermal delivery of systemic agents
CA1334646C (en) * 1988-04-08 1995-03-07 James Vanolden Peck Transdermal penetration enhancers
JPH04193826A (ja) * 1990-11-27 1992-07-13 Shirogane Seiyaku Kk ジクロフェナクナトリウム含有の経皮吸収型消炎・鎮痛貼布剤
DE9016291U1 (de) * 1990-11-30 1991-03-28 Kali-Chemie Pharma Gmbh, 3000 Hannover Topisch applizierbare Diclofenac-Zubereitungen
ATE121724T1 (de) * 1991-02-07 1995-05-15 Heumann Pharma Gmbh & Co Neue salze der 2-(2,6-dichloranilino)- phenylessigsäure, verfahren zu ihrer herstellung und ihre verwendung für topisch anwendbare pharmazeutische zubereitungen.
EP0592569A1 (en) * 1991-07-03 1994-04-20 Sano Corporation Composition and method for transdermal delivery of diclofenac
JP2523428B2 (ja) * 1992-12-04 1996-08-07 エスエス製薬株式会社 消炎鎮痛ゲル製剤
WO1994023748A1 (en) * 1993-04-08 1994-10-27 The University Of Queensland Administration of vaso-active agent and therapeutic agent
DE4313402A1 (de) * 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermale Wirkstoffzubereitung
US5474985A (en) * 1993-12-22 1995-12-12 The Regents Of The University Of California Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
EP0788794A4 (en) * 1994-08-09 2000-06-28 Tsumura & Co COMPOSITION FOR PREPARATION FOR EXTERNAL USE
US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
CA2201134A1 (en) * 1994-10-10 1996-04-18 Alfred Sallmann Ophthalmic and aural compositions containing diclofenac potassium
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US5674888A (en) * 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
EP0879597A4 (en) * 1996-02-07 2001-01-31 Tsumura & Co TRANSPARENT AQUEOUS SOLUTION OF DICLOFENAC SODIUM, MEDICINAL COMPOSITIONS, AND USES
KR19990026792A (ko) * 1997-09-26 1999-04-15 김윤 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
JP4854163B2 (ja) * 2000-04-18 2012-01-18 久光製薬株式会社 抗炎症剤含有貼付剤
JP4865958B2 (ja) * 2001-05-23 2012-02-01 株式会社トクホン 鎮痛抗炎症局所作用型の貼付剤
DE102007038413A1 (de) * 2007-08-09 2009-02-12 Beiersdorf Ag Kosmetische Emulgatorkombination
ITMI20111355A1 (it) 2011-07-20 2013-01-21 Epifarma Srl Cerotto transdermico contenente diclofenac e tiocolchicoside
WO2014068600A1 (en) 2012-11-02 2014-05-08 Zydus Technologies Limited Stable transdermal pharmaceutical drug delivery system comprising diclofenac
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US3989816A (en) * 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4405616A (en) * 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US4444762A (en) * 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
CH655656B (es) * 1982-10-07 1986-05-15
CA1225594A (en) * 1983-05-20 1987-08-18 Jourge Heller Method for percutaneously administering physiologically active agents
EP0139127A1 (en) * 1983-08-22 1985-05-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Transdermal drug delivery device and its preparation
DE3344691A1 (de) * 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
JPS60156080A (ja) * 1984-01-25 1985-08-16 Konishiroku Photo Ind Co Ltd 温度制御手段を備えた複写装置
EP0156080B2 (en) * 1984-03-05 1993-10-20 Nitto Denko Corporation Percutaneous absorption type adhesive pharmaceutical preparation
JPH06104624B2 (ja) * 1986-05-07 1994-12-21 太郎 小木曽 経皮吸収剤

Also Published As

Publication number Publication date
GR871002B (en) 1987-10-20
KR880000093A (ko) 1988-03-23
DD263448A5 (de) 1989-01-04
JPS638329A (ja) 1988-01-14
BE1000233A4 (fr) 1988-09-20
SE8702642L (sv) 1987-12-28
FR2601588A1 (fr) 1988-01-22
MY101570A (en) 1991-12-17
PH26781A (en) 1992-10-13
GB2192539A (en) 1988-01-20
HUT44180A (en) 1988-02-29
CA1315692C (en) 1993-04-06
PT85158A (en) 1987-07-01
GB2192539B (en) 1990-10-24
SE8702642D0 (sv) 1987-06-25
ZA874621B (en) 1988-02-24
PT85158B (pt) 1990-03-30
DK326587A (da) 1987-12-28
DE3720896A1 (de) 1988-01-14
AT397199B (de) 1994-02-25
FI872808A0 (fi) 1987-06-24
ATA160487A (de) 1993-07-15
GB8714625D0 (en) 1987-07-29
US4999379A (en) 1991-03-12
CH666621A5 (de) 1988-08-15
LU86929A1 (de) 1988-07-14
AU612323B2 (en) 1991-07-11
NL8701508A (nl) 1988-01-18
NO872685D0 (no) 1987-06-26
HU197984B (en) 1989-07-28
IT8748097A0 (it) 1987-06-24
NO872685L (no) 1987-12-28
AU7476287A (en) 1988-01-07
FI872808A (fi) 1987-12-28
NZ220861A (en) 1990-08-28
FR2601588B1 (fr) 1990-06-15
DK326587D0 (da) 1987-06-26
IT1216827B (it) 1990-03-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301