ES2053882T3 - Metodo para reducir la irritacion de la piel asociado con composiciones potenciadoras de penetracion del farmaco. - Google Patents
Metodo para reducir la irritacion de la piel asociado con composiciones potenciadoras de penetracion del farmaco.Info
- Publication number
- ES2053882T3 ES2053882T3 ES89114676T ES89114676T ES2053882T3 ES 2053882 T3 ES2053882 T3 ES 2053882T3 ES 89114676 T ES89114676 T ES 89114676T ES 89114676 T ES89114676 T ES 89114676T ES 2053882 T3 ES2053882 T3 ES 2053882T3
- Authority
- ES
- Spain
- Prior art keywords
- skin irritation
- reducing skin
- composition
- irritation associated
- strengthening compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 206010040880 Skin irritation Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000036556 skin irritation Effects 0.000 title abstract 2
- 231100000475 skin irritation Toxicity 0.000 title abstract 2
- 230000035515 penetration Effects 0.000 title 1
- 238000005728 strengthening Methods 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
UNA COMPOSICION Y METODO PARA REDUCIR LA PROPIEDAD IRRITANTE DE LA PIEL DE UNA COMPOSICION INCREMENTADORA DE LA PENETRACION MEDICAMENTOSA INTRADERMICA, QUE COMPRENDE, INCLUIDA EN DICHA COMPOSICION, ANTES O AL MISMO TIEMPO DE LA APLICACION EN LA PIEL, UNA CANTIDAD EFECTIVA DE GLICERINA. CUANDO SE INCLUYE EN LA COMPOSICION INCREMENTADORA MEDICAMENTOSA ANTES DE LA APLICACION EN LA PIEL, LA GLICERINA QUE CONTENGA SERA ENTRE 0,1 Y 70 WT.% APROXIMADAMENTE, PREFERIBLEMENTE ENTRE 1,0 Y 20 W.% Y MEJOR ENTRE 5,0 Y 20 WT.% DE LA COMPOSICION
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/240,688 US4855294A (en) | 1988-09-06 | 1988-09-06 | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2053882T3 true ES2053882T3 (es) | 1994-08-01 |
Family
ID=22907535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89114676T Expired - Lifetime ES2053882T3 (es) | 1988-09-06 | 1989-08-08 | Metodo para reducir la irritacion de la piel asociado con composiciones potenciadoras de penetracion del farmaco. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4855294A (es) |
EP (1) | EP0416137B1 (es) |
JP (1) | JP2953625B2 (es) |
KR (1) | KR0143916B1 (es) |
AT (1) | ATE96678T1 (es) |
CA (1) | CA1332570C (es) |
DE (1) | DE68910520T2 (es) |
ES (1) | ES2053882T3 (es) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0437225B1 (de) * | 1990-01-10 | 1994-04-20 | F. Hoffmann-La Roche Ag | Topische Präparate |
US5130139A (en) * | 1990-07-06 | 1992-07-14 | Alza Corporation | Reduction or prevention of skin irritation by drugs |
US5160741A (en) * | 1990-07-06 | 1992-11-03 | Alza Corporation | Reduction or prevention of skin irritation by drugs |
US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
US5705185A (en) * | 1991-09-25 | 1998-01-06 | Beta Pharmaceuticals Co. | Transdermal delivery of estradiol and process for manufacturing said device |
US5518734A (en) * | 1991-09-25 | 1996-05-21 | Beta Pharmaceuticals Co. | Transdermal delivery system for estradiol and process for manufacturing said device |
US5276079A (en) * | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
US6284754B1 (en) * | 1992-01-20 | 2001-09-04 | Schwarz Pharma Ag | Pharmaceutical compositions containing 1-oleylazacycloheptan-2-one as enhancing agent of transport across biological membranes |
JPH08501529A (ja) * | 1992-06-11 | 1996-02-20 | セラテック・インコーポレイテッド | 皮膚透過薬剤投与緩和のグリセリン使用 |
US5932227A (en) * | 1992-07-23 | 1999-08-03 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable base composition and drug composition prepared therefrom |
DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
DE19610396C2 (de) * | 1996-03-16 | 1998-11-26 | Krewel Meuselbach Gmbh | Dimethylsulfoxid-haltige topische Zubereitung |
JP2001503062A (ja) * | 1996-10-30 | 2001-03-06 | セラテック・インコーポレーテッド | 透過促進剤としての乳酸の脂肪酸エステルの塩 |
DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
ZA984649B (en) * | 1997-06-13 | 1999-12-17 | Cryopreservation Tech Cc | "Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes". |
CN1172674C (zh) * | 1997-11-10 | 2004-10-27 | 赛勒吉药物股份有限公司 | 促进渗透和减少刺激的系统 |
US6180133B1 (en) * | 1997-11-25 | 2001-01-30 | Watson Pharmaceuticals, Inc. | Antioxidant composition for topical/transdermal prevention and treatment of wrinkles |
US6136799A (en) * | 1998-04-08 | 2000-10-24 | Abbott Laboratories | Cosolvent formulations |
WO2000001351A1 (en) | 1998-07-07 | 2000-01-13 | Transdermal Technologies, Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
US6238683B1 (en) * | 1998-12-04 | 2001-05-29 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
US7179475B1 (en) | 1998-12-04 | 2007-02-20 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
WO2000072883A2 (en) * | 1999-06-02 | 2000-12-07 | Aviana Biopharm | Pharmaceutical transdermal compositions |
US6232366B1 (en) | 1999-06-09 | 2001-05-15 | 3M Innovative Properties Company | Pressure sensitive conductive adhesive having hot-melt properties and biomedical electrodes using same |
KR100369779B1 (ko) * | 1999-07-12 | 2003-01-29 | 주식회사 엘지생명과학 | 교감신경 흥분성 기관지확장 약물의 경피흡수 투여용 조성물및 이를 포함하는 경피흡수 투여용 제형 |
US7179483B2 (en) * | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
ATE338538T1 (de) * | 2000-05-01 | 2006-09-15 | Johnson & Johnson Consumer | Wasserfreie topische zubereitungen für die haut |
US20060121103A1 (en) * | 2000-05-11 | 2006-06-08 | Kenneth Kirby | Transdermal delivery system |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
DE10040592A1 (de) * | 2000-08-15 | 2002-03-07 | Aventis Res & Tech Gmbh & Co | Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung |
JP4358978B2 (ja) * | 2000-09-05 | 2009-11-04 | 日東電工株式会社 | 経皮吸収製剤 |
KR20030028253A (ko) * | 2001-09-27 | 2003-04-08 | (주)지씨아이 | 잔탄검과 알긴을 이용한 항고지단백혈증 경피투과제제의제조 |
US7921999B1 (en) * | 2001-12-20 | 2011-04-12 | Watson Laboratories, Inc. | Peelable pouch for transdermal patch and method for packaging |
US6765001B2 (en) * | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
MXPA05004278A (es) | 2002-10-25 | 2005-10-05 | Foamix Ltd | Espuma cosmetica y farmaceutica. |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US9278155B2 (en) | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
US20040247654A1 (en) * | 2003-06-05 | 2004-12-09 | 3M Innovative Properties Company | Hydrophilic adhesives for delivery of herbal medicines |
JP4596751B2 (ja) * | 2003-06-11 | 2010-12-15 | 帝國製薬株式会社 | 消炎鎮痛貼付剤 |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
DE102004009903A1 (de) * | 2004-02-26 | 2005-09-22 | Grünenthal GmbH | Pflaster mit reduzierter Hautirritation |
AU2005310072B2 (en) * | 2004-11-29 | 2011-06-02 | Ambria Dermatology Ab | A composition comprising at least 3 different diols |
CA2589549C (en) * | 2004-12-02 | 2011-05-17 | Omp, Inc. | System for improved percutaneous absorption of skin benefiting agents |
US7999023B2 (en) | 2004-12-03 | 2011-08-16 | 3M Innovative Properties Company | Process for making pressure sensitive adhesive hydrogels |
US10137135B2 (en) * | 2005-08-15 | 2018-11-27 | Allergan Sales, Llc | Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith |
US8147815B2 (en) * | 2005-12-16 | 2012-04-03 | Celmatrix Corporation | Topical administration carrier composition and therapeutic formulations comprising same |
US20070179121A1 (en) * | 2006-02-02 | 2007-08-02 | Plott R T | Method of treating pediatric patients with corticosteroids |
US7905852B2 (en) | 2006-05-16 | 2011-03-15 | Barbara Jennings-Spring | Skin-contacting-adhesive free dressing |
US7645252B2 (en) * | 2006-05-16 | 2010-01-12 | Barbara Brooke Jennings-Spring | Body or plant part dressing |
BRPI0717769A2 (pt) | 2006-10-17 | 2013-11-05 | Nuvo Res | Formulação de gel, método para o tratamento da osteoartrite em um indivíduo sofrendo de dor articular, e, uso de diclofenac de sódio |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US20080152592A1 (en) * | 2006-12-21 | 2008-06-26 | Bayer Healthcare Llc | Method of therapeutic drug monitoring |
WO2008092257A1 (en) * | 2007-01-29 | 2008-08-07 | National Research Council Of Canada | Use of catecholamines and related compounds as anti-angiogenic agents |
RU2428186C2 (ru) * | 2007-03-02 | 2011-09-10 | Теика Фармасьютикал Ко., Лтд. | Лекарственная композиция для чрескожной абсорбции, изделие, сохраняющее лекарственную композицию, и содержащий ее препарат для чрескожной абсорбции |
WO2008115224A2 (en) * | 2007-03-20 | 2008-09-25 | Bayer Healthcare Llc | Method of analyzing an analyte |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
EP2230911A4 (en) * | 2007-12-21 | 2013-07-03 | Zars Pharma Inc | STAMPS, FORMULATIONS, AND RELATED METHODS FOR THE TRANSDERMAL DELIVERY OF ALPRAZOLAM AND OTHER MEDICAMENTS |
EP2242476A2 (en) | 2008-01-14 | 2010-10-27 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
US8546450B1 (en) | 2009-03-31 | 2013-10-01 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US8174881B2 (en) | 2009-11-24 | 2012-05-08 | Micron Technology, Inc. | Techniques for reducing disturbance in a semiconductor device |
KR20150111970A (ko) | 2013-01-24 | 2015-10-06 | 아이리듬 테크놀로지스, 아이엔씨 | 생리학적 모니터링 기기 |
MX2016003922A (es) | 2013-09-30 | 2016-06-17 | 3M Innovative Properties Co | Copolimeros de silicona-polieter, adhesivos y articulos medicos que los comprenden, y metodos para elaborarlos. |
CN116530951A (zh) | 2014-10-31 | 2023-08-04 | 意锐瑟科技公司 | 无线生理监测装置和系统 |
US11612560B2 (en) * | 2015-09-08 | 2023-03-28 | The University Of Toledo | Treatment of Raynaud's phenomenon by inhibition of transient receptor potential melastatin-8 (TRPM-8) |
CN105833279B (zh) | 2016-05-30 | 2021-06-22 | 傅远桥 | 皮肤多种损伤创面治疗的外用药物组合物及其制备方法 |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
US9962444B2 (en) | 2016-09-27 | 2018-05-08 | Shane Malek | Pharmacokinetically extended action topical hair growth formulation, and administration method |
US10702495B2 (en) | 2017-02-20 | 2020-07-07 | Nexien Biopharma, Inc. | Method and compositions for treating dystrophies and myotonia |
US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
WO2020201878A1 (en) | 2019-04-01 | 2020-10-08 | 3M Innovative Properties Company | Process for making pressure sensitive adhesive hydrogels |
EP3750528A1 (en) | 2019-06-11 | 2020-12-16 | Nexien Biopharma, Inc. | Compositions for treating dystrophies and myotonia |
CN115426940A (zh) | 2020-02-12 | 2022-12-02 | 意锐瑟科技公司 | 非侵入性心脏监测器和使用记录的心脏数据推断患者生理特性的方法 |
KR20230047456A (ko) | 2020-08-06 | 2023-04-07 | 아이리듬 테크놀로지스, 아이엔씨 | 생리학적 모니터링 장치를 위한 전기 부품 |
KR20230047455A (ko) | 2020-08-06 | 2023-04-07 | 아이리듬 테크놀로지스, 아이엔씨 | 점착성 생리학적 모니터링 장치 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1408384A (en) * | 1920-06-21 | 1922-02-28 | Thomas J Newlyn | Cosmetic lotion |
CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
EP0095813A3 (en) * | 1982-06-01 | 1985-05-08 | THE PROCTER & GAMBLE COMPANY | Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine |
GR77517B (es) * | 1982-06-30 | 1984-09-24 | Procter & Gamble | |
EP0105657B1 (en) * | 1982-09-30 | 1992-05-27 | Lancaster Group Ag | Cosmetic compositions containing glycerine |
US4537776A (en) * | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
CA1248450A (en) * | 1984-04-05 | 1989-01-10 | Kazuo Kigasawa | Soft patch |
EP0267617B1 (en) * | 1986-11-14 | 1992-06-24 | Theratech, Inc. | Penetration enhancement with binary system of cell envelope disordering compounds and lower alcohols |
-
1988
- 1988-09-06 US US07/240,688 patent/US4855294A/en not_active Expired - Lifetime
-
1989
- 1989-08-08 EP EP89114676A patent/EP0416137B1/en not_active Expired - Lifetime
- 1989-08-08 AT AT89114676T patent/ATE96678T1/de not_active IP Right Cessation
- 1989-08-08 ES ES89114676T patent/ES2053882T3/es not_active Expired - Lifetime
- 1989-08-08 DE DE89114676T patent/DE68910520T2/de not_active Expired - Fee Related
- 1989-08-12 KR KR1019890011531A patent/KR0143916B1/ko not_active IP Right Cessation
- 1989-09-05 CA CA000610288A patent/CA1332570C/en not_active Expired - Lifetime
- 1989-09-05 JP JP1228476A patent/JP2953625B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE96678T1 (de) | 1993-11-15 |
DE68910520T2 (de) | 1994-04-07 |
KR0143916B1 (ko) | 1998-07-15 |
EP0416137B1 (en) | 1993-11-03 |
JP2953625B2 (ja) | 1999-09-27 |
US4855294A (en) | 1989-08-08 |
JPH02115131A (ja) | 1990-04-27 |
CA1332570C (en) | 1994-10-18 |
KR900004330A (ko) | 1990-04-12 |
DE68910520D1 (de) | 1993-12-09 |
EP0416137A1 (en) | 1991-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2053882T3 (es) | Metodo para reducir la irritacion de la piel asociado con composiciones potenciadoras de penetracion del farmaco. | |
US5091171B2 (en) | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use | |
MX9205937A (es) | Sistema de penetracion incrementada de la piel para surtido topico mejorado de farmacos | |
EP0164998A3 (en) | Compositions and methods of enhancing transdermal and transmembrane penetration of topical and systemic agents | |
AU582920B2 (en) | Continuous release pharmaceutical compositions | |
MY102378A (en) | Transdermal delivery system. | |
DE69230772D1 (de) | Arzneizubereitungen zur Behandlung von Onychomykosen | |
EP0489108A4 (en) | Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists | |
BR9206632A (pt) | Sistema de penetração na pele melhorado para melhorada liberação tópica de drogas | |
MY101570A (en) | Novel pharmaceutical compositions for topical application with systemic action | |
EE9900428A (et) | Köhavastased ravimkoostised | |
CA2070685A1 (en) | Method for treating painful, inflammatory or allergic disorders | |
KR900007424A (ko) | 세포보호성 약제로서의 n-아세틸글루코사민의 사용방법 및 그 조성물 | |
KR970009581B1 (en) | Composition for topical use containing depolymerized deoxyribonucleic acids in the skin and body cosmetic treathent | |
JPS53113787A (en) | Oil-in-water type emulsifier composition | |
KR880007068A (ko) | 13-시스 레티노산의 용도 | |
BR9001484A (pt) | Composicao inseticida e acaricida com efeito aperfeicoado,processo para aperfeicoar o efeito de uma substancia ativa inseticida | |
SU1459215A1 (ru) | Состав полимерной диффузионной матрицы для трансдермального введения лекарственных веществ | |
IE782515L (en) | Treating diarrhoea | |
KR920702623A (ko) | 진해제 | |
KR880013577A (ko) | 동물용 약품제형 | |
IE780730L (en) | Veterinary composition | |
KR930700110A (ko) | 세포독성제 및 침투 증진제로 이루어진 조성물 | |
KR930700109A (ko) | 신경 질환 치료용 4,4'-[9h-플루오렌-9-일리덴비스(메틸렌)]-비스피리미딘 | |
KR880012228A (ko) | 천식 치료제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 416137 Country of ref document: ES |