KR880000093A - 신규의 국소처리용 약제학적 조성물 - Google Patents

신규의 국소처리용 약제학적 조성물 Download PDF

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Publication number
KR880000093A
KR880000093A KR1019870006498A KR870006498A KR880000093A KR 880000093 A KR880000093 A KR 880000093A KR 1019870006498 A KR1019870006498 A KR 1019870006498A KR 870006498 A KR870006498 A KR 870006498A KR 880000093 A KR880000093 A KR 880000093A
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pharmaceutical composition
alkyl
optionally
treatment
substituents
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KR1019870006498A
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English (en)
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팡크하우저 페터
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카알 에프·요르다
시바-가이기 코포레이션
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Publication of KR880000093A publication Critical patent/KR880000093A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

신규의 국소처리용 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. a) 디클포페닉 또는 그의 약제학적으로 허용되는 염, b) 성분 (a)의 투과성을 증진시키는 일반식(I)의 화합물, 및 경우에 따라 c) 국소처리용으로 적합하고 체온에서 액체인 파라핀, 및/또는 d) 경피 전달용으로 적합한 추가의 부형제를 포함하는 약제학적 조성물.
    상기식에서,
    R1은 C9-C19알킬이고,
    R2및 R3은 C1-C4알킬이거나, 또는
    R1은 치환체 R2또는 R3중의 하나에
    결합되어 있고, 상기 치환체와 함께는 C5-C7알킬렌이며, R2또는 R3중의 나머지 치환체를 C10-C20알킬이다.
  2. 제 1 항에 있어서, a) 디클로페낙의 약제학적으로 허용되는 염, b) R1이 n-운데실이고, R2및 R3이메틸(N,N-디메틸라우로일아미드)이거나, 또는 R1이 치환체 R2및 R3중의 하나에 결합되어 있고 상기 치한체와 함께는 n-펜틸렌이며, 또한 질소가 n-도데실(1-n-도데실아자사이클로헵탄-2-은)로 정의되는 R3또는 R2로 치환된 일반식(I)의 화합물, c) 국소처리용으로 적합한 점성파라핀, 및 경우에 따라 d) 경피전달용으로 적합한 추가의 부형제를 포함하는 약제학적 조성물.
  3. 제 1 항에 있어서, a) 디클로페낙의 나트륨, 칼륨 또는 디메틸암모늄 염, b) N,N-디메틸라우로일아미드 또는 1-n-도 데실아자사이클로 헵탄-2-온, c) 국소처리용으로 적합한 점성 광유, 및 경우에 따라 d) 경피전달용으로 적합한 추가의 부형제를 포함하는 약제학적 조성물.
  4. 제 1 항에 따른 약제학적 조성물을 함유하는 경피치료 시스템.
  5. 제 3 항에 따른 약제학적 조성물을 함유하는 경피치료 시스템.
  6. 성분 a),b) 및 경우에 따라 c) 및/또는 d)를 서로 혼합시킴을 포함하는 제 1 항의 약제학적 조성물의 제조방법.
  7. 일반식(I)의 화합물 및 경우에 따라 국소처리용으로 적합한 액체 피라핀 및/또는 디클로페낙 또는 그의 약제학적으로 허용되는 염을 함유하는 국소제형용 기질로서 경피 전달용으로 적합한 추가의 부형제의 용도를 포함하는, 국소제형에서 디클로페낙 또는 그의 약제학적으로 허용되는 염의 투과성을 증진시키는 방법.
    상기식에서.
    R1C9-C19알킬이고,
    R2및 R3은 C1-C4알킬이거나 : 또는
    R1은 치한체 R2또는 R3중의 하나에 결합되어 있고,
    상기 치환체와 함께는 C5-C7알킬렌이며, R2또는 R3중의 나머지 치환체는 C10-C20알킬이다.
  8. 사람 또는 동물의 치료용 약제학적 조성물의 제조용으로서 제 1 항에 따른 성분 a),b) 및 경우에 따라 c) 및/또는 d)의 용도.
  9. 경피 치료 시스템의 제조용으로서 제 1 항에 따른 약제학적 조성물의 용도.
  10. 사람 또는 동물의 치료에 사용되는 제 1 항에 따른 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870006498A 1986-06-27 1987-06-26 신규의 국소처리용 약제학적 조성물 KR880000093A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02597/86-8 1986-06-27
CH2597/86A CH666621A5 (de) 1986-06-27 1986-06-27 Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung.

Publications (1)

Publication Number Publication Date
KR880000093A true KR880000093A (ko) 1988-03-23

Family

ID=4237351

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870006498A KR880000093A (ko) 1986-06-27 1987-06-26 신규의 국소처리용 약제학적 조성물

Country Status (27)

Country Link
US (1) US4999379A (ko)
JP (1) JPS638329A (ko)
KR (1) KR880000093A (ko)
AT (1) AT397199B (ko)
AU (1) AU612323B2 (ko)
BE (1) BE1000233A4 (ko)
CA (1) CA1315692C (ko)
CH (1) CH666621A5 (ko)
DD (1) DD263448A5 (ko)
DE (1) DE3720896A1 (ko)
DK (1) DK326587A (ko)
ES (1) ES2010224A6 (ko)
FI (1) FI872808A (ko)
FR (1) FR2601588B1 (ko)
GB (1) GB2192539B (ko)
GR (1) GR871002B (ko)
HU (1) HU197984B (ko)
IT (1) IT1216827B (ko)
LU (1) LU86929A1 (ko)
MY (1) MY101570A (ko)
NL (1) NL8701508A (ko)
NO (1) NO872685L (ko)
NZ (1) NZ220861A (ko)
PH (1) PH26781A (ko)
PT (1) PT85158B (ko)
SE (1) SE8702642L (ko)
ZA (1) ZA874621B (ko)

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CA1334646C (en) * 1988-04-08 1995-03-07 James Vanolden Peck Transdermal penetration enhancers
JPH04193826A (ja) * 1990-11-27 1992-07-13 Shirogane Seiyaku Kk ジクロフェナクナトリウム含有の経皮吸収型消炎・鎮痛貼布剤
DE9016291U1 (ko) * 1990-11-30 1991-03-28 Kali-Chemie Pharma Gmbh, 3000 Hannover, De
EP0498011B1 (de) * 1991-02-07 1995-04-26 HEUMANN PHARMA GMBH & CO Neue Salze der 2-(2,6-Dichloranilino)-phenylessigsäure, Verfahren zu ihrer Herstellung und ihre Verwendung für topisch anwendbare pharmazeutische Zubereitungen
WO1993000873A1 (en) * 1991-07-03 1993-01-21 Sano Corporation Composition and method for transdermal delivery of diclofenac
JP2523428B2 (ja) * 1992-12-04 1996-08-07 エスエス製薬株式会社 消炎鎮痛ゲル製剤
EP0692975A4 (en) * 1993-04-08 2000-11-29 Univ Queensland ADMINISTRATION OF A VASO ACTIVE AND A THERAPEUTIC ACTIVE
DE4313402A1 (de) * 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermale Wirkstoffzubereitung
US5474985A (en) * 1993-12-22 1995-12-12 The Regents Of The University Of California Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
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US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
US5891913A (en) * 1994-10-10 1999-04-06 Novartis Finance Corporation Ophthalmic and aural compositions containing diclofenac potassium
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US5674888A (en) * 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
WO1997028794A1 (fr) * 1996-02-07 1997-08-14 Tsumura & Co. Solution aqueuse transparente de diclofenac sodique, compositions medicinales, et utilisations
KR19990026792A (ko) * 1997-09-26 1999-04-15 김윤 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
BR0110178A (pt) * 2000-04-18 2003-12-30 Hisamitsu Pharmaceutical Co Emplastro contendo antiinflamatório
JP4865958B2 (ja) * 2001-05-23 2012-02-01 株式会社トクホン 鎮痛抗炎症局所作用型の貼付剤
DE102007038413A1 (de) * 2007-08-09 2009-02-12 Beiersdorf Ag Kosmetische Emulgatorkombination
ITMI20111355A1 (it) 2011-07-20 2013-01-21 Epifarma Srl Cerotto transdermico contenente diclofenac e tiocolchicoside
WO2014068600A1 (en) 2012-11-02 2014-05-08 Zydus Technologies Limited Stable transdermal pharmaceutical drug delivery system comprising diclofenac
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface

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US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
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Also Published As

Publication number Publication date
GB2192539B (en) 1990-10-24
BE1000233A4 (fr) 1988-09-20
ZA874621B (en) 1988-02-24
DK326587A (da) 1987-12-28
NO872685L (no) 1987-12-28
IT1216827B (it) 1990-03-14
US4999379A (en) 1991-03-12
DD263448A5 (de) 1989-01-04
DK326587D0 (da) 1987-06-26
CA1315692C (en) 1993-04-06
PH26781A (en) 1992-10-13
NZ220861A (en) 1990-08-28
FR2601588A1 (fr) 1988-01-22
PT85158B (pt) 1990-03-30
CH666621A5 (de) 1988-08-15
SE8702642D0 (sv) 1987-06-25
GB2192539A (en) 1988-01-20
JPS638329A (ja) 1988-01-14
IT8748097A0 (it) 1987-06-24
AT397199B (de) 1994-02-25
ES2010224A6 (es) 1989-11-01
AU7476287A (en) 1988-01-07
GR871002B (en) 1987-10-20
DE3720896A1 (de) 1988-01-14
GB8714625D0 (en) 1987-07-29
HU197984B (en) 1989-07-28
ATA160487A (de) 1993-07-15
LU86929A1 (de) 1988-07-14
FI872808A (fi) 1987-12-28
NL8701508A (nl) 1988-01-18
AU612323B2 (en) 1991-07-11
SE8702642L (sv) 1987-12-28
NO872685D0 (no) 1987-06-26
PT85158A (en) 1987-07-01
MY101570A (en) 1991-12-17
FI872808A0 (fi) 1987-06-24
FR2601588B1 (fr) 1990-06-15
HUT44180A (en) 1988-02-29

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