ES2131496T3 - Mejoras relativas a derivados glicopeptidicos. - Google Patents

Mejoras relativas a derivados glicopeptidicos.

Info

Publication number
ES2131496T3
ES2131496T3 ES90313410T ES90313410T ES2131496T3 ES 2131496 T3 ES2131496 T3 ES 2131496T3 ES 90313410 T ES90313410 T ES 90313410T ES 90313410 T ES90313410 T ES 90313410T ES 2131496 T3 ES2131496 T3 ES 2131496T3
Authority
ES
Spain
Prior art keywords
derivatives
glycopeptidic
improvements related
new
grama
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90313410T
Other languages
English (en)
Inventor
Ramakrishnan Nagarajan
Amelia Apolinaria Schabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2131496T3 publication Critical patent/ES2131496T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE SUMINISTRAN NUEVOS DERIVADOS N-ALQUILO Y N-ACILO DE A82846A, A82846B, A82846C Y PA-42867-A. LOS NUEVOS DERIVADOS GLICOPEPTIDOS SON UTILES PARA TRATAMIENTO DE INFECCIONES BACTERIANAS SUSCEPTIBLES, ESPECIALMENTE INFECCIONES DEBIDAS A MICROORGANISMOS GRAMA-POSITIVOS.
ES90313410T 1989-12-13 1990-12-11 Mejoras relativas a derivados glicopeptidicos. Expired - Lifetime ES2131496T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44917189A 1989-12-13 1989-12-13

Publications (1)

Publication Number Publication Date
ES2131496T3 true ES2131496T3 (es) 1999-08-01

Family

ID=23783157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90313410T Expired - Lifetime ES2131496T3 (es) 1989-12-13 1990-12-11 Mejoras relativas a derivados glicopeptidicos.

Country Status (20)

Country Link
US (1) US5591714A (es)
EP (1) EP0435503B1 (es)
JP (1) JP3590638B2 (es)
KR (1) KR910011896A (es)
CN (1) CN1034506C (es)
CA (1) CA2031803C (es)
DE (1) DE69033087T2 (es)
ES (1) ES2131496T3 (es)
FI (1) FI906083A (es)
HU (1) HUT55802A (es)
IE (1) IE904485A1 (es)
IL (1) IL96603A (es)
MX (1) MX23672A (es)
NO (1) NO303692B1 (es)
NZ (1) NZ236393A (es)
PH (1) PH27373A (es)
PT (1) PT96139B (es)
RU (2) RU2041237C1 (es)
YU (1) YU234790A (es)
ZA (1) ZA909847B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW213468B (es) * 1991-06-29 1993-09-21 Hoechst Ag
US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
AU703106B2 (en) * 1994-01-28 1999-03-18 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
US6670446B1 (en) 1998-05-01 2003-12-30 Eli Lilly And Company N1 modified glycopeptides
US6177101B1 (en) 1998-06-11 2001-01-23 Pharmacia & Upjohn Company Delavirdine high strength tablet formulation
HU230190B1 (hu) * 1998-12-23 2015-09-28 Theravance, Inc Glikopeptidszármazékok és ezeket tartalmazó gyógyászati kompozíciók
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20020004502A1 (en) 2000-01-05 2002-01-10 Redmond H. Paul Treatment of inflammatory bowel disease
JP2003522197A (ja) 2000-02-11 2003-07-22 イーライ リリー アンド カンパニー Ａ８２８４６グリコペプチドアナログの選択的ｎ−アシル化
SI1278549T1 (sl) * 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
KR100856479B1 (ko) * 2000-05-02 2008-09-04 세라밴스 인코포레이티드 환원성 알킬화 방법
AU2001259298A1 (en) * 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
EP1154663B1 (en) * 2000-05-09 2008-09-24 Lucent Technologies Inc. Improved quality of service control in a mobile telecommunications network
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
ES2302733T3 (es) * 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
US6828299B2 (en) 2000-06-22 2004-12-07 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) * 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
WO2004091578A2 (en) 2003-04-09 2004-10-28 Biodelivery Sciences International, Inc. Novel encochleation methods, cochleates and methods of use
EP1818340A4 (en) 2004-11-29 2009-02-25 Univ Nagoya Nat Univ Corp MONOMERIC ANTIBIOTIC DERIVATIVES OF GLYCOPEPTIDES
UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
EP1933881B1 (en) 2005-09-22 2019-03-13 Medivas, LLC Solid polymer delivery compositions and methods for use thereof
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
JP5517153B2 (ja) 2007-12-26 2014-06-11 塩野義製薬株式会社 グリコペプチド抗生物質配糖化誘導体
CN102083862A (zh) 2008-04-01 2011-06-01 康奈尔大学 有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料
CN101928331B (zh) * 2009-06-26 2014-05-28 上海来益生物药物研究开发中心有限责任公司 一种化合物及其应用
WO2012151517A1 (en) 2011-05-05 2012-11-08 Coordinated Program Development, Llc Cochleate compositions and methods of making and using same
CN104418941B (zh) * 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
WO2015040467A1 (en) 2013-09-23 2015-03-26 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
NZ728401A (en) * 2014-07-17 2020-08-28 The Medicines Co High purity oritavancin and method of producing same
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b

Also Published As

Publication number Publication date
HUT55802A (en) 1991-06-28
FI906083A0 (fi) 1990-12-11
EP0435503B1 (en) 1999-05-06
IE904485A1 (en) 1991-06-19
AU633165B2 (en) 1993-01-21
IL96603A (en) 1998-02-08
DE69033087D1 (de) 1999-06-10
DE69033087T2 (de) 1999-10-14
ZA909847B (en) 1992-08-26
JP3590638B2 (ja) 2004-11-17
RU2041237C1 (ru) 1995-08-09
CA2031803C (en) 2001-05-29
AU6796490A (en) 1991-06-20
NO303692B1 (no) 1998-08-17
EP0435503A1 (en) 1991-07-03
JPH04108800A (ja) 1992-04-09
RU2053240C1 (ru) 1996-01-27
CN1052483A (zh) 1991-06-26
YU234790A (sh) 1992-12-21
CN1034506C (zh) 1997-04-09
PT96139B (pt) 1998-04-30
NO905354L (no) 1991-06-14
PH27373A (en) 1993-06-21
CA2031803A1 (en) 1991-06-14
NZ236393A (en) 1992-05-26
PT96139A (pt) 1991-09-30
KR910011896A (ko) 1991-08-07
IL96603A0 (en) 1991-09-16
US5591714A (en) 1997-01-07
NO905354D0 (no) 1990-12-11
MX23672A (es) 1993-11-01
FI906083A (fi) 1991-06-14

Similar Documents

Publication Publication Date Title
ES2131496T3 (es) Mejoras relativas a derivados glicopeptidicos.
DK0817797T3 (da) Glycopeptidantibiotikumderivater
BG102616A (en) Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
ES2066603T3 (es) Fungicidas de 3-difluorometilpirazolcarboxamida.
ATE261450T1 (de) Makrolid-antibiotika und behandlung von pasteurellosis
AR005642A1 (es) Compuestos antibioticos de cefalosporina, uso de los mismos para preparar composiciones farmaceuticas, dichas composiciones farmaceuticas que los comprenden,compuestos intermediarios de aplicacion en la preparacion de los primeros y metodo para elaborar dichos compuestos intermediarios
DE3780644T2 (de) Glykopeptid-antibiotika.
ES2088965T3 (es) Derivados de rodanina aril-sustituidos.
DE68901415D1 (de) Antibiotikum.
DE68918944D1 (de) Künstliche rezeptor-analoge.
MY105128A (en) Bu-3608 derivatives.
DE69010924T2 (de) Antibiotikum L53-18A und dessen Herstellung.
CA1265131C (en) ERYTHROMYCYLAMINE DERIVATIVES
ES2098263T3 (es) 8-alfa-acilamino-ergolinas, su preparacion y su utilizacion como medicamentos.
NO971604L (no) Orale sabeluzolsuspensjoner
ES2106738T3 (es) Procedimiento de preparacion de derivados de manosil-teicoplanina y de aglicona de manosil-teicoplanina.
PT852497E (pt) Utilizacao de derivados de prostano e a sua combinacao com antibioticos no tratamento de infeccoes bacterianas
ATE97909T1 (de) Antibiotikum n-acetylbenanomicin b, dessen herstellung und verwendung.
DK0598719T3 (da) Receptorkonjugater til destinering af lægemidler og andre midler
ES2076107B1 (es) Derivados de antibioticos macrolidos de anillos de 16 miembros.
TR199701334T1 (xx) Antibakteriyel antibiyotikler.
ES2181768T3 (es) Estalobacinas antibioticos.
NO930315L (no) Fosfenoksidterminerte allen-en-yn dna-spaltende, antitumor- og antimikrobielle midler

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 435503

Country of ref document: ES