DE69033087D1 - Verbesserte Glykopeptid-Derivative - Google Patents

Verbesserte Glykopeptid-Derivative

Info

Publication number
DE69033087D1
DE69033087D1 DE69033087T DE69033087T DE69033087D1 DE 69033087 D1 DE69033087 D1 DE 69033087D1 DE 69033087 T DE69033087 T DE 69033087T DE 69033087 T DE69033087 T DE 69033087T DE 69033087 D1 DE69033087 D1 DE 69033087D1
Authority
DE
Germany
Prior art keywords
improved
glycopeptide derivatives
glycopeptide
derivatives
improved glycopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033087T
Other languages
English (en)
Other versions
DE69033087T2 (de
Inventor
Ramakrishnan Nagarajan
Amelia Apolinaria Schabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69033087D1 publication Critical patent/DE69033087D1/de
Application granted granted Critical
Publication of DE69033087T2 publication Critical patent/DE69033087T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69033087T 1989-12-13 1990-12-11 Verbesserte Glykopeptid-Derivative Expired - Fee Related DE69033087T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44917189A 1989-12-13 1989-12-13

Publications (2)

Publication Number Publication Date
DE69033087D1 true DE69033087D1 (de) 1999-06-10
DE69033087T2 DE69033087T2 (de) 1999-10-14

Family

ID=23783157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033087T Expired - Fee Related DE69033087T2 (de) 1989-12-13 1990-12-11 Verbesserte Glykopeptid-Derivative

Country Status (20)

Country Link
US (1) US5591714A (de)
EP (1) EP0435503B1 (de)
JP (1) JP3590638B2 (de)
KR (1) KR910011896A (de)
CN (1) CN1034506C (de)
CA (1) CA2031803C (de)
DE (1) DE69033087T2 (de)
ES (1) ES2131496T3 (de)
FI (1) FI906083A (de)
HU (1) HUT55802A (de)
IE (1) IE904485A1 (de)
IL (1) IL96603A (de)
MX (1) MX23672A (de)
NO (1) NO303692B1 (de)
NZ (1) NZ236393A (de)
PH (1) PH27373A (de)
PT (1) PT96139B (de)
RU (2) RU2053240C1 (de)
YU (1) YU234790A (de)
ZA (1) ZA909847B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
TW213468B (de) * 1991-06-29 1993-09-21 Hoechst Ag
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
RU2145609C1 (ru) * 1994-01-28 2000-02-20 Эли Лилли Энд Компани Производные гликопептида или их соли, способ получения, фармацевтическая композиция
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5972933A (en) * 1998-01-08 1999-10-26 Ed. Geistlich Sohne Ag Fur Chemische Industrie Method of treating microbial infections
DK1073447T3 (da) 1998-05-01 2007-09-03 Lilly Co Eli N1-modificerede glycopeptider
EA004311B1 (ru) 1998-06-11 2004-02-26 Фармация Энд Апджон Компани Таблетированная фармацевтическая композиция непролонгированного действия
WO2000039156A1 (en) 1998-12-23 2000-07-06 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
US20020004502A1 (en) * 2000-01-05 2002-01-10 Redmond H. Paul Treatment of inflammatory bowel disease
AU3818001A (en) 2000-02-11 2001-08-20 Lilly Co Eli Selective n-acylation of a82846 glycopeptide analogs
DE60136926D1 (de) * 2000-05-02 2009-01-22 Theravance Inc Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält
US6770621B2 (en) * 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
ATE402951T1 (de) * 2000-05-02 2008-08-15 Theravance Inc Verfahren zur reduktiven alkylierung von glykopeptiden
DE60040329D1 (de) * 2000-05-09 2008-11-06 Lucent Technologies Inc Verbesserte Steurung der Dienstequalität in einem mobilen Telekommunikationsnetz
ES2302733T3 (es) * 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
AU2001259816A1 (en) 2000-06-22 2002-01-02 Advanced Medecine, Inc. Polyhydroxy glycopeptide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6872804B2 (en) * 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
TWI312785B (en) * 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US20050013854A1 (en) 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
MX2007006319A (es) * 2004-11-29 2007-07-25 Univ Nagoya Nat Univ Corp Derivados de monomeros de glicopeptico antibioticos.
AR053347A1 (es) 2005-04-06 2007-05-02 Astrazeneca Ab Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
BRPI0821947A2 (pt) * 2007-12-26 2015-09-22 Shionogi & Co derivados de antibiótico de glicopetídeo glicosilatado
US8841440B2 (en) 2008-04-01 2014-09-23 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
CN101928331B (zh) * 2009-06-26 2014-05-28 上海来益生物药物研究开发中心有限责任公司 一种化合物及其应用
US20140220108A1 (en) 2011-05-05 2014-08-07 University Of Medicine And Dentistry Of New Jersey Cochleate compositions and methods of making and using same
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
AU2014322817A1 (en) 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
US9649352B2 (en) * 2014-07-17 2017-05-16 The Medicines Company High purity oritavancin and method of producing same
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b

Also Published As

Publication number Publication date
CN1034506C (zh) 1997-04-09
CA2031803A1 (en) 1991-06-14
ES2131496T3 (es) 1999-08-01
EP0435503A1 (de) 1991-07-03
PH27373A (en) 1993-06-21
NZ236393A (en) 1992-05-26
HUT55802A (en) 1991-06-28
NO303692B1 (no) 1998-08-17
ZA909847B (en) 1992-08-26
PT96139A (pt) 1991-09-30
JP3590638B2 (ja) 2004-11-17
PT96139B (pt) 1998-04-30
YU234790A (sh) 1992-12-21
NO905354D0 (no) 1990-12-11
CA2031803C (en) 2001-05-29
FI906083A (fi) 1991-06-14
IL96603A0 (en) 1991-09-16
FI906083A0 (fi) 1990-12-11
MX23672A (es) 1993-11-01
US5591714A (en) 1997-01-07
IE904485A1 (en) 1991-06-19
AU6796490A (en) 1991-06-20
EP0435503B1 (de) 1999-05-06
NO905354L (no) 1991-06-14
DE69033087T2 (de) 1999-10-14
RU2041237C1 (ru) 1995-08-09
RU2053240C1 (ru) 1996-01-27
JPH04108800A (ja) 1992-04-09
IL96603A (en) 1998-02-08
CN1052483A (zh) 1991-06-26
KR910011896A (ko) 1991-08-07
AU633165B2 (en) 1993-01-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee