MX2007006319A - Derivados de monomeros de glicopeptico antibioticos. - Google Patents

Derivados de monomeros de glicopeptico antibioticos.

Info

Publication number
MX2007006319A
MX2007006319A MX2007006319A MX2007006319A MX2007006319A MX 2007006319 A MX2007006319 A MX 2007006319A MX 2007006319 A MX2007006319 A MX 2007006319A MX 2007006319 A MX2007006319 A MX 2007006319A MX 2007006319 A MX2007006319 A MX 2007006319A
Authority
MX
Mexico
Prior art keywords
glycopeptide antibiotic
derivatives
sugar
sac
heteroatom
Prior art date
Application number
MX2007006319A
Other languages
English (en)
Inventor
Issei Kato
Hirokazu Arimoto
Jun Lu
Yoshinori Yamano
Tatsuro Yasukata
Yoshida Osamu
Tsutomu Iwaki
Yutaka Yoshida
Kenji Morimoto
Kayo Yasoshima
Original Assignee
Univ Nagoya Nat Univ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nagoya Nat Univ Corp filed Critical Univ Nagoya Nat Univ Corp
Publication of MX2007006319A publication Critical patent/MX2007006319A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados antibioticos de glicopeptido novedosos; estos derivados son representados por la formula (parte aglicon del derivado antibiotico de glicopeptidos)-(Sac-NH)-RA [en donde (la parte aglicon del derivado antibiotico de glicopeptido) es la parte formada al remover la parte de azucar a partir de un derivado antibiotico de glicopeptido conocido; la parte (Sac-NH) es una parte de azucar de amino o una parte de cadena de azucar que contiene una azucar de amino; y RA representa por ejemplo, la formula X1-Ar1-X-Y-Ar2 (en donde X1, X2, y X3 cada uno representa 1) un enlace individual o 2) un heteroatomo o un grupo que contiene un heteroatomo seleccionado del grupo que consiste en -N=, =N-, NR1-, -O-, etc.; Y representa -NR2CO- o -CONR2 -(en donde R2 representa hidrogeno o alquilo inferior), etc.)], estos derivados tienen actividad antibacteriana contra bacterias resistentes a vancomicina.
MX2007006319A 2004-11-29 2005-11-24 Derivados de monomeros de glicopeptico antibioticos. MX2007006319A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004344231 2004-11-29
JP2005212471 2005-07-22
PCT/JP2005/021587 WO2006057303A1 (ja) 2004-11-29 2005-11-24 グリコペプチド抗生物質モノマー誘導体

Publications (1)

Publication Number Publication Date
MX2007006319A true MX2007006319A (es) 2007-07-25

Family

ID=36498039

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006319A MX2007006319A (es) 2004-11-29 2005-11-24 Derivados de monomeros de glicopeptico antibioticos.

Country Status (11)

Country Link
US (1) US8778874B2 (es)
EP (2) EP1818340A4 (es)
JP (2) JP4330169B2 (es)
KR (1) KR20070092719A (es)
AU (1) AU2005308160A1 (es)
BR (1) BRPI0516657A (es)
CA (1) CA2588285A1 (es)
MX (1) MX2007006319A (es)
RU (1) RU2424248C2 (es)
TW (1) TW200626616A (es)
WO (1) WO2006057303A1 (es)

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AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
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CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
CN107325159A (zh) * 2016-04-29 2017-11-07 中国科学院上海药物研究所 一类万古霉素衍生物、其制备方法、药物组合物和用途
AU2017348434B2 (en) * 2016-10-31 2021-10-07 The Scripps Research Institute Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability
MX2022000937A (es) 2017-03-15 2022-10-21 Lunella Biotech Inc Mitorriboscinas: compuestos terapéuticos basados en mitocondrias que fijan como objetivo células cancerosas, bacterias y levaduras patógenas.
RU2708628C1 (ru) * 2019-01-23 2019-12-10 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Новые производные эремомицина и их применение для лечения бактериальных инфекций

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Also Published As

Publication number Publication date
JPWO2006057303A1 (ja) 2008-06-05
BRPI0516657A (pt) 2008-09-16
JP4330169B2 (ja) 2009-09-16
TW200626616A (en) 2006-08-01
RU2007124375A (ru) 2009-01-10
EP2314599A1 (en) 2011-04-27
JP2009079067A (ja) 2009-04-16
US8778874B2 (en) 2014-07-15
EP1818340A1 (en) 2007-08-15
RU2424248C2 (ru) 2011-07-20
KR20070092719A (ko) 2007-09-13
WO2006057303A1 (ja) 2006-06-01
CA2588285A1 (en) 2006-06-01
EP1818340A4 (en) 2009-02-25
US20080097078A1 (en) 2008-04-24
AU2005308160A1 (en) 2006-06-01
JP4377953B2 (ja) 2009-12-02

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