ES2126331T3 - Conjugados de bdnf y nt-3 con un polimero soluble en agua. - Google Patents

Conjugados de bdnf y nt-3 con un polimero soluble en agua.

Info

Publication number
ES2126331T3
ES2126331T3 ES95939123T ES95939123T ES2126331T3 ES 2126331 T3 ES2126331 T3 ES 2126331T3 ES 95939123 T ES95939123 T ES 95939123T ES 95939123 T ES95939123 T ES 95939123T ES 2126331 T3 ES2126331 T3 ES 2126331T3
Authority
ES
Spain
Prior art keywords
water soluble
soluble polymer
bdnf
conjugates
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95939123T
Other languages
English (en)
Inventor
Olaf F Kinstler
Qiao Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES2126331T3 publication Critical patent/ES2126331T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Abstract

SE HAN PREPARADO DERIVADOS DE FACTORES NEUROTROFICOS BDNF Y NT3 MEDIANTE INCORPORACION DE ESTOS POLIPEPTIDOS A UN POLIMERO SOLUBLE EN AGUA, POR EJEMPLO, POLIETILENGLICOL.
ES95939123T 1994-11-14 1995-11-13 Conjugados de bdnf y nt-3 con un polimero soluble en agua. Expired - Lifetime ES2126331T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,131 US5770577A (en) 1994-11-14 1994-11-14 BDNF and NT-3 polypeptides selectively linked to polyethylene glycol

Publications (1)

Publication Number Publication Date
ES2126331T3 true ES2126331T3 (es) 1999-03-16

Family

ID=23332020

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95939123T Expired - Lifetime ES2126331T3 (es) 1994-11-14 1995-11-13 Conjugados de bdnf y nt-3 con un polimero soluble en agua.

Country Status (22)

Country Link
US (1) US5770577A (es)
EP (1) EP0792288B1 (es)
JP (1) JPH10508853A (es)
KR (1) KR100253762B1 (es)
CN (1) CN1173183A (es)
AT (1) ATE175973T1 (es)
AU (1) AU694589B2 (es)
CA (1) CA2204640C (es)
CZ (1) CZ137597A3 (es)
DE (1) DE69507507T2 (es)
DK (1) DK0792288T3 (es)
ES (1) ES2126331T3 (es)
GR (1) GR3029790T3 (es)
HU (1) HUT77747A (es)
IL (1) IL115965A (es)
MX (1) MX9703362A (es)
NO (1) NO972176L (es)
NZ (1) NZ296452A (es)
RU (1) RU2136694C1 (es)
SK (1) SK283083B6 (es)
WO (1) WO1996015146A1 (es)
ZA (1) ZA959653B (es)

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US6656474B1 (en) * 1999-01-15 2003-12-02 Regeneron Pharmaceuticals, Inc. Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders
US6800607B2 (en) * 2000-02-29 2004-10-05 Ltt Bio-Pharma Co., Ltd. Modified BDNF
US7514239B2 (en) * 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
US7442370B2 (en) * 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
SI1355936T1 (sl) * 2001-02-01 2007-12-31 Biogen Idec Inc Polimerni konjugati neublastina in postopki njihove uporabe
PL362414A1 (en) 2001-02-19 2004-11-02 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
EA008866B1 (ru) * 2002-12-26 2007-08-31 Маунтин Вью Фамэсьютикэлс, Инк. ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
PL396711A1 (pl) * 2002-12-26 2011-12-19 Mountain View Pharmaceuticals, Inc. Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia
NZ541921A (en) * 2003-01-31 2010-01-29 Biogen Idec Inc Polymer conjugates of mutated neublastin
SI2248899T1 (sl) 2003-03-19 2015-07-31 Biogen Ma Inc. Vezavni protein receptorja Nogo
ES2479942T3 (es) 2003-04-18 2014-07-25 Biogen Idec Ma Inc. Neublastina glucosilada conjugada con polímero
EP1720564A1 (en) * 2004-02-20 2006-11-15 Rinat Neuroscience Corp. Methods of treating obesity or diabetes using nt-4/5
EP2474317A1 (en) 2004-06-24 2012-07-11 Biogen Idec MA Inc. Treatment of conditions involving demyelination
EP2238983B1 (en) * 2004-08-19 2014-07-23 Biogen Idec MA Inc. Neublastin variants
EP1784203B1 (en) 2004-08-19 2010-06-30 Biogen Idec MA Inc. Refolding transforming growth factor beta family proteins
US7750122B2 (en) 2005-06-06 2010-07-06 Wyeth Llc Anti-TrkB monoclonal antibodies and uses thereof
WO2007008547A2 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
CA2637707A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corporation Methods for treating obesity by administering a trkb antagonist
AU2007210862A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
WO2007103182A2 (en) * 2006-03-01 2007-09-13 Biogen Idec Ma Inc. Compostions and methods for administering gdnf ligand family proteins
AU2007249709A1 (en) * 2006-05-15 2007-11-22 Viral Logic Systems Technology Corp. CD47 related compositions and methods for treating immunological diseases and disorders
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
US20100086997A1 (en) * 2006-12-20 2010-04-08 Rinat Enuroscience Corp TrkB Agonists for Treating Autoimmune Disorders
EP2142205B1 (en) 2007-05-01 2014-04-02 Biogen Idec MA Inc. Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow
EP2205634A2 (en) * 2007-08-08 2010-07-14 Biogen Idec MA, Inc. Anti-neublastin antibodies and uses thereof
US20100297121A1 (en) * 2007-10-11 2010-11-25 Biogen Idec Ma Inc. Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists
CA2702630C (en) * 2007-11-08 2017-11-21 Biogen Idec Ma Inc. Use of lingo-4 antagonists in the treatment of conditions involving demyelination
US8058406B2 (en) 2008-07-09 2011-11-15 Biogen Idec Ma Inc. Composition comprising antibodies to LINGO or fragments thereof
MX2013000250A (es) 2010-07-02 2013-10-28 Angiochem Inc Polipeptidos cortos y que contienen d-aminoacido para conjugados terapeuticos y usos de los mismos.
CA2873623C (en) 2012-05-14 2021-11-09 Biogen Idec Ma Inc. Lingo-2 antagonists for treatment of conditions involving motor neurons
CN102964442B (zh) * 2012-11-19 2015-04-29 未名生物医药有限公司 一种聚乙二醇同神经生长因子结合物的制备方法
MX2017009038A (es) 2015-01-08 2017-10-25 Biogen Ma Inc Antagonistas de proteina 1 de interacción con el receptor de nogo que contiene el dominio de inmunoglobulina y repeticiones ricas en leucina (lingo-1) y usos para el tratamiento de trastornos desmielinizantes.
CN111514279B (zh) * 2020-06-16 2023-07-18 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 神经营养因子3在制备治疗男性性腺功能减退症的药物中的应用
CN115025723A (zh) * 2022-05-10 2022-09-09 吉林大学 经神经生长因子及多巴胺改良的peg-plga微球

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GR1000980B (el) * 1989-08-30 1993-03-31 Max Planck Gesellschaft Νευροτροφινη-3,ενας νεος neυροτροφικος παραγοντας που σχετιζεται με τον παραγοντα αναπτυξης νευρων και τον νευροτροφικο παραγοντα που προερχεται απο τον εγκεφαλο.
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US5182107A (en) * 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
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AU654302B2 (en) * 1990-09-25 1994-11-03 Genentech Inc. Novel neurothrophic factor
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
NZ244778A (en) * 1991-10-21 1994-03-25 Ortho Pharma Corp Peg imidates and protein derivatives thereof
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
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Also Published As

Publication number Publication date
CA2204640C (en) 2001-01-09
ATE175973T1 (de) 1999-02-15
CZ137597A3 (cs) 1998-10-14
DK0792288T3 (da) 1999-09-13
DE69507507T2 (de) 1999-05-27
NO972176L (no) 1997-07-14
CN1173183A (zh) 1998-02-11
MX9703362A (es) 1997-08-30
SK57197A3 (en) 1999-02-11
NZ296452A (en) 1999-01-28
DE69507507D1 (de) 1999-03-04
AU4107196A (en) 1996-06-06
GR3029790T3 (en) 1999-06-30
HUT77747A (hu) 1998-07-28
SK283083B6 (sk) 2003-02-04
EP0792288B1 (en) 1999-01-20
RU2136694C1 (ru) 1999-09-10
CA2204640A1 (en) 1996-05-23
US5770577A (en) 1998-06-23
AU694589B2 (en) 1998-07-23
IL115965A0 (en) 1996-01-31
IL115965A (en) 2001-01-28
NO972176D0 (no) 1997-05-12
ZA959653B (en) 1997-08-26
KR100253762B1 (ko) 2000-05-01
EP0792288A1 (en) 1997-09-03
JPH10508853A (ja) 1998-09-02
WO1996015146A1 (en) 1996-05-23

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