ES2108862T3 - Diamidas imidocarbonimidicas n,n' substituidas derivadas de hidroxilaminas. - Google Patents
Diamidas imidocarbonimidicas n,n' substituidas derivadas de hidroxilaminas.Info
- Publication number
- ES2108862T3 ES2108862T3 ES93903532T ES93903532T ES2108862T3 ES 2108862 T3 ES2108862 T3 ES 2108862T3 ES 93903532 T ES93903532 T ES 93903532T ES 93903532 T ES93903532 T ES 93903532T ES 2108862 T3 ES2108862 T3 ES 2108862T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- mono
- substituted
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/13—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Paints Or Removers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Luminescent Compositions (AREA)
- Seasonings (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PROPORCIONAN COMPUESTOS DE FORMULA (I) DONDE R1 ES UN GRUPO ALIFATICO DIVALENTE SUSTITUIDO O NO SUSTITUIDO, DE 1 A 16 ATOMOS DE CARBONO; DONDE LOS SUSTITUYENTES SON MONO O POLY, Y SE SELECCIONAN DEL GRUPO FORMADO POR ALQUILO INFERIOR, ARILO Y ARALQUILO; R3 SE SELECCIONA DEL GRUPO FORMADO POR EL MISMO GRUPO DE VALORES COMO R5; R5 SE SELECCIONA DEL GRUPO FORMADO POR ALQUILO SUSTITUIDO O NO SUSTITUIDO DE 1 CARBONO, DONDE LOS SUSTITUYENTES SON MONO O POLY, Y SE SELECCIONAN DEL GRUPO FORMADO POR ALQUILO INFERIOR, CICLOALQUILO DE 3 NITRO, ALCOXI INFERIOR, ALCOXICARBONILO INFERIOR, ALQUILO INFERIOR DE FENILO, FENILO, MONO Y POLYHALOFENILO, FENOXI, MONO Y POLYHALOFENOXI; R6 Y R7 PUEDEN SER LOS MISMOS O DIFERENTES, Y SON HIDROGENO, ALCANONOILO Y ALCOXIALCANOILO; R7 PUEDE TAMBIEN TENER EL MISMO VALOR QUE R5, Y ES OXIGENO O AZUFRE, M ES 0 O 1, 1 ES 0 O 1, DONDE EL PREFIJO "ALK" DESIGNA MITADES QUE SON CADENA RECTA O CADENA RAMIFICADA, Y EL TERMINO "LOWER" (INFERIOR) DESIGNA DE 1 A 6 ATOMOS DE CARBONO Y EL TERMINO NO MODIFICADO "ALK" SIGNIFICA DE 1 A 24 ATOMOS DE CARBONO, LOS RESPECTIVOS TAUTOMEROS (ORGANOS SITUADOS POR COMPLETO EN UNO DE LOS LADOS DEL ORGANISMO) DE LOS MISMOS, LAS SALES FARMACEUTICAMENTE ACEPTABLES Y SALES ADICIONALES DE LOS MISMOS Y LOS HIDRATOS DE LAS CITADAS SALES Y SALES DE ADICION. TAMBIEN SE PROPORCIONAN METODOS DE PROTEGER A PERSONAS EXPUESTAS A LOS MISMOS DE INFECCIONES ORIGINADAS POR UN ORGANISMO DEL GRUPO PLASMODIUM SP., MYOCOBACTERIUM SP. Y PNEUMOCUSTIS CARINII, MEDIANTE LA ADMINISTRACION A UNA PERSONA EXPUESTA A TAL INFECCION, DE UNA CANTIDAD PROFILACTICAMENTE EFICAZ DE UN COMPUESTO DE LA FORMULA PRECEDENTE. ESTOS COMPUESTOS REDUCEN LA INFECCION DONDE TALES PERSONAS HAN SIDO YA INFECTADAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/837,258 US5322858A (en) | 1992-02-14 | 1992-02-14 | N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2108862T3 true ES2108862T3 (es) | 1998-01-01 |
Family
ID=25273975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93903532T Expired - Lifetime ES2108862T3 (es) | 1992-02-14 | 1993-01-19 | Diamidas imidocarbonimidicas n,n' substituidas derivadas de hidroxilaminas. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5322858A (es) |
| EP (1) | EP0625967B1 (es) |
| JP (1) | JP3207200B2 (es) |
| KR (1) | KR950700243A (es) |
| CN (1) | CN1057520C (es) |
| AT (1) | ATE157352T1 (es) |
| AU (1) | AU668709B2 (es) |
| CA (1) | CA2129430C (es) |
| CZ (1) | CZ294257B6 (es) |
| DE (1) | DE69313438T2 (es) |
| DK (1) | DK0625967T3 (es) |
| EG (1) | EG20476A (es) |
| ES (1) | ES2108862T3 (es) |
| FI (1) | FI943738A (es) |
| GR (1) | GR3025429T3 (es) |
| HU (1) | HU220389B (es) |
| IL (1) | IL104484A (es) |
| MX (1) | MX9300688A (es) |
| NO (1) | NO302616B1 (es) |
| NZ (1) | NZ245865A (es) |
| OA (1) | OA10094A (es) |
| PL (2) | PL173258B1 (es) |
| RU (1) | RU2133737C1 (es) |
| WO (1) | WO1993016037A1 (es) |
| ZA (1) | ZA93974B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
| US6551614B2 (en) | 2001-03-14 | 2003-04-22 | Jacobus Pharmaceutical Co., Inc. | Antimalarial N,N′-substituted biguanides derived from hydroxylamines |
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| CN1738794B (zh) * | 2002-11-22 | 2010-12-22 | 雅各布斯制药公司 | 双胍和二氢三嗪衍生物 |
| US7256218B2 (en) * | 2002-11-22 | 2007-08-14 | Jacobus Pharmaceutical Company, Inc. | Biguanide and dihydrotriazine derivatives |
| WO2006084033A1 (en) * | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| EP2194985B1 (en) | 2007-10-08 | 2019-02-20 | MMV Medicines for Malaria Venture | Antimalarial compounds with flexible side-chains |
| KR20100098602A (ko) * | 2007-10-13 | 2010-09-08 | 코넬 유니버시티 | 마이코박테리움 아비움 아종 파라투베르쿨로시스에 대한 면역 응답을 유발하기 위한 조성물 |
| CA2758424C (en) | 2008-04-21 | 2018-03-06 | Signum Biosciences, Inc. | Tryptamine derivatives as pp2a methylation modulators |
| BRPI0908701A2 (pt) * | 2008-05-09 | 2015-07-21 | Tolmar Inc | Composição, método para o tratamento de uma doença ou distúrbio de pelo ou mucosa, método para o tratamento de acne, método de extermínio ou inibição do crescimento de bactérias, protozoários ou fungos e uso de proguanil |
| US10829440B2 (en) | 2015-06-12 | 2020-11-10 | Brown University | Antibacterial compounds and methods of making and using same |
| US11261157B2 (en) | 2016-12-08 | 2022-03-01 | Novatarg, Inc. | Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therapy |
| US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB603070A (en) * | 1946-01-25 | 1948-06-08 | Albert Frederick Crowther | Manufacture of biguanide derivatives |
| GB665680A (en) * | 1948-02-20 | 1952-01-30 | Rhone Poulenc Sa | Improvements in or relating to the production of n-p-chlorophenyl-n-isopropyl biguanide |
| DE824942C (de) * | 1949-01-31 | 1951-12-17 | Ici Ltd | Verfahren zur Herstellung von Biguanidderivaten |
| GB667116A (en) * | 1949-04-25 | 1952-02-27 | Albert Frederick Crowther | Manufacture of biguanide derivatives |
| GB814563A (en) * | 1956-11-15 | 1959-06-10 | Vitamins Ltd | Biguanides |
| GB1270831A (en) * | 1968-11-22 | 1972-04-19 | Beecham Group Ltd | Di-hydro triazine derivatives and processes for their manufacture |
| GB1250531A (es) * | 1969-01-01 | 1971-10-20 | ||
| US3723429A (en) * | 1969-11-06 | 1973-03-27 | Beecham Group Ltd | Di-hydro triazine derivatives |
| US3660394A (en) * | 1970-01-23 | 1972-05-02 | Vitamins Ltd | 4 6-dibenzo-1 2-dihydro-aryloxy-1 3 5-triazines |
-
1992
- 1992-02-14 US US07/837,258 patent/US5322858A/en not_active Expired - Lifetime
-
1993
- 1993-01-19 HU HU9401976A patent/HU220389B/hu not_active IP Right Cessation
- 1993-01-19 RU RU94039539A patent/RU2133737C1/ru not_active IP Right Cessation
- 1993-01-19 PL PL93315533A patent/PL173258B1/pl not_active IP Right Cessation
- 1993-01-19 AT AT93903532T patent/ATE157352T1/de active
- 1993-01-19 WO PCT/US1993/000395 patent/WO1993016037A1/en active IP Right Grant
- 1993-01-19 ES ES93903532T patent/ES2108862T3/es not_active Expired - Lifetime
- 1993-01-19 KR KR1019940702810A patent/KR950700243A/ko not_active IP Right Cessation
- 1993-01-19 DE DE69313438T patent/DE69313438T2/de not_active Expired - Fee Related
- 1993-01-19 AU AU34759/93A patent/AU668709B2/en not_active Ceased
- 1993-01-19 CA CA002129430A patent/CA2129430C/en not_active Expired - Fee Related
- 1993-01-19 EP EP93903532A patent/EP0625967B1/en not_active Expired - Lifetime
- 1993-01-19 PL PL93304776A patent/PL172001B1/pl not_active IP Right Cessation
- 1993-01-19 DK DK93903532.5T patent/DK0625967T3/da active
- 1993-01-19 JP JP51407193A patent/JP3207200B2/ja not_active Expired - Fee Related
- 1993-01-19 CZ CZ19941964A patent/CZ294257B6/cs not_active IP Right Cessation
- 1993-01-22 IL IL10448493A patent/IL104484A/en not_active IP Right Cessation
- 1993-02-08 NZ NZ245865A patent/NZ245865A/en not_active IP Right Cessation
- 1993-02-09 MX MX9300688A patent/MX9300688A/es unknown
- 1993-02-11 EG EG7993A patent/EG20476A/xx active
- 1993-02-12 ZA ZA93974A patent/ZA93974B/xx unknown
- 1993-02-13 CN CN93101894A patent/CN1057520C/zh not_active Expired - Fee Related
-
1994
- 1994-08-12 NO NO942988A patent/NO302616B1/no not_active IP Right Cessation
- 1994-08-12 FI FI943738A patent/FI943738A/fi unknown
- 1994-08-12 OA OA60554A patent/OA10094A/en unknown
-
1997
- 1997-11-19 GR GR970403074T patent/GR3025429T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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