ES2103309T3 - Proceso cromatografico en fase invertida. - Google Patents

Proceso cromatografico en fase invertida.

Info

Publication number
ES2103309T3
ES2103309T3 ES91906732T ES91906732T ES2103309T3 ES 2103309 T3 ES2103309 T3 ES 2103309T3 ES 91906732 T ES91906732 T ES 91906732T ES 91906732 T ES91906732 T ES 91906732T ES 2103309 T3 ES2103309 T3 ES 2103309T3
Authority
ES
Spain
Prior art keywords
nonionic
soluble
water
column
contrast media
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906732T
Other languages
English (en)
Inventor
Narcisco O Doran
Thomas J Dunn
Mills T Kneller
Youlin Lin
David Ming-Lee Wong
David H White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2103309T3 publication Critical patent/ES2103309T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCESO MEJORADO PARA LA DESCOLORIZACION, SEPARACION Y PURIFICACION DE COMPUESTOS DE MEDIOS DE CONTRASTE NO IONICOS SOLUBLES EN EL AGUA CROMATOGRAFICOS DE FASE INVERTIDA, DE SOLUCIONES QUE CONTIENEN IMPUREZAS DE COMPUESTOS NO IONICOS QUE INCORPORAN LOS PASOS DE (A) EMBALAR UNA COLUMNA CROMATOGRAFICA CON UN MATERIAL DE EMBALAJE CROMATOGRAFICO; (B) PASAR UNA SOLUCION QUE CONTIENE UN COMPUESTO DE MEDIOS DE CONTRASTE NO IONICOS SOLUBLES EN EL AGUA, A TRAVES DE LA COLUMNA Y COMPUESTOS NO IONICOS COMO IMPUREZAS EN UNA PROPORCION DE CARGA ENTRE APROXIMADAMENTE 10 A 1 Y 1.5 A 1 DE SU PESO, MATERIAL DE EMBALAJE/COMPUESTOS NO IONICOS DE PESO TOTAL; Y (C) ELUDIR LA COLUMNA PARA PRODUCIR UN ELUIDO QUE CONTIENE UN COMPUESTO DE MEDIOS DE CONTRASTE NO IONICOS SOLUBLES EN EL AGUA SUSTANCIALMENTE PURO, UN COMPUESTO DE MEDIOS DE CONTRASTE NO IONICO O UN AGENTE MRI. EL PROCESO PUEDE SER ECONOMICAMENTE PRACTICO EN LA ESCALA DE UNA FABRICA Y RETIRA EFICAZMENTE LAS IMPUREZAS NO POLARES DIFICILES DE RETIRAR CON MEDIOS CONVENCIONALES.
ES91906732T 1990-02-26 1991-02-21 Proceso cromatografico en fase invertida. Expired - Lifetime ES2103309T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48426190A 1990-02-26 1990-02-26
US07/646,836 US5204005A (en) 1990-02-26 1991-01-28 Reversed phase chromatographic process

Publications (1)

Publication Number Publication Date
ES2103309T3 true ES2103309T3 (es) 1997-09-16

Family

ID=27047932

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906732T Expired - Lifetime ES2103309T3 (es) 1990-02-26 1991-02-21 Proceso cromatografico en fase invertida.

Country Status (12)

Country Link
US (1) US5204005A (es)
EP (1) EP0470247B1 (es)
AT (1) ATE151655T1 (es)
AU (1) AU626755B2 (es)
CA (1) CA2062962A1 (es)
DE (1) DE69125665T2 (es)
DK (1) DK0470247T3 (es)
ES (1) ES2103309T3 (es)
GR (1) GR3023716T3 (es)
IE (1) IE910617A1 (es)
NO (1) NO310062B1 (es)
WO (1) WO1991012868A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811581A (en) * 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
IT1282674B1 (it) * 1996-02-23 1998-03-31 Bracco Spa Processo per la purificazione di agenti contrastografici opacizzanti
GB2321860A (en) * 1995-12-01 1998-08-12 Mallinckrodt Med Imaging Ie Reversed phase chromatographic process
GB2321859B (en) * 1995-12-01 2000-06-21 Mallinckrodt Med Imaging Ie Reversed phase chromatographic process
US5972225A (en) * 1996-05-07 1999-10-26 Cook Imaging Corporation Process for remediating endotoxin-contaminated bulk non-ionic contrast media
WO1997046299A1 (en) * 1996-06-05 1997-12-11 Mallinckrodt Medical Imaging-Ireland Reversed phase chromatographic process
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
JP4879392B2 (ja) * 2000-11-09 2012-02-22 日本錬水株式会社 クロマト分離方法
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
US8480889B2 (en) * 2006-04-27 2013-07-09 Agilent Technologies, Inc. Chromatographic stationary phase
EP2185272B1 (en) * 2007-08-27 2018-05-02 Liebel-Flarsheim Company LLC Removal of silica from water soluble compounds by nanofiltration and reverse phase chromatography
JP5504513B2 (ja) * 2008-02-19 2014-05-28 株式会社タニタ カラム充填剤、これを用いたカラムおよび分離方法
EP2365874A1 (en) * 2008-11-19 2011-09-21 Avantor Performance Materials, Inc. New chromatographic media based on phenoxy alkyl and alkoxy-or phenoxy-phenyl alkyl ligands
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
US20120184773A1 (en) 2009-09-30 2012-07-19 Mallinckrodt Llc Reduction of fused bicyclic impurities in triiodinated x-ray contrast media
US20120184772A1 (en) 2009-09-30 2012-07-19 Bailey Allan R Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system
WO2011063551A1 (en) 2009-11-26 2011-06-03 Hovione China Holding Limited Preparation and purification of iodixanol
KR101418431B1 (ko) * 2012-09-28 2014-07-11 경북대학교 산학협력단 인산염을 포함하는 삼요오드화 화합물 및 이를 포함하는 ｘ-선 조영제
CN104045580A (zh) * 2014-06-25 2014-09-17 上海华震科技有限公司 一种碘普罗胺脱色纯化工艺
KR20190061526A (ko) 2017-11-28 2019-06-05 엠에프씨 주식회사 크로마토그래피에 의한 조영제의 정제 방법
FR3084668A1 (fr) 2018-08-02 2020-02-07 Guerbet Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法
CN113061099A (zh) * 2021-03-27 2021-07-02 浙江司太立制药股份有限公司 一种高纯度碘造影剂单体的分离纯化方法
CN115078600B (zh) * 2021-08-30 2023-11-03 清华苏州环境创新研究院 一种固相萃取小柱填料的前处理方法
CN116106431B (zh) * 2021-11-09 2024-10-11 北京北陆药业股份有限公司 利用高效液相色谱法分离碘普罗胺及相关杂质的分离及定量分析方法
CN115382518A (zh) * 2022-05-24 2022-11-25 青岛科技大学 一种液相色谱填料及其制备方法
CN117486750A (zh) * 2022-12-30 2024-02-02 西安蓝晓科技新材料股份有限公司 一种碘克沙醇的纯化方法
CN117756660B (zh) * 2024-01-19 2026-03-17 重庆圣华曦药业股份有限公司 一种碘佛醇杂质的去除方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110737A1 (de) * 1981-03-16 1982-10-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zum abtrennen und reinigen von wasserloeslichen, nicht-ionischen verbindungen
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent

Also Published As

Publication number Publication date
GR3023716T3 (en) 1997-09-30
NO920175D0 (no) 1992-01-14
IE910617A1 (en) 1991-08-28
CA2062962A1 (en) 1991-08-27
US5204005A (en) 1993-04-20
EP0470247A1 (en) 1992-02-12
DE69125665T2 (de) 1997-10-30
WO1991012868A1 (en) 1991-09-05
AU7580591A (en) 1991-09-18
DE69125665D1 (de) 1997-05-22
EP0470247B1 (en) 1997-04-16
DK0470247T3 (da) 1997-10-27
EP0470247A4 (en) 1992-07-08
NO920175L (no) 1992-01-14
ATE151655T1 (de) 1997-05-15
NO310062B1 (no) 2001-05-14
AU626755B2 (en) 1992-08-06

Similar Documents

Publication Publication Date Title
ES2103309T3 (es) Proceso cromatografico en fase invertida.
CA2159823A1 (en) Processes for chromatographic fractionation of fatty acids and their derivatives
BR8401744A (pt) Processo de separacao de etanol de uma solucao contendo etanol
EP1099479A3 (en) A method of chromatographically detecting sample ions by regenerating a stationary phase
NZ509257A (en) Method for purifying haemoglobin by eluting the haemoglobin with tris(hydroxymethyl)aminomethane acetate buffer solution in an anion exchange chromatography column
AU5565586A (en) Improvements in or relating to a process for purifying proinsulin-like materials
GB908333A (en) Method for the production of substantially protein-free callicrein
FR2657545B1 (fr) Procede de raffinage de melanges issus de traitements de milieux gras a l'aide de cyclodextrine et comprenant des complexes de cyclodextrine avec des composes lipophiles.
DE3461779D1 (en) Process for the purification of a water-c1-c2-alcohol mixture, produced by the industrial manufacture of ethanol, by means of an extraction agent
US3419619A (en) Process for preparing pure dimethylsulfoxide
DE3687469D1 (de) Reinigung von dem wachstumshormon angehoerenden stoffen.
GB2328385B (en) Reversed phase chromatographic process
JPS55148098A (en) Concentration and purification of interferon
ES2162117T3 (es) Procedimiento cromatografico en fase inversa.
GB2321860A (en) Reversed phase chromatographic process
EP0074670A3 (en) Process for removing impurities from polyalkyleneoxy coloring agents
Lewis The use of porous glass beads in the separation and purification of ruthenium complexes with large organic ligands
JPS52128294A (en) Separation and purification of cephalosporins
JPS55167228A (en) Purification of high-purity kallikrein
JPS5572145A (en) Enzyme-adsorbent and purification of enzyme
JPS54152027A (en) Separation and purification of chlorophyll
JPS5625199A (en) Purification of coenzyme a
JPS5455519A (en) Purification of isoleucine
JPS5747485A (en) Production of l-2-amino-4-methylphosphinobutyric acid
JPS51151867A (en) Solid liquid separator

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 470247

Country of ref document: ES