JPS5572145A - Enzyme-adsorbent and purification of enzyme - Google Patents

Enzyme-adsorbent and purification of enzyme

Info

Publication number
JPS5572145A
JPS5572145A JP14352678A JP14352678A JPS5572145A JP S5572145 A JPS5572145 A JP S5572145A JP 14352678 A JP14352678 A JP 14352678A JP 14352678 A JP14352678 A JP 14352678A JP S5572145 A JPS5572145 A JP S5572145A
Authority
JP
Japan
Prior art keywords
compound
enzyme
adsorbent
substituted derivative
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14352678A
Other languages
Japanese (ja)
Other versions
JPS5837832B2 (en
Inventor
Daigaku Takiguchi
Eiji Ito
Hiroaki Nakamura
Izumi Kumita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Soda Co Ltd
Original Assignee
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co Ltd filed Critical Nippon Soda Co Ltd
Priority to JP53143526A priority Critical patent/JPS5837832B2/en
Publication of JPS5572145A publication Critical patent/JPS5572145A/en
Publication of JPS5837832B2 publication Critical patent/JPS5837832B2/en
Expired legal-status Critical Current

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  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound I [X is amino or carboxyl; R is guanidino or amidino group II, III (r1, r2 and r3 are H or lower alkyl); n is 0W2].
EXAMPLE: The compound IV.
USE: It has strong affinity for urokinase frequently used as a remedy for thrombosis or together with a carcinostatic substance, and for serine-protease, e.g. trypsin, kallikrein, etc., and is useful as the ligand of an adsorbent of the affinity chromatography for those medicines. Adsorbents having ligands of 2,5-substituted derivative, 2,8-substituted derivative, etc., have particularly excellent adsorbtivity, a high elimination degree of pyrogenic substance and a high enzyme yield.
PROCESS: For example, the compound VII among the compounds I is prepared from the compound V as the starting material via the compound VI.
COPYRIGHT: (C)1980,JPO&Japio
JP53143526A 1978-11-22 1978-11-22 Enzyme adsorbent and enzyme purification method Expired JPS5837832B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53143526A JPS5837832B2 (en) 1978-11-22 1978-11-22 Enzyme adsorbent and enzyme purification method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53143526A JPS5837832B2 (en) 1978-11-22 1978-11-22 Enzyme adsorbent and enzyme purification method

Publications (2)

Publication Number Publication Date
JPS5572145A true JPS5572145A (en) 1980-05-30
JPS5837832B2 JPS5837832B2 (en) 1983-08-18

Family

ID=15340782

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53143526A Expired JPS5837832B2 (en) 1978-11-22 1978-11-22 Enzyme adsorbent and enzyme purification method

Country Status (1)

Country Link
JP (1) JPS5837832B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104311444A (en) * 2014-09-27 2015-01-28 张远强 Nitronaphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives
CN104311443A (en) * 2014-09-27 2015-01-28 张远强 Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives
CN104311445A (en) * 2014-09-27 2015-01-28 张远强 Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104311444A (en) * 2014-09-27 2015-01-28 张远强 Nitronaphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives
CN104311443A (en) * 2014-09-27 2015-01-28 张远强 Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives
CN104311445A (en) * 2014-09-27 2015-01-28 张远强 Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives
CN104311443B (en) * 2014-09-27 2016-03-09 张远强 The naphthalene-ring containing succinamide derivative of one class, Preparation Method And The Use
CN104311445B (en) * 2014-09-27 2016-04-13 张远强 Naphthalene-ring containing succinamide derivative, Preparation Method And The Use
CN104311444B (en) * 2014-09-27 2016-05-18 张远强 Nitro replaces succinamide derivative, the Preparation Method And The Use of naphthalene nucleus

Also Published As

Publication number Publication date
JPS5837832B2 (en) 1983-08-18

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