JPS5572145A - Enzyme-adsorbent and purification of enzyme - Google Patents
Enzyme-adsorbent and purification of enzymeInfo
- Publication number
- JPS5572145A JPS5572145A JP14352678A JP14352678A JPS5572145A JP S5572145 A JPS5572145 A JP S5572145A JP 14352678 A JP14352678 A JP 14352678A JP 14352678 A JP14352678 A JP 14352678A JP S5572145 A JPS5572145 A JP S5572145A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- enzyme
- adsorbent
- substituted derivative
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound I [X is amino or carboxyl; R is guanidino or amidino group II, III (r1, r2 and r3 are H or lower alkyl); n is 0W2].
EXAMPLE: The compound IV.
USE: It has strong affinity for urokinase frequently used as a remedy for thrombosis or together with a carcinostatic substance, and for serine-protease, e.g. trypsin, kallikrein, etc., and is useful as the ligand of an adsorbent of the affinity chromatography for those medicines. Adsorbents having ligands of 2,5-substituted derivative, 2,8-substituted derivative, etc., have particularly excellent adsorbtivity, a high elimination degree of pyrogenic substance and a high enzyme yield.
PROCESS: For example, the compound VII among the compounds I is prepared from the compound V as the starting material via the compound VI.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53143526A JPS5837832B2 (en) | 1978-11-22 | 1978-11-22 | Enzyme adsorbent and enzyme purification method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53143526A JPS5837832B2 (en) | 1978-11-22 | 1978-11-22 | Enzyme adsorbent and enzyme purification method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5572145A true JPS5572145A (en) | 1980-05-30 |
JPS5837832B2 JPS5837832B2 (en) | 1983-08-18 |
Family
ID=15340782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53143526A Expired JPS5837832B2 (en) | 1978-11-22 | 1978-11-22 | Enzyme adsorbent and enzyme purification method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5837832B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104311444A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Nitronaphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
CN104311443A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
CN104311445A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
-
1978
- 1978-11-22 JP JP53143526A patent/JPS5837832B2/en not_active Expired
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104311444A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Nitronaphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
CN104311443A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
CN104311445A (en) * | 2014-09-27 | 2015-01-28 | 张远强 | Naphthalene-ring-containing butanedioic acid amide derivatives, preparing method thereof and uses of the derivatives |
CN104311443B (en) * | 2014-09-27 | 2016-03-09 | 张远强 | The naphthalene-ring containing succinamide derivative of one class, Preparation Method And The Use |
CN104311445B (en) * | 2014-09-27 | 2016-04-13 | 张远强 | Naphthalene-ring containing succinamide derivative, Preparation Method And The Use |
CN104311444B (en) * | 2014-09-27 | 2016-05-18 | 张远强 | Nitro replaces succinamide derivative, the Preparation Method And The Use of naphthalene nucleus |
Also Published As
Publication number | Publication date |
---|---|
JPS5837832B2 (en) | 1983-08-18 |
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