ES2098180B1 - Una composicion farmaceutica a base de compuestos de la clase de la rapamicina. - Google Patents

Una composicion farmaceutica a base de compuestos de la clase de la rapamicina.

Info

Publication number
ES2098180B1
ES2098180B1 ES09401166A ES9401166A ES2098180B1 ES 2098180 B1 ES2098180 B1 ES 2098180B1 ES 09401166 A ES09401166 A ES 09401166A ES 9401166 A ES9401166 A ES 9401166A ES 2098180 B1 ES2098180 B1 ES 2098180B1
Authority
ES
Spain
Prior art keywords
rapamicine
pharmaceutical composition
composition based
class compounds
concentrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09401166A
Other languages
English (en)
Other versions
ES2098180A1 (es
Inventor
Gerd Fricker
Barbara Haeberlin
Armin Meinzer
Jacky Vonderscher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939310974A external-priority patent/GB9310974D0/en
Priority claimed from GB939320463A external-priority patent/GB9320463D0/en
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Publication of ES2098180A1 publication Critical patent/ES2098180A1/es
Application granted granted Critical
Publication of ES2098180B1 publication Critical patent/ES2098180B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UNA COMPOSICION FARMACEUTICA A BASE DE COMPUESTOS DE LA CLASE DE LA RAPAMICINA, EN FORMA DE UN PRECONCENTRADO DE EMULSION O UN PRECONCENTRADO DE MICRO-EMULSION, PARA ADMINISTRACION POR VIA ORAL. EL VEHICULO DEL COMPUESTO DE RAPAMICINA INCLUYE UNA FASE HIDROFILICA, UNA FASE LIPOFILICA Y UN TENSIOACTIVO. LA COMPOSICION ES ESTABLE Y DISPONE DE UNA ELEVADA EFICIENCIA DE ABSORCION.
ES09401166A 1993-05-27 1994-05-26 Una composicion farmaceutica a base de compuestos de la clase de la rapamicina. Expired - Fee Related ES2098180B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310974A GB9310974D0 (en) 1993-05-27 1993-05-27 Organic compounds
GB939320463A GB9320463D0 (en) 1993-10-05 1993-10-05 Organic compounds

Publications (2)

Publication Number Publication Date
ES2098180A1 ES2098180A1 (es) 1997-04-16
ES2098180B1 true ES2098180B1 (es) 1998-07-01

Family

ID=26302958

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401166A Expired - Fee Related ES2098180B1 (es) 1993-05-27 1994-05-26 Una composicion farmaceutica a base de compuestos de la clase de la rapamicina.

Country Status (11)

Country Link
US (4) US5932243A (es)
JP (3) JP3121203B2 (es)
AT (1) AT408521B (es)
BE (1) BE1008329A3 (es)
CA (1) CA2124259C (es)
CH (1) CH686761A5 (es)
DE (1) DE4418115B4 (es)
ES (1) ES2098180B1 (es)
FR (1) FR2705566B1 (es)
HK (1) HK1011278A1 (es)
IT (1) IT1272992B (es)

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CH686761A5 (de) 1996-06-28
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JPH07138161A (ja) 1995-05-30
AT408521B (de) 2001-12-27
DE4418115B4 (de) 2009-07-23
FR2705566B1 (fr) 1996-04-05
CA2124259C (en) 2012-01-10
US20030166517A1 (en) 2003-09-04
US7025975B2 (en) 2006-04-11
FR2705566A1 (fr) 1994-12-02
US20040209911A1 (en) 2004-10-21
BE1008329A3 (fr) 1996-04-02
JPH11315022A (ja) 1999-11-16
CA2124259A1 (en) 1994-11-28
ES2098180A1 (es) 1997-04-16
JP2007039471A (ja) 2007-02-15
ITRM940324A1 (it) 1995-11-24
HK1011278A1 (en) 1999-07-09
US5932243A (en) 1999-08-03
ATA106594A (de) 2001-05-15
DE4418115A1 (de) 1994-12-01
JP3121203B2 (ja) 2000-12-25
ITRM940324A0 (it) 1994-05-24
JP4709729B2 (ja) 2011-06-22
US6565859B1 (en) 2003-05-20

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