PE20040103A1 - Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada - Google Patents
Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controladaInfo
- Publication number
- PE20040103A1 PE20040103A1 PE2003000646A PE2003000646A PE20040103A1 PE 20040103 A1 PE20040103 A1 PE 20040103A1 PE 2003000646 A PE2003000646 A PE 2003000646A PE 2003000646 A PE2003000646 A PE 2003000646A PE 20040103 A1 PE20040103 A1 PE 20040103A1
- Authority
- PE
- Peru
- Prior art keywords
- solubility
- increase
- dosage forms
- drug compositions
- controlled administration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION TERAPEUTICA DE LIBERACION CONTROLADA, QUE COMPRENDE: 1)UN AGENTE TERAPEUTICO DE BAJA SOLUBILIDAD; 2)UN PORTADOR DE POLIMERO ESTRUCTURAL; Y, 3)ENTRE 5% Y 50% DE UN SURFACTANTE SOLUBILIZANTE ADAPTADO PARA LIBERAR UNA ALTA DOSIS DE AGENTE TERAPEUTICO ENTRE 1µg Y 750 mg, SELECCIONADO ENTRE POLIOXIL 40 ESTEARATO, POLIOXIL 50 ESTEARATO, POLOXAMEROS, ENTRE OTROS. SIENDO, EL POLIMERO ESTRUCTURAL OXIDO DE POLIETILENO CON UN PESO MOLECULAR DE 100 000 A 200 000
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39212802P | 2002-06-26 | 2002-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040103A1 true PE20040103A1 (es) | 2004-02-25 |
Family
ID=30000814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000646A PE20040103A1 (es) | 2002-06-26 | 2003-06-26 | Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040091529A1 (es) |
EP (1) | EP1517671A2 (es) |
CN (1) | CN1678290A (es) |
AR (1) | AR039744A1 (es) |
AU (1) | AU2003280087A1 (es) |
CA (1) | CA2489688A1 (es) |
PE (1) | PE20040103A1 (es) |
TW (1) | TW200500098A (es) |
WO (1) | WO2004002447A2 (es) |
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EP2957281A1 (en) | 2001-09-21 | 2015-12-23 | Egalet Ltd. | Polymer release system |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
EP1325740B1 (en) * | 2001-12-12 | 2004-04-21 | Chemistry & Health International B.V. | Stable granulates containing S-Adenosylmethionine and process for the preparation thereof |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
US20050208132A1 (en) * | 2002-07-29 | 2005-09-22 | Gayatri Sathyan | Methods and dosage forms for reducing side effects of benzisozazole derivatives |
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DE602004031096D1 (de) | 2003-03-26 | 2011-03-03 | Egalet As | Morphin-system mit kontrollierter freisetzung |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
PL1635792T3 (pl) * | 2003-06-26 | 2009-08-31 | Teva Pharmaceutical Industries Ltd | Stabilne kompozycje farmaceutyczne pochodnych kwasu 2-aza-bicyklo[3.3.0]-oktano-3-karboksylowego |
CN103040773A (zh) * | 2003-07-25 | 2013-04-17 | 沃纳奇尔科特有限责任公司 | 多西环素金属络合物固体剂型 |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US7611728B2 (en) * | 2003-09-05 | 2009-11-03 | Supernus Pharmaceuticals, Inc. | Osmotic delivery of therapeutic compounds by solubility enhancement |
WO2005065653A1 (en) * | 2003-12-19 | 2005-07-21 | E.I. Du Pont De Nemours And Company | Intimate coating of ibuprofen with poloxamers to enhance aqueous dissolution |
JPWO2005065715A1 (ja) * | 2003-12-25 | 2007-07-26 | 武田薬品工業株式会社 | 造粒性改善方法 |
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EP1701706A2 (en) * | 2003-12-29 | 2006-09-20 | Alza Corporation | Novel drug compositions and dosage forms |
WO2005065647A2 (en) * | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc. | Drug granule coatings that impart smear resistance during mechanical compression |
CN1960709A (zh) * | 2004-05-21 | 2007-05-09 | 阿尔扎公司 | 递送多种药物形式的剂型 |
WO2006007323A2 (en) * | 2004-06-28 | 2006-01-19 | Alza Corporation | Dosage forms for low solubility and/or low dissolution rate free acid pharmaceutical agents |
WO2006007351A2 (en) * | 2004-06-28 | 2006-01-19 | Alza Corporation | Squeeze controlled oral dosage form |
CN1320887C (zh) * | 2004-09-28 | 2007-06-13 | 马晶 | 一种甲氨蝶呤口腔崩解片及其制备方法 |
AU2005302497A1 (en) * | 2004-10-29 | 2006-05-11 | Smith & Nephew, Inc. | Bioabsorbable polymers comprising calcium carbonate |
ES2588584T3 (es) * | 2005-01-21 | 2016-11-03 | Warner Chilcott Company, Llc | Un complejo metálico de tetraciclina en una forma de dosificación sólida |
WO2007056424A2 (en) * | 2005-11-07 | 2007-05-18 | Penwest Pharmaceuticals, Co. | Controlled-release emulsion compositions |
US20070231390A1 (en) * | 2006-03-29 | 2007-10-04 | Andrx Labs, Llc | Formulations including hygroscopic compounds |
US20080015188A1 (en) * | 2006-04-19 | 2008-01-17 | Julia Hrakovsky | Stable pharmaceutical compositions of 2-aza-bicyclo(3.3.0)-octane-3-carboxylic acid derivatives |
WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
GB2443738A (en) * | 2006-11-09 | 2008-05-14 | Proprius Pharmaceuticals Inc | A sustained release methotrexate composition and methods of use thereof |
JP5489719B2 (ja) | 2006-11-17 | 2014-05-14 | スパーナス ファーマシューティカルズ インコーポレイテッド | トピラマートの徐放性配合物 |
MX2009003911A (es) * | 2006-12-04 | 2009-05-28 | Supernus Pharmaceuticals Inc | Formulaciones de liberacion inmediata, mejoradas de topiramato. |
CA2687192C (en) | 2007-06-04 | 2015-11-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
WO2010149169A2 (en) | 2009-06-24 | 2010-12-29 | Egalet A/S | Controlled release formulations |
CA2877183A1 (en) | 2012-07-06 | 2014-01-09 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
EP3522890A4 (en) | 2016-10-10 | 2020-06-03 | Rhodes Pharmaceuticals L.P. | RESINATE-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME |
US11690840B2 (en) | 2017-10-09 | 2023-07-04 | Rhodes Pharmaceuticals L.P. | Pharmaceutical resinate compositions and methods of making and using thereof |
CN110420191A (zh) * | 2019-09-06 | 2019-11-08 | 北京兴源联合医药科技有限公司 | 一种包含左甲状腺素钠的口腔崩解片 |
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-
2003
- 2003-06-25 AR ARP030102278A patent/AR039744A1/es unknown
- 2003-06-26 CA CA002489688A patent/CA2489688A1/en not_active Abandoned
- 2003-06-26 AU AU2003280087A patent/AU2003280087A1/en not_active Abandoned
- 2003-06-26 WO PCT/US2003/020070 patent/WO2004002447A2/en not_active Application Discontinuation
- 2003-06-26 PE PE2003000646A patent/PE20040103A1/es not_active Application Discontinuation
- 2003-06-26 US US10/606,575 patent/US20040091529A1/en not_active Abandoned
- 2003-06-26 CN CNA038201119A patent/CN1678290A/zh active Pending
- 2003-06-26 EP EP03742204A patent/EP1517671A2/en not_active Withdrawn
- 2003-06-27 TW TW092117729A patent/TW200500098A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2004002447A3 (en) | 2004-06-10 |
AU2003280087A8 (en) | 2004-01-19 |
TW200500098A (en) | 2005-01-01 |
EP1517671A2 (en) | 2005-03-30 |
CN1678290A (zh) | 2005-10-05 |
AU2003280087A1 (en) | 2004-01-19 |
WO2004002447A2 (en) | 2004-01-08 |
AR039744A1 (es) | 2005-03-09 |
US20040091529A1 (en) | 2004-05-13 |
CA2489688A1 (en) | 2004-01-08 |
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