PE20040103A1 - Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada - Google Patents

Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada

Info

Publication number
PE20040103A1
PE20040103A1 PE2003000646A PE2003000646A PE20040103A1 PE 20040103 A1 PE20040103 A1 PE 20040103A1 PE 2003000646 A PE2003000646 A PE 2003000646A PE 2003000646 A PE2003000646 A PE 2003000646A PE 20040103 A1 PE20040103 A1 PE 20040103A1
Authority
PE
Peru
Prior art keywords
solubility
increase
dosage forms
drug compositions
controlled administration
Prior art date
Application number
PE2003000646A
Other languages
English (en)
Inventor
David Edgren
Shu Li
Gurdih Bhatti
Ayer Atul
Patricia Wong
Robert Skluzacek
Frank Jao
Winnie To
Shaoling Li
Andrew Lam
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of PE20040103A1 publication Critical patent/PE20040103A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION TERAPEUTICA DE LIBERACION CONTROLADA, QUE COMPRENDE: 1)UN AGENTE TERAPEUTICO DE BAJA SOLUBILIDAD; 2)UN PORTADOR DE POLIMERO ESTRUCTURAL; Y, 3)ENTRE 5% Y 50% DE UN SURFACTANTE SOLUBILIZANTE ADAPTADO PARA LIBERAR UNA ALTA DOSIS DE AGENTE TERAPEUTICO ENTRE 1µg Y 750 mg, SELECCIONADO ENTRE POLIOXIL 40 ESTEARATO, POLIOXIL 50 ESTEARATO, POLOXAMEROS, ENTRE OTROS. SIENDO, EL POLIMERO ESTRUCTURAL OXIDO DE POLIETILENO CON UN PESO MOLECULAR DE 100 000 A 200 000
PE2003000646A 2002-06-26 2003-06-26 Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada PE20040103A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39212802P 2002-06-26 2002-06-26

Publications (1)

Publication Number Publication Date
PE20040103A1 true PE20040103A1 (es) 2004-02-25

Family

ID=30000814

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000646A PE20040103A1 (es) 2002-06-26 2003-06-26 Metodo y formas de dosificacion para incrementar la solubilidad de composiciones de farmaco para administracion controlada

Country Status (9)

Country Link
US (1) US20040091529A1 (es)
EP (1) EP1517671A2 (es)
CN (1) CN1678290A (es)
AR (1) AR039744A1 (es)
AU (1) AU2003280087A1 (es)
CA (1) CA2489688A1 (es)
PE (1) PE20040103A1 (es)
TW (1) TW200500098A (es)
WO (1) WO2004002447A2 (es)

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Also Published As

Publication number Publication date
AR039744A1 (es) 2005-03-09
AU2003280087A8 (en) 2004-01-19
AU2003280087A1 (en) 2004-01-19
TW200500098A (en) 2005-01-01
CN1678290A (zh) 2005-10-05
WO2004002447A3 (en) 2004-06-10
WO2004002447A2 (en) 2004-01-08
US20040091529A1 (en) 2004-05-13
EP1517671A2 (en) 2005-03-30
CA2489688A1 (en) 2004-01-08

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