AR040722A1 - Formulaciones y formas de dosificacion para la administracion controlada de topiramato - Google Patents
Formulaciones y formas de dosificacion para la administracion controlada de topiramatoInfo
- Publication number
- AR040722A1 AR040722A1 AR20030102718A ARP030102718A AR040722A1 AR 040722 A1 AR040722 A1 AR 040722A1 AR 20030102718 A AR20030102718 A AR 20030102718A AR P030102718 A ARP030102718 A AR P030102718A AR 040722 A1 AR040722 A1 AR 040722A1
- Authority
- AR
- Argentina
- Prior art keywords
- release
- composition
- topiramate
- dosage forms
- drug core
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 title abstract 4
- 239000002552 dosage form Substances 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229960004394 topiramate Drugs 0.000 abstract 3
- 238000013270 controlled release Methods 0.000 abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000009747 swallowing Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Abstract
Formas de dosificación y dispositivos para mejorar la liberación controlada de agentes activos poco solubles que incluyen topiramato mediante el uso de una composición de un núcleo de droga que aumenta la solubilidad del agente farmacéutico. Provee una composición de un núcleo de droga para liberar elevadas dosis de topiramato poco soluble en los sistemas de liberación de droga oral sólida que son convenientes para deglutir, en una administración de una vez por día. La composición del núcleo de droga contiene topiramato y un portador en relaciones para una solubilidad y liberación óptimas. Reivindicación 1: Una composición terapéutica de liberación controlada que comprende aproximadamente 50-60% de un agente activo, aproximadamente 5-15% de un surfactante solubilizante adaptado para liberar el agente activo por un período de tiempo prolongado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39999302P | 2002-07-29 | 2002-07-29 | |
US46851903P | 2003-05-07 | 2003-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040722A1 true AR040722A1 (es) | 2005-04-20 |
Family
ID=31191336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102718A AR040722A1 (es) | 2002-07-29 | 2003-07-29 | Formulaciones y formas de dosificacion para la administracion controlada de topiramato |
Country Status (12)
Country | Link |
---|---|
US (1) | US20040115262A1 (es) |
EP (1) | EP1534238A1 (es) |
JP (1) | JP2005536568A (es) |
AR (1) | AR040722A1 (es) |
AU (1) | AU2003256848A1 (es) |
CA (1) | CA2494233A1 (es) |
MX (1) | MXPA05001184A (es) |
NZ (1) | NZ537543A (es) |
PE (1) | PE20040131A1 (es) |
TW (1) | TW200410728A (es) |
UY (1) | UY27908A1 (es) |
WO (1) | WO2004010970A1 (es) |
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ES2360102T3 (es) | 2003-03-26 | 2011-05-31 | Egalet A/S | Sistema para la liberación controlada de morfina. |
JP4989217B2 (ja) * | 2003-03-26 | 2012-08-01 | エガレット エイ/エス | 薬剤物質の送達制御用マトリックス組成物 |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
AU2004268549A1 (en) * | 2003-08-22 | 2005-03-10 | Alza Corporation | Stepwise delivery of topiramate over prolonged period of time |
WO2005020959A2 (en) * | 2003-09-02 | 2005-03-10 | Alza Corporation | Novel drug compositions and dosage forms of topiramate |
ATE544447T1 (de) | 2003-09-26 | 2012-02-15 | Alza Corp | Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung |
KR101169614B1 (ko) * | 2003-09-26 | 2012-08-03 | 알자 코포레이션 | 상승한 방출 속도를 나타내는 제어 방출 제제 |
CN1905857A (zh) * | 2003-11-14 | 2007-01-31 | 阿尔扎公司 | 液体剂型的托吡酯的受控释放 |
EP1701706A2 (en) * | 2003-12-29 | 2006-09-20 | Alza Corporation | Novel drug compositions and dosage forms |
JP2007517063A (ja) * | 2003-12-29 | 2007-06-28 | アルザ・コーポレーシヨン | トピラメートの新規な薬剤組成物および剤形 |
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US20070281007A1 (en) * | 2004-08-27 | 2007-12-06 | Jacob Jules S | Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs |
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CA2751667C (en) | 2009-02-06 | 2016-12-13 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
WO2010100657A2 (en) | 2009-03-04 | 2010-09-10 | Fdc Limited | A novel oral controlled release dosage forms for water soluble drugs |
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BR112019025286A2 (pt) | 2017-06-02 | 2020-06-23 | Jazz Pharmaceuticals Ireland Limited | Métodos e composições para tratamento de sonolência excessiva |
US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
CN115318353B (zh) * | 2022-08-31 | 2023-09-22 | 江苏举世检测有限公司 | 一种应用于管、瓶类卷口容器的恒温水浴锅及使用方法 |
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-
2003
- 2003-07-28 AU AU2003256848A patent/AU2003256848A1/en not_active Abandoned
- 2003-07-28 WO PCT/US2003/023438 patent/WO2004010970A1/en active Application Filing
- 2003-07-28 JP JP2005505623A patent/JP2005536568A/ja not_active Withdrawn
- 2003-07-28 CA CA002494233A patent/CA2494233A1/en not_active Abandoned
- 2003-07-28 MX MXPA05001184A patent/MXPA05001184A/es unknown
- 2003-07-28 NZ NZ537543A patent/NZ537543A/en unknown
- 2003-07-28 EP EP03771915A patent/EP1534238A1/en not_active Withdrawn
- 2003-07-28 US US10/628,970 patent/US20040115262A1/en not_active Abandoned
- 2003-07-29 AR AR20030102718A patent/AR040722A1/es unknown
- 2003-07-29 TW TW092120701A patent/TW200410728A/zh unknown
- 2003-07-30 PE PE2003000750A patent/PE20040131A1/es not_active Application Discontinuation
- 2003-07-31 UY UY27908A patent/UY27908A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
NZ537543A (en) | 2007-08-31 |
AU2003256848A1 (en) | 2004-02-16 |
TW200410728A (en) | 2004-07-01 |
UY27908A1 (es) | 2003-11-28 |
EP1534238A1 (en) | 2005-06-01 |
PE20040131A1 (es) | 2004-03-06 |
MXPA05001184A (es) | 2005-09-12 |
WO2004010970A1 (en) | 2004-02-05 |
CA2494233A1 (en) | 2004-02-05 |
US20040115262A1 (en) | 2004-06-17 |
JP2005536568A (ja) | 2005-12-02 |
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