ES2092263T3 - Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores. - Google Patents

Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores.

Info

Publication number
ES2092263T3
ES2092263T3 ES93402795T ES93402795T ES2092263T3 ES 2092263 T3 ES2092263 T3 ES 2092263T3 ES 93402795 T ES93402795 T ES 93402795T ES 93402795 T ES93402795 T ES 93402795T ES 2092263 T3 ES2092263 T3 ES 2092263T3
Authority
ES
Spain
Prior art keywords
immunosuppressive agents
deoxispergualine
therapeutics
analogs
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93402795T
Other languages
English (en)
Inventor
Patrice Renaut
Luc Lebreton
Patrick Dutartre
Philippe Derrepas
Soth Samreth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Industrie et Sante SAS
Original Assignee
Fournier Industrie et Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Application granted granted Critical
Publication of ES2092263T3 publication Critical patent/ES2092263T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION CONCIERNE, COMO PRODUCTOS INDUSTRIALES NUEVOS, A COMPUESTOS DE ESTRUCTURA PARECIDA A LA DE LA 15DEOXIESPERGUALINA. ESTOS NUEVOS COMPUESTOS RESPONDEN A LA FORMULA (I), EN LA CUAL: MPLE ENLACE, CH2, CHF, CH(OH), CH(OCH3), CH2NH O CH2O, Y SUS SALES DE ADICION. ESTOS NUEVOS COMPUESTOS SON UTILES COMO AGENTES INMUNOSUPRESORES.
ES93402795T 1992-12-02 1993-11-17 Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores. Expired - Lifetime ES2092263T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9214517A FR2698628B1 (fr) 1992-12-02 1992-12-02 Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.

Publications (1)

Publication Number Publication Date
ES2092263T3 true ES2092263T3 (es) 1996-11-16

Family

ID=9436147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93402795T Expired - Lifetime ES2092263T3 (es) 1992-12-02 1993-11-17 Analogos de la 15-deoxispergualina, su metodo de preparacion y su utilizacion en terapeutica como agentes inmunosupresores.

Country Status (24)

Country Link
US (1) US5476870A (es)
EP (1) EP0600762B1 (es)
JP (1) JP2945261B2 (es)
KR (1) KR100187328B1 (es)
CN (1) CN1045431C (es)
AT (1) ATE140215T1 (es)
AU (1) AU664124B2 (es)
CA (1) CA2110437C (es)
CZ (1) CZ284958B6 (es)
DE (1) DE69303583T2 (es)
DK (1) DK0600762T3 (es)
ES (1) ES2092263T3 (es)
FI (1) FI112211B (es)
FR (1) FR2698628B1 (es)
GR (1) GR3021269T3 (es)
HK (1) HK1000467A1 (es)
HU (1) HU218908B (es)
NO (1) NO180483C (es)
NZ (1) NZ250330A (es)
RU (1) RU2114823C1 (es)
SK (1) SK280286B6 (es)
TW (1) TW311132B (es)
UA (1) UA39920C2 (es)
ZA (1) ZA938821B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2187281A1 (en) * 1995-02-10 1996-08-15 Luc Lebreton 15-deoxyspergualin analogs, their use in therapeutics and their method of preparation
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique
WO1998028263A1 (de) * 1996-12-20 1998-07-02 Skw Trostberg Aktiengesellschaft Kreatin-pyruvate und verfahren zu deren herstellung
DE19728436A1 (de) * 1997-07-03 1999-01-07 Niels Franke Niedrigdosierte 15-Desoxyspergualin-Präparate
EP1107998B1 (en) * 1998-08-28 2004-02-04 Gryphon Sciences Method for the preparation of polyamide chains of precise length, their conjugates with proteins
DE19923961A1 (de) * 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Verwendung von 15-Deoxyspergualin zur Behandlung von hyperreaktiven entzündlichen Erkrankungen und Autoimmunerkrankungen
ES2668826T3 (es) 2004-05-05 2018-05-22 Silence Therapeutics Gmbh Lípidos, complejos lipídicos y uso de los mismos
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
US8350077B2 (en) 2008-12-24 2013-01-08 Vertex Closed Joint Stock Company Amides of creatine, method of their preparation, and remedy possessing a neuroprotective activity
RU2428414C2 (ru) 2009-11-03 2011-09-10 Закрытое Акционерное Общество "Вертекс" Способ получения амидов креатина
FR2963238B1 (fr) * 2010-07-29 2012-12-28 Fournier Lab Sa Derives de 15-desoxyspergualine pour le traitement et/ou la prevention des maladies inflammatoires oculaires
KR20130099926A (ko) * 2010-07-29 2013-09-06 라보라뚜와르 푸르니에 에스.아. 염증성 눈질환의 치료/예방용 화합물
KR101695730B1 (ko) 2015-03-10 2017-01-12 하경훈 마늘꼭지 절단기의 절단장치
FR3050455B1 (fr) * 2016-04-26 2019-06-14 Temisis Derives amides des acides polycafeoylquiniques, procede de preparation et utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions

Also Published As

Publication number Publication date
HU9303406D0 (en) 1994-03-28
HU218908B (hu) 2000-12-28
DE69303583D1 (de) 1996-08-14
NO934338D0 (no) 1993-11-30
CZ262293A3 (en) 1994-06-15
HK1000467A1 (en) 1998-03-27
AU664124B2 (en) 1995-11-02
NO180483C (no) 1997-04-30
JPH06293728A (ja) 1994-10-21
CA2110437C (en) 1999-04-13
CN1045431C (zh) 1999-10-06
GR3021269T3 (en) 1997-01-31
FI935318L (fi) 1994-06-03
ATE140215T1 (de) 1996-07-15
EP0600762A1 (fr) 1994-06-08
SK135793A3 (en) 1994-06-08
HUT65782A (en) 1994-07-28
KR100187328B1 (ko) 1999-05-15
FI112211B (fi) 2003-11-14
US5476870A (en) 1995-12-19
FR2698628A1 (fr) 1994-06-03
KR940014435A (ko) 1994-07-18
NZ250330A (en) 1995-06-27
ZA938821B (en) 1994-06-30
TW311132B (es) 1997-07-21
SK280286B6 (sk) 1999-11-08
FI935318A0 (fi) 1993-11-29
RU2114823C1 (ru) 1998-07-10
UA39920C2 (uk) 2001-07-16
CZ284958B6 (cs) 1999-04-14
CN1095709A (zh) 1994-11-30
JP2945261B2 (ja) 1999-09-06
AU5188393A (en) 1994-06-16
CA2110437A1 (en) 1994-06-03
EP0600762B1 (fr) 1996-07-10
NO180483B (no) 1997-01-20
NO934338L (no) 1994-06-03
DK0600762T3 (da) 1996-11-11
DE69303583T2 (de) 1996-11-21
FR2698628B1 (fr) 1995-02-17

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