ES2103131T3 - Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias. - Google Patents

Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.

Info

Publication number
ES2103131T3
ES2103131T3 ES94918130T ES94918130T ES2103131T3 ES 2103131 T3 ES2103131 T3 ES 2103131T3 ES 94918130 T ES94918130 T ES 94918130T ES 94918130 T ES94918130 T ES 94918130T ES 2103131 T3 ES2103131 T3 ES 2103131T3
Authority
ES
Spain
Prior art keywords
carbociclic
pro
new
inflammatory cytokines
agents useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918130T
Other languages
English (en)
Inventor
Carl K Edwards Iii
David R Borcherding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2103131T3 publication Critical patent/ES2103131T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A AGENTES NUCLEOSIDOS CARBOCICLICOS QUE SON UTILES COMO INHIBIDORES SELECTIVOS DE CITOQUINAS PROINFLAMATORIAS.
ES94918130T 1993-06-21 1994-05-25 Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias. Expired - Lifetime ES2103131T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8024993A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
ES2103131T3 true ES2103131T3 (es) 1997-08-16

Family

ID=22156170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918130T Expired - Lifetime ES2103131T3 (es) 1993-06-21 1994-05-25 Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.

Country Status (20)

Country Link
US (1) US6541482B2 (es)
EP (1) EP0705263B1 (es)
JP (1) JP3479077B2 (es)
KR (1) KR100337720B1 (es)
CN (1) CN1041631C (es)
AT (1) ATE151423T1 (es)
AU (1) AU677851B2 (es)
CA (1) CA2165779C (es)
DE (1) DE69402548T2 (es)
DK (1) DK0705263T3 (es)
ES (1) ES2103131T3 (es)
FI (1) FI956142A0 (es)
GR (1) GR3023373T3 (es)
HU (1) HUT73412A (es)
IL (1) IL110041A0 (es)
NO (1) NO312836B1 (es)
NZ (1) NZ267322A (es)
TW (1) TW356471B (es)
WO (1) WO1995000514A1 (es)
ZA (1) ZA944256B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111497D0 (en) * 2001-05-11 2001-07-04 Medical Res Council Therapeutic methods
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2004056868A2 (en) * 2002-12-19 2004-07-08 Endocube Sas Nf-hev compositions and methods of use
US7196093B2 (en) 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US7868011B2 (en) * 2003-04-09 2011-01-11 General Atomics Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
US7517887B2 (en) 2003-04-09 2009-04-14 General Atomics Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US11033821B2 (en) 2003-09-02 2021-06-15 Jeffrey D. Mullen Systems and methods for location based games and employment of the same on location enabled devices
CA2569016C (en) * 2004-06-02 2012-11-27 Takeda Pharmaceutical Company Limited Fused heterocyclic compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164556B (es) 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4916224A (en) 1988-01-20 1990-04-10 Regents Of The University Of Minnesota Dideoxycarbocyclic nucleosides
US4931559A (en) 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
AU642526B2 (en) 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
AU647822B2 (en) * 1990-09-14 1994-03-31 Marion Merrell Dow Inc. Novel carbocyclic adenosine analogs useful as immunosuppressants
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
AU658698B2 (en) 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
SK285229B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
JPH11255768A (ja) * 1998-03-09 1999-09-21 Ajinomoto Co Inc 抗ウイルス剤の製造方法

Also Published As

Publication number Publication date
CA2165779A1 (en) 1995-01-05
TW356471B (en) 1999-04-21
EP0705263A1 (en) 1996-04-10
NO955197D0 (no) 1995-12-20
ZA944256B (en) 1995-02-08
JPH08511558A (ja) 1996-12-03
HU9503689D0 (en) 1996-02-28
DE69402548D1 (de) 1997-05-15
HUT73412A (en) 1996-07-29
AU677851B2 (en) 1997-05-08
FI956142A (fi) 1995-12-20
IL110041A0 (en) 1994-10-07
EP0705263B1 (en) 1997-04-09
NZ267322A (en) 1997-09-22
WO1995000514A1 (en) 1995-01-05
FI956142A0 (fi) 1995-12-20
NO312836B1 (no) 2002-07-08
JP3479077B2 (ja) 2003-12-15
CA2165779C (en) 1998-06-16
GR3023373T3 (en) 1997-08-29
ATE151423T1 (de) 1997-04-15
CN1125946A (zh) 1996-07-03
KR100337720B1 (ko) 2002-11-02
CN1041631C (zh) 1999-01-13
DE69402548T2 (de) 1997-07-17
AU6958394A (en) 1995-01-17
KR960703122A (ko) 1996-06-19
US6541482B2 (en) 2003-04-01
DK0705263T3 (da) 1997-05-05
NO955197L (no) 1996-02-16
US20020004508A1 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
HUP0001446A2 (hu) HIV reverz transzkriptáz inhibitor hatású 4,4-diszubsztituált-3,4-dihidro-2(1H)-kinazolinon-származékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
TW370529B (en) Pyrazolopyrimidines
HUP0101031A2 (hu) Biciklo[2.2.1]heptán-származékok és rokon vegyületek
HUP0001309A2 (hu) 1-Fenil-4-benzil-piperazinok és a vegyületeket tartalmazó gyógyászati készítmények
HUP0201722A2 (hu) Gyógyászati készítmények alkoholizmus és alkoholfüggőség kezelésére
ES2103131T3 (es) Nuevos agentes de nucleosido carbociclico utiles como inhibidores selectivos de citoquinas proinflamatorias.
DK0759027T3 (da) Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase
HUP0001010A2 (hu) Benzimidazol-származékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
GB2334032B (en) Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents
HUP9900246A2 (hu) Liofilizált tio-xantenont tartalmazó tumorellenes gyógyszerkészítmények
DK0475413T3 (da) Carbocycliske nukleosidanaloge, der kan anvendes som immunsuppressorer
MY131365A (en) Carbamic acid derivatives
HUP9700558A2 (hu) Mikrobicid készítmények
NO20023892D0 (no) Anvendelse av en forbindelse for fremstilling av et medikament
TH18165A (th) สารยับยั้งการเกิดคีโมแทกซิของอีโอซีโนฟีล

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 705263

Country of ref document: ES