FI956142A - Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina käyttökelpoiset karbosykliset nukleosidiaineet - Google Patents

Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina käyttökelpoiset karbosykliset nukleosidiaineet Download PDF

Info

Publication number
FI956142A
FI956142A FI956142A FI956142A FI956142A FI 956142 A FI956142 A FI 956142A FI 956142 A FI956142 A FI 956142A FI 956142 A FI956142 A FI 956142A FI 956142 A FI956142 A FI 956142A
Authority
FI
Finland
Prior art keywords
alkyl
compounds
substituent
selective inhibitors
proinflammatory cytokines
Prior art date
Application number
FI956142A
Other languages
English (en)
Swedish (sv)
Other versions
FI956142A0 (fi
Inventor
Iii Carl Keith Edwards
David Roger Borcherding
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI956142A publication Critical patent/FI956142A/fi
Publication of FI956142A0 publication Critical patent/FI956142A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI956142A 1993-06-21 1995-12-20 Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina käyttökelpoiset karbosykliset nukleosidiaineet FI956142A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8024993A 1993-06-21 1993-06-21
PCT/US1994/005916 WO1995000514A1 (en) 1993-06-21 1994-05-25 Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines

Publications (2)

Publication Number Publication Date
FI956142A true FI956142A (fi) 1995-12-20
FI956142A0 FI956142A0 (fi) 1995-12-20

Family

ID=22156170

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956142A FI956142A0 (fi) 1993-06-21 1995-12-20 Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina käyttökelpoiset karbosykliset nukleosidiaineet

Country Status (20)

Country Link
US (1) US6541482B2 (fi)
EP (1) EP0705263B1 (fi)
JP (1) JP3479077B2 (fi)
KR (1) KR100337720B1 (fi)
CN (1) CN1041631C (fi)
AT (1) ATE151423T1 (fi)
AU (1) AU677851B2 (fi)
CA (1) CA2165779C (fi)
DE (1) DE69402548T2 (fi)
DK (1) DK0705263T3 (fi)
ES (1) ES2103131T3 (fi)
FI (1) FI956142A0 (fi)
GR (1) GR3023373T3 (fi)
HU (1) HUT73412A (fi)
IL (1) IL110041A0 (fi)
NO (1) NO312836B1 (fi)
NZ (1) NZ267322A (fi)
TW (1) TW356471B (fi)
WO (1) WO1995000514A1 (fi)
ZA (1) ZA944256B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111497D0 (en) * 2001-05-11 2001-07-04 Medical Res Council Therapeutic methods
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2004056868A2 (en) * 2002-12-19 2004-07-08 Endocube Sas Nf-hev compositions and methods of use
US7517887B2 (en) 2003-04-09 2009-04-14 General Atomics Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US7196093B2 (en) * 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US7868011B2 (en) 2003-04-09 2011-01-11 General Atomics Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
US11033821B2 (en) 2003-09-02 2021-06-15 Jeffrey D. Mullen Systems and methods for location based games and employment of the same on location enabled devices
EP1752457B1 (en) * 2004-06-02 2014-03-19 Takeda Pharmaceutical Company Limited Fused heterocyclic compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164556B (fi) 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4931559A (en) 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US4916224A (en) 1988-01-20 1990-04-10 Regents Of The University Of Minnesota Dideoxycarbocyclic nucleosides
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
AU642526B2 (en) 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
AU647822B2 (en) * 1990-09-14 1994-03-31 Marion Merrell Dow Inc. Novel carbocyclic adenosine analogs useful as immunosuppressants
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
AU658698B2 (en) 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
JPH11255768A (ja) * 1998-03-09 1999-09-21 Ajinomoto Co Inc 抗ウイルス剤の製造方法

Also Published As

Publication number Publication date
ZA944256B (en) 1995-02-08
HUT73412A (en) 1996-07-29
NZ267322A (en) 1997-09-22
ATE151423T1 (de) 1997-04-15
AU677851B2 (en) 1997-05-08
DK0705263T3 (da) 1997-05-05
US20020004508A1 (en) 2002-01-10
NO312836B1 (no) 2002-07-08
WO1995000514A1 (en) 1995-01-05
KR960703122A (ko) 1996-06-19
GR3023373T3 (en) 1997-08-29
NO955197D0 (no) 1995-12-20
ES2103131T3 (es) 1997-08-16
IL110041A0 (en) 1994-10-07
JPH08511558A (ja) 1996-12-03
CA2165779A1 (en) 1995-01-05
NO955197L (no) 1996-02-16
EP0705263A1 (en) 1996-04-10
KR100337720B1 (ko) 2002-11-02
EP0705263B1 (en) 1997-04-09
TW356471B (en) 1999-04-21
FI956142A0 (fi) 1995-12-20
AU6958394A (en) 1995-01-17
US6541482B2 (en) 2003-04-01
DE69402548D1 (de) 1997-05-15
HU9503689D0 (en) 1996-02-28
DE69402548T2 (de) 1997-07-17
JP3479077B2 (ja) 2003-12-15
CA2165779C (en) 1998-06-16
CN1125946A (zh) 1996-07-03
CN1041631C (zh) 1999-01-13

Similar Documents

Publication Publication Date Title
TW370529B (en) Pyrazolopyrimidines
ES2067500T3 (es) 1-indolilalquil-4-(piridinil-sustituidas)piperazinas.
ES2188280T3 (es) Acetales heteroaril-ciclicos.
HUP0204474A2 (hu) 1H-imidazopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0004221A2 (hu) O-Helyettesített hidroxi-kumaranon-származékok, alkalmazásuk tumor- és metasztázis-ellenes gyógyszerkészítmények előállítására és a gyógyszerkészítmények
EP0363085A3 (en) Novel compounds
KR910007883A (ko) 퀴놀린 유도체, 그의 제조방법 및 용도
FI956142A0 (fi) Uudet proinflammatoristen sytokiinien selektiivisinä inhibiittoreina käyttökelpoiset karbosykliset nukleosidiaineet
FI953935A (fi) Polyamiinijohdannaisia radiosuojaavina aineina
HUP0201722A2 (hu) Gyógyászati készítmények alkoholizmus és alkoholfüggőség kezelésére
FI964463A (fi) Bisykliset amidiinijohdannaiset typpioksidinsyntetaasin inhibiittoreina
HUP0001010A2 (hu) Benzimidazol-származékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
AU4713797A (en) Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents
MY131365A (en) Carbamic acid derivatives
DK0475413T3 (da) Carbocycliske nukleosidanaloge, der kan anvendes som immunsuppressorer
HUP9700558A2 (hu) Mikrobicid készítmények
HUP9802938A2 (hu) 4-Cikloalkil-piperidin és 4-cikloalkil-alkil-piperidin-származékok, eljárás a vegyületek előállítására és a vegyületek alkalmazása a gyógyászatban
SE0000537D0 (sv) Use of a compound for preparing a drug
FI955680A (fi) Psoraleenijohdannaiset, niiden valmistus ja käyttö
UA41868C2 (uk) N-заміщені похідні 3-азабіцикло[3.2.0]гептану
TH18165A (th) สารยับยั้งการเกิดคีโมแทกซิของอีโอซีโนฟีล

Legal Events

Date Code Title Description
FD Application lapsed