ES2087868T3 - Derivados de piridina. - Google Patents
Derivados de piridina.Info
- Publication number
- ES2087868T3 ES2087868T3 ES89310772T ES89310772T ES2087868T3 ES 2087868 T3 ES2087868 T3 ES 2087868T3 ES 89310772 T ES89310772 T ES 89310772T ES 89310772 T ES89310772 T ES 89310772T ES 2087868 T3 ES2087868 T3 ES 2087868T3
- Authority
- ES
- Spain
- Prior art keywords
- disease
- hydroxy
- variety
- acid derivatives
- dioxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA INVENCION CONCIERNE A NUEVOS, DERIVADOS 1,3-DIOXANO ACIDO ALQUENOICOS USADOS FARMACEUTICAMENTE DE LA FORMULA I, CONTENIENDO UN SEMI PIRIDILO EN LA POSICION 4 DEL ANILLO DE DIOXANO Y EN EL CUAL LOS GRUPOS DE LAS POSICIONES 2,4 Y 5 TIENEN ESTEREOQUIMICAMENTE ISOMERIA RELATIVA, X ES HIDROGENO, ALCOXI O HIDROXI, Y ES VINILENO, N ES 1 O 2, A1 ES ALQUILENO, LOS SUSTITUYENTES R1 Y R2 EN LA POSICION 2 DEL ANILLO DE DIOXANO TIENEN UNA VARIEDAD DE VALORES ANTERIORMENTE DEFINIDOS AQUI, Y R4 ES HIDROXI, UN ALCOHOL RESIDUAL FISIOLOGICAMENTE ACEPTABLE O ALCANOSULFONAMIDO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LA INVENCION TAMBIEN INCLUYE PROCESOS PARA LA FABRICACION Y USO DE DERIVADOS ACIDOS ASI COMO COMPOSICIONES FARMACEUTICAS PARA USO TERAPEUTICO EN UNA O MAS DE UNA VARIEDAD DE ENFERMEDADES TALES COMO CORAZON ISTEMICO, DESORDENES CEREBROVASCULARES, ASMATICOS Y/O INFLAMATORIOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888824667A GB8824667D0 (en) | 1988-10-21 | 1988-10-21 | Carboxylic acids |
GB888824668A GB8824668D0 (en) | 1988-10-21 | 1988-10-21 | Alkenoic acids |
GB898918937A GB8918937D0 (en) | 1989-08-18 | 1989-08-18 | Acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2087868T3 true ES2087868T3 (es) | 1996-08-01 |
Family
ID=27264134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89310772T Expired - Lifetime ES2087868T3 (es) | 1988-10-21 | 1989-10-19 | Derivados de piridina. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5053415A (es) |
EP (1) | EP0365328B1 (es) |
JP (1) | JPH0699426B2 (es) |
KR (1) | KR0161260B1 (es) |
AT (1) | ATE136304T1 (es) |
AU (1) | AU627230B2 (es) |
CA (1) | CA2001160C (es) |
DE (1) | DE68926144T2 (es) |
DK (1) | DK513789A (es) |
ES (1) | ES2087868T3 (es) |
FI (1) | FI93545C (es) |
GR (1) | GR3019550T3 (es) |
HU (2) | HU212263B (es) |
IE (1) | IE81170B1 (es) |
IL (1) | IL92028A (es) |
MY (1) | MY104242A (es) |
NO (1) | NO173735C (es) |
PH (1) | PH27054A (es) |
PL (2) | PL163178B1 (es) |
PT (1) | PT92035B (es) |
RU (1) | RU2045526C1 (es) |
ZW (1) | ZW12889A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
US5248780A (en) * | 1988-02-16 | 1993-09-28 | Imperial Chemical Industries, Plc | Pyridyl substituted alkenoic acid derivatives |
IE66512B1 (en) * | 1989-02-28 | 1996-01-10 | Ici Plc | Heterocyclic ethers as 5-lipoxygenase inhibitors |
GB9021571D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Heterocyclic acids |
FR2702213B1 (fr) * | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R). |
US5371096A (en) * | 1993-08-27 | 1994-12-06 | Ciba-Geigy Corporation | (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids |
WO2007138485A2 (en) * | 2006-01-18 | 2007-12-06 | Evolva Sa | Ppar modulators |
EP2124551A4 (en) * | 2007-01-18 | 2010-07-28 | Evolva Sa | SUBSTITUTED 1, 3-DIOXANES AND THEIR USE |
MX2009007670A (es) * | 2007-01-18 | 2011-11-18 | Evolva Sa | 1,3-dioxanos sustituidos utiles como moduladores de paar. |
EP2797597B1 (en) | 2011-12-28 | 2020-02-26 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
SG11201403645VA (en) | 2011-12-28 | 2014-07-30 | Global Blood Therapeutics Inc | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
AU2014237340C1 (en) | 2013-03-15 | 2018-11-08 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CA2902711C (en) | 2013-03-15 | 2021-07-06 | Global Blood Therapeutics, Inc. | Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin |
EA033555B1 (ru) | 2013-03-15 | 2019-10-31 | Global Blood Therapeutics Inc | Фармацевтические композиции для лечения серповидно-клеточного нарушения |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
AP2016009261A0 (en) | 2014-02-07 | 2016-06-30 | Global Blood Therapeutics Inc | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
WO2017096230A1 (en) | 2015-12-04 | 2017-06-08 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
CN106700129B (zh) * | 2016-10-20 | 2018-11-23 | 北京吉海川科技发展有限公司 | 一种位阻酚的酯类抗氧化剂及其制备方法和应用 |
ES2966707T3 (es) | 2018-10-01 | 2024-04-23 | Global Blood Therapeutics Inc | Moduladores de la hemoglobina para el tratamiento de la drepanocitosis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8310407D0 (en) * | 1982-05-12 | 1983-05-25 | Ici Plc | 1 3 - dioxan -5- ylalkenoic acids |
GB8330099D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Cycloalkane derivatives |
US4554011A (en) * | 1984-08-24 | 1985-11-19 | Chevron Research Company | Herbicidal 2S-(2β,4β,5β)-5-Arylmethoxy-4-substituted 2-alkyl-1,3-dioxane derivatives |
GB8511894D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Phenol derivatives |
ES8802508A1 (es) * | 1985-05-10 | 1988-07-16 | Ici Plc | Procedimiento para preparar derivados alquenicos. |
GB8511895D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Heterocyclic compounds |
AT387860B (de) * | 1985-09-16 | 1989-03-28 | Optical Sensing Technology | Verfahren und vorrichtung zur tumordiagnose mittels sera |
GB8709794D0 (en) * | 1987-04-24 | 1987-05-28 | Ici Plc | Heterocyclic acids |
GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
-
1989
- 1989-10-12 IE IE330089A patent/IE81170B1/en not_active IP Right Cessation
- 1989-10-15 ZW ZW128/89A patent/ZW12889A1/xx unknown
- 1989-10-16 HU HU895320A patent/HU212263B/hu not_active IP Right Cessation
- 1989-10-16 AU AU42936/89A patent/AU627230B2/en not_active Ceased
- 1989-10-16 DK DK513789A patent/DK513789A/da not_active Application Discontinuation
- 1989-10-17 IL IL9202889A patent/IL92028A/en not_active IP Right Cessation
- 1989-10-17 MY MYPI89001432A patent/MY104242A/en unknown
- 1989-10-18 PH PH39377A patent/PH27054A/en unknown
- 1989-10-19 AT AT89310772T patent/ATE136304T1/de not_active IP Right Cessation
- 1989-10-19 ES ES89310772T patent/ES2087868T3/es not_active Expired - Lifetime
- 1989-10-19 EP EP89310772A patent/EP0365328B1/en not_active Expired - Lifetime
- 1989-10-19 PT PT92035A patent/PT92035B/pt not_active IP Right Cessation
- 1989-10-19 DE DE68926144T patent/DE68926144T2/de not_active Expired - Fee Related
- 1989-10-20 RU SU894742319A patent/RU2045526C1/ru active
- 1989-10-20 NO NO894190A patent/NO173735C/no not_active IP Right Cessation
- 1989-10-20 CA CA002001160A patent/CA2001160C/en not_active Expired - Fee Related
- 1989-10-20 KR KR1019890015088A patent/KR0161260B1/ko not_active IP Right Cessation
- 1989-10-20 US US07/424,611 patent/US5053415A/en not_active Expired - Fee Related
- 1989-10-20 FI FI895007A patent/FI93545C/fi not_active IP Right Cessation
- 1989-10-20 JP JP1271923A patent/JPH0699426B2/ja not_active Expired - Lifetime
- 1989-10-20 PL PL89286429A patent/PL163178B1/pl unknown
- 1989-10-20 PL PL89281921A patent/PL163045B1/pl unknown
-
1995
- 1995-06-16 HU HU95P/P00227P patent/HU211522A9/hu unknown
-
1996
- 1996-04-04 GR GR960400645T patent/GR3019550T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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