DE68926144T2 - Pyridinderivate - Google Patents

Pyridinderivate

Info

Publication number
DE68926144T2
DE68926144T2 DE68926144T DE68926144T DE68926144T2 DE 68926144 T2 DE68926144 T2 DE 68926144T2 DE 68926144 T DE68926144 T DE 68926144T DE 68926144 T DE68926144 T DE 68926144T DE 68926144 T2 DE68926144 T2 DE 68926144T2
Authority
DE
Germany
Prior art keywords
disease
hydroxy
variety
acid derivatives
dioxane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926144T
Other languages
English (en)
Other versions
DE68926144D1 (de
Inventor
Andrew George Brewster
George Robert Brown
Alan Wellington Faull
Reginald Jessup
Michael James Smithers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888824668A external-priority patent/GB8824668D0/en
Priority claimed from GB888824667A external-priority patent/GB8824667D0/en
Priority claimed from GB898918937A external-priority patent/GB8918937D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE68926144D1 publication Critical patent/DE68926144D1/de
Application granted granted Critical
Publication of DE68926144T2 publication Critical patent/DE68926144T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DE68926144T 1988-10-21 1989-10-19 Pyridinderivate Expired - Fee Related DE68926144T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888824668A GB8824668D0 (en) 1988-10-21 1988-10-21 Alkenoic acids
GB888824667A GB8824667D0 (en) 1988-10-21 1988-10-21 Carboxylic acids
GB898918937A GB8918937D0 (en) 1989-08-18 1989-08-18 Acid derivatives

Publications (2)

Publication Number Publication Date
DE68926144D1 DE68926144D1 (de) 1996-05-09
DE68926144T2 true DE68926144T2 (de) 1996-10-17

Family

ID=27264134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926144T Expired - Fee Related DE68926144T2 (de) 1988-10-21 1989-10-19 Pyridinderivate

Country Status (22)

Country Link
US (1) US5053415A (de)
EP (1) EP0365328B1 (de)
JP (1) JPH0699426B2 (de)
KR (1) KR0161260B1 (de)
AT (1) ATE136304T1 (de)
AU (1) AU627230B2 (de)
CA (1) CA2001160C (de)
DE (1) DE68926144T2 (de)
DK (1) DK513789A (de)
ES (1) ES2087868T3 (de)
FI (1) FI93545C (de)
GR (1) GR3019550T3 (de)
HU (2) HU212263B (de)
IE (1) IE81170B1 (de)
IL (1) IL92028A (de)
MY (1) MY104242A (de)
NO (1) NO173735C (de)
PH (1) PH27054A (de)
PL (2) PL163178B1 (de)
PT (1) PT92035B (de)
RU (1) RU2045526C1 (de)
ZW (1) ZW12889A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives
US5248780A (en) * 1988-02-16 1993-09-28 Imperial Chemical Industries, Plc Pyridyl substituted alkenoic acid derivatives
IE66512B1 (en) * 1989-02-28 1996-01-10 Ici Plc Heterocyclic ethers as 5-lipoxygenase inhibitors
GB9021571D0 (en) * 1990-10-04 1990-11-21 Ici Plc Heterocyclic acids
FR2702213B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R).
US5371096A (en) * 1993-08-27 1994-12-06 Ciba-Geigy Corporation (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids
WO2007138485A2 (en) * 2006-01-18 2007-12-06 Evolva Sa Ppar modulators
WO2008089463A2 (en) 2007-01-18 2008-07-24 Evolva Sa Substituted 1,3-dioxanes and their uses
JP5662682B2 (ja) * 2007-01-18 2015-02-04 エヴォルヴァ エスアー Ｐｐａｒモジュレータとして有用な置換１，３−ジオキサン
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
PT2797416T (pt) * 2011-12-28 2017-10-23 Global Blood Therapeutics Inc Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CN106700129B (zh) * 2016-10-20 2018-11-23 北京吉海川科技发展有限公司 一种位阻酚的酯类抗氧化剂及其制备方法和应用
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
US4554011A (en) * 1984-08-24 1985-11-19 Chevron Research Company Herbicidal 2S-(2β,4β,5β)-5-Arylmethoxy-4-substituted 2-alkyl-1,3-dioxane derivatives
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
GB8511894D0 (en) * 1985-05-10 1985-06-19 Ici Plc Phenol derivatives
ES8802508A1 (es) * 1985-05-10 1988-07-16 Ici Plc Procedimiento para preparar derivados alquenicos.
AT387860B (de) * 1985-09-16 1989-03-28 Optical Sensing Technology Verfahren und vorrichtung zur tumordiagnose mittels sera
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives

Also Published As

Publication number Publication date
HU211522A9 (en) 1995-11-28
IE893300L (en) 1990-04-21
PH27054A (en) 1993-02-01
CA2001160A1 (en) 1990-04-21
JPH0699426B2 (ja) 1994-12-07
HUT58075A (en) 1992-01-28
NO173735B (no) 1993-10-18
EP0365328B1 (de) 1996-04-03
NO894190L (no) 1990-04-23
RU2045526C1 (ru) 1995-10-10
FI93545B (fi) 1995-01-13
IL92028A (en) 1994-06-24
ZW12889A1 (en) 1989-12-06
ATE136304T1 (de) 1996-04-15
HU212263B (en) 1996-04-29
PT92035A (pt) 1990-04-30
PT92035B (pt) 1995-05-31
EP0365328A2 (de) 1990-04-25
MY104242A (en) 1994-02-28
PL163178B1 (pl) 1994-02-28
NO173735C (no) 1994-01-26
US5053415A (en) 1991-10-01
DK513789D0 (da) 1989-10-16
HU895320D0 (en) 1990-01-28
KR900006324A (ko) 1990-05-07
AU4293689A (en) 1990-04-26
FI895007A0 (fi) 1989-10-20
ES2087868T3 (es) 1996-08-01
KR0161260B1 (ko) 1998-12-01
AU627230B2 (en) 1992-08-20
PL286429A1 (en) 1991-04-22
CA2001160C (en) 2000-09-05
NO894190D0 (no) 1989-10-20
IE81170B1 (en) 2000-05-31
EP0365328A3 (en) 1990-11-28
DE68926144D1 (de) 1996-05-09
DK513789A (da) 1990-04-22
PL163045B1 (pl) 1994-02-28
JPH02164877A (ja) 1990-06-25
FI93545C (fi) 1995-04-25
IL92028A0 (en) 1990-07-12
GR3019550T3 (en) 1996-07-31

Similar Documents

Publication Publication Date Title
ATE136304T1 (de) Pyridinderivate
LU91362I2 (fr) Palipéridone et ses dérivés pharmaceutiquement acceptables (INVEGA)
NO874350D0 (no) Fremgangsmaate for fremstilling av antibakterielle forbindelser.
CA2203274A1 (en) Apolipoprotein-b synthesis inhibitors
MY132062A (en) Apolipoprotein-b synthesis inhibitors
DK196688A (da) Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
DK268289A (da) Cephemforbindelser og fremgangsmaade til fremstilling deraf
MY103699A (en) Pyridine derivatives.
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
MY103368A (en) 1,3-dioxanes
JO1604B1 (en) Pyridine derivatives
DK474089A (da) Indolderivater og fremgangsmaader til fremstilling deraf

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee