DK513789A - Pyridinderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse - Google Patents

Pyridinderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse

Info

Publication number
DK513789A
DK513789A DK513789A DK513789A DK513789A DK 513789 A DK513789 A DK 513789A DK 513789 A DK513789 A DK 513789A DK 513789 A DK513789 A DK 513789A DK 513789 A DK513789 A DK 513789A
Authority
DK
Denmark
Prior art keywords
disease
hydroxy
preparing
procedure
variety
Prior art date
Application number
DK513789A
Other languages
English (en)
Other versions
DK513789D0 (da
Inventor
Andrew George Brewster
George Robert Brown
Alan Wellington Faull
Reginald Jessup
Michael James Smithers
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888824668A external-priority patent/GB8824668D0/en
Priority claimed from GB888824667A external-priority patent/GB8824667D0/en
Priority claimed from GB898918937A external-priority patent/GB8918937D0/en
Application filed by Ici Plc filed Critical Ici Plc
Publication of DK513789D0 publication Critical patent/DK513789D0/da
Publication of DK513789A publication Critical patent/DK513789A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DK513789A 1988-10-21 1989-10-16 Pyridinderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse DK513789A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888824668A GB8824668D0 (en) 1988-10-21 1988-10-21 Alkenoic acids
GB888824667A GB8824667D0 (en) 1988-10-21 1988-10-21 Carboxylic acids
GB898918937A GB8918937D0 (en) 1989-08-18 1989-08-18 Acid derivatives

Publications (2)

Publication Number Publication Date
DK513789D0 DK513789D0 (da) 1989-10-16
DK513789A true DK513789A (da) 1990-04-22

Family

ID=27264134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK513789A DK513789A (da) 1988-10-21 1989-10-16 Pyridinderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse

Country Status (22)

Country Link
US (1) US5053415A (da)
EP (1) EP0365328B1 (da)
JP (1) JPH0699426B2 (da)
KR (1) KR0161260B1 (da)
AT (1) ATE136304T1 (da)
AU (1) AU627230B2 (da)
CA (1) CA2001160C (da)
DE (1) DE68926144T2 (da)
DK (1) DK513789A (da)
ES (1) ES2087868T3 (da)
FI (1) FI93545C (da)
GR (1) GR3019550T3 (da)
HU (2) HU212263B (da)
IE (1) IE81170B1 (da)
IL (1) IL92028A (da)
MY (1) MY104242A (da)
NO (1) NO173735C (da)
PH (1) PH27054A (da)
PL (2) PL163178B1 (da)
PT (1) PT92035B (da)
RU (1) RU2045526C1 (da)
ZW (1) ZW12889A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives
US5248780A (en) * 1988-02-16 1993-09-28 Imperial Chemical Industries, Plc Pyridyl substituted alkenoic acid derivatives
IE66512B1 (en) * 1989-02-28 1996-01-10 Ici Plc Heterocyclic ethers as 5-lipoxygenase inhibitors
GB9021571D0 (en) * 1990-10-04 1990-11-21 Ici Plc Heterocyclic acids
FR2702213B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R).
US5371096A (en) * 1993-08-27 1994-12-06 Ciba-Geigy Corporation (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids
WO2007138485A2 (en) * 2006-01-18 2007-12-06 Evolva Sa Ppar modulators
WO2008089463A2 (en) 2007-01-18 2008-07-24 Evolva Sa Substituted 1,3-dioxanes and their uses
JP5662682B2 (ja) * 2007-01-18 2015-02-04 エヴォルヴァ エスアー Ｐｐａｒモジュレータとして有用な置換１，３−ジオキサン
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
PT2797416T (pt) * 2011-12-28 2017-10-23 Global Blood Therapeutics Inc Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CN106700129B (zh) * 2016-10-20 2018-11-23 北京吉海川科技发展有限公司 一种位阻酚的酯类抗氧化剂及其制备方法和应用
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
US4554011A (en) * 1984-08-24 1985-11-19 Chevron Research Company Herbicidal 2S-(2β,4β,5β)-5-Arylmethoxy-4-substituted 2-alkyl-1,3-dioxane derivatives
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
GB8511894D0 (en) * 1985-05-10 1985-06-19 Ici Plc Phenol derivatives
ES8802508A1 (es) * 1985-05-10 1988-07-16 Ici Plc Procedimiento para preparar derivados alquenicos.
AT387860B (de) * 1985-09-16 1989-03-28 Optical Sensing Technology Verfahren und vorrichtung zur tumordiagnose mittels sera
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives

Also Published As

Publication number Publication date
HU211522A9 (en) 1995-11-28
IE893300L (en) 1990-04-21
PH27054A (en) 1993-02-01
CA2001160A1 (en) 1990-04-21
JPH0699426B2 (ja) 1994-12-07
HUT58075A (en) 1992-01-28
NO173735B (no) 1993-10-18
EP0365328B1 (en) 1996-04-03
NO894190L (no) 1990-04-23
RU2045526C1 (ru) 1995-10-10
FI93545B (fi) 1995-01-13
IL92028A (en) 1994-06-24
ZW12889A1 (en) 1989-12-06
ATE136304T1 (de) 1996-04-15
HU212263B (en) 1996-04-29
PT92035A (pt) 1990-04-30
PT92035B (pt) 1995-05-31
EP0365328A2 (en) 1990-04-25
MY104242A (en) 1994-02-28
PL163178B1 (pl) 1994-02-28
NO173735C (no) 1994-01-26
US5053415A (en) 1991-10-01
DK513789D0 (da) 1989-10-16
HU895320D0 (en) 1990-01-28
KR900006324A (ko) 1990-05-07
AU4293689A (en) 1990-04-26
FI895007A0 (fi) 1989-10-20
ES2087868T3 (es) 1996-08-01
KR0161260B1 (ko) 1998-12-01
AU627230B2 (en) 1992-08-20
PL286429A1 (en) 1991-04-22
CA2001160C (en) 2000-09-05
NO894190D0 (no) 1989-10-20
IE81170B1 (en) 2000-05-31
EP0365328A3 (en) 1990-11-28
DE68926144D1 (de) 1996-05-09
PL163045B1 (pl) 1994-02-28
DE68926144T2 (de) 1996-10-17
JPH02164877A (ja) 1990-06-25
FI93545C (fi) 1995-04-25
IL92028A0 (en) 1990-07-12
GR3019550T3 (en) 1996-07-31

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Legal Events

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AHB Application shelved due to non-payment