ES2068810T3 - Preparacion particulada de liberacion mantenida y procedimiento para la produccion de la misma. - Google Patents

Preparacion particulada de liberacion mantenida y procedimiento para la produccion de la misma.

Info

Publication number
ES2068810T3
ES2068810T3 ES87114584T ES87114584T ES2068810T3 ES 2068810 T3 ES2068810 T3 ES 2068810T3 ES 87114584 T ES87114584 T ES 87114584T ES 87114584 T ES87114584 T ES 87114584T ES 2068810 T3 ES2068810 T3 ES 2068810T3
Authority
ES
Spain
Prior art keywords
preparation
particulated
procedure
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87114584T
Other languages
English (en)
Inventor
Minoru Machida
Masayuki Arakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2068810T3 publication Critical patent/ES2068810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UNA PREPARACION DE LIBERACION CONTROLADA, EN FORMA DE PARTICULAS, DE UN AGENTE FARMACOLOGICAMENTE ACTIVO, Y UN PROCEDIMIENTO PARA PREPARARLO. LA PREPARACION CONTIENE UN COMPUESTO POLIMERICO CAPAZ DE SER DEGRADADO EN EL CUERPO Y QUE ES BIOCOMPATIBLE, UN AGENTE FARMACOLOGICAMENTE ACTIVO Y UN COMPUESTO NATURAL DE ALTO PESO MOLECULAR DERIVADO DE UN AZUCAR. LA PREPARACION TIENE UN TAMAÑO DE PARTICULA FINA Y UNIFORME Y PUEDE ADMINISTRARSE POR VIA SUBCUTANEA O INTRAMUSCULAR PARA CONSEGUIR UNA ACTIVIDAD FARMACOLOGICA PROLONGADA.
ES87114584T 1986-10-07 1987-10-06 Preparacion particulada de liberacion mantenida y procedimiento para la produccion de la misma. Expired - Lifetime ES2068810T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61237027A JPH0725689B2 (ja) 1986-10-07 1986-10-07 顆粒球コロニ−刺激因子を含有する徐放性製剤

Publications (1)

Publication Number Publication Date
ES2068810T3 true ES2068810T3 (es) 1995-05-01

Family

ID=17009307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87114584T Expired - Lifetime ES2068810T3 (es) 1986-10-07 1987-10-06 Preparacion particulada de liberacion mantenida y procedimiento para la produccion de la misma.

Country Status (10)

Country Link
US (1) US4853226A (es)
EP (1) EP0263490B1 (es)
JP (1) JPH0725689B2 (es)
KR (1) KR930007247B1 (es)
AT (1) ATE116540T1 (es)
AU (1) AU608250B2 (es)
CA (1) CA1315200C (es)
DE (1) DE3750943T2 (es)
ES (1) ES2068810T3 (es)
GR (1) GR3015485T3 (es)

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US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
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DE59003337D1 (de) * 1989-10-16 1993-12-09 Danubia Petrochem Polymere Pressling mit retardierter Wirkstofffreisetzung.
AT397345B (de) * 1990-04-04 1994-03-25 Chemiefaser Lenzing Ag Pharmazeutisches präparat mit verzögerter wirkstofffreisetzung auf basis von hemicellulosen
JP3249147B2 (ja) * 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
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US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
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US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
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US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
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US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
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Also Published As

Publication number Publication date
US4853226A (en) 1989-08-01
AU608250B2 (en) 1991-03-28
GR3015485T3 (en) 1995-06-30
EP0263490A3 (en) 1990-05-16
KR880004802A (ko) 1988-06-27
JPS6391325A (ja) 1988-04-22
DE3750943D1 (de) 1995-02-16
CA1315200C (en) 1993-03-30
JPH0725689B2 (ja) 1995-03-22
DE3750943T2 (de) 1995-05-11
EP0263490A2 (en) 1988-04-13
KR930007247B1 (ko) 1993-08-04
ATE116540T1 (de) 1995-01-15
AU7940487A (en) 1988-04-14
EP0263490B1 (en) 1995-01-04

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