ES2058073T3 - Derivados de 5-fluorouracilo. - Google Patents
Derivados de 5-fluorouracilo.Info
- Publication number
- ES2058073T3 ES2058073T3 ES87106264T ES87106264T ES2058073T3 ES 2058073 T3 ES2058073 T3 ES 2058073T3 ES 87106264 T ES87106264 T ES 87106264T ES 87106264 T ES87106264 T ES 87106264T ES 2058073 T3 ES2058073 T3 ES 2058073T3
- Authority
- ES
- Spain
- Prior art keywords
- same
- fluorouracilo
- derivatives
- hydrogen atom
- against cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical class FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10128586 | 1986-04-30 | ||
| JP4575487 | 1987-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2058073T3 true ES2058073T3 (es) | 1994-11-01 |
Family
ID=26385819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87106264T Expired - Lifetime ES2058073T3 (es) | 1986-04-30 | 1987-04-29 | Derivados de 5-fluorouracilo. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5047521A (enExample) |
| EP (1) | EP0247381B1 (enExample) |
| JP (1) | JPH07103112B2 (enExample) |
| KR (1) | KR950002161B1 (enExample) |
| DE (1) | DE3786834T2 (enExample) |
| DK (1) | DK166088C (enExample) |
| ES (1) | ES2058073T3 (enExample) |
| GB (1) | GB2200352B (enExample) |
| WO (1) | WO1987006582A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| KR20050109505A (ko) * | 2003-02-22 | 2005-11-21 | 메르크 파텐트 게엠베하 | 액정인 시아노피리돈 유도체 |
| EP1631301A4 (en) * | 2003-05-20 | 2006-06-07 | Aronex Pharmaceuticals Inc | COMBINATION SCHEMOTHERAPY WITH 5-FLUOROURACIL OR A DERIVATIVE AND A LIPOSOMAL PLATIN COMPLEX |
| JP2007077109A (ja) * | 2005-09-16 | 2007-03-29 | Tokyo Institute Of Technology | ヌクレオシド誘導体及びその製造方法 |
| US7561776B2 (en) * | 2005-11-29 | 2009-07-14 | Petrospec Engineering Ltd. | Method of preventing hydrogen darkening of optic fibre |
| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| PT2495243T (pt) * | 2009-10-27 | 2017-03-13 | Delta-Fly Pharma Inc | Novos derivados de 5-fluoruracilo |
| EP3746134A1 (en) | 2018-02-02 | 2020-12-09 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124765A (en) * | 1975-05-13 | 1978-11-07 | Ono Pharmaceutical Co., Ltd. | 5-Fluorouracil derivatives |
| JPS6011704B2 (ja) * | 1976-07-30 | 1985-03-27 | 大鵬薬品工業株式会社 | ５−フルオルウラシル誘導体の製造法 |
| JPS5379879A (en) * | 1976-12-23 | 1978-07-14 | Mitsui Toatsu Chem Inc | 1,3-substituted-5-fluorouracils and process for their preparation |
| DE2658672A1 (de) * | 1976-12-23 | 1978-06-29 | Robugen Gmbh | Neue nucleosid-verbindungen und verfahren zu ihrer herstellung |
| JPS5924999B2 (ja) * | 1978-06-10 | 1984-06-13 | 富山化学工業株式会社 | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法 |
| JPS5535057A (en) * | 1978-09-05 | 1980-03-11 | Funai Corp | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it |
| US4340728A (en) * | 1979-11-28 | 1982-07-20 | Fuji Kagaku Kogyo Kabushiki Kaisha | Nucleoside derivatives and process for preparing same |
| GB2072164B (en) * | 1980-02-15 | 1983-12-21 | Funai Pharmaceutical Ind Ltd | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives |
| JPS5929699A (ja) * | 1982-08-11 | 1984-02-16 | Funai Corp | ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤 |
| JPS58185522A (ja) * | 1983-02-28 | 1983-10-29 | Toyama Chem Co Ltd | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体 |
| KR860001865B1 (ko) * | 1983-05-23 | 1986-10-24 | 다이호야꾸힝 고오교 가부시끼가이샤 | 2'-데옥시-5-치환 우리딘 유도체의 제조방법 |
| JPS6061593A (ja) * | 1983-09-14 | 1985-04-09 | Taiho Yakuhin Kogyo Kk | ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤 |
| WO1985000608A1 (fr) * | 1983-07-20 | 1985-02-14 | Teijin Limited | Agent antineoplastique |
| US4515618A (en) * | 1983-12-07 | 1985-05-07 | Chevron Research Company | 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives |
| EP0180188B1 (en) * | 1984-10-30 | 1992-04-15 | Otsuka Pharmaceutical Co., Ltd. | A composition for increasing the anti-cancer activity of an anti-cancer compound |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| JPH02187484A (ja) * | 1989-01-13 | 1990-07-23 | Okitsumo Kk | 紙用瞬間接着剤 |
-
1987
- 1987-04-29 ES ES87106264T patent/ES2058073T3/es not_active Expired - Lifetime
- 1987-04-29 DE DE87106264T patent/DE3786834T2/de not_active Expired - Fee Related
- 1987-04-29 EP EP87106264A patent/EP0247381B1/en not_active Expired - Lifetime
- 1987-04-30 US US07/150,407 patent/US5047521A/en not_active Expired - Fee Related
- 1987-04-30 WO PCT/JP1987/000275 patent/WO1987006582A1/ja not_active Ceased
- 1987-04-30 JP JP62-502695A patent/JPH07103112B2/ja not_active Expired - Lifetime
- 1987-04-30 KR KR1019870701257A patent/KR950002161B1/ko not_active Expired - Fee Related
- 1987-04-30 GB GB8730031A patent/GB2200352B/en not_active Expired - Fee Related
- 1987-12-29 DK DK691287A patent/DK166088C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK691287D0 (da) | 1987-12-29 |
| DE3786834T2 (de) | 1994-03-03 |
| EP0247381A2 (en) | 1987-12-02 |
| US5047521A (en) | 1991-09-10 |
| EP0247381A3 (en) | 1988-11-23 |
| JPH07103112B2 (ja) | 1995-11-08 |
| DK166088C (da) | 1993-08-23 |
| WO1987006582A1 (fr) | 1987-11-05 |
| DE3786834D1 (de) | 1993-09-09 |
| EP0247381B1 (en) | 1993-08-04 |
| GB2200352A (en) | 1988-08-03 |
| JPH07103112B1 (enExample) | 1995-11-08 |
| DK166088B (da) | 1993-03-08 |
| DK691287A (da) | 1988-02-19 |
| GB2200352B (en) | 1990-07-25 |
| KR880701232A (ko) | 1988-07-26 |
| KR950002161B1 (ko) | 1995-03-14 |
| GB8730031D0 (en) | 1988-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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