JPH07103112B2 - ５‐フルオロウラシル誘導体 - Google Patents
５‐フルオロウラシル誘導体Info
- Publication number
- JPH07103112B2 JPH07103112B2 JP62-502695A JP50269587A JPH07103112B2 JP H07103112 B2 JPH07103112 B2 JP H07103112B2 JP 50269587 A JP50269587 A JP 50269587A JP H07103112 B2 JPH07103112 B2 JP H07103112B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- pyridyl
- groups
- pyridin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-502695A JPH07103112B2 (ja) | 1986-04-30 | 1987-04-30 | ５‐フルオロウラシル誘導体 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61-101285 | 1986-04-30 | ||
| JP10128586 | 1986-04-30 | ||
| JP62-45754 | 1987-02-27 | ||
| JP4575487 | 1987-02-27 | ||
| PCT/JP1987/000275 WO1987006582A1 (fr) | 1986-04-30 | 1987-04-30 | Derives de 5-fluorouracyle |
| JP62-502695A JPH07103112B2 (ja) | 1986-04-30 | 1987-04-30 | ５‐フルオロウラシル誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO1987006582A1 JPWO1987006582A1 (ja) | 1988-03-03 |
| JPH07103112B2 true JPH07103112B2 (ja) | 1995-11-08 |
| JPH07103112B1 JPH07103112B1 (enExample) | 1995-11-08 |
Family
ID=26385819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62-502695A Expired - Lifetime JPH07103112B2 (ja) | 1986-04-30 | 1987-04-30 | ５‐フルオロウラシル誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5047521A (enExample) |
| EP (1) | EP0247381B1 (enExample) |
| JP (1) | JPH07103112B2 (enExample) |
| KR (1) | KR950002161B1 (enExample) |
| DE (1) | DE3786834T2 (enExample) |
| DK (1) | DK166088C (enExample) |
| ES (1) | ES2058073T3 (enExample) |
| GB (1) | GB2200352B (enExample) |
| WO (1) | WO1987006582A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864021A (en) * | 1984-10-30 | 1989-09-05 | Otsuka Pharmaceutical Co., Ltd. | 5-fluorouracil derivatives |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| US7442475B2 (en) * | 2003-02-22 | 2008-10-28 | Merck Patent Gmbh | Cyanopyridone derivatives as liquid crystals |
| US20080050425A1 (en) * | 2003-05-20 | 2008-02-28 | Jonathan Lewis | Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex |
| JP2007077109A (ja) * | 2005-09-16 | 2007-03-29 | Tokyo Institute Of Technology | ヌクレオシド誘導体及びその製造方法 |
| US7561776B2 (en) * | 2005-11-29 | 2009-07-14 | Petrospec Engineering Ltd. | Method of preventing hydrogen darkening of optic fibre |
| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| CN102574837B (zh) * | 2009-10-27 | 2013-11-27 | 德尔塔菲制药股份有限公司 | 新的5-氟尿嘧啶衍生物 |
| CA3091027A1 (en) | 2018-02-02 | 2019-08-08 | Maverix Oncology, Inc. | Small molecule drug conjugates of gemcitabine monophosphate |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124765A (en) * | 1975-05-13 | 1978-11-07 | Ono Pharmaceutical Co., Ltd. | 5-Fluorouracil derivatives |
| JPS6011704B2 (ja) * | 1976-07-30 | 1985-03-27 | 大鵬薬品工業株式会社 | ５−フルオルウラシル誘導体の製造法 |
| JPS5379879A (en) * | 1976-12-23 | 1978-07-14 | Mitsui Toatsu Chem Inc | 1,3-substituted-5-fluorouracils and process for their preparation |
| DE2658672A1 (de) * | 1976-12-23 | 1978-06-29 | Robugen Gmbh | Neue nucleosid-verbindungen und verfahren zu ihrer herstellung |
| JPS5924999B2 (ja) * | 1978-06-10 | 1984-06-13 | 富山化学工業株式会社 | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法 |
| JPS5535057A (en) * | 1978-09-05 | 1980-03-11 | Funai Corp | 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it |
| US4340728A (en) * | 1979-11-28 | 1982-07-20 | Fuji Kagaku Kogyo Kabushiki Kaisha | Nucleoside derivatives and process for preparing same |
| GB2072164B (en) * | 1980-02-15 | 1983-12-21 | Funai Pharmaceutical Ind Ltd | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives |
| JPS5929699A (ja) * | 1982-08-11 | 1984-02-16 | Funai Corp | ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤 |
| JPS58185522A (ja) * | 1983-02-28 | 1983-10-29 | Toyama Chem Co Ltd | 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体 |
| JPS6061593A (ja) * | 1983-09-14 | 1985-04-09 | Taiho Yakuhin Kogyo Kk | ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤 |
| AU548712B2 (en) * | 1983-05-23 | 1986-01-02 | Taiho Pharmaceutical Co., Ltd. | 2:-deoxy-5-substituted uridine derivatives |
| WO1985000608A1 (fr) * | 1983-07-20 | 1985-02-14 | Teijin Limited | Agent antineoplastique |
| US4515618A (en) * | 1983-12-07 | 1985-05-07 | Chevron Research Company | 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives |
| DE3585869D1 (de) * | 1984-10-30 | 1992-05-21 | Otsuka Pharma Co Ltd | Zusammensetzung zur steigerung der antikrebsaktivitaet einer antikrebsverbindung. |
| AU610913B2 (en) * | 1987-07-31 | 1991-05-30 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| US4992534A (en) * | 1987-08-12 | 1991-02-12 | Otsuka Pharmaceutical Co., Ltd. | 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine |
| JPH02187484A (ja) * | 1989-01-13 | 1990-07-23 | Okitsumo Kk | 紙用瞬間接着剤 |
-
1987
- 1987-04-29 DE DE87106264T patent/DE3786834T2/de not_active Expired - Fee Related
- 1987-04-29 ES ES87106264T patent/ES2058073T3/es not_active Expired - Lifetime
- 1987-04-29 EP EP87106264A patent/EP0247381B1/en not_active Expired - Lifetime
- 1987-04-30 JP JP62-502695A patent/JPH07103112B2/ja not_active Expired - Lifetime
- 1987-04-30 US US07/150,407 patent/US5047521A/en not_active Expired - Fee Related
- 1987-04-30 GB GB8730031A patent/GB2200352B/en not_active Expired - Fee Related
- 1987-04-30 WO PCT/JP1987/000275 patent/WO1987006582A1/ja not_active Ceased
- 1987-04-30 KR KR1019870701257A patent/KR950002161B1/ko not_active Expired - Fee Related
- 1987-12-29 DK DK691287A patent/DK166088C/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK691287A (da) | 1988-02-19 |
| DK166088C (da) | 1993-08-23 |
| EP0247381A2 (en) | 1987-12-02 |
| KR880701232A (ko) | 1988-07-26 |
| EP0247381B1 (en) | 1993-08-04 |
| US5047521A (en) | 1991-09-10 |
| DK166088B (da) | 1993-03-08 |
| EP0247381A3 (en) | 1988-11-23 |
| WO1987006582A1 (fr) | 1987-11-05 |
| GB2200352A (en) | 1988-08-03 |
| JPH07103112B1 (enExample) | 1995-11-08 |
| ES2058073T3 (es) | 1994-11-01 |
| DK691287D0 (da) | 1987-12-29 |
| GB8730031D0 (en) | 1988-02-03 |
| DE3786834D1 (de) | 1993-09-09 |
| GB2200352B (en) | 1990-07-25 |
| KR950002161B1 (ko) | 1995-03-14 |
| DE3786834T2 (de) | 1994-03-03 |
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