JPH07103112B1 - - Google Patents

Info

Publication number
JPH07103112B1
JPH07103112B1 JP62502695A JP50269587A JPH07103112B1 JP H07103112 B1 JPH07103112 B1 JP H07103112B1 JP 62502695 A JP62502695 A JP 62502695A JP 50269587 A JP50269587 A JP 50269587A JP H07103112 B1 JPH07103112 B1 JP H07103112B1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62502695A
Other languages
Japanese (ja)
Other versions
JPH07103112B2 (ja
JPWO1987006582A1 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP62-502695A priority Critical patent/JPH07103112B2/ja
Publication of JPWO1987006582A1 publication Critical patent/JPWO1987006582A1/ja
Publication of JPH07103112B2 publication Critical patent/JPH07103112B2/ja
Publication of JPH07103112B1 publication Critical patent/JPH07103112B1/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP62-502695A 1986-04-30 1987-04-30 ５‐フルオロウラシル誘導体 Expired - Lifetime JPH07103112B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62-502695A JPH07103112B2 (ja) 1986-04-30 1987-04-30 ５‐フルオロウラシル誘導体

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP10128586 1986-04-30
JP61-101285 1986-04-30
JP4575487 1987-02-27
JP62-45754 1987-02-27
JP62-502695A JPH07103112B2 (ja) 1986-04-30 1987-04-30 ５‐フルオロウラシル誘導体
PCT/JP1987/000275 WO1987006582A1 (fr) 1986-04-30 1987-04-30 Derives de 5-fluorouracyle

Publications (3)

Publication Number Publication Date
JPWO1987006582A1 JPWO1987006582A1 (ja) 1988-03-03
JPH07103112B2 JPH07103112B2 (ja) 1995-11-08
JPH07103112B1 true JPH07103112B1 (enExample) 1995-11-08

Family

ID=26385819

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62-502695A Expired - Lifetime JPH07103112B2 (ja) 1986-04-30 1987-04-30 ５‐フルオロウラシル誘導体

Country Status (9)

Country Link
US (1) US5047521A (enExample)
EP (1) EP0247381B1 (enExample)
JP (1) JPH07103112B2 (enExample)
KR (1) KR950002161B1 (enExample)
DE (1) DE3786834T2 (enExample)
DK (1) DK166088C (enExample)
ES (1) ES2058073T3 (enExample)
GB (1) GB2200352B (enExample)
WO (1) WO1987006582A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011052554A1 (ja) * 2009-10-27 2013-03-21 Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 新規５−フルオロウラシル誘導体
JP2015117248A (ja) * 2009-05-01 2015-06-25 ユニバーシティー コート オブ ジユニバーシティー オブ ダンディー 増殖性状態の処置または予防

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
KR20050109505A (ko) * 2003-02-22 2005-11-21 메르크 파텐트 게엠베하 액정인 시아노피리돈 유도체
EP1631301A4 (en) * 2003-05-20 2006-06-07 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH 5-FLUOROURACIL OR A DERIVATIVE AND A LIPOSOMAL PLATIN COMPLEX
JP2007077109A (ja) * 2005-09-16 2007-03-29 Tokyo Institute Of Technology ヌクレオシド誘導体及びその製造方法
US7561776B2 (en) * 2005-11-29 2009-07-14 Petrospec Engineering Ltd. Method of preventing hydrogen darkening of optic fibre
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
EP3746134A1 (en) 2018-02-02 2020-12-09 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124765A (en) * 1975-05-13 1978-11-07 Ono Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS6011704B2 (ja) * 1976-07-30 1985-03-27 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体の製造法
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
JPS5929699A (ja) * 1982-08-11 1984-02-16 Funai Corp ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤
JPS58185522A (ja) * 1983-02-28 1983-10-29 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体
KR860001865B1 (ko) * 1983-05-23 1986-10-24 다이호야꾸힝 고오교 가부시끼가이샤 2'-데옥시-5-치환 우리딘 유도체의 제조방법
JPS6061593A (ja) * 1983-09-14 1985-04-09 Taiho Yakuhin Kogyo Kk ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
WO1985000608A1 (fr) * 1983-07-20 1985-02-14 Teijin Limited Agent antineoplastique
US4515618A (en) * 1983-12-07 1985-05-07 Chevron Research Company 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives
EP0180188B1 (en) * 1984-10-30 1992-04-15 Otsuka Pharmaceutical Co., Ltd. A composition for increasing the anti-cancer activity of an anti-cancer compound
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
JPH02187484A (ja) * 1989-01-13 1990-07-23 Okitsumo Kk 紙用瞬間接着剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015117248A (ja) * 2009-05-01 2015-06-25 ユニバーシティー コート オブ ジユニバーシティー オブ ダンディー 増殖性状態の処置または予防
JPWO2011052554A1 (ja) * 2009-10-27 2013-03-21 Ｄｅｌｔａ−Ｆｌｙ Ｐｈａｒｍａ株式会社 新規５−フルオロウラシル誘導体

Also Published As

Publication number Publication date
DK691287D0 (da) 1987-12-29
DE3786834T2 (de) 1994-03-03
EP0247381A2 (en) 1987-12-02
US5047521A (en) 1991-09-10
EP0247381A3 (en) 1988-11-23
JPH07103112B2 (ja) 1995-11-08
ES2058073T3 (es) 1994-11-01
DK166088C (da) 1993-08-23
WO1987006582A1 (fr) 1987-11-05
DE3786834D1 (de) 1993-09-09
EP0247381B1 (en) 1993-08-04
GB2200352A (en) 1988-08-03
DK166088B (da) 1993-03-08
DK691287A (da) 1988-02-19
GB2200352B (en) 1990-07-25
KR880701232A (ko) 1988-07-26
KR950002161B1 (ko) 1995-03-14
GB8730031D0 (en) 1988-02-03

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