ES2053699T3 - Metodo para preparar dispersiones que contienen polvo antibiotico. - Google Patents

Metodo para preparar dispersiones que contienen polvo antibiotico.

Info

Publication number
ES2053699T3
ES2053699T3 ES88121627T ES88121627T ES2053699T3 ES 2053699 T3 ES2053699 T3 ES 2053699T3 ES 88121627 T ES88121627 T ES 88121627T ES 88121627 T ES88121627 T ES 88121627T ES 2053699 T3 ES2053699 T3 ES 2053699T3
Authority
ES
Spain
Prior art keywords
antibiotic powder
antibiotic
containing antibiotic
dispersions containing
preparing dispersions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88121627T
Other languages
English (en)
Inventor
Tatuo Yamamoto
Masashi Uchida
Yasuo Kurihara
Ichiro Nakayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shinagawa Fuel Co Ltd
Shinanen New Ceramic Corp
Original Assignee
Shinagawa Fuel Co Ltd
Shinanen New Ceramic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shinagawa Fuel Co Ltd, Shinanen New Ceramic Corp filed Critical Shinagawa Fuel Co Ltd
Application granted granted Critical
Publication of ES2053699T3 publication Critical patent/ES2053699T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00Compositions of unspecified macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Colloid Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN METODO PARA PREPARAR UNA DISPERSION CONTENIENDO POLVO ANTIBIOTICO COMPRENDE LA MEZCLA DEL POLVO ANTIBIOTICO Y UN MEDIO DISPERSANTE A UNA TEMPERATURA A LA QUE EL MEDIO DE DISPERSION ESTA EN LA FORMA DE UN LIQUIDO BAJO UNA PRESION REDUCIDA DE NO MAS DE 470 TORR. SEGUN ESTE METODO, EL POLVO ANTIBIOTICO ES DISPERSADO UNIFORMEMENTE EN VARIOS MEDIOS DISPERSANTES Y PRODUCTOS ANTIBIOTICOS, CON ELEVADA ACCION ANTIBIOTICA PUEDEN SUMINISTRARSE USANDO LA RESULTANTE DISPERSION.
ES88121627T 1987-12-26 1988-12-23 Metodo para preparar dispersiones que contienen polvo antibiotico. Expired - Lifetime ES2053699T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62331112A JPH0688885B2 (ja) 1987-12-26 1987-12-26 抗菌性粉体を含有する分散体の製造方法

Publications (1)

Publication Number Publication Date
ES2053699T3 true ES2053699T3 (es) 1994-08-01

Family

ID=18239992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88121627T Expired - Lifetime ES2053699T3 (es) 1987-12-26 1988-12-23 Metodo para preparar dispersiones que contienen polvo antibiotico.

Country Status (9)

Country Link
US (1) US4906464A (es)
EP (1) EP0322814B1 (es)
JP (1) JPH0688885B2 (es)
KR (1) KR910007311B1 (es)
AT (1) ATE86069T1 (es)
AU (1) AU613129B2 (es)
CA (1) CA1329668C (es)
DE (1) DE3878874T2 (es)
ES (1) ES2053699T3 (es)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8616294D0 (en) * 1986-07-03 1986-08-13 Johnson Matthey Plc Antimicrobial compositions
JPS6323960A (ja) * 1986-07-16 1988-02-01 Zenji Hagiwara 非晶質アルミノ珪酸塩粒子を含有する高分子体及びその製造方法
JPH03199403A (ja) * 1989-12-27 1991-08-30 Chugoku Pearl Hanbai Kk 無菌性手袋
US5180402A (en) * 1990-05-08 1993-01-19 Toray Industries, Inc. Dyed synthetic fiber comprising silver-substituted zeolite and copper compound, and process for preparing same
US5766611A (en) * 1991-02-22 1998-06-16 Ishizuka Garasu Kabushiki Kaisha Cosmetic products containing a soluble glass
US5296238A (en) * 1991-02-26 1994-03-22 Toagosei Chemical Industry Co., Inc. Microbicides
JP3259853B2 (ja) * 1991-10-21 2002-02-25 尚明 山本 害虫駆除材
JP3448896B2 (ja) * 1992-05-21 2003-09-22 東亞合成株式会社 抗菌剤の製造方法
FR2693991B1 (fr) * 1992-07-21 1994-11-25 Oreal Ensemble de distribution d'au moins un produit liquide ou pâteux, comportant un système de fermeture sans reprise d'air et procédé de conservation utilisant ledit ensemble.
US5320843A (en) * 1992-12-10 1994-06-14 Polymer Technology Corporation Method for improving antibacterial properties of ophthalmic solutions
DE4425278A1 (de) * 1994-07-16 1996-01-18 Basf Ag Mischungen enthaltend Silber auf nicht zeolithischen Trägeroxiden
AU6763798A (en) 1997-03-31 1998-10-22 Fibermark, Inc. Method of making a metal fiber sheet
US6432416B1 (en) 1997-10-03 2002-08-13 Dupont Powder Coatings Usa, Inc. Anti-microbial power coating
KR100482298B1 (ko) * 1997-12-30 2005-07-18 대림산업 주식회사 항균성제올라이트조성물및이를함유하는항균수지
US6123925A (en) * 1998-07-27 2000-09-26 Healthshield Technologies L.L.C. Antibiotic toothpaste
US20020043447A1 (en) 1998-09-03 2002-04-18 John E. Barry Belt having antimicrobial action
EP1044139A4 (en) 1998-10-29 2002-11-06 Healthshield Technologies L L BACTERICIDAL PLASTIC CLOSURES FOR BEVERAGE CONTAINERS
US6596401B1 (en) 1998-11-10 2003-07-22 C. R. Bard Inc. Silane copolymer compositions containing active agents
US6296863B1 (en) 1998-11-23 2001-10-02 Agion Technologies, Llc Antimicrobial fabric and medical graft of the fabric
US6436422B1 (en) 1998-11-23 2002-08-20 Agion Technologies L.L.C. Antibiotic hydrophilic polymer coating
US6585767B1 (en) 1998-11-23 2003-07-01 Agion Technologies, Inc. Antimicrobial suturing ring for heart valve
DE19916562A1 (de) * 1999-04-13 2000-10-19 Basf Ag Zusammensetzungen mit Silber auf Zinksilikat-Trägern und antibiotischen Eigenschaften
WO2000064259A1 (en) 1999-04-23 2000-11-02 Agion Technologies, L.L.C. Cooler chest with antimicrobial properties
US20050191355A1 (en) * 1999-05-27 2005-09-01 Foss Manufacturing Co., Inc. Anti-microbial and antifungal fluid conduits and methods of manufacture thereof
US6843697B2 (en) * 1999-06-25 2005-01-18 Micron Display Technology, Inc. Black matrix for flat panel field emission displays
US6267590B1 (en) 1999-11-24 2001-07-31 Agion Technologies, Llc Antimicrobial dental products
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
WO2001047705A1 (en) 1999-12-28 2001-07-05 Kimberly-Clark Worldwide, Inc. Controlled release anti-microbial wipe for hard surfaces
AU775841B2 (en) 1999-12-28 2004-08-19 Kimberly-Clark Worldwide, Inc. A wiper containing a controlled-release anti-microbial agent
US6794318B2 (en) 1999-12-28 2004-09-21 Kimberly-Clark Worldwide, Inc. Use-dependent indicator system for absorbent articles
US6640371B2 (en) * 2000-06-02 2003-11-04 Milliken & Company Topical incorporation of solid antimicrobial compounds on yarn surfaces through high pressure
US8354050B2 (en) * 2000-07-24 2013-01-15 High Voltage Graphics, Inc. Co-molded direct flock and flock transfer and methods of making same
US7338697B2 (en) * 2000-07-24 2008-03-04 High Voltage Graphics, Inc. Co-molded direct flock and flock transfer and methods of making same
US6866859B2 (en) 2000-08-30 2005-03-15 Biocoat Incorporated Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
KR100383454B1 (ko) * 2000-10-02 2003-05-12 (주) 실버라이트 이온교환 일라이트 및 그의 제조방법
US6929705B2 (en) 2001-04-30 2005-08-16 Ak Steel Corporation Antimicrobial coated metal sheet
EP1449889B1 (en) * 2001-10-17 2013-03-06 Fuji Xerox Co., Ltd. Antibacterial composite particles and antibacterial resin composition
US20030091767A1 (en) * 2001-11-02 2003-05-15 Podhajny Richard M. Anti-microbial packaging materials and methods for making the same
EP1542556B1 (en) * 2002-01-08 2011-09-21 Bernard Technologies, Inc. Antimicrobial body covering articles
US20040050482A1 (en) * 2002-07-03 2004-03-18 Abrams Louis Brown Flocked articles and methods of making same
US20040106340A1 (en) * 2002-11-29 2004-06-03 Kreider Jason L. Fabrics having a topically applied silver-based finish exhibiting improved wash durability
US8282951B2 (en) 2003-01-13 2012-10-09 EnviroCare Corporation Antimicrobial coatings for treatment of surfaces in a building setting and method of applying same
US7641912B1 (en) 2003-01-13 2010-01-05 EnviroCare Corporation Antimicrobial coatings for treatment of surfaces in a building setting and method of applying same
US20040186528A1 (en) * 2003-03-20 2004-09-23 Medtronic, Inc. Subcutaneous implantable medical devices with anti-microbial agents for chronic release
US7132378B2 (en) * 2003-04-23 2006-11-07 Milliken & Company Fabrics having a topically applied silver-based finish with a cross-linked binder system for improved high-temperature wash durability
US7678314B1 (en) * 2003-06-25 2010-03-16 Eckert Ronald C Prophylaxis cup having perlite particles, methods of forming and method of use
US7465485B2 (en) * 2003-12-23 2008-12-16 High Voltage Graphics, Inc. Process for dimensionalizing flocked articles or wear, wash and abrasion resistant flocked articles
US7393576B2 (en) * 2004-01-16 2008-07-01 High Voltage Graphics, Inc. Process for printing and molding a flocked article
SE528045C2 (sv) * 2004-02-23 2006-08-15 Polygiene Ab Användning av en plastkomposition för att förse en yta med antivirusaktivitet
US7910171B2 (en) 2004-10-05 2011-03-22 Anthony Trajkovich Method of making antibiotic laminating film
US20060126751A1 (en) * 2004-12-10 2006-06-15 Anthony Bessios Technique for disparity bounding coding in a multi-level signaling system
US20060166024A1 (en) * 2005-01-21 2006-07-27 Microban Products Company Antimicrobial melamine resin and products
JP2009502485A (ja) 2005-07-28 2009-01-29 ハイ ボルテイジ グラフィックス インコーポレイテッド 多孔質フィルムを有するフロック加工された物品
EP2160491A4 (en) 2007-02-14 2014-03-05 High Voltage Graphics Inc PRINTED TEXTILE IN THE SUBLIMATION PROCESS
EP2154974A2 (en) 2007-05-18 2010-02-24 AgION Technologies, Inc. Bioactive acid agrichemical compositions and use thereof
DE102007048107A1 (de) 2007-10-05 2009-06-04 Hunck, Wolfgang, Dipl.-Ing. Antibiotisch wirkendes Substrat zu Impfzwecken zur Herstellung von Materialien wie Farbe, Papiere, Stoffe, Fasen und Gewebe und Baumaterialien, insbesondere Suspensionen für Oberflächenbeschichtungen
US20090246258A1 (en) * 2008-03-28 2009-10-01 Piyush Shukla Antimicrobial and odor adsorbing textile
US20090304762A1 (en) * 2008-06-05 2009-12-10 Bayer Materialscience Llc Antimicrobial thermoplastic molding composition
WO2011032845A2 (en) 2009-09-15 2011-03-24 Basf Se Aqueous dispersions containing antimicrobials in a hybrid network
BR112012012603B1 (pt) * 2009-11-25 2019-03-19 Difusion Technologies, Inc. Método de pós-carregamento de partículas de cerâmica com cátions metálicos antimicrobianos e método de conferir atividade antimicrobiana a um dispositivo através do controle da liberação de cátions antimicrobianos a partir do referido dispositivo por meio de troca iônica
BR112012016027B1 (pt) 2009-12-11 2019-01-15 Difusion Technologies, Inc. método de produção de implantes antimicrobianos de polieteretercetona
JP2011167218A (ja) * 2010-02-16 2011-09-01 Beru:Kk 複合型殺菌消臭剤組成物
US9504313B2 (en) 2010-02-25 2016-11-29 Daniel Boorstein Toothbrush cover and related dispenser
US8245840B2 (en) * 2010-02-25 2012-08-21 Daniel Boorstein Toothbrush cover and related dispenser
BR112012026636B1 (pt) 2010-05-07 2019-01-15 Difusion Technologies, Inc. implantes médicos com hidrofilicidade aumentada e método para minimizar a formação de biofilme em um paciente
US9295254B2 (en) 2011-12-08 2016-03-29 Sciessent Llc Nematicides
KR101402354B1 (ko) * 2012-08-30 2014-06-02 주식회사 포스코건설 항균도료
WO2014059424A2 (en) 2012-10-12 2014-04-17 High Voltage Graphics, Inc. Flexible heat sealable decorative articles and method for making the same
KR102402524B1 (ko) * 2020-09-22 2022-05-27 엘지전자 주식회사 냉장고
CN112679944B (zh) * 2020-12-24 2022-08-19 沧州东鸿制膜科技有限公司 一种抗菌bopa薄膜的制造方法
DE102022116274A1 (de) 2022-06-29 2024-01-04 Gehr-Kunststoff-Extrusionsgesellschaft mbH Antibakterielles thermoplastisches substrat

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5292000A (en) * 1976-01-29 1977-08-02 Toray Industries Antiibacterial fiber
JPS5814405B2 (ja) * 1978-09-12 1983-03-18 日東電工株式会社 抗菌性材料
JPS5777022A (en) * 1980-10-27 1982-05-14 Nippon Chem Ind Co Ltd:The Metal-substituted a-type zeolite and its manufacture
JPS5937956A (ja) * 1982-08-24 1984-03-01 カネボウ株式会社 粒子充填繊維構造物
JPS59133235A (ja) * 1983-01-21 1984-07-31 Kanebo Ltd 殺菌性ポリマー組成物及びその製造法
JPS6064611A (ja) * 1983-09-19 1985-04-13 Nitta Kk 無菌フィルタの製法
JPS6079433A (ja) * 1983-10-07 1985-05-07 Nec Corp プログラム処理装置
JPS60100504A (ja) * 1983-11-07 1985-06-04 Zenji Hagiwara 抗菌性組成物およびその製造方法
US4672369A (en) * 1983-11-07 1987-06-09 Tektronix, Inc. System and method for smoothing the lines and edges of an image on a raster-scan display
JPS60136796A (ja) * 1983-12-26 1985-07-20 シャープ株式会社 カラ−デイスプレイ装置
JPS60174707A (ja) * 1984-02-21 1985-09-09 Kanebo Ltd 頭髪用化粧料
JPS60178810A (ja) * 1984-02-23 1985-09-12 Kanebo Ltd 防臭化粧料
JPS60181370A (ja) * 1984-02-24 1985-09-17 Kanebo Ltd 殺菌性を有する合成皮革
JPS60181002A (ja) * 1984-02-29 1985-09-14 Kanebo Ltd ゼオライトを担体とする抗菌性組成物およびその製造方法
JPS60184325A (ja) * 1984-02-29 1985-09-19 カネボウ株式会社 人工培地
JPS60202162A (ja) * 1984-03-28 1985-10-12 Kanebo Ltd 防腐、防カビ性の塗料組成物
JPS61103401A (ja) * 1984-10-26 1986-05-21 東洋ゴム工業株式会社 スパイクシュ−ズ底とその製法
JPS61136530A (ja) * 1984-12-06 1986-06-24 Kanebo Ltd ゼオライト系固体粒子含有高分子成形体の処理方法
JPS61138795A (ja) * 1984-12-11 1986-06-26 カネボウ株式会社 抗菌性壁紙
JPS61137564A (ja) * 1984-12-11 1986-06-25 カネボウ株式会社 空気を乾燥及び殺菌する方法
JPS61138647A (ja) * 1984-12-11 1986-06-26 Kanebo Ltd 防藻性高分子体
JPS61138658A (ja) * 1984-12-11 1986-06-26 Kanebo Ltd 抗菌性ポリウレタンフイルム
NZ215076A (en) * 1985-03-04 1988-09-29 Thiokol Morton Inc Non-foamed porous thermoplastic resin and microbiocide masterbatch and method of making same
JPS61232253A (ja) * 1985-04-08 1986-10-16 株式会社イナックス タイル目地材
JPS6241775A (ja) * 1985-08-15 1987-02-23 日本特殊陶業株式会社 工具用ウイスカー強化複合材料
JPS627748A (ja) * 1985-07-04 1987-01-14 Kanebo Ltd 防湿能を有する抗菌性ゼオライト粒子及びその製造方法
JPS627747A (ja) * 1985-07-04 1987-01-14 Kanebo Ltd シリコーン系コーティング被膜を有する疎水性の抗菌性ゼオライト粒子及びその製造方法
JPS627746A (ja) * 1985-07-04 1987-01-14 Kanebo Ltd 疎水性を有する抗菌性ゼオライト粒子及びその製造方法
DE3689932T2 (de) * 1985-08-23 1994-11-24 Hagiwara Research Corp Amorfes Alumosilikat und Verfahren zu dessen Herstellung.
JPH062570B2 (ja) * 1985-08-23 1994-01-12 善次 萩原 抗菌剤
JPH0694534B2 (ja) * 1986-02-20 1994-11-24 鐘紡株式会社 抗菌性を有するポリエステル系成形体
JPS62195038A (ja) * 1986-02-21 1987-08-27 Kanebo Ltd 抗菌性ポリエステル系成形体
JPS62238900A (ja) * 1986-04-07 1987-10-19 カネボウ株式会社 抗菌ならびに防カビ機能を有する紙及びその製造方法
JPS62241939A (ja) * 1986-04-14 1987-10-22 Shinagawa Nenryo Kk 抗菌ならびに防カビ能を有するポリオレフイン系樹脂成形体及びその製造方法
JPS62241932A (ja) * 1986-04-14 1987-10-22 Shinagawa Nenryo Kk 抗菌ならびに防カビ機能を有する高分子発泡体及びその製造方法
JPS62243665A (ja) * 1986-04-16 1987-10-24 Hagiwara Giken:Kk 防カビならびに抗菌能を有する目地材組成物

Also Published As

Publication number Publication date
KR890010067A (ko) 1989-08-05
JPH01172301A (ja) 1989-07-07
KR910007311B1 (ko) 1991-09-24
DE3878874T2 (de) 1993-06-17
AU2741288A (en) 1989-06-29
ATE86069T1 (de) 1993-03-15
JPH0688885B2 (ja) 1994-11-09
AU613129B2 (en) 1991-07-25
DE3878874D1 (de) 1993-04-08
EP0322814B1 (en) 1993-03-03
US4906464A (en) 1990-03-06
CA1329668C (en) 1994-05-17
EP0322814A2 (en) 1989-07-05
EP0322814A3 (en) 1989-11-02

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