ES2052881T3 - Agentes reductores de la presion sanguinea. - Google Patents

Agentes reductores de la presion sanguinea.

Info

Publication number
ES2052881T3
ES2052881T3 ES89200661T ES89200661T ES2052881T3 ES 2052881 T3 ES2052881 T3 ES 2052881T3 ES 89200661 T ES89200661 T ES 89200661T ES 89200661 T ES89200661 T ES 89200661T ES 2052881 T3 ES2052881 T3 ES 2052881T3
Authority
ES
Spain
Prior art keywords
blood pressure
pressure reducing
reducing agents
derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89200661T
Other languages
English (en)
Spanish (es)
Inventor
Raymond Mathieu Xhonneux
Lommen Guy Rosalia Eugene Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22629045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2052881(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2052881T3 publication Critical patent/ES2052881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES89200661T 1988-03-23 1989-03-16 Agentes reductores de la presion sanguinea. Expired - Lifetime ES2052881T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17274788A 1988-03-23 1988-03-23

Publications (1)

Publication Number Publication Date
ES2052881T3 true ES2052881T3 (es) 1994-07-16

Family

ID=22629045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89200661T Expired - Lifetime ES2052881T3 (es) 1988-03-23 1989-03-16 Agentes reductores de la presion sanguinea.

Country Status (19)

Country Link
EP (1) EP0334429B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0637487B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970011287B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU621591B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1337432C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1802A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE19675037I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK174422B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2052881T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006972T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK123594A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU211539A9 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE62159B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL89691A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU88842I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL950031I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ228321A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT90095B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA892179B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
KR100264348B1 (ko) * 1994-12-28 2000-08-16 디르크 반테 항-죽종형성제로서 네비볼롤을 함유하는 조성물
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
ATE457169T1 (de) 1998-10-15 2010-02-15 Imp Innovations Ltd Verbindungen für die behandlung von gewichtsverlust
AU2002338528B2 (en) 2001-05-02 2008-01-24 Nicox S.A. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
KR100896266B1 (ko) 2004-07-30 2009-05-08 토렌트 파마슈티칼스 리미티드 네비볼올 및 그의 약학적으로 허용되는 염, 네비볼올의제조방법 및 네비볼올의 약학적 조성물
ES2341250T3 (es) * 2004-08-11 2010-06-17 Hetero Drugs Limited Procedimiento novedoso de preparacion de intermediarios de nebivolol.
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
CA2596428A1 (en) * 2005-01-31 2006-08-10 Mylan Laboratories, Inc. Glucuronidated nebivolol_metabolites
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
CN100546987C (zh) * 2005-03-03 2009-10-07 浙江医药股份有限公司新昌制药厂 Dl-奈必洛尔及其盐酸盐的制备方法
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
WO2007083318A1 (en) 2006-01-18 2007-07-26 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
ES2391911T3 (es) * 2006-11-27 2012-12-03 Zach System S.P.A. Proceso para preparación de nebivolol
CN103087028B (zh) * 2006-11-27 2014-12-24 Zach系统股份公司 制备奈必洛尔的方法
GB0624282D0 (en) 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
EP2124931A4 (en) 2007-01-22 2013-08-28 Mylan Pharmaceuticals Ulc PHARMACEUTICAL COMPOSITIONS COMPRISING NEBIVOLOL OR AN ANALOGUE OF NEBIVOLOL
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
CN101531651B (zh) * 2008-03-13 2011-05-04 四川大学 光学活性3,4-二氢-2h-1-苯并吡喃-2-羧酸和3,4-二氢-4-氧-2h-1-苯并吡喃-2-羧酸类化合物的制备方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) * 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
US8785664B2 (en) 2010-02-11 2014-07-22 Menarini International Operations Luxembourg S.A. Process for the preparation of nebivolol
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
WO2014111903A2 (en) 2013-01-21 2014-07-24 Cadila Pharmaceuticals Limited A process for the preparation of 6-fluoro-3,4-dihydro-2h-chromene- 2-carbaldehyde
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
EP2907809B1 (en) 2014-02-14 2018-08-22 Corden Pharma International GmbH Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
CN113563295A (zh) 2015-05-19 2021-10-29 浙江奥翔药业股份有限公司 奈必洛尔的合成方法及其中间体化合物
CN105085499B (zh) * 2015-08-07 2018-09-25 上海现代制药海门有限公司 盐酸奈必洛尔中间体混合物的结晶分离方法
ITUB20160227A1 (it) 2016-01-21 2017-07-21 Menarini Int Operations Luxembourg Sa Processo per la sintesi di intermedi di Nebivololo

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol

Also Published As

Publication number Publication date
NL950031I2 (nl) 1997-01-06
JPH0637487B2 (ja) 1994-05-18
EP0334429A1 (en) 1989-09-27
CY1802A (en) 1995-02-17
LU88842I2 (fr) 1997-01-27
AU621591B2 (en) 1992-03-19
NZ228321A (en) 1991-02-26
DK174422B1 (da) 2003-02-24
GR3006972T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-30
KR890014510A (ko) 1989-10-24
IE62159B1 (en) 1994-12-28
HU211539A9 (en) 1995-12-28
IE890906L (en) 1989-09-23
DE68903516T2 (de) 1993-04-01
DE19675037I1 (de) 2003-09-04
CA1337432C (en) 1995-10-24
ZA892179B (en) 1990-11-28
PT90095A (pt) 1989-11-10
HK123594A (en) 1994-11-18
NL950031I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-02-01
DK146289D0 (da) 1989-03-22
DE68903516C5 (de) 2017-07-13
JPH01283220A (ja) 1989-11-14
DE68903516D1 (de) 1992-12-24
EP0334429B1 (en) 1992-11-19
IL89691A0 (en) 1989-09-28
DK146289A (da) 1989-09-24
PT90095B (pt) 1994-11-30
AU3074289A (en) 1989-09-28
KR970011287B1 (ko) 1997-07-09
IL89691A (en) 1994-04-12

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