ES2039278T3 - Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides. - Google Patents

Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides.

Info

Publication number
ES2039278T3
ES2039278T3 ES198888303878T ES88303878T ES2039278T3 ES 2039278 T3 ES2039278 T3 ES 2039278T3 ES 198888303878 T ES198888303878 T ES 198888303878T ES 88303878 T ES88303878 T ES 88303878T ES 2039278 T3 ES2039278 T3 ES 2039278T3
Authority
ES
Spain
Prior art keywords
alpha
reductase inhibitors
procedure
preparing steroid
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888303878T
Other languages
English (en)
Spanish (es)
Inventor
Dennis Alan Holt
Conrad John Kowalski
Mark Alan Levy
Brian Walter Metcalf
Ann Marie Tickner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26720806&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2039278(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2039278T3 publication Critical patent/ES2039278T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES198888303878T 1987-04-29 1988-04-28 Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides. Expired - Lifetime ES2039278T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4377387A 1987-04-29 1987-04-29
US07/127,147 US4910226A (en) 1987-04-29 1987-12-01 Steroid 5-alpha-reductase inhibitors

Publications (1)

Publication Number Publication Date
ES2039278T3 true ES2039278T3 (es) 1993-09-16

Family

ID=26720806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888303878T Expired - Lifetime ES2039278T3 (es) 1987-04-29 1988-04-28 Procedimiento para preparar inhibidores de 5-alfa-reductasa de esteroides.

Country Status (23)

Country Link
US (1) US4910226A (OSRAM)
EP (1) EP0289327B1 (OSRAM)
JP (1) JPH0745511B2 (OSRAM)
KR (1) KR0131207B1 (OSRAM)
CN (2) CN1026236C (OSRAM)
AU (1) AU615439B2 (OSRAM)
CA (1) CA1327352C (OSRAM)
CY (1) CY1822A (OSRAM)
DE (1) DE3866938D1 (OSRAM)
DK (1) DK175522B1 (OSRAM)
ES (1) ES2039278T3 (OSRAM)
FI (1) FI95712C (OSRAM)
GR (1) GR3003768T3 (OSRAM)
HK (1) HK22695A (OSRAM)
HU (2) HU201956B (OSRAM)
IE (1) IE60545B1 (OSRAM)
IL (1) IL86185A (OSRAM)
MY (1) MY103518A (OSRAM)
NO (1) NO172586C (OSRAM)
NZ (1) NZ224377A (OSRAM)
PH (1) PH25963A (OSRAM)
PT (1) PT87380B (OSRAM)
ZW (1) ZW4488A1 (OSRAM)

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US4970205A (en) * 1988-12-23 1990-11-13 Smithkline Beecham Corporation Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
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US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
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US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5100917A (en) * 1989-12-29 1992-03-31 Merrell Dow Pharmaceuticals Inc. Novel a-nor-steroid-3-carboxylic acid derivatives
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TW202208376A (zh) 2020-05-20 2022-03-01 美國凱斯西方瑞瑟夫大學 調節短鏈脫氫酶活性之組成物及方法
CN116606340A (zh) * 2022-10-14 2023-08-18 上海醇健实业发展有限公司 一种甾体化合物及其制备方法、其用途和其药物组合物

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Also Published As

Publication number Publication date
MY103518A (en) 1993-07-31
JPS6456694A (en) 1989-03-03
HK22695A (en) 1995-02-24
PT87380A (pt) 1988-05-01
FI95712C (fi) 1996-03-11
AU1516588A (en) 1988-11-03
NO172586B (no) 1993-05-03
EP0289327B1 (en) 1991-12-18
DK226888D0 (da) 1988-04-26
IL86185A (en) 1996-06-18
ZW4488A1 (en) 1988-09-21
DK226888A (da) 1988-10-30
PT87380B (pt) 1992-08-31
CN1030765A (zh) 1989-02-01
DE3866938D1 (de) 1992-01-30
GR3003768T3 (OSRAM) 1993-03-16
NO172586C (no) 1993-08-11
EP0289327A2 (en) 1988-11-02
NO881857D0 (no) 1988-04-28
IE881269L (en) 1988-10-29
JPH0745511B2 (ja) 1995-05-17
FI882007A0 (fi) 1988-04-28
US4910226A (en) 1990-03-20
CN1041054C (zh) 1998-12-09
FI95712B (fi) 1995-11-30
IE60545B1 (en) 1994-07-27
HU906229D0 (en) 1991-03-28
AU615439B2 (en) 1991-10-03
KR0131207B1 (ko) 1998-04-11
CN1079747A (zh) 1993-12-22
CA1327352C (en) 1994-03-01
KR880012636A (ko) 1988-11-28
EP0289327A3 (en) 1989-01-11
HUT47131A (en) 1989-01-30
FI882007L (fi) 1988-10-30
HU201956B (en) 1991-01-28
NZ224377A (en) 1992-06-25
CY1822A (en) 1995-10-20
NO881857L (no) 1988-10-31
PH25963A (en) 1992-01-13
IL86185A0 (en) 1988-11-15
DK175522B1 (da) 2004-11-22
CN1026236C (zh) 1994-10-19

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