NO881857D0 - Steroide 5-d-reduktase-inhibitorer. - Google Patents
Steroide 5-d-reduktase-inhibitorer.Info
- Publication number
- NO881857D0 NO881857D0 NO881857A NO881857A NO881857D0 NO 881857 D0 NO881857 D0 NO 881857D0 NO 881857 A NO881857 A NO 881857A NO 881857 A NO881857 A NO 881857A NO 881857 D0 NO881857 D0 NO 881857D0
- Authority
- NO
- Norway
- Prior art keywords
- steroid
- reductase inhibitors
- reductase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO891776A NO172052C (no) | 1987-04-29 | 1989-04-28 | Analogifremgangsmaate ved fremstilling av steroide 5-alfa-reduktase inhibitorer |
NO891775A NO173240C (no) | 1987-04-29 | 1989-04-28 | Androst-3,5-dien-3-halogen-forbindelser |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4377387A | 1987-04-29 | 1987-04-29 | |
US07/127,147 US4910226A (en) | 1987-04-29 | 1987-12-01 | Steroid 5-alpha-reductase inhibitors |
Publications (4)
Publication Number | Publication Date |
---|---|
NO881857D0 true NO881857D0 (no) | 1988-04-28 |
NO881857L NO881857L (no) | 1988-10-31 |
NO172586B NO172586B (no) | 1993-05-03 |
NO172586C NO172586C (no) | 1993-08-11 |
Family
ID=26720806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO881857A NO172586C (no) | 1987-04-29 | 1988-04-28 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive steroide 5-alfa-reduktase-inhibitorer |
Country Status (23)
Country | Link |
---|---|
US (1) | US4910226A (no) |
EP (1) | EP0289327B1 (no) |
JP (1) | JPH0745511B2 (no) |
KR (1) | KR0131207B1 (no) |
CN (2) | CN1026236C (no) |
AU (1) | AU615439B2 (no) |
CA (1) | CA1327352C (no) |
CY (1) | CY1822A (no) |
DE (1) | DE3866938D1 (no) |
DK (1) | DK175522B1 (no) |
ES (1) | ES2039278T3 (no) |
FI (1) | FI95712C (no) |
GR (1) | GR3003768T3 (no) |
HK (1) | HK22695A (no) |
HU (2) | HU201956B (no) |
IE (1) | IE60545B1 (no) |
IL (1) | IL86185A (no) |
MY (1) | MY103518A (no) |
NO (1) | NO172586C (no) |
NZ (1) | NZ224377A (no) |
PH (1) | PH25963A (no) |
PT (1) | PT87380B (no) |
ZW (1) | ZW4488A1 (no) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US5041433A (en) * | 1987-04-29 | 1991-08-20 | Smithkline Beecham Corporation | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase |
WO1989011282A1 (en) * | 1988-05-25 | 1989-11-30 | Smithkline Beckman Corporation | AROMATIC STEROID 5-alpha-REDUCTASE INHIBITORS |
US4970205A (en) * | 1988-12-23 | 1990-11-13 | Smithkline Beecham Corporation | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US5026882A (en) * | 1988-12-23 | 1991-06-25 | Smithkline Beecham Corporation | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase |
US4937237A (en) * | 1988-12-23 | 1990-06-26 | Smithkline Beckman Corporation | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
US4946834A (en) * | 1988-12-23 | 1990-08-07 | Smithkline Beecham Corporation | Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors |
US4882319A (en) * | 1988-12-23 | 1989-11-21 | Smithkline Beckman Corporation | Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase |
US4970204A (en) * | 1989-08-23 | 1990-11-13 | Smithkline Beecham Corporation | 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors |
US5032586A (en) * | 1989-08-24 | 1991-07-16 | Smithkline Beecham Corporation | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase |
US5100917A (en) * | 1989-12-29 | 1992-03-31 | Merrell Dow Pharmaceuticals Inc. | Novel a-nor-steroid-3-carboxylic acid derivatives |
US5137882A (en) * | 1990-06-11 | 1992-08-11 | Holt Dennis A | Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
CA2045865A1 (en) * | 1990-06-28 | 1991-12-29 | Gary H. Rasmusson | Intermediates on the synthesis of 17 beta-acyl-3-carboxy-androsta-3,5-dienes |
US5075450A (en) * | 1990-06-28 | 1991-12-24 | Merck & Co., Inc. | Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
CA2045866A1 (en) * | 1990-06-28 | 1991-12-29 | Gary H. Rasmusson | 17-beta-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5 alpha-reductase inhibitors |
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
IT1259419B (it) * | 1991-05-24 | 1996-03-18 | Erba Carlo Spa | Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi |
US5196411A (en) * | 1991-08-16 | 1993-03-23 | Merck & Co., Inc. | 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors |
EP0548793A3 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Ag | Ethylenic-unsaturated bile acid derivatives, process for their production and preliminary processes therefor |
GB9206413D0 (en) * | 1992-03-24 | 1992-05-06 | Smithkline Beecham Corp | N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a |
GB9206414D0 (en) * | 1992-03-24 | 1992-05-06 | Smithkline Beecham Corp | N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph b |
US5698720A (en) * | 1992-04-20 | 1997-12-16 | Sankyo Company, Limited | Steroid derivatives |
DK0567271T3 (da) * | 1992-04-20 | 1998-02-16 | Sankyo Co | Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf |
US5620986A (en) * | 1992-05-20 | 1997-04-15 | Merck & Co., Inc. | 17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
US5639741A (en) * | 1992-05-20 | 1997-06-17 | Merck & Co., Inc. | 17-amino substituted 4-azasteroid 5α-reductase inhibitors |
CZ283894A3 (en) * | 1992-05-20 | 1995-09-13 | Merck & Co Inc | 7beta-substituted 4-aza-5alpha-cholestanones, their use for the preparation of pharmaceutical preparations and pharmaceutical compositions containing thereof |
DE69313114T2 (de) * | 1992-05-20 | 1998-03-19 | Merck & Co Inc | NEUE DELTA-17 UND DELTA-20 UNGESÄTIGTE UND GESATIGTE 17--g(b)-SUBSTITUIERTE-4-AZA-5-g(a)-ANDROSTAN-3-ON VERBINDUNGEN ALS INHIBITOREN VON 5-ALPHA-REDUCTASE |
JPH07508038A (ja) * | 1992-05-20 | 1995-09-07 | メルク エンド カンパニー インコーポレーテッド | 4−アザステロイドの17−エーテル及びチオエーテル |
ATE198601T1 (de) * | 1992-05-20 | 2001-01-15 | Merck & Co Inc | Ester derivate von 4-aza-steroiden |
GB9210880D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Corp | Compounds |
GB9213901D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Compounds |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
IL107611A0 (en) * | 1992-11-18 | 1994-02-27 | Smithkline Beecham Corp | Steroid compounds and pharmaceutical compositions containing them |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
AU6413594A (en) * | 1993-03-24 | 1994-10-11 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors |
WO1994022897A1 (en) * | 1993-04-02 | 1994-10-13 | Ciba-Geigy Ag | 17β-SUBSTITUTED ANDROSTA-3,5-DIENE DERIVATIVES |
AU679769B2 (en) * | 1993-06-28 | 1997-07-10 | Merck & Co., Inc. | 4-AZA-pregnane 5alpha-reductase isozyme 1 inhibitors |
TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
GB2282324A (en) * | 1993-10-01 | 1995-04-05 | Merck & Co Inc | 17ß-Acyl-3-Carboxy-Androsta-3,5-dienes as anti-androgenic alopecia agents |
US5637310A (en) * | 1993-12-20 | 1997-06-10 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
FR2724174B1 (fr) * | 1994-09-06 | 1997-01-17 | Roussel Uclaf | Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires |
AU3826095A (en) * | 1994-10-05 | 1996-05-02 | Smithkline Beecham Corporation | Process for preparing 17-beta-substituted-androsta-3,5-dien-3-carboxylic acids |
US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US5595996A (en) * | 1994-10-25 | 1997-01-21 | Merck & Co., Inc. | 7-substituted 4-aza cholanic acid derivatives and their use |
US6372712B1 (en) | 1998-05-22 | 2002-04-16 | The Board Of Trustees Of The Leland Stanford Jr. University | Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand |
US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
EP1422234A3 (en) * | 1999-03-23 | 2010-12-08 | Harbor BioSciences, Inc. | Immunomodulatory steroids, in particular the hemihydrate of 16.alpha.-bromoepiandrosterone |
AP2001002285A0 (en) * | 1999-03-23 | 2001-12-31 | Hollis Eden Pharmaceuticals Inc | Immunomodulatory steroids, in particular the hemihydrate of. 16 alpha.-bromoepiandrosterone. |
JP2000309599A (ja) | 1999-04-13 | 2000-11-07 | Kyowa Hakko Kogyo Co Ltd | エストラ−1,3,5(10),16−テトラエン誘導体 |
CA2522784C (en) | 2003-04-01 | 2012-06-19 | Hollis-Eden Pharmaceuticals, Inc. | Antiandrogens with marginal agonist activity and methods of use |
US7326717B2 (en) * | 2003-05-06 | 2008-02-05 | L'oreal | Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof |
US20060193804A1 (en) * | 2005-02-24 | 2006-08-31 | L'oreal | Haircare use of cyclic amine derivatives |
CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
CN100355772C (zh) * | 2005-12-28 | 2007-12-19 | 天津大学 | 具有5α-还原酶抑制活性的甾体化合物及其制备方法 |
EP1897533A1 (en) * | 2006-09-08 | 2008-03-12 | Revotar Biopharmaceuticals AG | Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions |
EP1946756A1 (en) * | 2007-01-17 | 2008-07-23 | Revotar Biopharmaceuticals AG | Use of entacapone in cosmetic, dermatological and pharmaceutical compositions |
FR2920309B1 (fr) | 2007-08-28 | 2010-05-28 | Galderma Res & Dev | Utilisation de travoprost pour traiter la chute des cheveux |
FR2929118B1 (fr) | 2008-03-28 | 2010-05-07 | Oreal | Utilisation de l'association de madecassoside et/ou de terminoloside et d'une arginine pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute |
FR2929117B1 (fr) | 2008-03-28 | 2010-05-07 | Oreal | Utilisation de l'association du 2,4-diaminopyrimidine 3-n-oxyde et du madecassosside et/ou du terminoloside pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute |
PT3395372T (pt) | 2009-02-20 | 2022-05-05 | Enhanx Biopharm Inc | Sistema de entrega de medicamentos à base de glutationa |
KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
FR2949052B1 (fr) | 2009-08-13 | 2015-03-27 | Oreal | Procede de traitement cosmetique du cuir chevelu. |
WO2013158649A1 (en) | 2012-04-16 | 2013-10-24 | Case Western Reserve University | Compositions and methods of modulating 15-pgdh activity |
CA2927730A1 (en) | 2013-10-15 | 2015-05-07 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
CA3052466A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
JP2022507888A (ja) | 2018-11-21 | 2022-01-18 | ケース ウェスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物及び方法 |
CN111362999B (zh) * | 2020-03-16 | 2022-03-29 | 江苏联环药业股份有限公司 | 一种爱普列特杂质及其制备方法和应用 |
JP2023527279A (ja) | 2020-05-20 | 2023-06-28 | ロデオ・セラピューティクス・コーポレイション | 短鎖デヒドロゲナーゼ活性を調節する組成物及び方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3129233A (en) * | 1961-08-28 | 1964-04-14 | American Home Prod | 17beta-acetoxy-3-chloro-3, 5-androstadiene |
US3530170A (en) * | 1968-09-04 | 1970-09-22 | Du Pont | Selected 2-acyl-a-nor-5alpha-androstane derivatives |
JPS539216B2 (no) * | 1973-11-28 | 1978-04-04 | ||
US4088760A (en) * | 1976-06-23 | 1978-05-09 | Richardson-Merrell Inc. | Testosterone 5α-reductase inhibitors |
US4191759A (en) * | 1978-04-13 | 1980-03-04 | Merck & Co., Inc. | N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors |
US4317817A (en) * | 1979-08-27 | 1982-03-02 | Richardson-Merrell Inc. | Novel steroid 5α-reductase inhibitors |
-
1987
- 1987-12-01 US US07/127,147 patent/US4910226A/en not_active Expired - Lifetime
-
1988
- 1988-04-25 ZW ZW44/88A patent/ZW4488A1/xx unknown
- 1988-04-26 DK DK198802268A patent/DK175522B1/da not_active IP Right Cessation
- 1988-04-26 CA CA000565067A patent/CA1327352C/en not_active Expired - Fee Related
- 1988-04-26 NZ NZ224377A patent/NZ224377A/en unknown
- 1988-04-26 AU AU15165/88A patent/AU615439B2/en not_active Expired
- 1988-04-26 IL IL8618588A patent/IL86185A/en not_active IP Right Cessation
- 1988-04-28 NO NO881857A patent/NO172586C/no not_active IP Right Cessation
- 1988-04-28 HU HU882141A patent/HU201956B/hu unknown
- 1988-04-28 EP EP88303878A patent/EP0289327B1/en not_active Expired - Lifetime
- 1988-04-28 FI FI882007A patent/FI95712C/fi not_active IP Right Cessation
- 1988-04-28 ES ES198888303878T patent/ES2039278T3/es not_active Expired - Lifetime
- 1988-04-28 JP JP63107376A patent/JPH0745511B2/ja not_active Expired - Lifetime
- 1988-04-28 MY MYPI88000458A patent/MY103518A/en unknown
- 1988-04-28 DE DE8888303878T patent/DE3866938D1/de not_active Expired - Lifetime
- 1988-04-28 IE IE126988A patent/IE60545B1/en not_active IP Right Cessation
- 1988-04-29 PH PH36868A patent/PH25963A/en unknown
- 1988-04-29 PT PT87380A patent/PT87380B/pt not_active IP Right Cessation
- 1988-04-29 KR KR1019880004910A patent/KR0131207B1/ko not_active IP Right Cessation
- 1988-04-29 CN CN88103306A patent/CN1026236C/zh not_active Expired - Lifetime
-
1989
- 1989-06-12 HU HU906229A patent/HU906229D0/hu unknown
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1992
- 1992-02-11 GR GR920400190T patent/GR3003768T3/el unknown
-
1993
- 1993-02-13 CN CN93101897A patent/CN1041054C/zh not_active Expired - Fee Related
-
1995
- 1995-02-16 HK HK22695A patent/HK22695A/xx not_active IP Right Cessation
- 1995-10-20 CY CY182295A patent/CY1822A/xx unknown
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MK1K | Patent expired |