EP3709948B1 - Dispositif permettant le remplissage dosé d'un contenant avec un produit de remplissage - Google Patents

Dispositif permettant le remplissage dosé d'un contenant avec un produit de remplissage Download PDF

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Publication number
EP3709948B1
EP3709948B1 EP18717820.7A EP18717820A EP3709948B1 EP 3709948 B1 EP3709948 B1 EP 3709948B1 EP 18717820 A EP18717820 A EP 18717820A EP 3709948 B1 EP3709948 B1 EP 3709948B1
Authority
EP
European Patent Office
Prior art keywords
container
metering chamber
filling
metering
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18717820.7A
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German (de)
English (en)
Other versions
EP3709948A1 (fr
Inventor
Elke Sternberger-Rützel
Philipp GAUS
Michael Röhrle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ds-Technology GmbH
Original Assignee
Ds-Technology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ds-Technology GmbH filed Critical Ds-Technology GmbH
Publication of EP3709948A1 publication Critical patent/EP3709948A1/fr
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Publication of EP3709948B1 publication Critical patent/EP3709948B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
    • B65B1/36—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by volumetric devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0038—Straws

Definitions

  • the invention relates to a device for the metered filling of a container with a pourable or flowable filling material.
  • Such devices are used in particular in the production of food supplements or drugs.
  • an active ingredient-containing filling material is filled into a suitable container so that the filling material and thus also the active ingredient can be swallowed as a capsule, for example.
  • the active ingredient can already be correctly pre-dosed, for example in the form of tablets, filled hard gelatine capsules or injection ampoules.
  • Each unit of the dosage form already contains the correct, predetermined dose of the active ingredient.
  • dosage forms in non-dosed form from a reservoir (container), for example in the form of ointments, powders, granules or pellets. In this case, the required amount of product and thus also the active ingredient is withdrawn individually. As long as the respective active substance has a large therapeutic window, such an individual withdrawal can take place directly by the patient or consumer.
  • the active ingredient has only a very narrow therapeutic window - the limit between a dose that is still ineffective and a dose that already causes undesirable side effects, i.e. is very low - one should Individual removal of the active ingredient no longer takes place in an uncontrolled manner by the patient himself.
  • Dosage forms with pre-dosed active ingredients are produced industrially in particular when the respective dosage is to be made available in large numbers. This is the case with antibiotics, for example.
  • Other therapeutic agents require a patient-specific dosage that relates, for example, to the respective body weight. In this case, industrial production is usually cost-intensive and therefore economically unfavorable. Therefore, an individual dosage is carried out regularly in the pharmacy or hospital pharmacy. For example, a number of oncological and psychotropic drugs must be dosed individually. Especially in geriatrics and pediatrics, comparatively common medications such as antibiotics often have to be dosed individually. This is necessary in order to take into account the differences in body weight and physical condition and, in some cases, also to take into account the particularities of the metabolism, especially in small children.
  • an active ingredient When an active ingredient is dosed for individual delivery to a patient, it is regularly weighed, for example in the hospital pharmacy. Alternatively, a specific volume of the active ingredient can also be measured, which corresponds to the required dose of the active ingredient. To make it easier for the patient to take, the individual dose is often filled into hard gelatine capsules.
  • Such capsules which are assembled from a capsule lower part and a capsule upper part, are a widespread form of administration of powder or pellet-shaped active ingredients. They can be industrially produced and filled in very large numbers, but they can also be used in pharmacies for the production of individual single doses.
  • drinking straws are also used for the administration of active ingredients and / or food supplements.
  • a Drinking straw is for example from the EP 1 843 683 B1 known.
  • the active ingredient is in particular in the form of granules, pellets, micro-tablets or powders and preferably has a size in the range from about 250 micrometers to about 4 millimeters. The average size is around 250 micrometers to 710 micrometers.
  • the active ingredient is already in the drinking straw and is sucked into the patient's mouth with a liquid from the drinking straw and then swallowed. This makes it easier for the patient to take his active ingredient because it is usually much easier to swallow.
  • the active ingredient By absorbing the active ingredient as an in-situ suspension with the liquid, the taste of the active ingredient can be masked by the liquid, for example.
  • the patient can customize the taste through different drinks according to his own wishes. When using pellets, they are regularly functionally coated. In this way, taste masking can also be possible. In addition, a specific release profile can also be obtained.
  • the drinking straws are regularly manufactured industrially and therefore contain an exactly prescribed dose of an active ingredient. Devices for the metered filling of a container with a filling material are off DE 20 2013 005759 U1 and US 2007/169836 A1 known.
  • the invention is based on the object of specifying an improved device for the metered filling of a container with an active substance-containing product, which in particular enables the containers to be filled individually at the point of administration.
  • smaller numbers of containers should be able to be filled inexpensively, quickly and reliably.
  • the device according to the invention for the metered filling of a container with a filling material is given by the features of main claim 1. Useful further developments of the invention are Subject of further claims following this claim.
  • the device according to the invention for the metered filling of a container with a filling material has a receiving unit for receiving the container to be filled and a filling unit.
  • the filling unit By means of the filling unit, a defined amount of filling material can be removed from a material store and transferred into the container.
  • the filling unit has at least one metering chamber, which is displaceably mounted.
  • the at least one metering chamber can be present alternately in a first position and in a second position. In its first position, the dosing chamber is in contact with the material reservoir, so that filling material can be poured into the dosing chamber from the material reservoir.
  • the dosing chamber In its second position, the dosing chamber is arranged above the container to be filled, so that the filling material located in the dosing chamber can be emptied into the container.
  • the material store is provided as a separate container which can be releasably attached to the device by means of a fastening unit.
  • the device can be used directly at the point of care of the active substance.
  • the patient can be prescribed a certain number of containers to be filled and a certain amount of active ingredient via a doctor's prescription.
  • the patient receives the containers and the active ingredient from a pharmacy or hospital pharmacy, the active ingredient being in stock in a suitable container.
  • the patient is informed of the required dose of the active ingredient.
  • the appropriately trained patient or a caregiver (for example also the trained parents of sick children) can then fill the containers accordingly immediately before taking them and then also administer them.
  • the metering chamber can in particular be displaceable in the upward direction and in the opposite direction. Such a back and forth movement can regularly be carried out with just one hand, at the same time it is not necessary to put it down and change your grip in the meantime. This facilitates the operation of the device according to the invention for the bottler.
  • the device can only have the one metering chamber described above. In this case, it would be necessary to perform the forward movement and the return movement to complete a fill pass.
  • the metering chamber can preferably be mounted so as to be longitudinally displaceable. Such a storage is structurally simple to implement and at the same time enables simple and convenient operation.
  • the device can have a first metering chamber and a second metering chamber.
  • the two metering chambers can then alternate in a first and in a second position. While one of the two dosing chambers is in its first position and is being filled with the product to be filled, the second of the two dosing chambers is in its second position and empties the product in the dosing chamber into the container.
  • Both metering chambers must be present in their second position in the identical position above the container in order to enable an exact and reproducible filling of the container.
  • the first position of the two metering chambers on the other hand, can be different as long as both metering chambers can be filled with the same amount of the same product in their respective first position.
  • the two metering chambers can each be moved from their first position to their second position by a rotary movement. If the rotary movement encompasses an angle of 180 degrees in each case, the two metering chambers can become theirs as a result of the rotary movement Exchanging positions exactly. In this case, both metering chambers would be present in their second position at identical positions below the material store.
  • a funnel element can be arranged between the at least one dosing chamber and the upper edge of the container.
  • the fastening unit for the material storage device can preferably have a screw cap or a snap lock.
  • the containers used as material storage can be securely closed with a screw cap and - after removing the screw cap - can also be attached to the screw cap of the device with the same thread.
  • existing standard containers that are already used in the prior art for the storage and transport of smaller quantities of filling material can continue to be used.
  • containers with a click lid could still be used, provided the device was equipped with a corresponding snap lock.
  • the container can be designed as a drinking straw.
  • the drinking straw should already be sealed at its lower end by suitable means, so that the filling material cannot fall out of the drinking straw at the bottom.
  • the drinking straw can be closed by means of a separate cap.
  • the device according to the invention can preferably have a counting unit.
  • the number of changes in position of the at least one metering chamber can be counted and displayed by the counting unit.
  • a container is filled with several cans of filling material.
  • the active substance is therefore regularly present in the filling material in a relatively low concentration, so that different doses of active substance can be achieved by filling a defined number of dosing chamber fillings with filling material.
  • the counting unit can prevent errors during filling, which can occur, for example, due to distraction.
  • a printer unit can be present. Automatic documentation of the filling process is possible through the printer unit. This can be done afterwards or in parallel to the filling process.
  • the device according to the invention is not restricted to any specific type of filling material.
  • any substance can be seen as a filling material, provided that it can be subdivided into units, all of which have essentially the same amount of active substance. This is particularly the case with solids that are in the form of granules, pellets or micro-tablets.
  • liquids can also be dosed accordingly, especially if they are in the form of microcapsules.
  • the invention is of particular interest in the case of filling goods with high-priced active ingredients, in order not to unnecessarily increase the costs for a treatment. Even in the case of active ingredients with a short shelf life, individual filling of the doses required in each case can be advantageous.
  • FIG Figs. 1 and 2 A first embodiment of the device 10 according to the invention is shown in FIG Figs. 1 and 2 shown schematically.
  • the device 10 has a container 20 as a material store.
  • a filling material 22 can be kept in stock in the container 20.
  • the filling material 22 is in the form of pellets, each of which contains a defined amount of active ingredient. A constant distribution of the active substance concentration in the filling material 22 can thus be achieved.
  • the container 20 has an external thread 24.
  • a screw cap not shown here, can be fastened to the external thread 24, provided that the container 20 is not fastened to the device 10.
  • the screw cap is removed and the container 20 is screwed with the external thread 24 into the internal thread 26 of the cover disk 28 of the device 10.
  • the device 10 is normally rotated in such a way that the container 20 with the external thread 24 points upwards and the cover disk 28 with the internal thread 26 points downwards. In this state, the device 10 can be attached to the container 20 without the filling material 22 being able to trickle out of the container.
  • a metering disk 30 is located below the cover disk 28.
  • a single metering chamber 32 is formed in the metering disk 30.
  • the dosing chamber 32 can accommodate a defined amount of filling material 22.
  • the metering disk 30 can be displaced back and forth in the longitudinal direction 34. As a result, the metering chamber 32 is out of its in Fig. 1 first position 36 shown below the material store 20 in an in Fig. 2 second position 38 shown transferred. The metering chamber 32 can be moved back into its first position 36 from this second position 38.
  • the metering chamber 32 is located above the opening of a container 40 to be filled.
  • the container 40 is designed as a drinking straw.
  • the upper edge region of the drinking straw 40 is fastened to a receiving unit 42.
  • the receiving unit 42 has a cantilevered tube over which the upper edge region of the drinking straw can be pushed and fastened with a friction fit.
  • the drinking straw 40 only has to be pulled down from the receiving unit 42.
  • a new drinking straw 40 can then be attached to the receiving unit 42.
  • the receiving unit 42 is provided on a stationary plate 44 below the metering disk 30.
  • a funnel element in the form of a funnel-shaped opening 46 is formed in this stationary plate 44.
  • This funnel-shaped opening 46 opens directly into the receiving unit 42.
  • the removal of the filling material 22 from the material store 20 is checked by means of a counting unit 50.
  • the counting unit 50 determines the number of changes in position of the metering chamber 32.
  • the counting unit 50 is connected to a printer unit 52. The result can thereby be output via the printer unit 52 and thus documented.
  • the counting unit 50 and / or the printer unit 52 could also be dispensed with.
  • FIG Fig. 3 A second embodiment of the device 12 according to the invention is shown in FIG Fig. 3 shown schematically.
  • the device 12 also has a container 20.2 designed as a material store, in which a filling material 22 is kept in stock.
  • the container 20.2 has an external thread 24.2.
  • a screw cap (not shown here) can be fastened to the external thread 24.2, provided that the container 20.2 is not fastened to the device 12.
  • the screw cap is removed and the container 20.2 with the external thread 24.2 is screwed into the internal thread 26.2 of the cover disk 28.2 of the device 12.
  • the cover disk 28.2 of the device 12 is shown Fig. 3 clearly thicker.
  • a funnel element 60 can be formed in the cover disk 28.2. Due to the funnel element 60, the opening of the container 20.2 can have a significantly larger diameter.
  • a metering disk 62 is located below the cover disk 28.2.
  • two metering chambers 64, 66 are formed in the metering disk 62.
  • the two metering chambers 64, 66 can each hold a certain amount of filling material 22, with both metering chambers 64, 66 each having exactly the same amount of filling material 22 be able to record.
  • the metering disk 62 can be rotated back and forth. While the first metering chamber 64 in Fig. 3 is present in its first position 68 below the material store 20, the second metering chamber 66 is in Fig. 3 in its second position 70 above the drinking straw 40 to be filled.
  • the first metering chamber 64 After rotating the metering disk 62, the first metering chamber 64 would be in its second position above the drinking straw 40 and the second metering chamber 66 would be in its first position below the material store 20.2.
  • the device 10 according to Figs. 1 and 2 also has the device 12 according to FIG Fig. 3 Below the metering disk 62, a stationary plate 44 with a funnel-shaped opening 46 and a receiving unit 42 for the drinking straw 40.
  • the removal of the filling material 22 from the material storage 20.2 is checked by means of a counting unit 50.
  • the counting unit 50 determines the number of changes in position of the two metering chambers 64, 66.
  • the counting unit 50 is corresponding Fig. 3 connected to a printer unit 52. The result can thereby be output via the printer unit 52 and thus documented.
  • the counting unit 50 and / or the printer unit 52 could also be dispensed with.
  • the dosing chamber 32, 64, 66 is required in order to fill the desired amount of filling material 22 and thus also the desired dose of the active ingredient into the drinking straw 40.
  • the metering disk 30, 62 is therefore regularly moved back and forth several times before the drinking straw 40 is removed. With a known concentration of active ingredient in the filling material 22, different amounts of active ingredient can be filled exactly in this way.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Quality & Reliability (AREA)
  • Basic Packing Technique (AREA)

Claims (10)

  1. Dispositif (10, 12) permettant le remplissage dosé d'un contenant (40) avec un produit de remplissage (22), comprenant
    - une unité de réception (42) destinée à recevoir un contenant (40),
    - une unité de remplissage qui permet de prélever une quantité définie du produit de remplissage (22) d'un réservoir de matière (20, 20.2) et de la transférer dans le contenant (40),
    - l'unité de remplissage présentant au moins une chambre de dosage (32, 64, 66),
    - ladite au moins une chambre de dosage (32, 64, 66) étant montée coulissante de sorte que la chambre de dosage (32, 64, 66) se trouve en alternance dans une première position (36, 68) et dans une deuxième position (38, 70),
    - la chambre de dosage (32, 64, 66) étant en contact avec un réservoir de matière (20, 20.2) dans la première position (36, 68) de sorte que le produit de remplissage (22) peut être versé du réservoir de matière (20, 20.2) dans la chambre de dosage (32, 64, 66),
    - la chambre de dosage (32, 64, 66) étant disposée dans la deuxième position (38, 70) au-dessus du contenant (40) de sorte que le produit de remplissage (22) se trouvant dans la chambre de dosage (32, 64, 66) peut être vidé dans le contenant (40),
    - caractérisé en ce que
    - le réservoir de matière est réalisé sous la forme d'un contenant séparé (20, 20.2),
    - une unité de fixation (26, 26.2) pour la fixation amovible du réservoir de matière (20, 20.2) est présente.
  2. Dispositif selon la revendication 1,
    - caractérisé en ce que
    - la chambre de dosage (32, 64, 66) peut être déplacée dans une direction aller et dans la direction opposée à celle-ci.
  3. Dispositif selon la revendication 2,
    - caractérisé en ce que
    - la chambre de dosage (32) est montée coulissante dans le sens longitudinal.
  4. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - une première chambre de dosage (64) et une deuxième chambre de dosage (66) sont présentes,
    - les deux chambres de dosage (64, 66) se trouvent en alternance dans une première position (68) et une deuxième position (70),
    - les deux chambres de dosage (64, 66) dans leur deuxième position (70) se trouvent au-dessus du contenant (40) dans une position identique.
  5. Dispositif selon la revendication 4,
    - caractérisé en ce que
    - les deux chambres de dosage (64, 66) sont coulissantes respectivement par un mouvement de rotation de leur première position (68) à leur deuxième position (70).
  6. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - entre ladite au moins une chambre de dosage (32, 64, 66) et le bord supérieur du contenant (40), un élément formant entonnoir (46) est disposé.
  7. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - l'unité de fixation pour le réservoir de matière (20, 20.2) présente une fermeture à visser (24, 26, 24.2, 26.2) ou une fermeture à encliqueter.
  8. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - le contenant est réalisé sous la forme d'une paille (40).
  9. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - une unité de comptage (50) est présente,
    - l'unité de comptage (50) indique le nombre des changements de position de ladite au moins une chambre de dosage (32, 64, 66).
  10. Dispositif selon l'une quelconque des revendications précédentes,
    - caractérisé en ce que
    - une unité d'imprimante (52) est présente.
EP18717820.7A 2018-03-07 2018-03-07 Dispositif permettant le remplissage dosé d'un contenant avec un produit de remplissage Active EP3709948B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DE2018/000056 WO2019170180A1 (fr) 2018-03-07 2018-03-07 Dispositif permettant le remplissage dosé d'un contenant avec un produit de remplissage

Publications (2)

Publication Number Publication Date
EP3709948A1 EP3709948A1 (fr) 2020-09-23
EP3709948B1 true EP3709948B1 (fr) 2021-12-08

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EP18717820.7A Active EP3709948B1 (fr) 2018-03-07 2018-03-07 Dispositif permettant le remplissage dosé d'un contenant avec un produit de remplissage

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Country Link
US (1) US11155371B2 (fr)
EP (1) EP3709948B1 (fr)
CN (1) CN111801085A (fr)
CA (1) CA3092267A1 (fr)
DE (1) DE112018007227A5 (fr)
WO (1) WO2019170180A1 (fr)

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CN112722353A (zh) * 2020-12-28 2021-04-30 咸宁尚科医疗设备有限公司 一种振动竖直下料的药丸分量取料装置

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US20070262164A1 (en) * 2006-05-01 2007-11-15 Daniel Gelfand Drinking Straw
DE602006019068D1 (de) * 2006-05-16 2011-02-03 Mg2 Srl Füllmaschine zum Füllen von Behältern mit zumindest einem Granulat
CN100427057C (zh) * 2006-08-02 2008-10-22 昆明四创药业有限公司 多种物料胶囊充填方法及设备
ITBO20070196A1 (it) * 2007-03-20 2008-09-21 Azionaria Costruzioni Acma Spa Macchina e metodo per la produzione di bustine di materiale incoerente.
US9296501B2 (en) * 2010-07-22 2016-03-29 Signode Industrial Group Llc Modular strap feeder with motor for indexing and gripping
JP2013535756A (ja) * 2010-08-13 2013-09-12 インテリメディシン インコーポレイテッド 個別化された医薬品の生産のためのシステムおよび方法
US9271590B2 (en) * 2011-09-01 2016-03-01 Silman Invest & Trade Ltd. Drinking straw and method and device for manufacturing a drinking straw
DE202013005759U1 (de) * 2013-06-26 2013-07-15 Harro Höfliger Verpackungsmaschinen GmbH Kapselfülleinrichtung
US10327994B2 (en) * 2016-05-02 2019-06-25 Dose Pack Llc System and methods for customized medicine dosages in a capsule

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CA3092267A1 (fr) 2019-09-12
CN111801085A (zh) 2020-10-20
WO2019170180A1 (fr) 2019-09-12
EP3709948A1 (fr) 2020-09-23
US20210002006A1 (en) 2021-01-07
DE112018007227A5 (de) 2020-11-26
US11155371B2 (en) 2021-10-26

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