EP3082707B1 - Schutzkappe für einen spender und spender zum austrag von pharmazeutischen und/oder kosmetischen flüssigkeiten - Google Patents

Schutzkappe für einen spender und spender zum austrag von pharmazeutischen und/oder kosmetischen flüssigkeiten Download PDF

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Publication number
EP3082707B1
EP3082707B1 EP14802906.9A EP14802906A EP3082707B1 EP 3082707 B1 EP3082707 B1 EP 3082707B1 EP 14802906 A EP14802906 A EP 14802906A EP 3082707 B1 EP3082707 B1 EP 3082707B1
Authority
EP
European Patent Office
Prior art keywords
protective cap
sterile filter
dispenser
discharging device
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14802906.9A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3082707A1 (de
Inventor
Matthias Wochele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar Radolfzell GmbH
Original Assignee
Aptar Radolfzell GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Aptar Radolfzell GmbH filed Critical Aptar Radolfzell GmbH
Publication of EP3082707A1 publication Critical patent/EP3082707A1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/16—Closures not otherwise provided for with means for venting air or gas
    • B65D51/1605—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior
    • B65D51/1616—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior by means of a filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2062—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2062—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem
    • B65D47/2068—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem in which the stem is lowered by the pressure of the contents and thereby opening the valve
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes

Definitions

  • the invention relates to a discharge device for the discharge of pharmaceutical and / or cosmetic liquids.
  • a discharge device for the discharge of pharmaceutical and / or cosmetic liquids.
  • Such a device is out WO2013140069 and comprises a liquid reservoir and an outlet opening through which the liquid can be discharged into a surrounding atmosphere.
  • the liquid reservoir liquid will be promoted for discharge in the direction of the outlet opening, which can be done via many different mechanisms.
  • the liquid reservoir may be formed as a squeeze bottle, the content of which can be pressurized by deformation of the walls. Also, a separate pumping device is used.
  • the dispenser comprises an outlet channel connecting the liquid reservoir to the outlet opening and a pressure-dependent opening or manually operable outlet valve arranged in the outlet channel, the outlet valve closing the outlet channel in the closed state.
  • the outlet valve divides the outlet channel into a first partial section and a second partial section, wherein the second partial section extends adjacent to the outlet opening in the direction of the liquid reservoir.
  • the second portion corresponds to a drop formation surface at the exit opening.
  • the exhaust valve results in that after closing it no liquid, which has passed into a portion of the outlet channel on a side facing away from the liquid reservoir side of the outlet valve or which is left in the vicinity of the outlet opening outside the outlet channel, sucked back into the dispenser can be. A possible contamination of the contents of the liquid reservoir by liquid residues that have been sucked back is thereby prevented. The residual liquid therefore remains in an externally accessible area. Upon contact with the atmosphere, the residual liquid dries quickly.
  • the object of the invention is to provide a discharge device which allows rapid drying and in which the problem of microorganisms entering the protective cap is alleviated. This object is solved by the objects with the features of claims 1 and 10. Further advantages of the invention will become apparent from the dependent claims.
  • a protective cap for a dispenser for dispensing pharmaceutical and / or cosmetic liquids having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere
  • the protective cap has at least one ventilation opening for communicating an interior space with an external environment, and a sterile filter covering the at least one ventilation opening is arranged on the protective cap in order to reduce or prevent germination via the at least one ventilation opening into the interior of the protective cap.
  • a dispensing apparatus comprising a dispenser for dispensing pharmaceutical and / or cosmetic liquids having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere, and a protective cap which is at least a ventilation opening for communicating an interior with an external environment wherein a sterile filter covering the at least one ventilation opening is arranged on the protective cap in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap.
  • germ introduction into an interior of the protective cap via the at least one ventilation opening is prevented or at least reduced.
  • germs or microorganisms in the context of the present invention all microbial pathogens, especially bacteria and viruses, understood.
  • the dispenser is particularly suitable for unpreserved ophthalmics.
  • the dispenser comprises an outlet channel which connects the liquid reservoir to the outlet opening, and a pressure-dependent opening or manually operable outlet valve which is arranged in the outlet channel and which closes the outlet channel in a closed state.
  • the outlet valve prevents penetration of germs into the liquid reservoir.
  • the outlet valve is preferably a pressure-dependent opening outlet valve which is opened by pressurizing the liquid in the liquid reservoir or a partial charge taken from it and automatically closes again as soon as the corresponding overpressure relative to the environment is eliminated. In principle, however, other types of valves can be used here.
  • the liquid in the liquid reservoir is permanently under pressure and the handling of the dispenser via a handle, whose manual operation opens the outlet valve.
  • the outlet valve prevents a sucked back liquid in the liquid reservoir.
  • the at least one ventilation opening causes a rapid drying of this residual liquid.
  • the sterile filter preferably has an average pore diameter or a separation limit of at most about 0.1 .mu.m to about 0.3 .mu.m, preferably at most about 0.2 .mu.m.
  • the separation limit describes the size at which particles are retained by the sterile filter.
  • the sterile filter is preferably designed as a membrane filter.
  • a membrane filter with a separation limit between about 0.1 .mu.m to about 0.3 .mu.m is also referred to as microfiltration membrane.
  • Bacteria have a size of about 0.2 to about 5 microns and can be filtered out efficiently by means of a microfiltration membrane. Depending on the application, stricter requirements may also be imposed on the sterile filter.
  • sterilization filters having an average pore diameter or a separation limit of approximately 10 nm are provided in one embodiment.
  • Such membrane filters are also referred to as ultrafiltration membrane. With an ultrafiltration membrane also viruses with a size of 15 nm can be filtered out.
  • the sterile filter is fabricated from a polymer or from an inorganic material, for example a ceramic.
  • the sterile filter is formed as a microporous polymer membrane from a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof.
  • the sterile filter also serves as an absorber surface, whereby liquid is transported away from the outlet opening via the sterile filter and the sterile filter thus advantageously assists in rapid drying of the dispenser.
  • the sterile filter is designed for this purpose as a hydrophilic polymer membrane.
  • the design of the protective cap with an absorber surface contacting the outlet opening is also advantageous in embodiments without a sterile filter.
  • two membranes are provided, which act as a sterile filter or absorber surface.
  • a multilayer membrane is provided in the protective cap, wherein a first layer facing the outlet opening of the dispenser has absorbent properties and a second layer facing the ventilation opening has filter properties.
  • the sterile filter is designed in one embodiment as an insert, which is connected to the protective cap by molding. In other embodiments, the sterile filter is locked with a wall of the protective cap.
  • the protective cap comprises a cylindrical portion and a lid portion connected thereto, wherein the at least one ventilation opening is provided on the lid portion.
  • radially inwardly directed latching projections or a circumferential latching projection are provided on an inner wall of the cylindrical portion, through which (n) the sterile filter is received.
  • protruding latching arms for fastening the sterile filter are provided by an inner side of the lid section. Such locking arms allow reliable, error-free installation.
  • the sterile filter is made of a material which has a sufficient mechanical strength, so that the sterile filter can be engaged in the latching arms or locking projections.
  • the sterile filter is applied to a carrier layer.
  • the carrier layer has material properties deviating from the sterile filter.
  • a gas-permeable, hydrophilic carrier layer is provided, so that the carrier layer is a drying of the dispenser also supported.
  • the carrier layer and the sterile filter are preferably fixed, in particular materially connected to one another, for example adhesively bonded or welded.
  • the sterile filter is vapor-deposited or sputtered onto the carrier layer.
  • the sterile filter is preferably arranged such that in use it contacts an outlet opening of the dispenser, wherein in particular the protective cap has a stop which forces the sterile filter into contact with the outlet opening during use.
  • FIG. 1 first shows a dispenser 2 for the discharge of pharmaceutical and / or cosmetic liquids, which is particularly suitable for unpreserved ophthalmic.
  • This dispenser 2 has a liquid reservoir 21 delimited by a container body 20.
  • the liquid 4 is stored in the liquid reservoir 21.
  • An outlet assembly 22 is placed on the container body 20 and fastened by means of a latching connection.
  • This outlet assembly 22 serves the purpose of passing liquid through an outlet channel 23 from the liquid reservoir 21 to an outlet opening 24.
  • the illustrated outlet opening 24 is designed as a drop formation surface and widens conically in the discharge direction.
  • an outlet valve 25 is arranged, which closes the outlet channel 23 in a closed state, so that in the discharge direction downstream of the outlet valve 25 located liquid can not get back into the liquid reservoir 21.
  • the outlet valve 25 shown comprises a valve body 27 which can be adjusted against the force of a restoring spring 26 and which cooperates with a valve seat 28 formed on a housing wall. An inflow of air into the liquid reservoir 21 for pressure equalization via a filter element 29.
  • the filter element 29 comprises in advantageous embodiments, a pointing to the liquid reservoir 21 and a liquid-side facing away from the liquid reservoir 21 bacterial filter with a separation limit of about 0.2 .mu.m so that bacteria with a size of about 0.2 to about 5 microns are safely retained by the bacteria filter.
  • the illustrated dispenser 2 is designed as a so-called squeeze bottle.
  • the use of this dispenser 2 takes place in such a way that it is brought into an overhead position with the outlet opening 24 facing downwards.
  • walls of the container body 20 are compressed to pressurize the liquid 4 in the liquid reservoir 21 with a pressure.
  • This pressure causes opening of the exhaust valve 25. More specifically, as soon as the fluid pressure in a portion of the exhaust passage 23 upstream of the exhaust valve 25 is sufficiently high, the valve body 27 is displaced by this pressure against the force of the return spring 26 and provides the path for the liquid in Direction of the outlet opening 24 free.
  • the outlet valve 25 is closed again.
  • a remainder of the liquid the so-called residual drop, remains at the outlet opening 24 designed as a droplet formation surface and in a partial section of the outlet channel 23 assigned to the outlet opening 24 downstream of the outlet valve 25 in the discharge direction.
  • a backflow into the liquid reservoir 12 is not possible due to the pressure-dependent opening exhaust valve 25.
  • the Fig. 2 shows the outlet assembly 22 with a protective cap 3 placed thereon.
  • the illustrated protective cap 3 has a plurality of ventilation openings 30 for communicating an interior space 31 with an external environment.
  • the protective cap 3 comprises a substantially cylindrical portion 32 and a cover portion 33 connected thereto.
  • the ventilation openings 30 are provided on the lid portion 33.
  • the number of ventilation openings 30 can be suitably selected by the person skilled in the art.
  • the protective cap 3 has three uniformly distributed ventilation openings 30, of which in Fig. 1 only one is visible.
  • the protective cap 3 is manufactured as an injection-molded part and has a tamper-evident seal 34 which is to be removed when it is used for the first time.
  • the locking elements 35 are designed such that they prevent removal of the protective cap 3 and / or removal of the outlet assembly 22 of the container body 20 without removing the tamper-evident seal 34.
  • the protective cap 3 is also designed such that a repeated removal and clamping of the protective cap 3 on the dispenser 2 is possible.
  • the protective cap 3 is slightly deformed when placed, so that the elastic restoring forces of a protective cap 3 made of plastic produce a clamping action.
  • locking elements are provided for this purpose.
  • the protective cap 3 has a sterile filter 5 covering the ventilation openings 30, by means of which germ introduction into an interior 31 of the protective cap 3 via the ventilation openings 30 is prevented or at least reduced.
  • the sterile filter 5 has a separation limit of a maximum of 0.2 .mu.m, so that bacteria with a size of about 0.2 to about 5 microns are securely retained.
  • the sterile filter 5 is arranged in the illustrated embodiment parallel to the lid portion 33 of the protective cap 3 on an inner side of the lid portion 33, the ventilation openings 30 covering.
  • locking arms 37 are provided in the illustrated embodiment on the cap 3 on the inside of the lid portion.
  • the latching arms 37 protrude in the longitudinal direction of the protective cap 3 from the lid portion 33.
  • the latching arms 37 are elastically deformed.
  • a material of the sterile filter 5 is selected such that the sterile filter 5 as absorber surface for a rapid distribution of the in the region of the outlet opening 24th remaining residual drop and thus a quick drying is available.
  • the sterile filter 5 is designed for this purpose as a hydrophilic polymer membrane of a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof.
  • the illustrated sterile filter 5 is made of a material which has a sufficient rigidity, so that the sterile filter 5 can be engaged in the latching arms 37.
  • FIGS. 3 and 4 show a discharge device 1 comprising a dispenser 2 according to Fig. 1 and a protective cap 3 similar Fig. 2 in a perspective overall view or a sectional view.
  • the protective cap 3 according to 3 and 4 also essentially corresponds to the protective cap 3 according to Fig. 2 and for the same or similar components, the same reference numerals are used.
  • the sterile filter 5 according to 3 and 4 attached to a carrier layer 50.
  • a material of the carrier layer 50 is chosen such that the carrier layer 50 gives the associated sterile filter 5 a higher mechanical strength.
  • the carrier layer 50 is also made in advantageous embodiments of a hydrophilic material, so that a sufficient moisture release over the carrier layer 50 is ensured to the environment.
  • the carrier layer 50 is disposed on an outer side of the sterile filter 5 facing the environment.
  • the carrier layer 50 is arranged on an inner side 31 of the protective cap 3 facing inside of the sterile filter 5.
  • FIGS. 5 and 6 show a discharge device 1 comprising a dispenser 2 according to Fig. 1 and a further embodiment of a protective cap 3 similar Fig. 2 in a perspective overall view or a sectional view.
  • the protective cap 3 according to FIGS. 5 and 6 also essentially corresponds to the protective cap 3 according to Fig. 2 and for the same or similar components, the same reference numerals are used.
  • the protective cap 3 has four ventilation openings 30.
  • the sterile filter 5 in the attached state of the protective cap 3 touches a tip of the dispenser 2 assigned to the outlet opening 24.
  • the protective cap 3 according to the FIGS. 5 and 6 a protruding from the inside of the lid portion 33 stop 38.
  • an additional overcap (not shown) is attached over the protective cap 3.
  • the cap 3 For a fastening of this cap, not shown, the cap 3 according to the FIGS. 5 and 6 Receiving openings 39.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP14802906.9A 2013-12-17 2014-11-27 Schutzkappe für einen spender und spender zum austrag von pharmazeutischen und/oder kosmetischen flüssigkeiten Active EP3082707B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013226253.1A DE102013226253B4 (de) 2013-12-17 2013-12-17 Schutzkappe für einen Spender und Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten
PCT/EP2014/075754 WO2015090887A1 (de) 2013-12-17 2014-11-27 Schutzkappe für einen spender und spender zum austrag von pharmazeutischen und/oder kosmetischen flüssigkeiten

Publications (2)

Publication Number Publication Date
EP3082707A1 EP3082707A1 (de) 2016-10-26
EP3082707B1 true EP3082707B1 (de) 2019-01-02

Family

ID=51982577

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14802906.9A Active EP3082707B1 (de) 2013-12-17 2014-11-27 Schutzkappe für einen spender und spender zum austrag von pharmazeutischen und/oder kosmetischen flüssigkeiten

Country Status (7)

Country Link
US (2) US20160311588A1 (enrdf_load_stackoverflow)
EP (1) EP3082707B1 (enrdf_load_stackoverflow)
JP (1) JP6515099B2 (enrdf_load_stackoverflow)
CN (1) CN105792791B (enrdf_load_stackoverflow)
BR (1) BR112016012660B1 (enrdf_load_stackoverflow)
DE (1) DE102013226253B4 (enrdf_load_stackoverflow)
WO (1) WO2015090887A1 (enrdf_load_stackoverflow)

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DE102011100450B8 (de) 2011-04-27 2013-10-17 Jörg Gerlach Apparat zum Sprühen von Zellen, Herstellung des Apparates, Methode zum Sprühen mit dem Apparat und eine Zellsuspension gesprüht mit dem Apparat
FR2988015B1 (fr) * 2012-03-19 2015-12-11 Rexam Healthcare La Verpillier Dispositif de distribution de liquide muni d'un capuchon amovible
DE102013226253B4 (de) 2013-12-17 2016-03-24 Aptar Radolfzell Gmbh Schutzkappe für einen Spender und Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten
JP6537319B2 (ja) * 2015-03-30 2019-07-03 東京ライト工業株式会社 キャップ
DE102016109612B4 (de) * 2016-05-25 2018-10-31 Gerresheimer Regensburg Gmbh Abgabeeinrichtung zur dosierten Abgabe eines sterilen Fluids und Behältnis für ein steriles Fluid
EP4008440A1 (en) * 2016-06-14 2022-06-08 RenovaCare Sciences Corp. Modular device for cell spraying
DE102016212892C5 (de) 2016-07-14 2020-01-30 F. Holzer Gmbh Pumpkopf sowie Dosiervorrichtung
WO2018141350A1 (de) * 2017-02-01 2018-08-09 Silgan Dispensing Systems Hemer Gmbh Austragvorrichtung für ein flüssiges medium
FR3067011B1 (fr) * 2017-05-31 2019-08-02 Nemera La Verpilliere Embout et dispositif de distribution de liquide comprenant un capuchon
CA3065307C (en) * 2017-06-01 2022-06-07 Counteract, Llc Prescription bottle cap capable of administering opioid overdose reversal agent
IT201800002752A1 (it) 2018-02-16 2019-08-16 Lameplast Spa Contenitore, particolarmente per prodotti medicali, farmaceutici, cosmetici, alimentari o simili
FR3080844B1 (fr) * 2018-05-07 2020-06-05 Horus Pharma Dispositif de conditionnement et distribution d'un produit avec flacon et embout doseur muni d'un filtre
KR20210055714A (ko) * 2018-08-31 2021-05-17 후지필름 어바인 싸이언티픽, 인크. 혼합 장치를 위한 통기 시스템
CN113490473B (zh) * 2019-02-26 2023-04-14 3M创新有限公司 用于准备液体的系统和方法
EP3730101B1 (de) 2019-04-26 2024-08-21 Aptar Radolfzell GmbH Belüftete schutzkappe für einen flüssigkeitsspender
CN111572988B (zh) * 2020-05-19 2024-06-07 深圳市通产丽星科技集团有限公司 包装容器
ES2952019T3 (es) * 2020-05-25 2023-10-26 Serve Sterile Pc Producto con una bebida sin alcohol y método para conservar dicha bebida
US20240197691A1 (en) * 2022-12-15 2024-06-20 Cn2 Therapeutics, Inc. Tacrolimus compositions and methods of use
CN117284637A (zh) * 2023-05-25 2023-12-26 黄细星 一种液体瓶的瓶盖
EP4492017A1 (en) 2023-07-13 2025-01-15 Brill Engines, S.L. A method and a system for dispensing a dose of a liquid or pasty product occupying a storage enclosure of variable volume in a container

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BR112016012660B1 (pt) 2021-09-28
WO2015090887A1 (de) 2015-06-25
JP6515099B2 (ja) 2019-05-15
JP2017507081A (ja) 2017-03-16
BR112016012660A2 (enrdf_load_stackoverflow) 2017-08-08
CN105792791B (zh) 2019-09-10
DE102013226253B4 (de) 2016-03-24
DE102013226253A1 (de) 2015-06-18
CN105792791A (zh) 2016-07-20
US11059639B2 (en) 2021-07-13
US20200262622A1 (en) 2020-08-20
EP3082707A1 (de) 2016-10-26

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