EP1901920A1 - Blisterbodenteil und blisterpackung - Google Patents
Blisterbodenteil und blisterpackungInfo
- Publication number
- EP1901920A1 EP1901920A1 EP06849375A EP06849375A EP1901920A1 EP 1901920 A1 EP1901920 A1 EP 1901920A1 EP 06849375 A EP06849375 A EP 06849375A EP 06849375 A EP06849375 A EP 06849375A EP 1901920 A1 EP1901920 A1 EP 1901920A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- layer
- blister
- polyolefin
- inner layer
- barrier layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2250/00—Layers arrangement
- B32B2250/24—All layers being polymeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
- B32B2264/10—Inorganic particles
- B32B2264/102—Oxide or hydroxide
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7246—Water vapor barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
- Y10T428/24521—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness with component conforming to contour of nonplanar surface
Definitions
- the invention relates to a blister base part of a laminate with molded out by this cold forming chambers for the production of a blister pack for packaging sensitive to moisture, oxygen and acid products, with a barrier layer as a barrier to water vapor and gases, one on a first side of the Plastic layer disposed as a barrier layer outer layer and a sealable inner layer disposed on the second side of the barrier layer. Furthermore, the invention relates to a blister pack with a blister bottom portion of a sealed against the inner layer of the laminate against the inside of the Blister foundedteils cover sheet with a barrier layer as a barrier to water vapor and gases and arranged on a first side of the barrier layer sealable inner layer.
- Moisture-sensitive products can, for example, be coated with a plastic film that is virtually impermeable to water mous kies.
- a plastic film that is virtually impermeable to water mous kies.
- a barrier to the passage of moisture e.g. a high-density polyethylene (HDPE) film or a polyvinylidene chloride-methyl acrylate copolymer (PVDC-MA) may be used.
- Films of oriented polypropylene (oPP), optionally metallized, or metallized polyester films also serve as a barrier material against moisture penetration.
- metal foils are known as barrier material against the passage of moisture and / or oxygen and are often used in conjunction with plastic films.
- a good barrier against water vapor and gases can also be achieved with a layer of ethylene-vinyl alcohol copolymer (EVOH).
- EVOH ethylene-vinyl alcohol copolymer
- WO-A-2004/000541 and WO-A-2004/080808 disclose multilayer films having a barrier layer and a sealant layer containing a moisture-absorbing material.
- the films are used to package moisture-sensitive articles, e.g. Diagnostic test strips, and are heat-sealed either after folding against itself or against a second film.
- moisture absorbing material with strong water binding calcium oxide (CaO) is preferably used.
- the invention has for its object to provide a Blisterteil suitable for the production of blister packagings for packaging sensitive to moisture, oxygen and acid products Blisterteilteil and a blister packs of the type mentioned, which compared to Blisterboden warmth or Büsterpackungen according to the prior art, a higher Protect against the passage of moisture, oxygen and acid.
- an absorber material absorbing moisture, oxygen and acid is arranged on the second side of the barrier layer.
- the laminate used according to the invention can be used on all packaging machines with cold forming stations and is suitable for a large number of moisture-sensitive products whose durability can be substantially increased by the special arrangement of a moisture absorber.
- the invention makes use of the findings obtained on packaging films and packages produced therefrom according to WO-A-2004/000541 and WO-A-2004/080808.
- the inner layer is preferably made of polyolefin and preferably contains at least one oxide from the group of alkali and alkaline earth metals as the absorber material. Particularly preferred is calcium oxide (CaO) as the absorber material.
- CaO calcium oxide
- CaO offers the additional advantage that acid generators, such as chlorine ions or organic acids, which are split off from products, react as gases or as an acid formed by reaction with water with the CaO to the salt and are thus bound.
- acid generators such as chlorine ions or organic acids
- CaO is also able to absorb oxygen, ie has the properties of an oxygen scavenger.
- the preferred content of the polyolefin of the inner layer is 0.5 to 50% by weight of CaO, in particular 10 to 30% by weight of CaO.
- the inner layer polyolefin preferably consists of a high density polyethylene (HDPE) and / or a linear low density polyethylene (LLDPE) and / or a low density polyethylene (LDPE) and / or polypropylene (PP). It may also contain components acid-modified polyolefins, such as lo nomere such as Surlyn ®, EAA or PP-MSA. These acid-modified polyolefins act as adhesion promoters, so that in some cases a separate primer can be dispensed with.
- HDPE high density polyethylene
- LLDPE linear low density polyethylene
- LDPE low density polyethylene
- PP polypropylene
- acid-modified polyolefins such as lo nomere such as Surlyn ®, EAA or PP-MSA. These acid-modified polyolefins act as adhesion promoters, so that in some cases a separate primer can be dispensed with.
- the polyolefin of the inner layer may consist of a single layer or of several layers.
- a bottom part made of a laminate in which the polyolefin of the inner layer consists of at least two layers, wherein the outermost layer furthest from the aluminum foil contains substantially no absorber material.
- the additive-free outermost layer also prevents a change in the pH from negatively influencing the contents in the stability.
- a bottom part made of a laminate, in which the polyolefin of the inner layer is a coextrusion layer of at least two layers, the outermost layer furthest from the aluminum foil containing substantially no absorber material.
- the barrier layer is preferably an aluminum foil and preferably coated on the polyolefin side with an adhesion promoter, in particular with a water- or solvent-based primer, or with a polymeric adhesion promoter.
- the innermost layer closest to the barrier layer contains substantially no absorber material.
- the particles of the absorber material can not be pressed into the aluminum foil used as a barrier layer during the cold-forming step carried out under pressure. With this measure, the particles can not generate any potential weak spots in the aluminum foil and thus also can not reduce the non-porous deformability.
- the outer layer is preferably a plastic film of oriented polyamide (oPA), oriented polypropylene (oPP) or oriented polyester bonded to the aluminum foil via an adhesive layer.
- oPA oriented polyamide
- oPP oriented polypropylene
- a cover film sealed against the inside of the blister base part has a barrier layer as a barrier against water vapor and gases and a sealable inner layer arranged on a first side of the barrier layer.
- the polyolefin of the inner layer is preferably made of a high density polyethylene (HDPE) and / or a linear low density polyethylene (LLDPE) and / or a low density polyethylene (LDPE) and / or polypropylene (PP) and / or contains components acid-modified polyolefins, such as lonomers, EAA or PP-MSA.
- the polyolefin of the inner layer preferably consists of a single layer.
- the sealable inner layer comprises a sealing medium in the form of a layer, in particular a hot sealing lacquer, a film or a sealable coating and serves to seal the cover sheet against the inside of Blisterteils, the seal is a solid seal or a seal with less adhesive force to form a can be peelable opening.
- the barrier layer is preferably an aluminum foil.
- a Blisterteil is first made by cold deformation of the laminate according to the invention. After filling the Blisterteils then a cover sheet, which includes a barrier layer as a barrier to water vapor and gases, sealed against the inner layer of the laminate on the Blisterteil.
- the inventive Büsterpackung is preferably used for packaging of pharmaceutical products such as moisture-sensitive tablets and powders.
- FIG. 2 shows the layer structure of a push-through cover foil for blister base parts according to FIG. 5, corresponding to the section line
- FIG. 3 shows the layer structure of a peelable cover film for blister base parts
- FIG. 4 is a plan view of a cold formed from the laminate of FIG. 1.
- FIG. 6 shows the blister base part of FIG. 5 with the puff-on film of FIG. 2 and a peelable cover film of FIG. 3, respectively.
- a cold-formable laminate 10 for the production of blister base parts for the packaging of moisture-sensitive products has, according to FIG. 1, the following layer structure:
- HDPE high-density polyethylene
- PE polyethylene
- CaO particles as absorber of moisture, oxygen and acid
- HDPE high density polyethylene
- the OPA film 12 forms the later outer side of a blister produced from the laminate 10, the PE layers 20, 21, 22 form the inner side as a sealing layer.
- a cover sheet 30 designed as a push-through film for one out of the laminate 10 produced blister according to FIG. 21 has the following layer structure:
- the printing 38 with the pressure overcoat forms the later outer side of the cover film 30, the heat seal lacquer or the seal coating 32 serves to seal the cover film 30 against the sealing layer 22 of a blister base part produced from the laminate 10.
- a cover film 50 designed as a peelable film for a blister base part produced from the laminate 10 has the following layer structure according to FIG. 3:
- PET polyethylene terephthalate
- the printing 64 with the Drucküberlack 66 forms the later outer side of the peelable cover sheet 50, the Heissgueellack or the seal coating 52 serves to seal the cover sheet 50 against the PE layer 22 of a Blisterteilteils 10 produced from the laminate.
- a blister base 70 shown in FIG. 4 is made from the laminate 10, wherein the cups 72 formed out of the laminate 10 are shaped out of the laminate 10 for receiving, for example, tablets by cold forming, such as by deep-drawing by means of a punch and die.
- a push-through cover sheet 30 or a peelable cover sheet 50 is sealed onto the blister bottom portion 70 as needed.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06849375.8A EP1901920B1 (de) | 2005-06-15 | 2006-06-13 | Blisterbodenteil und blisterpackung |
SI200632087A SI1901920T1 (sl) | 2005-06-15 | 2006-06-13 | Spodnji del pretisnega omota in ovojnina iz pretisnega omota |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05405383A EP1733872A1 (de) | 2005-06-15 | 2005-06-15 | Kaltverformbares Laminat |
PCT/EP2006/005635 WO2007104344A1 (de) | 2005-06-15 | 2006-06-13 | Blisterbodenteil und blisterpackung |
EP06849375.8A EP1901920B1 (de) | 2005-06-15 | 2006-06-13 | Blisterbodenteil und blisterpackung |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1901920A1 true EP1901920A1 (de) | 2008-03-26 |
EP1901920B1 EP1901920B1 (de) | 2016-05-04 |
Family
ID=35414504
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05405383A Withdrawn EP1733872A1 (de) | 2005-06-15 | 2005-06-15 | Kaltverformbares Laminat |
EP06849375.8A Revoked EP1901920B1 (de) | 2005-06-15 | 2006-06-13 | Blisterbodenteil und blisterpackung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05405383A Withdrawn EP1733872A1 (de) | 2005-06-15 | 2005-06-15 | Kaltverformbares Laminat |
Country Status (16)
Country | Link |
---|---|
US (1) | US20090294319A1 (de) |
EP (2) | EP1733872A1 (de) |
JP (1) | JP2008543681A (de) |
KR (1) | KR20080016844A (de) |
CN (1) | CN101218096A (de) |
AR (1) | AR057068A1 (de) |
AU (1) | AU2006339869B2 (de) |
BR (1) | BRPI0611796A2 (de) |
CA (1) | CA2611192A1 (de) |
ES (1) | ES2578702T3 (de) |
IL (1) | IL187851A0 (de) |
PL (1) | PL1901920T3 (de) |
RU (1) | RU2007147945A (de) |
SI (1) | SI1901920T1 (de) |
WO (1) | WO2007104344A1 (de) |
ZA (1) | ZA200710437B (de) |
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SI2135738T1 (sl) | 2008-06-20 | 2011-07-29 | Amcor Flexibles Kreuzlingen | Postopek kondicioniranja absorptivnega materiala v laminatu |
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JP3460789B2 (ja) | 1998-02-24 | 2003-10-27 | 三菱瓦斯化学株式会社 | 脱酸素性多層フィルム |
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US6500519B2 (en) | 2000-06-19 | 2002-12-31 | Toyo Seikan Kaisha, Ltd. | Oxygen absorbable laminate and production method thereof |
EP1241110A1 (de) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Ausgabeeinheit für sauerstoff-empfindlichen Medikamenten |
US20040131805A1 (en) * | 2002-06-20 | 2004-07-08 | Merical Rick L. | Films having a desiccant material incorporated therein and methods of use and manufacture |
US20030235664A1 (en) | 2002-06-20 | 2003-12-25 | Rick Merical | Films having a desiccant material incorporated therein and methods of use and manufacture |
JP3983131B2 (ja) | 2002-07-30 | 2007-09-26 | 東洋アルミニウム株式会社 | 包装体 |
DE10321203A1 (de) | 2003-05-12 | 2004-12-23 | Siemens Ag | Kartenaufnahmevorrichtung |
US20050026893A1 (en) | 2003-05-30 | 2005-02-03 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants |
EP1488921A1 (de) * | 2003-06-17 | 2004-12-22 | Alcan Technology & Management Ltd. | Kaltverformbares Laminat |
JP4659523B2 (ja) | 2005-04-26 | 2011-03-30 | 共同印刷株式会社 | ブリスター用フィルム及びブリスター用包装容器 |
-
2005
- 2005-06-15 EP EP05405383A patent/EP1733872A1/de not_active Withdrawn
-
2006
- 2006-06-13 BR BRPI0611796-1A patent/BRPI0611796A2/pt not_active IP Right Cessation
- 2006-06-13 ES ES06849375.8T patent/ES2578702T3/es active Active
- 2006-06-13 KR KR1020077028830A patent/KR20080016844A/ko not_active Application Discontinuation
- 2006-06-13 RU RU2007147945/15A patent/RU2007147945A/ru not_active Application Discontinuation
- 2006-06-13 AU AU2006339869A patent/AU2006339869B2/en not_active Expired - Fee Related
- 2006-06-13 WO PCT/EP2006/005635 patent/WO2007104344A1/de active Application Filing
- 2006-06-13 JP JP2008516210A patent/JP2008543681A/ja not_active Withdrawn
- 2006-06-13 CA CA002611192A patent/CA2611192A1/en not_active Abandoned
- 2006-06-13 EP EP06849375.8A patent/EP1901920B1/de not_active Revoked
- 2006-06-13 CN CNA2006800212634A patent/CN101218096A/zh active Pending
- 2006-06-13 US US11/921,071 patent/US20090294319A1/en not_active Abandoned
- 2006-06-13 SI SI200632087A patent/SI1901920T1/sl unknown
- 2006-06-13 PL PL06849375.8T patent/PL1901920T3/pl unknown
- 2006-06-14 AR ARP060102513A patent/AR057068A1/es unknown
-
2007
- 2007-12-03 ZA ZA200710437A patent/ZA200710437B/xx unknown
- 2007-12-03 IL IL187851A patent/IL187851A0/en unknown
Non-Patent Citations (1)
Title |
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See references of WO2007104344A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2008543681A (ja) | 2008-12-04 |
ES2578702T3 (es) | 2016-07-29 |
BRPI0611796A2 (pt) | 2010-09-28 |
AU2006339869A1 (en) | 2007-09-20 |
ZA200710437B (en) | 2008-11-26 |
WO2007104344A1 (de) | 2007-09-20 |
CA2611192A1 (en) | 2007-09-30 |
IL187851A0 (en) | 2008-03-20 |
RU2007147945A (ru) | 2009-07-20 |
PL1901920T3 (pl) | 2016-10-31 |
CN101218096A (zh) | 2008-07-09 |
KR20080016844A (ko) | 2008-02-22 |
WO2007104344A8 (de) | 2007-12-27 |
EP1901920B1 (de) | 2016-05-04 |
US20090294319A1 (en) | 2009-12-03 |
AU2006339869B2 (en) | 2010-01-07 |
AR057068A1 (es) | 2007-11-14 |
SI1901920T1 (sl) | 2016-09-30 |
EP1733872A1 (de) | 2006-12-20 |
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