EP2408616B1 - Deckfolie als durchdrückfolie für eine blisterpackung - Google Patents

Deckfolie als durchdrückfolie für eine blisterpackung Download PDF

Info

Publication number
EP2408616B1
EP2408616B1 EP10708723.1A EP10708723A EP2408616B1 EP 2408616 B1 EP2408616 B1 EP 2408616B1 EP 10708723 A EP10708723 A EP 10708723A EP 2408616 B1 EP2408616 B1 EP 2408616B1
Authority
EP
European Patent Office
Prior art keywords
drying agent
layer
foil
plastics material
cover foil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10708723.1A
Other languages
English (en)
French (fr)
Other versions
EP2408616A1 (de
Inventor
Oliver Brandl
Karl-Heinz Senger
Erwin Pasbrig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amcor Flexibles Kreuzlingen AG
Original Assignee
Amcor Flexibles Kreuzlingen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42166774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2408616(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amcor Flexibles Kreuzlingen AG filed Critical Amcor Flexibles Kreuzlingen AG
Priority to PL10708723T priority Critical patent/PL2408616T3/pl
Publication of EP2408616A1 publication Critical patent/EP2408616A1/de
Application granted granted Critical
Publication of EP2408616B1 publication Critical patent/EP2408616B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/308—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising acrylic (co)polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/12—Interconnection of layers using interposed adhesives or interposed materials with bonding properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/06—Coating on the layer surface on metal layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/26—Polymeric coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
    • B32B2264/10—Inorganic particles
    • B32B2264/102—Oxide or hydroxide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2264/00—Composition or properties of particles which form a particulate layer or are present as additives
    • B32B2264/10—Inorganic particles
    • B32B2264/104—Oxysalt, e.g. carbonate, sulfate, phosphate or nitrate particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/31—Heat sealable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/724—Permeability to gases, adsorption
    • B32B2307/7242—Non-permeable
    • B32B2307/7246—Water vapor barrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/726—Permeability to liquids, absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
    • Y10T428/2804—Next to metal

Definitions

  • the invention relates to a cover film as a push-through film for a blister pack according to the preamble of claim 1.
  • Moisture-sensitive products can be enveloped, for example, with a plastic film that is virtually impermeable to water molecules.
  • a plastic film that is virtually impermeable to water molecules.
  • a barrier to the passage of moisture e.g. a high-density polyethylene (HDPE) film or a polyvinylidene chloride-methyl acrylate copolymer (PVDC-MA) may be used.
  • Films of oriented polypropylene (oPP), optionally metallized, or metallized polyester films also serve as a barrier material against moisture penetration.
  • metal foils are known as barrier material against the passage of moisture and / or oxygen and are often used in conjunction with plastic films.
  • a good barrier against water vapor and gases can also be achieved with a layer of ethylene-vinyl alcohol copolymer (EVOH).
  • EVOH ethylene-vinyl alcohol copolymer
  • multilayer films having a barrier layer and a sealant layer containing moisture adsorbing material are known.
  • the films are used to package moisture-sensitive articles, such as diagnostic test strips, and are heat-sealed either after folding against themselves or against a second film.
  • a moisture adsorbing material with strong water binding calcium oxide (CaO) is preferably used.
  • WO 2007/104344 For packaging of moisture-sensitive products, such as tablets and powders, it is known to use blister packs with a blister pack part of a laminate with a barrier layer against water vapor and gases.
  • a barrier layer which is directed against the inside of Blisterteils and against the Blisterteilteil occlusive cover sheet, disposed for example CaO as a desiccant containing layer of polyolefin.
  • a cover film designed as a push-through film has, for example, the following layer structure: sealing layer / aluminum foil / printing pre-coat / printing / printing overcoat.
  • the water absorption capacity of Blister founded too with a desiccant-containing inner layer is limited due to the limited thickness of the inner layer to basis weights of the inner layer including desiccant of typically about 35-65 g / m 2 .
  • the desiccant fraction is typically about 30 to 50% of the total basis weight of the desiccant loaded Layer.
  • the invention has for its object to further increase the water absorption capacity of blister packs for packaging moisture-sensitive products with a cover sheet as push-through and with a desiccant-containing layer having Blisterteilteil.
  • the invention generally relates to packaging films and packages made therefrom WO-A-2004/080808 and on Blisterboden negligence according to WO 2007/104344 exploited findings.
  • the inner layer ie the plastic layer containing desiccant on the side of the aluminum foil provided for sealing against a blister base part
  • the inner layer can have a thickness of two to three times that of the sealable inner layers customary with push-through foils of the prior art, without the push through the film decreases.
  • the reason for this is that the desiccant-bearing layer has much higher brittleness compared to non-desiccant layers. Only this finding cleared the way for the development of the cover sheet according to the invention with a considerable and therefore economically meaningful content of desiccant.
  • the desiccant-containing plastic layer preferably contains as a desiccant at least one oxide from the group of alkali and alkaline earth metals.
  • a particularly preferred, desiccant-containing plastic layer contains as drying agent calcium oxide (CaO), in particular 0.5 to 95 wt .-% CaO, preferably 10 to 65 wt .-%.
  • silicates silica gels, alumino-silicates, physically drying substances, crystal water-absorbing substances, sugar and hydroxyl-bearing compounds.
  • desiccants are usually present as powders in granular form, care must be taken that the desiccant grains do not press into the aluminum foil and puncture it, as holes formed in the aluminum foil destroy the integrity of the blister pack and destroy the desired high moisture protection would.
  • Desiccants are usually applied to the aluminum foil in the form of a desiccant-bearing masterbatch in an extrusion or coextrusion process.
  • the layer thickness of the layer bearing the desiccant must not be too large, since otherwise the relatively low force required when pushing out a tablet, especially for seniors, is exceeded and the pushability of the cover foil is lost.
  • the desiccant has particle sizes (d 100 )> 10-20 ⁇ m. Such particle sizes are capable of commonly used for push-through films in the state "hard” aluminum foils of a thickness of z. B. to penetrate 20 microns.
  • the desiccant-containing plastic layer and / or the buffer layer and / or the sealing layer are preferably made of polyolefin, preferably of polyethylene (PE), in particular of a high density polyethylene (HDPE) and / or a linear low density polyethylene (LLDPE) and / or a low density polyethylene (LDPE) and / or made of polypropylene (PP) and optionally contain components of acid-modified polyolefins, such as ionomers, EAA or PP-MSA. These acid-modified polyolefins act as adhesion promoters, so that in some cases a separate primer can be dispensed with.
  • PE polyethylene
  • HDPE high density polyethylene
  • LLDPE linear low density polyethylene
  • LDPE low density polyethylene
  • PP polypropylene
  • acid-modified polyolefins such as ionomers, EAA or PP-MSA.
  • the buffer layer, the plastic layer containing the desiccant and the sealing layer are preferably formed from a coextruded layer applied to the aluminum foil.
  • the aluminum foil may be coated on the side provided with the sealing layer with an adhesion promoter, in particular with a water- or solvent-based primer or with a polymeric adhesion promoter.
  • cover sheet may be printed and the print may be overpainted.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
  • Wrappers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Laminated Bodies (AREA)

Description

  • Die Erfindung betrifft eine Deckfolie als Durchdrückfolie für eine Blisterpackung gemäss dem Oberbegriff von Anspruch 1.
  • Es ist allgemein bekannt, gegen Feuchtigkeit und Sauerstoff empfindliche Produkte durch Verpacken in Kunststoffmaterialien vor schädlichen atmosphärischen Einflüssen zu schützen. Feuchteempfindliche Produkte können beispielsweise mit einem für Wassermoleküle praktisch undurchlässigen Kunststofffilm umhüllt werden. Als Barriere gegen den Durchtritt von Feuchtigkeit kann z.B. ein Film aus einem Polyethylen hoher Dichte (HDPE) oder aus einem Polyvinylidenchlorid-Methylacrylat-Copolymer (PVDC-MA) verwendet werden. Filme aus orientiertem Polypropylen (oPP), gegebenenfalls metallisiert, oder metallisierte Polyesterfilme, dienen ebenfalls als Barrierematerial gegen Feuchtigkeitsdurchtritt. Weiter sind Metallfolien als Barrierematerial gegen den Durchtritt von Feuchtigkeit und/oder Sauerstoff bekannt und werden oft im Verbund mit Kunststofffilmen eingesetzt. Eine gute Barrierewirkung gegen Wasserdampf und Gase kann auch mit einer Schicht aus Ethylen-Vinylalkohol-Copolymer (EVOH) erreicht werden.
  • Obschon heute Laminate mit Barriereschichten mit hoher Durchtrittssperrwirkung gegen Feuchtigkeit und Sauerstoff bekannt sind, kann der Durchtritt von Feuchtigkeit gerade bei gesiegelten Verpackungen nicht vollständig verhindert werden, da die Kanten der Laminate durch die Barriereschicht nicht geschützt sind. Über diese ungeschützten Kanten im Bereich von Siegelungen kann Feuchtigkeit und Sauerstoff in das Innere heissgesiegelter Verpackungen eindringen und die Qualität feuchteempfindlicher Produkte beeinträchtigen.
  • Aus WO-A-2004/080808 sind mehrschichtige Filme mit einer Barriereschicht und mit einer Feuchte adsorbierendes Material enthaltenden Siegelschicht bekannt. Die Filme dienen zum Verpacken feuchteempfindlicher Gegenstände, wie z.B. Diagnostik-Teststreifen, und werden entweder nach Faltung gegen sich selbst oder gegen einen zweiten Film heissgesiegelt. Als Feuchte adsorbierendes Material mit starker Wasserbindung wird bevorzugt Kalziumoxid (CaO) eingesetzt.
  • Aus WO-A-2007/104344 ist es bekannt, zum Verpacken feuchteempfindlicher Produkte, wie Tabletten und Pulvern, Blisterpackungen mit einem Blisterbodenteil aus einem Laminat mit einer Barriereschicht gegen Wasserdampf und Gase einzusetzen. Zusätzlich ist auf der Seite der Barriereschicht, welche gegen die Innenseite des Blisterbodenteils und gegen eine das Blisterbodenteil verschliessende Deckfolie gerichtet ist, eine beispielsweise CaO als Trockenmittel enthaltende Schicht aus Polyolefin angeordnet. Eine als Durchdrückfolie ausgestaltete Deckfolie weist beispielsweise den folgenden Schichtaufbau auf: Siegelschicht / Aluminiumfolie / Druckvorlack / Bedruckung / Drucküberlack.
  • Typischerweise weist eine Durchdrückfolie von Blisterpackungen eine 20 µm dicke Aluminiumfolie im Zustand "hart" auf. Um die Durchdrückbarkeit auch für schwächere Personen, wie z.B. Senioren, zu gewährleisten, darf auch die u.a. zur Siegelung gegen ein Blisterbodenteil benötigte Innenschicht eine gewisse Dicke nicht überschreiten. Eine herkömmliche Durchdrückfolie mit einer LDPE Beschichtung als Siegelschicht ist beispielsweise wie folgt aufgebaut:
    • Lack, 1-2 g/m2 / Aluminiumfolie hart, 20 µm / Primer 1 g/m2 / LDPE 15 g/m2.
  • Die Wasseraufnahmekapazität von Blisterbodenteilen mit einer Trockenmittel enthaltenden Innenschicht ist wegen der beschränkten Dicke der Innenschicht auf Flächengewichte der Innenschicht inklusive Trockenmittel von typischerweise etwa 35-65 g/m2 begrenzt. Der Trockenmittelanteil liegt typisch bei etwa 30 bis 50 % des Gesamtflächengewichts der mit Trockenmittel beladenen Schicht. Um aber auch "feuchte Tabletten" mit Hilfe eines Trockenmittels zu trocknen, ist grundsätzlich eine möglichst hohe Wasseraufnahmekapazität in der Blisterpackung anzustreben.
  • Der Erfindung liegt die Aufgabe zugrunde, die Wasseraufnahmekapazität von Blisterpackungen zum Verpacken von feuchteempfindlichen Produkten mit einer Deckfolie als Durchdrückfolie und mit einem eine Trockenmittel enthaltende Schicht aufweisenden Blisterbodenteil weiter zu erhöhen.
  • Zur erfindungsgemässen Lösung der Aufgabe führt eine Deckfolie mit den Merkmalen von Anspruch 1.
  • Die Erfindung macht sich die allgemein an Verpackungsfolien und daraus hergestellten Verpackungen gemäss WO-A-2004/080808 und an Blisterbodenteilen gemäss WO-A-2007/104344 gewonnenen Erkenntnisse zunutze.
  • Überraschenderweise hat sich herausgestellt, dass die Innenschicht, d.h., die auf der zur Siegelung gegen ein Blisterbodenteil vorgesehenen Seite der Aluminiumfolie angeordnete, Trockenmittel enthaltende Kunststoffschicht gegenüber den bei Durchdrückfolien nach dem Stand der Technik üblichen, siegelfähigen Innenschichten eine zwei- bis dreifache Dicke aufweisen kann, ohne dass die Durchdrückbarkeit der Folie abnimmt. Der Grund hierfür liegt darin, dass die Trockenmittel tragende Schicht im Vergleich zu Schichten ohne Trockenmittel eine viel höhere Brüchigkeit aufweisen. Erst diese Erkenntnis machte den Weg frei für die Entwicklung der erfindungsgemässen Deckfolie mit einem erheblichen und daher wirtschaftlich sinnvollen Gehalt an Trockenmittel.
  • Die Trockenmittel enthaltende Kunststoffschicht enthält als Trockenmittel bevorzugt wenigstens ein Oxid aus der Gruppe der Alkali- und Erdalkalimetalle. Eine besonders bevorzugte, Trockenmittel enthaltende Kunststoffschicht enthält als Trockenmittel Kalziumoxid (CaO), insbesondere 0,5 bis 95 Gew.-% CaO, vorzugsweise 10 bis 65 Gew.-%.
  • Es können aber auch andere, als Trockenmittel geeignete Substanzen eingesetzt werden, wie z. B. Silicate, Silicagele, Alumo-Silicate, physikalisch trocknende Substanzen, Kristallwasser aufnehmende Substanzen, Zucker und Hydroxyl-Gruppen tragende Verbindungen.
  • Da Trockenmittel üblicherweise als Pulver in körniger Form vorliegen, muss darauf geachtet werden, dass die Körner des Trockenmittels nicht in die Aluminiumfolie drücken und diese durchstossen, da auf diese Weise in der Aluminiumfolie entstandene Löcher die Integrität der Blisterpackung zerstören und den angestrebten hohen Feuchtschutz zunichte machen würden. Trockenmittel werden üblicherweise in der Form eines Trockenmittel tragenden Masterbatches in einem Extrusions- oder Coextrusionsverfahren auf die Aluminiumfolie aufgebracht. Dabei darf die Schichtdicke der das Trockenmittel tragenden Schicht nicht zu gross sein, da sonst der vor allem für Senioren wichtige, relativ niedrige Kraftaufwand beim Herausdrücken einer Tablette überschritten wird und die Durchdrückbarkeit der Deckfolie verloren geht. Bei den auf dem Markt erhältlichen, Trockenmittel tragenden Masterbatches aus beispielsweise Polyethylen (PE) und CaO weist das Trockenmittel Partikelgrössen (d100) > 10-20 µm auf. Solche Partikelgrössen sind in der Lage, üblicherweise für Durchdrückfolien im Zustand "hart" eingesetzte Aluminiumfolien einer Dicke von z. B. 20 µm zu durchstossen.
  • Aus diesem Grund kann es sich als zweckmässig erweisen, zwischen der Aluminiumfolie und der das Trockenmittel enthaltenden Kunststoffschicht eine Pufferschicht aus Kunststoff anzuordnen.
  • Die das Trockenmittel enthaltende Kunststoffschicht und/oder die Pufferschicht und/oder die Siegelschicht bestehen bevorzugt aus Polyolefin, vorzugsweise aus Polyethylen (PE), insbesondere aus einem Polyethylen hoher Dichte (HDPE) und/oder einem linearen Polyethylen niedriger Dichte (LLDPE) und/oder einem Polyethylen niedriger Dichte (LDPE) und/oder aus Polypropylen (PP) und enthalten optional Bestandteile säuremodifizierter Polyolefine, wie lonomere, EAA oder PP-MSA. Diese säuremodifizierten Polyolefine wirken als Haftvermittler, so dass in gewissen Fällen auf einen separaten Primer verzichtet werden kann.
  • Die Pufferschicht, die das Trockenmittel enthaltende Kunststoffschicht und die Siegelschicht sind bevorzugt aus einer auf die Aluminiumfolie aufgetragenen Coextrusionsschicht gebildet.
  • Die Aluminiumfolie kann auf der mit der Siegelschicht versehenen Seite mit einem Haftvermittler, insbesondere mit einem wasser- oder lösemittelbasierten Primer oder mit einem polymeren Haftvermittler beschichtet sein.
  • Ein typischer Aufbau einer Deckfolie ist z. B.:
    • Lack, 1-2 g/m2
    • Aluminiumfolie 20 µm, hart
    • Primer, 1 g/m2
    • LDPE, 12 g/m2 als Pufferschicht
    • PE + Trockenmittel, 30 g/m2
    • LDPE, 4 g/m2 als Siegelschicht
  • Zusätzlich kann die Deckfolie bedruckt und die Bedruckung gegebenenfalls überlackiert sein.
  • Messungen zeigen, dass bei einer Trockenmittel enthaltenden Kunststoffschicht bis zu einem Flächengewicht von ca. 38 g/m2 keine Verschlechterung der Durchdrückbarkeit im Vergleich zu einer Standard Durchdrückfolie mit dem Schichtaufbau
    • Lack, 1-2 g/m2
    • Aluminiumfolie 20 µm, hart
    • Primer, 1 g/m2
    • LDPE, 15 g/m2 als Siegelschicht
    festgestellt wird.

Claims (7)

  1. Deckfolie als Durchdrückfolie für eine Blisterpackung zum Verpacken von feuchteempfindlichen Produkten, mit einer Aluminiumfolie als Barriereschicht gegen den Durchtritt von Wasserdampf und Gasen und einer Siegelschicht zur Siegelung gegen ein Blisterbodenteil, wobei auf der mit der Siegelschicht versehenen Seite der Aluminiumfolie eine Feuchte adsorbierendes Trockenmittel enthaltende Kunststoffschicht angeordnet ist,
    dadurch gekennzeichnet, dass
    die das Trockenmittel enthaltenden Kunststoffschicht aus Polyethylen (PE) ist, und zwischen der Aluminiumfolie und der das Trockenmittel enthaltenden Kunststoffschicht eine Pufferschicht aus Polyehylen niedriger Dichte (LDPE) angeordnet ist, und die Pufferschicht, die das Trockenmittel enthaltende Kunststoffschicht und die Siegelschicht aus einer auf die Aluminiumfolie aufgetragenen Coextrusionsschicht gebildet sind.
  2. Deckfolie nach Anspruch 1, dadurch gekennzeichnet, dass das Trockenmittel wenigstens ein Oxid aus der Gruppe der Alkali- und Erdalkalimetalle enthält.
  3. Deckfolie nach Anspruch 2, dadurch gekennzeichnet, dass die Trockenmittel enthaltende Kunststoffschicht als Trockenmittel Kalziumoxid (CaO), insbesondere 0,5 bis 95 Gew.-% CaO, vorzugsweise 10 bis 65 Gew.-% CaO, enthält.
  4. Deckfolie nach Anspruch 1, dadurch gekennzeichnet, dass als Trockenmittel Silicate, Silicagele, Alumo-Silicate, physikalisch trocknende Substanzen, Kristallwasser aufnehmende Substanzen, Zucker und Hydroxyl-Gruppen tragende Verbindungen eingesetzt werden.
  5. Deckfolie nach Anspruch 1, dadurch gekennzeichnet, dass die Siegelschicht aus Polyethylen (PE), insbesondere aus einem Polyethylen niedriger Dichte (LDPE), besteht.
  6. Deckfolie nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die Aluminiumfolie auf der mit der Siegelschicht versehenen Seite mit einem Haftvermittler, insbesondere mit einem wasser- oder lösemittelbasierten Primer oder mit einem polymeren Haftvermittler beschichtet ist.
  7. Blisterpackung mit einer Deckfolie gemäss einem der vorangehenden Ansprüche zum Verpacken von pharmazeutischen Produkten, wie feuchteempfindlichen Tabletten und Pulvern.
EP10708723.1A 2009-03-20 2010-03-09 Deckfolie als durchdrückfolie für eine blisterpackung Active EP2408616B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL10708723T PL2408616T3 (pl) 2009-03-20 2010-03-09 Folia osłonowa, jako folia wyciskana dla opakowania blistrowego

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00433/09A CH700645A2 (de) 2009-03-20 2009-03-20 Deckfolie als Durchdrückfolie für eine Blisterpackung.
PCT/EP2010/001469 WO2010105756A1 (de) 2009-03-20 2010-03-09 Deckfolie als durchdrückfolie für eine blisterpackung

Publications (2)

Publication Number Publication Date
EP2408616A1 EP2408616A1 (de) 2012-01-25
EP2408616B1 true EP2408616B1 (de) 2014-05-07

Family

ID=42166774

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10708723.1A Active EP2408616B1 (de) 2009-03-20 2010-03-09 Deckfolie als durchdrückfolie für eine blisterpackung

Country Status (10)

Country Link
US (1) US9834356B2 (de)
EP (1) EP2408616B1 (de)
JP (2) JP6145269B2 (de)
CN (1) CN102438825B (de)
AU (1) AU2010225247A1 (de)
BR (1) BRPI1012537B1 (de)
CH (1) CH700645A2 (de)
MX (1) MX2011009204A (de)
PL (1) PL2408616T3 (de)
WO (1) WO2010105756A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5671397B2 (ja) * 2011-03-30 2015-02-18 共同印刷株式会社 蓋材，包装容器及び包装体
DE202014002192U1 (de) * 2014-03-13 2015-06-17 Va-Q-Tec Ag Vakuumisolationspaneel und Behälter mit Vakuumisolationspaneelen
CN106042552B (zh) * 2016-06-12 2018-06-26 苏州海顺包装材料有限公司 吸湿型高阻隔泡罩包装硬片
KR20200074967A (ko) * 2017-10-24 2020-06-25 다나팍 플렉시블스 에이/에스 시트 라미네이트, 블리스터 패키지 및 제조 방법
JP7002298B2 (ja) 2017-11-10 2022-01-20 共同印刷株式会社 ブリスターパック用蓋材
WO2020245147A1 (en) * 2019-06-03 2020-12-10 Amcor Flexibles Singen Gmbh Process for the conditioned packaging of hard gelatin capsules
JP2024524660A (ja) 2021-07-10 2024-07-05 オーキリウス ファーマ スポルカ ゼット オグラニクゾナ オドパウイエドジアルノシア 放出調節ニコランジル化合物製剤

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5886347U (ja) * 1981-12-07 1983-06-11 住友ベークライト株式会社 防湿性蓋材
JPH0241930U (de) * 1988-09-12 1990-03-22
DE69018312T2 (de) 1989-05-23 1995-12-14 Sasaki Chemicals Co Ltd Feuchtigkeitssorbentmittelzusammenstellungen.
CH684788A5 (de) * 1993-03-04 1994-12-30 Alusuisse Lonza Services Ag Metallfolienfreie Deckelfolie für Durchdrückpackungen.
US6063503A (en) 1995-12-28 2000-05-16 Mitsubishi Gas Chemical Company, Inc. Oxygen-absorbing multi-layer film and method for preparing same
US20050079306A1 (en) 1996-10-18 2005-04-14 Toyo Seikan Kaisha, Ltd. Oxygen-absorbing resin composition and packaging container, packaging material, cap or liner material having oxygen absorbability
US6119853A (en) * 1998-12-18 2000-09-19 Glaxo Wellcome Inc. Method and package for storing a pressurized container containing a drug
JP2001009985A (ja) 1999-07-02 2001-01-16 Hisamitsu Pharmaceut Co Inc 貼付剤用包装袋及び包装貼付剤
US20030235664A1 (en) * 2002-06-20 2003-12-25 Rick Merical Films having a desiccant material incorporated therein and methods of use and manufacture
US20040131805A1 (en) 2002-06-20 2004-07-08 Merical Rick L. Films having a desiccant material incorporated therein and methods of use and manufacture
US8003179B2 (en) * 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
GB0225621D0 (en) * 2002-11-02 2002-12-11 Glaxo Group Ltd Medicament carrier
US7758936B2 (en) * 2003-09-18 2010-07-20 Boehringer Ingelheim Gmbh Pharmaceutical blister
JP4659523B2 (ja) * 2005-04-26 2011-03-30 共同印刷株式会社 ブリスター用フィルム及びブリスター用包装容器
EP1733872A1 (de) * 2005-06-15 2006-12-20 Alcan Technology & Management Ltd. Kaltverformbares Laminat
JP3979542B1 (ja) 2006-08-30 2007-09-19 佐々木化学薬品株式会社 乾燥剤組成物、乾燥剤成型品、及びその平衡湿度制御方法、並びに平衡湿度維持時間の制御方法
CA2664380C (en) 2006-09-25 2016-08-23 Takeda Pharmaceutical Company Limited Medicinal package

Also Published As

Publication number Publication date
WO2010105756A1 (de) 2010-09-23
US9834356B2 (en) 2017-12-05
BRPI1012537B1 (pt) 2020-02-18
BRPI1012537A2 (pt) 2016-03-29
MX2011009204A (es) 2011-09-30
PL2408616T3 (pl) 2014-09-30
CN102438825B (zh) 2015-05-13
JP6145269B2 (ja) 2017-06-07
US20120018344A1 (en) 2012-01-26
JP2016104650A (ja) 2016-06-09
AU2010225247A1 (en) 2011-10-13
CN102438825A (zh) 2012-05-02
JP2012520802A (ja) 2012-09-10
JP6302496B2 (ja) 2018-03-28
EP2408616A1 (de) 2012-01-25
CH700645A2 (de) 2010-09-30

Similar Documents

Publication Publication Date Title
EP2408616B1 (de) Deckfolie als durchdrückfolie für eine blisterpackung
EP1901920B1 (de) Blisterbodenteil und blisterpackung
EP2935500B1 (de) Gettermaterial enthaltendes klebeband
EP2612824B1 (de) Laminat, verpackungsbehälter und verpackungskörper
JP6573607B2 (ja) 易カット性の吸収性積層体、及びそれを用いた包装袋
WO2005108063A1 (de) Schichtförmiges material, insbesondere zur verpackung von sauerstoffempfindlinchen produkten
DE69823584T2 (de) Sauerstoff absorbierende Zusammensetzung, Sauerstoff absorbierende Verpackung und diese enthaltender Sauerstoff absorbierender mehrschichtiger Körper
EP2478886A1 (de) Verpackungsmaterial für feuchteempfindliche Produkte
EP2935499B1 (de) Verfahren zum entfernen von permeaten aus flächengebilden
EP3269548B1 (de) Laminat für wärmeversiegelung
EP0812677A1 (de) Sauerstoffentziehender mehrschichtiger körper und verfahren zu dessen herstellung
JP6648806B2 (ja) 吸湿性易剥離性包装体
EP3543009B1 (de) Mehrschichtige schutzschicht für wasserabsorption
EP2033775A1 (de) Thermoformbares Laminat für Blisterbodentelle
JP7412088B2 (ja) 吸収性透明蓋材
EP2135738B1 (de) Verfahren zum Konditionieren eines Absorbermaterials in einem Laminat
JP2020175935A (ja) 内容物入りブリスターパック
DE102021116098A1 (de) Recyclebares Kunststofflaminat mit wirksamer Sauerstoffbarriere und daraus gebildete recyclebare Verpackung
WO2009043563A1 (de) Laminate für leicht zu öffnende verpackungen
WO2017219152A1 (en) Polymeric film useful as water vapor barrier

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20111020

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SENGER, KARL-HEINZ

Inventor name: BRANDL, OLIVER

Inventor name: PASBRIG, ERWIN

DAX Request for extension of the european patent (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20131011

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: SUISSE TECHNOLOGY PARTNERS AG, CH

Ref country code: AT

Ref legal event code: REF

Ref document number: 666285

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140515

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502010006899

Country of ref document: DE

Effective date: 20140618

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2477557

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20140717

REG Reference to a national code

Ref country code: PL

Ref legal event code: T3

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20140507

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140807

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140907

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140808

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140908

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 502010006899

Country of ref document: DE

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

26 Opposition filed

Opponent name: CONSTANTIA FLEXIBLES INTERNATIONAL GMBH

Effective date: 20150130

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 502010006899

Country of ref document: DE

Effective date: 20150130

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150309

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 7

PLCK Communication despatched that opposition was rejected

Free format text: ORIGINAL CODE: EPIDOSNREJ1

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

APBM Appeal reference recorded

Free format text: ORIGINAL CODE: EPIDOSNREFNO

APBP Date of receipt of notice of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA2O

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20100309

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

APBQ Date of receipt of statement of grounds of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA3O

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140507

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: QUERSTRASSE 5, 8212 NEUHAUSEN AM RHEINFALL (CH)

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

REG Reference to a national code

Ref country code: DE

Ref legal event code: R100

Ref document number: 502010006899

Country of ref document: DE

APBU Appeal procedure closed

Free format text: ORIGINAL CODE: EPIDOSNNOA9O

PLBN Opposition rejected

Free format text: ORIGINAL CODE: 0009273

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: OPPOSITION REJECTED

27O Opposition rejected

Effective date: 20201126

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20240327

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20240221

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240327

Year of fee payment: 15

Ref country code: GB

Payment date: 20240327

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20240220

Year of fee payment: 15

Ref country code: IT

Payment date: 20240321

Year of fee payment: 15

Ref country code: FR

Payment date: 20240325

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20240402

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20240401

Year of fee payment: 15