EP1898863B1 - Etui zur aufnahme einer arzneimittelpackung sowie deren verwendung - Google Patents

Etui zur aufnahme einer arzneimittelpackung sowie deren verwendung Download PDF

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Publication number
EP1898863B1
EP1898863B1 EP06818215A EP06818215A EP1898863B1 EP 1898863 B1 EP1898863 B1 EP 1898863B1 EP 06818215 A EP06818215 A EP 06818215A EP 06818215 A EP06818215 A EP 06818215A EP 1898863 B1 EP1898863 B1 EP 1898863B1
Authority
EP
European Patent Office
Prior art keywords
case
case according
week
days
compartment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP06818215A
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German (de)
English (en)
French (fr)
Other versions
EP1898863A1 (de
Inventor
Sabine Leifeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to PL06818215T priority Critical patent/PL1898863T3/pl
Publication of EP1898863A1 publication Critical patent/EP1898863A1/de
Application granted granted Critical
Publication of EP1898863B1 publication Critical patent/EP1898863B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D73/00—Packages comprising articles attached to cards, sheets or webs
    • B65D73/0035—Packages comprising articles attached to cards, sheets or webs the articles being retained within a recess or a series of recesses provided in a single card

Definitions

  • the present invention relates to a case for receiving a package of medicament packs, which are arranged in columns for solid medicament portions, in particular for receiving a pack for means for contraception or hormone replacement therapy.
  • Solid form medicaments are usually prepared in the form of pills, dragees, capsules, tablets and other solid dosage forms. If such medicines are not packaged in bulk containers, they can also be put together in so-called push-through packs (PTPs).
  • PTPs push-through packs
  • the latter packages generally consist of a mostly transparent plastic sheath, which has receiving troughs for the drug portions, as well as an aluminum foil welded to this sheath.
  • the drug portions may be removed by pushing through the receiving well through the aluminum foil which is tearing.
  • the containers formed by the individual receiving wells thus hermetically seal the portions from the time of welding until use, so that the drugs are protected against mechanical and chemical damage.
  • the containers are usually arranged in the blister packs in columns and rows. This results in wise application of an order for the removal of the individual drug portions, namely a removal from top left row by row to the bottom right.
  • dispensers are used for the blister packs, which protect them against impairments and hide discreetly from the outside, in that a medicament is stored therein.
  • Such donors are used for example in DE 44 29 503 C .
  • This blister pack dispenser includes a housing body having first and second plate-shaped members for receiving the blister pack therebetween.
  • the first element has elongated holes through which the receiving spaces of the pack pass and protrude outwards out of them.
  • the blister pack is thereby displaceable between the elements.
  • the second member has dispensing portions facing the elongated holes and corresponding to the positions of the receiving spaces of the blister pack when displaced to a predetermined position.
  • JP-A-2003-226360 proposed a housing for a blister pack in which the blister pack itself and the instructions for use can be easily accommodated at the same time.
  • JP-A-2001-070404 ( WO 01/00135 A1 ) proposed to provide a holder for the blister pack, which has three areas, of which a first area contains a collection rule. A second and a third area with openings arranged like a matrix serve to accommodate the blister pack between them. On at least one of the second and third areas, the daily data and times associated with the intake to the individual openings are attached.
  • the solution chosen there comprises a dispenser with a flat surface with a plurality of through openings and with a lid hinged to the support surface.
  • the openings in the airfoil are arranged to correspond to a selected array of tablets in a blister pack.
  • the lid further includes a rim portion having a larger area than the tableted area on the blister pack and an open window portion, the window portion having a smaller area than the predetermined area of the blister pack but having a larger area than the tablet area.
  • the container has a daily calendar that can be aligned with the field of tablets to position a selected start day on a first tablet in the field of tablets. Near the open window, the lid further has a pointer indicating the first tablet to be taken after positioning the blister pack in the container.
  • a recess is arranged in a plate, in which a strip with the daily information, preferably a continuous loop, is arranged. Through a slot in the edge part of the lid, the daily information is visible and can be assigned to the individual tablets in the blister pack.
  • a cylindrical calendar container is provided with a cylindrical 7-day calendar. Each daily calendar starts with a new day and can be selectively aligned to a window.
  • the tablets are used, for example, for contraception or hormone replacement therapy.
  • a similar solution is also in DE 1 909 932 A
  • a blister pack containing tablets for oral contraception is placed in a lid and bottom tablet pack.
  • the bottom contains seven parallel rows of tablet spaces in the form of openings.
  • At the top of each row is a window with an inscription that represents a day of the week.
  • the inscription is printed on a sheet wound on a cylinder, with the days of the week extending axially along the cylinder.
  • NL 6911920 describes such a solution.
  • the container described therein comprises a blister pack of tablets for oral contraception, for example, and a cylindrical chamber integrally connected thereto which extends parallel to the rows of tablet spaces in the drug compartments in the blister pack, a plurality of apertures in the chamber which are aligned with the spaces and an elongate indicator tube rotatably disposed within the chamber and having weekday indicia extending along the axis of the tube and coinciding with the apertures in the chamber. Furthermore, a display mark is provided on the blister pack, the on a the openings is aligned. With the latter display, the beginning of an interruption of taking the tablets can be set for five days and then the first day of the restart after the interruption and the subsequent days of a 21-day intake period are automatically displayed and read.
  • blister pack dispensers meet the stated requirements regarding the required safety when taking the medicaments, they provide suitable information, for example on the time of ingestion (date, time) associated with certain medicament portions.
  • time of ingestion date, time
  • these donors especially if a safe ingestion of the drug is to be guaranteed, extremely complicated:
  • expensive dispensers are used for the blister packs.
  • the display means are expensive: in the case of WO 01/00135 A
  • a donor is given, which appears easy to produce. By imprinting the days of the week on the donor, however, this is inflexible. The same basically applies to the solution according to DE 39 05 851 A ,
  • the present invention is therefore an object of the invention to provide a case that is suitable for the storage of a blister pack and has the required mechanical stability and thus everyday practicality, which further ensures that the presented drug portions safely taken in a predetermined by an instruction manual rhythm and that moreover can be made very easily and simply and therefore cost-effectively.
  • the case according to the invention serves to receive a blister pack for medicaments in solid form, for example in the form of pills, dragees, capsules, tablets and other solid dosage forms.
  • a blister pack a package for solid drugs is referred to, which is usually arranged in a matrix-like manner in columns and rows Containers for solid drug portions, typically each of these containers containing a drug portion.
  • the pack is composed of at least two components, namely an upper, usually transparent part of deep-drawn plastic film, which has receiving cavities for the individual medicament portions, and a lower part, which is usually made of aluminum foil.
  • the drug portions are after the joining of the two parts in the receptacles forming the receptacles and can be pushed through the aluminum foil by pressing on the receiving troughs, wherein the aluminum foil tears. Both sides can be provided with suitable imprints, such as manufacturer and drug information and instructions for use. Examples of imprints for application notes are in DE 692 20 842 T specified.
  • the medicament portions included in the blister pack are preferably for contraception or hormone replacement therapy.
  • the case according to the invention has a first and a second half of the case, which are articulated to each other.
  • the first Etuihffy is designed as a pocket for receiving the blister pack and has an outer part and an inner visible part and first openings in the visible part and second openings in the outer part.
  • the first openings are at least partially aligned with the second openings, at least where the containers are in the pocket after receiving the blister pack.
  • the second half of the case has a first compartment for receiving a weekday display first display means and first windows for displaying the days of the week in an inner visible area of the second half of the case in the area of the first shelf.
  • the first windows are arranged to be associated with the columns of containers of a blister pack received in the pocket.
  • a blister pack can be easily accommodated in a manner that a clear assignment of displayed days of the week to the columns of containers on the blister pack is possible.
  • the display means are interchangeably and variably received in a suitable tray, the blister pack can be used case-related with intake instructions, ie the first to be taken portion of medication can be provided with the associated time, so that adjacent portions are automatically assigned to the following intake times.
  • the structure of the case is very simple, so that it is inexpensive to produce:
  • the case can be made of cardboard or plastic. It is only necessary to provide a corresponding pocket for receiving the blister pack and a first compartment for receiving the first display means. If the case is made of cardboard, for example, this can be done by simply punching, folding and gluing the individual components in a suitable form. This is possible mechanized in a very cost effective manner.
  • the case according to the invention fulfills the required functionality in a secure manner.
  • the second half of the case has a second compartment and at least one second window in the region of the second compartment.
  • the second compartment serves to receive a second display means indicating a day of the week pair, for example for displaying a drug intake interruption.
  • the at least one second window is used to display these weekday pairs.
  • the weekday pair indicates, on the one hand, the day of the week on which the last medication portion of the last intake phase was taken and, on the other hand, the day of the week on which the first medication portion of the next intake phase is to be taken.
  • the medicament portions are to be continuously taken approximately in a 24-hour rhythm during an intake phase. After typically 21 days, the drug intake is discontinued. This is followed by an income-free (interruption) period.
  • the second display means serve to indicate the end of the ingestion-free period of time to ensure that the first medication portion in the next intake phase is taken in time.
  • the revenue-free period can be 7 days.
  • the second display means indicate weekday pairs, so in the said case the day of the week of the last intake in a revenue phase before the revenue-free phase and the day of the week, which is 7 days after the first-mentioned day of the week.
  • the weekday of the last intake is set as the first day of the weekday pair
  • the weekday of the first intake of the next intake phase is automatically displayed as the second day of the weekday pair.
  • certain periods of contraception may be prescribed for certain medicinal products, for example a taking phase lasting at least 24 days and not more than 120 days, and an interruption period of 4 days in this case ongoing.
  • the next Ingestion Phase will begin on a different day of the week than the last Ingestion Phase. For this reason, the first display means must then be switched at the beginning of the next intake phase so that the first displayed day of the week corresponds to the day of the weekday pair displayed the second display means indicating the first intake day of the next intake phase. In contrast, if the total period includes a number of days divisible by 7, the day of the week of the first intake day of the next intake phase is identical to the day of the week of the first intake day of the last intake phase. In this case, the first display means can continue to be used without conversion.
  • the first compartment is designed for insertion of the first display means and has a slot.
  • the first compartment could also be hinged and record the first display means in the unfolded state.
  • a structure in which the display means is inserted into the tray is, very easy to be realized: For this purpose, only two layers of a suitable material are required, which are bound together to form a compartment inextricably linked edge and form only one side of a slot through which the display means can be pushed into the tray.
  • the slot may be open for articulation between the first and second half of the case.
  • This allows an arrangement of the first windows for the first display means at a short distance from the blister pack, without the display means otherwise having to be pushed deep into the compartment, say from the opposite edge. In the latter case, the operation would be problematic, because an exchange and resetting the days of the week would be difficult. Due to the small distance between the windows and the blister pack, a fast and reliable allocation of the windows to the respective columns is possible. In addition, it is ensured that the display means can not easily slip out of the case and thus lost. Namely, even if the display means would not be kept sufficiently strong in the tray, it could not fall out of the tray in this arrangement of the slot.
  • the at least one second window is located in the inner visible surface of the second half of the case. Since the first window for the first display means are already arranged in the inner visible surface of the second half of the case, an overview of the revenue situation is possible by simply opening the case. If the second window were located on the outside of the second half of the case, orientation on both sides would be required.
  • two second windows are provided in each of which one of the weekdays of the weekday pair is visible. These windows are provided at a suitable distance from each other. If all days of the week are shown on the second display means and if one weekday pair can be assigned to the two second windows, the set weekday pair automatically appears if the two second windows are spaced apart from one another.
  • This embodiment opens up the possibility that a weekday strip is used for the display of the weekday pairs, which is otherwise used as the first display means. Thus, different first and second display means are not necessary.
  • the second windows are introduced into the inner viewing area at the desired daily distance, for example 5-day intervals, the desired weekday pair is automatically displayed.
  • the weekday pairs on the display means may of course also be shown in pairs one above the other or side by side, so that the pairs then appear in a single window or in two immediately adjacent, for example, side by side or one above the other, arranged windows.
  • strips can be used as a second display means with different distances of the weekdays shown, so that each different day intervals are displayed in two spaced-apart second windows. If second display means are provided on which the weekday pairs are displayed directly adjacent to one another or one above the other, weekday pairs are shown on different display means, each of which can indicate a certain period of a phase free of taking.
  • the first compartment may be designed for insertion of the first display means, and the second compartment for inserting the second display means may be formed so that a simple production is possible.
  • the advantages over a hinged embodiment have already been described with respect to the first compartment.
  • the second compartment has an insertion opening for the second display means.
  • the insertion opening may in particular be open towards an outer edge of the second half of the housing. This ensures easy accessibility of this compartment for insertion or removal of the display means.
  • the insertion opening may further comprise a handle recess.
  • the first and second display means may preferably be in the form of strips, namely in the form of a weekday strip or a strip of evidence for the weekday pairs. This ensures easy manufacturability.
  • the strips can be made, for example, from paper, cardboard, plastic or metal and from composite (filled, for example, with reinforcement reinforcing materials, in particular fibers filled) materials of paper, cardboard, plastic, metal with each other or with other materials or laminates of these Materials exist.
  • the strip used as the first display means may comprise, for example, a weekday series of 13 days starting from Sun (Sunday) through Mon, Tue, Wed, Thu, Fri, Sat, Sun, Mon, Tue, Wed, Thu to Fri such that all conceivable weekday series of a week, starting with any day of the week, can be formed by folding at the folds.
  • Such a folded weekday strip can then be inserted into the first compartment and displays the intake days, starting with the selected first day of the week.
  • the indicator strip selected as the second display means can be formed like the aforementioned weekday strip, whereby in the formation of the weekday pair then it has to be taken into account which interruption period is to be displayed.
  • this can have a retaining tab on one of the longitudinal edges. As a result, for example, a strip can be more easily inserted into the first compartment and removed from it again.
  • the blister pack is picked up from the bag in the first half of the case.
  • the bag can also be designed in such a way that the blister pack can be inserted into it.
  • the pocket has an insertion opening.
  • the insertion opening on the bag can as well as the first compartment for articulation be open between the first and the second half.
  • the bag is preferably designed so that the pack received by it snaps into the pocket immovable. This facilitates the handling in a significant way. In particular, this prevents the blister pack in the pocket from slipping so that the association between the days of the week displayed in the first windows and the blister pack containers is lost. This would significantly affect the safety of the intake.
  • the first and / or second openings may be elongated holes.
  • at least the perforations in the inner visible part can be designed as elongated holes through which the containers of the blister pack are intended to protrude.
  • the blister pack is guided when inserted into the bag as it were, because the containers slide into the slots.
  • the slots preferably extend along the columns of the containers.
  • the blister pack when inserted into the pocket also immovably locks
  • the containers are preferably raised domes, which penetrate into the slots after receiving the blister pack in the slots or through them, and the slots are the same length as the columns of the containers on the blister pack. After inserting the pack, all containers protrude into the oblong holes. Since there is no longer a game because of the equality of the lengths of the slots and the columns of the containers, the pack sits immovably firmly in the bag.
  • the case can be made of any material, such as paper, cardboard, plastic or metal and composite materials of paper, cardboard, plastic, metal with each other or with other materials or laminates of these materials.
  • the case can be additionally inserted into a slipcase, which may consist of one of the aforementioned materials.
  • a case 1 according to the invention which has a first half-case 2 and a second half-half 3.
  • the first and second half of the case are hinged to each other via a linkage 10.
  • the first half-case 2 is formed by an inner visible part 4 and an outer part 5. Both parts are permanently connected to each other, for example, by gluing on the edge.
  • an insertion opening 6 between the inner visible part and the outer part opens and forms access to a pocket for a blister pack.
  • the package has raised containers 60 containing tablets or other solid dosage forms of a drug.
  • the blister pack can over the insertion opening are inserted into the gap forming the pocket between the inner visible part and the outer part.
  • the containers of the blister pack slide into the elongated holes 7 introduced into the inner visible part.
  • the elongated holes are formed in a grid in the inner view part corresponding columns 61 a, 61 b, 61 c, 61 d, 61 e, 61 f, 61 g, in which the containers are received on the blister pack, so that all containers snap fit into these holes can.
  • the blister pack has seven columns that correspond to the seven days of the week. Since the blister contains 24 containers, are in three of the seven slots corresponding to the columns 61 a, 61 b, 61 c in each case four containers and four slots corresponding to the columns 61 d, 61 e, 61 f, 61 g each three containers. The length of the slots is adjusted accordingly.
  • holes are also introduced (not shown), which are located at the places where the containers of the blister pack are placed.
  • a tablet in a container can be pushed out by pressing on the container through a lower aluminum foil, which closes the container below, and through these lower holes.
  • the second Etuihgan 3 is formed as the first Etuihgan 2 of two parts.
  • the first part forms an inner visible surface 11.
  • the second part forms an outer surface (not shown).
  • the two parts are permanently connected to each other, for example glued.
  • a first compartment 13 and a second compartment 14 are formed between the first part and the second part.
  • the first compartment is accessible via a slot 15, which opens to the articulation 10 out. Through this slot a weekday strip can be inserted. For better handling, this has a retaining tab 105.
  • Weekdays 101a, 101b, 101c, 101d, 101e, 101f, 101g are indicated by first windows 16 on the weekday strip.
  • the first windows are associated with columns 61a, 61b, 61c, 61d, 61e, 61f, 61g.
  • second windows 17 are embedded in the inner viewing surface, can be seen by the displayed weekday pairs 210a, 210b. These weekday pairs are on a reference strip 200 which can be inserted via an insertion opening 18 in the second compartment.
  • a weekday strip 100 is shown. Weekdays 101a, 101b, 101c, 101d, 101e, 101f, 101g are displayed thereon. If the first day of intake after the
  • Such a prepared weekday strip 100 may, as in Fig. 3 shown inserted through the slot 15 in the second compartment in the second Etuihgan 3.
  • the indicator strip 200 may, as in Fig. 4 shown inserted from the left via the insertion opening 18 in the second compartment.
  • folds 201 are provided in the indicator strip, which serve to place the strip in the correct position, as shown to fold backwards.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
EP06818215A 2005-07-01 2006-06-27 Etui zur aufnahme einer arzneimittelpackung sowie deren verwendung Not-in-force EP1898863B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL06818215T PL1898863T3 (pl) 2005-07-01 2006-06-27 Etui do przechowywania opakowania środka leczniczego i jego zażywania

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005032015A DE102005032015A1 (de) 2005-07-01 2005-07-01 Etui zur Aufnahme einer Arzneimittelpackung sowie deren Verwendung
PCT/EP2006/006533 WO2007025593A1 (de) 2005-07-01 2006-06-27 Etui zur aufnahme einer arzneimittelpackung sowie deren verwendung

Publications (2)

Publication Number Publication Date
EP1898863A1 EP1898863A1 (de) 2008-03-19
EP1898863B1 true EP1898863B1 (de) 2011-06-22

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EP06818215A Not-in-force EP1898863B1 (de) 2005-07-01 2006-06-27 Etui zur aufnahme einer arzneimittelpackung sowie deren verwendung

Country Status (30)

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US (1) US8047372B2 (es)
EP (1) EP1898863B1 (es)
JP (1) JP4903203B2 (es)
KR (1) KR101217974B1 (es)
CN (1) CN101212948B (es)
AR (1) AR057424A1 (es)
AT (1) ATE513537T1 (es)
AU (1) AU2006286894B2 (es)
BR (1) BRPI0613949B1 (es)
CA (1) CA2613857C (es)
CR (1) CR9629A (es)
DE (1) DE102005032015A1 (es)
DK (1) DK1898863T3 (es)
DO (1) DOP2006000157A (es)
EA (1) EA012830B1 (es)
EC (1) ECSP088141A (es)
ES (1) ES2366384T3 (es)
HK (1) HK1120400A1 (es)
IL (1) IL188444A0 (es)
MX (1) MX2007016460A (es)
NO (1) NO20076646L (es)
NZ (1) NZ563882A (es)
PE (1) PE20070312A1 (es)
PL (1) PL1898863T3 (es)
PT (1) PT1898863E (es)
TW (1) TWI444182B (es)
UA (1) UA91370C2 (es)
UY (1) UY29647A1 (es)
WO (1) WO2007025593A1 (es)
ZA (1) ZA200801044B (es)

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DE102009008027A1 (de) 2009-02-06 2010-08-12 Bayer Schering Pharma Aktiengesellschaft Vorrichtung und Verwendung zur Aufbewahrung und Bereitstellung von Arzneimittelwafern
EP2393467A1 (de) 2009-02-06 2011-12-14 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung eines stapels von zur aufbewahrung und bereitstellung von arzneimittelwafern dienenden arzneimitteltaschen, arzneimitteltaschenvorlage zur herstellung des stapels sowie verwendung der arzneimitteltaschenvorlage
DE102009008028A1 (de) 2009-02-06 2010-08-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung eines Taschenstapels von zur Aufbewahrung und Bereitstellung von Arzneimittelwafern dienenden Arzneimitteltaschen
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DE102005032015A1 (de) 2007-01-04
PE20070312A1 (es) 2007-05-12
UY29647A1 (es) 2007-01-31
BRPI0613949B1 (pt) 2018-01-23
TW200711647A (en) 2007-04-01
ATE513537T1 (de) 2011-07-15
ECSP088141A (es) 2008-02-20
HK1120400A1 (en) 2009-04-03
TWI444182B (zh) 2014-07-11
PT1898863E (pt) 2011-08-24
DK1898863T3 (da) 2011-08-29
KR20080032134A (ko) 2008-04-14
KR101217974B1 (ko) 2013-01-02
JP4903203B2 (ja) 2012-03-28
PL1898863T3 (pl) 2012-01-31
US8047372B2 (en) 2011-11-01
DOP2006000157A (es) 2010-08-31
JP2009507724A (ja) 2009-02-26
EA200800173A1 (ru) 2008-06-30
US20070017847A1 (en) 2007-01-25
UA91370C2 (ru) 2010-07-26
ES2366384T3 (es) 2011-10-19
CN101212948B (zh) 2011-10-26
AR057424A1 (es) 2007-12-05
CR9629A (es) 2008-02-20
MX2007016460A (es) 2008-03-07
ZA200801044B (en) 2009-07-29
AU2006286894B2 (en) 2011-06-09
AU2006286894A1 (en) 2007-03-08
CN101212948A (zh) 2008-07-02
NO20076646L (no) 2008-02-28
BRPI0613949A2 (pt) 2011-02-22
CA2613857A1 (en) 2007-03-08
NZ563882A (en) 2010-06-25
CA2613857C (en) 2014-02-11
EA012830B1 (ru) 2009-12-30
IL188444A0 (en) 2008-04-13
WO2007025593A1 (de) 2007-03-08
EP1898863A1 (de) 2008-03-19

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