EP1660111A1 - Hydrolysat de collagene - Google Patents

Hydrolysat de collagene

Info

Publication number
EP1660111A1
EP1660111A1 EP04763893A EP04763893A EP1660111A1 EP 1660111 A1 EP1660111 A1 EP 1660111A1 EP 04763893 A EP04763893 A EP 04763893A EP 04763893 A EP04763893 A EP 04763893A EP 1660111 A1 EP1660111 A1 EP 1660111A1
Authority
EP
European Patent Office
Prior art keywords
collagen hydrolyzate
infants
collagen
hydrolyzate according
food
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04763893A
Other languages
German (de)
English (en)
Inventor
Michael Butzengeiger
Bernd EGGERSGLÜSS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gelita AG
Original Assignee
Gelita AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelita AG filed Critical Gelita AG
Publication of EP1660111A1 publication Critical patent/EP1660111A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/28—Substances of animal origin, e.g. gelatin or collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the invention relates to novel therapeutic applications of collagen hydrolyzate as a nutritional supplement in infants.
  • Collagen hydrolyzate is a denatured and partially hydrolyzed protein, obtained from collagenous substances from vertebrates, especially mammals, poultry or fish. Collagen hydrolysis produces peptides with different structures and different biological effects. Collagen hydrolyzate contains approximately twice the proportion of the amino acids lysine, glycine and glutamine as the average of the dietary protein. Collagen hydrolyzate is also rich in the amino acids proline and hydroxyproiin. No other concentration of hydroxyproiin has been detected in any other food. The amino acids mentioned are indispensable for the construction of human collagen, i.e. for connective tissue metabolism, especially bone and cartilage metabolism.
  • Gelatin-containing preparations have found their way into the treatment of degenerative joint diseases, as has hydrolyzed collagen in the treatment of osteoporosis in adults (cf. US Pat. No. 5,948,766 A).
  • the use of the hydrolyzed gelatin as a carrier means that the instant tea has a very low nutritional value, so that additional nutrients can be avoided unintentionally and in an uncontrolled manner.
  • gelatin hydrolyzate in combination with another protein hydrolyzate, in particular whey hydrolyzate, was already known from DE 24 05 589 C3.
  • the gelatin is used there as an aid in the recovery of the whey hydrolyzate and avoids the formation of degradation products with an intense bitter taste in the hydrolysis reaction. It also emphasizes that gelatin hydrolyzate alone is disadvantageous as a food because it has only a low content of essential amino acids.
  • a protein from the group of whey, milk, soybean, corn, potato, wheat, oil, nut kernel, sunflower seed and egg proteins is used there in the presence of gelatin or gelatin degradation products , These breakdown products are then also recommended as a food additive. Children's nutrition and dietetic foods are also mentioned there. The only function of gelatin is to avoid bitter substances as breakdown products.
  • Hydrolyzed collagen and hydrolyzed gelatin are essentially the same.
  • hydrolyzed gelatin only the intermediate step of obtaining and isolating gelatin was interposed before the polypeptide chains are broken down to molecular weights or chain lengths corresponding to those of the hydrolyzed collagen, also called collagen hydrolyzate, by means of further hydrolysis.
  • Collagen hydrolyzate and gelatin hydrolyzate are therefore often used interchangeably.
  • collagen hydrolyzate which has been produced in an enzymatic proteolytic process.
  • the inventors were able to demonstrate in a study that the addition of collagen hydrolyzate to baby food manifests itself in an increased, improved general well-being in infants and is very specific. fish reduces the restlessness of the infants. It was also surprisingly found that the addition of collagen hydrolyzate to the infant formula results in a suppression of flatulence in the infant. It was also found that the spitting of infants after ingestion when collagen hydrolyzate was added to the infant formula was significantly reduced.
  • collagen hydrolyzate is recommended to support rickets treatment and / or prophylaxis in infants, in particular in combination with vitamin D.
  • Collagen hydrolyzates obtained by enzymatic proteolytic methods are particularly preferred. With this type of collagen hydrolyzate, the amount of bitter substances is minimal.
  • collagen hydrolyzate for use as a nutritional supplement for baby food is its cold solubility in water, i.e. the solubility to a clear solution at 23 ° C. This has particular advantages for use and administration with the food to infants.
  • the hip ultrasound examination was carried out in a standardized manner in a storage tray according to the guidelines of Graf [11,11].
  • a 7.5 MHz linear scan (Ultramark 11+) was used as the transducer, 2 images each were frozen and then printed out and evaluated on a 2: 1 scale using a video printer.
  • Analogue to the criteria according to Graf alpha and beta angles were determined as well as the following descriptive features: bony shape, bony oriel, socket roof, cartilaginous roofing, femoral head position and femoral core.
  • the hip type was determined from this.
  • the time of the sonographically detectable occurrence of ossification of the femoral core was included
  • FIGS 3 and 4 illustrate the sonographic finding
  • the proposed form of application was to dissolve the powder in water or milk and to administer vitamin D prophylaxis (500 IU (vitamin D fluorine)) simultaneously orally using a pipette.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Afin d'améliorer l'état général de nourrissons et afin de réduire l'agitation et les régurgitations après ingestion de nourriture, de même que pour limiter l'aérophagie, il est prévu, selon l'invention, d'utiliser de l'hydrolysat de collagène comme complément alimentaire pour d'alimentation de nourrissons.
EP04763893A 2003-08-21 2004-08-06 Hydrolysat de collagene Withdrawn EP1660111A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10339180A DE10339180A1 (de) 2003-08-21 2003-08-21 Kollagenhydrolysat
PCT/EP2004/008864 WO2005021027A1 (fr) 2003-08-21 2004-08-06 Hydrolysat de collagène

Publications (1)

Publication Number Publication Date
EP1660111A1 true EP1660111A1 (fr) 2006-05-31

Family

ID=34202040

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04763893A Withdrawn EP1660111A1 (fr) 2003-08-21 2004-08-06 Hydrolysat de collagene

Country Status (14)

Country Link
US (1) US20060275345A1 (fr)
EP (1) EP1660111A1 (fr)
JP (1) JP2007502607A (fr)
AU (1) AU2004267925A1 (fr)
BR (1) BRPI0413799A (fr)
CA (1) CA2536968A1 (fr)
CR (1) CR8240A (fr)
DE (1) DE10339180A1 (fr)
EA (1) EA011482B1 (fr)
EC (1) ECSP066387A (fr)
MX (1) MXPA06001968A (fr)
NO (1) NO20061263L (fr)
WO (1) WO2005021027A1 (fr)
ZA (1) ZA200601487B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104017071B (zh) * 2006-06-13 2017-08-15 赫里克斯生物医疗公司 用于诱导细胞外基质蛋白合成的肽片段
ES2298071B1 (es) * 2006-10-25 2009-07-28 Masterfarm,S.L. Hidrolizado enzimatico de colageno y procedimiento de obtencion.
DE102007002295A1 (de) * 2007-01-09 2008-07-10 Gelita Ag Nahrungsmittelprodukt auf Proteinbasis und Verfahren zur Herstellung
JP2008266222A (ja) * 2007-04-20 2008-11-06 Nippi:Kk 強皮症に合併する指先の潰瘍に対するコラーゲンペプチドの作用
JP2011136945A (ja) * 2009-12-28 2011-07-14 Lotte Co Ltd 皮脂分泌抑制剤及びそれを用いた飲食物及び組成物
EP2948003B1 (fr) 2013-01-23 2020-03-18 Bottled Science Limited Composition de boisson améliorant la peau
DE102014108502A1 (de) * 2014-06-17 2015-12-17 Gelita Ag Zusammensetzung in Form von kompaktierten Partikeln und deren Verwendung
WO2016102275A1 (fr) * 2014-12-22 2016-06-30 Nestec S.A. Piégeage de peptides amers par un gel comprenant de la gélatine
DE102019202606A1 (de) * 2018-11-06 2020-05-07 Gelita Ag Rekombinante Herstellung eines Kollagenpeptidpräparates und dessen Verwendung

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
GB1227534A (fr) * 1967-08-31 1971-04-07
DE2405589C3 (de) * 1974-02-06 1980-08-07 Agfa-Gevaert Ag, 5090 Leverkusen Verfahren zur Herstellung leicht benetzbarer, wasserlöslicher natürlicher Eiweißprodukte
DE3237077A1 (de) * 1982-10-07 1984-04-12 Krüger GmbH & Co KG, 5060 Bergisch Gladbach Instant-tees und verfahren zu ihrer herstellung
US4732773A (en) * 1982-07-17 1988-03-22 Kruger Gmbh & Co. Kg Instant beverage and instant tea
JP3153237B2 (ja) * 1990-03-09 2001-04-03 ノボ ノルディスク アクティーゼルスカブ タンパク質加水分解物
PT777491E (pt) * 1994-08-23 2005-01-31 Stoess & Co Gelatine Utilizacao de colagenio hidrolisado, de sabor neutro e agente que o contem
JP4609807B2 (ja) * 1996-03-28 2011-01-12 雪印乳業株式会社 骨強化用医薬、飲食品及び飼料
US6248378B1 (en) * 1998-12-16 2001-06-19 Universidad De Sevilla Enhanced food products
US6011038A (en) * 1997-09-05 2000-01-04 Merck & Co., Inc. Pyrazinone thrombin inhibitors
RU2133097C1 (ru) * 1997-11-12 1999-07-20 Закрытое акционерное общество "Фермент плюс" Способ получения кормовой добавки "витапептид", кормовая добавка "витапептид"
JP3881453B2 (ja) * 1998-05-14 2007-02-14 新田ゼラチン株式会社 カルシウム吸収促進剤およびその製造方法
JP2000083695A (ja) * 1998-09-16 2000-03-28 Ajinomoto Co Inc 低苦味ペプチドの製造法
JP2001031586A (ja) * 1999-07-14 2001-02-06 Sunstar Inc 動脈硬化症及び動脈硬化症に起因する疾患の予防又は治療組成物
US6383534B1 (en) * 2000-01-18 2002-05-07 Lorin Dyrr Mineral water composition
US6365218B1 (en) * 2000-02-04 2002-04-02 Abbott Laboratories Pediatric formula and methods for providing nutrition and improving tolerance

Non-Patent Citations (1)

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Title
See references of WO2005021027A1 *

Also Published As

Publication number Publication date
US20060275345A1 (en) 2006-12-07
WO2005021027A1 (fr) 2005-03-10
ZA200601487B (en) 2007-04-25
DE10339180A1 (de) 2005-03-24
AU2004267925A1 (en) 2005-03-10
EA200600382A1 (ru) 2006-10-27
EA011482B1 (ru) 2009-04-28
ECSP066387A (es) 2006-08-30
CA2536968A1 (fr) 2005-03-10
NO20061263L (no) 2006-03-20
BRPI0413799A (pt) 2006-10-31
CR8240A (es) 2006-10-18
JP2007502607A (ja) 2007-02-15
MXPA06001968A (es) 2006-08-31

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