EP1404676A1 - Pyrrolopyrimidines as protein kinase inhibitors - Google Patents

Pyrrolopyrimidines as protein kinase inhibitors

Info

Publication number
EP1404676A1
EP1404676A1 EP02740895A EP02740895A EP1404676A1 EP 1404676 A1 EP1404676 A1 EP 1404676A1 EP 02740895 A EP02740895 A EP 02740895A EP 02740895 A EP02740895 A EP 02740895A EP 1404676 A1 EP1404676 A1 EP 1404676A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
compound according
heteroaryl
group
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02740895A
Other languages
German (de)
English (en)
French (fr)
Inventor
Paul Joseph Aventis Pharma Ltd. COX
Tahir Nadeem Aventis Pharma Limited MAJID
Shelley Amendola
Stephanie Daniele Aventis Pharma Limited DEPRETS
Chris Aventis Pharma Limited EDLIN
Brian Leslie Aventis Pharma Limited PEDGRIFT
Frank Aventis Pharma Limited HALLEY
Michael Aventis Pharma Limited EDWARDS
Bernard Aventis Pharma Limited BAUDOIN
Iain Mcfarlane Mclay
Davis John Aventis Pharma Limited ALDOUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of EP1404676A1 publication Critical patent/EP1404676A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP02740895A 2001-06-23 2002-06-21 Pyrrolopyrimidines as protein kinase inhibitors Withdrawn EP1404676A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0115393.1A GB0115393D0 (en) 2001-06-23 2001-06-23 Chemical compounds
GB0115393 2001-06-23
US30167801P 2001-06-28 2001-06-28
US301678P 2001-06-28
PCT/GB2002/002835 WO2003000695A1 (en) 2001-06-23 2002-06-21 Pyrrolopyrimidines as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
EP1404676A1 true EP1404676A1 (en) 2004-04-07

Family

ID=9917225

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02740895A Withdrawn EP1404676A1 (en) 2001-06-23 2002-06-21 Pyrrolopyrimidines as protein kinase inhibitors

Country Status (22)

Country Link
EP (1) EP1404676A1 (et)
JP (1) JP4344607B2 (et)
CN (1) CN1294135C (et)
AU (1) AU2002314325B8 (et)
BR (1) BR0210652A (et)
CA (1) CA2451932C (et)
CZ (1) CZ20033443A3 (et)
EA (1) EA007415B1 (et)
EC (1) ECSP034922A (et)
EE (1) EE05432B1 (et)
GB (1) GB0115393D0 (et)
HU (1) HUP0400300A3 (et)
ME (1) MEP19308A (et)
NZ (1) NZ529766A (et)
OA (1) OA12632A (et)
PL (1) PL374096A1 (et)
RS (1) RS51698B (et)
SK (1) SK15882003A3 (et)
TN (1) TNSN03144A1 (et)
TR (1) TR200302242T2 (et)
UA (1) UA76760C2 (et)
WO (1) WO2003000695A1 (et)

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FR2876103B1 (fr) * 2004-10-01 2008-02-22 Aventis Pharma Sa Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
WO2006044687A2 (en) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Kinase inhibitors
FR2878849B1 (fr) 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation
WO2006135915A2 (en) 2005-06-13 2006-12-21 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
TWI468162B (zh) 2005-12-13 2015-01-11 英塞特公司 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
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US8349847B2 (en) 2008-01-11 2013-01-08 Durga Prasad Konakanchi Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents
WO2009152133A1 (en) 2008-06-10 2009-12-17 Abbott Laboratories Novel tricyclic compounds
EA025520B1 (ru) 2009-05-22 2017-01-30 Инсайт Холдингс Корпорейшн N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
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WO2011028685A1 (en) 2009-09-01 2011-03-10 Incyte Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
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MX347851B (es) 2010-03-10 2017-05-16 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
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US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
WO2012068450A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
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CN103476776B (zh) * 2011-01-07 2016-09-28 北京赛林泰医药技术有限公司 作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
CA2839767A1 (en) 2011-06-20 2012-12-27 Incyte Corporation Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
CN104662018B (zh) 2012-04-20 2017-10-24 阿迪维纳斯治疗有限公司 取代的杂双环化合物、组合物及其医疗应用
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
PL2877467T3 (pl) 2012-07-26 2017-08-31 Glaxo Group Limited 2-(azaindolo-2-ylo)benzoimidazole jako inhibitory pad4
US10227357B2 (en) 2012-09-06 2019-03-12 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
BR112015010663B1 (pt) 2012-11-15 2022-12-06 Incyte Holdings Corporation Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo
CN105189509B (zh) 2013-03-06 2017-12-19 因赛特公司 用于制备jak抑制剂的方法及中间体
CN105026393A (zh) 2013-03-13 2015-11-04 艾伯维公司 Cdk9激酶抑制剂
JP2016516710A (ja) 2013-03-13 2016-06-09 アッヴィ・インコーポレイテッド ピリジン系ｃｄｋ９キナーゼ阻害薬
WO2014160028A1 (en) * 2013-03-14 2014-10-02 Abbvie Inc. Pyrrolopyrimindine cdk9 kinase inhibitors
TW201446763A (zh) 2013-03-14 2014-12-16 Abbvie Inc 吡咯并［２，３－ｂ］吡啶ｃｄｋ９激酶抑制劑
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Also Published As

Publication number Publication date
CA2451932C (en) 2009-12-29
OA12632A (en) 2006-06-14
EA007415B1 (ru) 2006-10-27
HUP0400300A3 (en) 2010-12-28
ECSP034922A (es) 2004-04-28
JP4344607B2 (ja) 2009-10-14
EA200400073A1 (ru) 2004-08-26
CZ20033443A3 (en) 2004-03-17
GB0115393D0 (en) 2001-08-15
BR0210652A (pt) 2004-08-10
AU2002314325B2 (en) 2009-01-08
CN1294135C (zh) 2007-01-10
TR200302242T2 (tr) 2004-12-21
RS51698B (en) 2011-10-31
WO2003000695A8 (en) 2004-03-11
SK15882003A3 (sk) 2004-07-07
HUP0400300A2 (en) 2007-08-28
JP2005508300A (ja) 2005-03-31
MEP19308A (en) 2010-06-10
TNSN03144A1 (en) 2005-12-23
NZ529766A (en) 2008-11-28
RS99203A (en) 2006-12-15
EE05432B1 (et) 2011-06-15
UA76760C2 (uk) 2006-09-15
CN1518552A (zh) 2004-08-04
CA2451932A1 (en) 2003-01-03
WO2003000695A1 (en) 2003-01-03
EE200400003A (et) 2004-02-16
PL374096A1 (en) 2005-09-19
AU2002314325B8 (en) 2009-01-29

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Inventor name: ALDOUS, DAVIS JOHN,AVENTIS PHARMA LIMITED

Inventor name: MCLAY, IAIN MCFARLANE

Inventor name: BAUDOIN, BERNARD,AVENTIS PHARMA LIMITED

Inventor name: EDWARDS, MICHAEL,AVENTIS PHARMA LIMITED

Inventor name: HALLEY, FRANK,AVENTIS PHARMA LIMITED

Inventor name: PEDGRIFT, BRIAN LESLIE,AVENTIS PHARMA LIMITED

Inventor name: EDLIN, CHRIS

Inventor name: DEPRETS, STEPHANIE DANIELE

Inventor name: AMENDOLA, SHELLEY

Inventor name: MAJID, TAHIR NADEEM

Inventor name: COX, PAUL JOSEPH

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ALDOUS, DAVIS JOHN,AVENTIS PHARMA LIMITED

Inventor name: MCLAY, IAIN MCFARLANE

Inventor name: BAUDOIN, BERNARD,AVENTIS PHARMA LIMITED

Inventor name: EDWARDS, MICHAEL,AVENTIS PHARMA LIMITED

Inventor name: HALLEY, FRANK,AVENTIS PHARMA LIMITED

Inventor name: PEDGRIFT, BRIAN LESLIE,AVENTIS PHARMA LIMITED

Inventor name: EDLIN, CHRIS

Inventor name: DEPRETS, STEPHANIE DANIELE

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Inventor name: EDLIN, CHRIS

Inventor name: MCLAY, IAIN MCFARLANE

Inventor name: BAUDOIN, BERNARD, AVENTIS PHARMA LIMITED

Inventor name: COX, PAUL JOSEPH

Inventor name: PEDGRIFT, BRIAN LESLIE, AVENTIS PHARMA LIMITED

Inventor name: DEPRETS, STEPHANIE DANIELE

Inventor name: ALDOUS, DAVIS JOHN, AVENTIS PHARMA LIMITED

Inventor name: MAJID, TAHIR NADEEM

Inventor name: HALLEY, FRANK, AVENTIS PHARMA LIMITED

Inventor name: AMENDOLA, SHELLEY

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