RS51698B - Pyrrolopyrimidines as protein kinase inhibitors - Google Patents
Pyrrolopyrimidines as protein kinase inhibitorsInfo
- Publication number
- RS51698B RS51698B YU99203A YUP99203A RS51698B RS 51698 B RS51698 B RS 51698B YU 99203 A YU99203 A YU 99203A YU P99203 A YUP99203 A YU P99203A RS 51698 B RS51698 B RS 51698B
- Authority
- RS
- Serbia
- Prior art keywords
- ny1y2
- ny3y4
- heteroaryl
- aryl
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Jedinjenje formulegdeR1 predstavlja vodonik, -C(=O)-NY1Y2, -C(=O)-OR5, -SO2-NY1Y2, -SO2-R7, -C(=O)R7, iliR1 predstavlja alkenil, alkeniloksi, alkil, alkynil, aril, heteroaril, heterocikloalkil, cikloalkil ili cikloalkilalkil, svaki po izboru supstituisan jednom ili više grupa odabranih od aril, cikloalkil, cijano, halo, heteroaril, heterocikloalkil, -CHO, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -OR7, -C(=O)-R7, hidroksi, alkoksi i karboksi;R2 predstavalja jednu ili više grupa odabranih od vodonika, acil, alkilenedioksi, alkenil, alkeniloksi, alkinil, aril, cijano, halo, hidroksi, heteroaril, heterocikloalkil, nitro,R4, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, N(R6)-C(=O)-NY3Y4, -N(R6)-C(=O)-OR7, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -SO2-NY1Y2 i -ZR4;R3 predstavlja H, cijano, halo, hidroksi, nitro, R4, NY1Y2, -ZR4, -C(=O)-OR5, C(=O)-R7, -C(=O)-NY1Y2, -N(R8)-C(=O)-R4, -N(R8)-C(=O)NY1Y2; -N(R8)-C(=O)-OR5, -SO2-NY3Y4 ili -N(R8)-SO2-R7, iliR3 predstavlja aril, heteroaril, alkenil ili alkinil, svaki po izboru supstituisan jednom ili više grupa odabranih od aril, cijano, halo, hidroksi, heteroaril, heterocikloalkil, nitro,-C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -SO2-NY1Y2 i -ZR4;R4 predstavlja alkil, cikloalkil ili cikloalklalkil svaki po izboru supstituisan jednom ili više grupa odabranih od aril, cikloalkil, cijano, halo, heteroaril, heterocikloalkil, hidroksi, -CHO, -C(=O)-NY1Y2, -C(=O)-OR5, -NY1Y2, -N(R6)-C(=O)-R7,-N(R6)-C(=O)-NY3Y4,-N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4, -OR7 i -C(=O)-R7pri čemu je u R4 je po izboru umetnuta grupa odabranaod O, S(O)n, i NR6R5 predstavlja vodonik, alkil, alkenil, aril, arilalkil, heteroaril ili heteroarilalkil;R6 predstavlja vodonik ili niži alkil;R7 predstavlja alkil, aril, arilalkil, cikloalkil, cikoalkilalkil, heteroaril, heteroarilalkil, heterocikloalkil ili heterocikloalkilalkil;R8 predstavlja vodonik ili niži alkil;Y1 i Y2 su nezavisno vodonik, alkenil, aril, cikloalkil, heteroaril ili alkil po izboru supstituisan jednom ili više grupa odabranih od aril, halo, heteroaril, hidroksi, -C(=O)-NY3Y4, -C(=O)-OR5, -NY3Y4, -N(R6)-C(=O)- R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-SO2-R7, -N(R6)-SO2-NY3Y4 i -OR7; or the grupa – NY1Y2 može da formira ciklični amin;Y3 i Y4 su nezavinso vodonik, alkenil, alkil, aril, arilalkil, cikloalkil, heteroaril ili heteroarilalkil; ili -NY3Y4 grupa može da formira ciklični amin;Z predstavlja O ili S(O)n; n je nula ili broj 1 ili 2; iliN-oksid, bioizoster kiseline, farmaceutski prihvatljiva so ili solvat datog jedinjenja; ili N-oksid, ili kiseli bioizostar date soli ili solvata,pri čemu alkenil je alifatična ugljovodonična grupa koja sadrži ugljenik-ugljenik dvostruku vezu i prav ili razgranat lanac sa 2 do 15 atoma ugljenika,pri čemThe compound of the formula R1 represents hydrogen, -C (= O) -NY1Y2, -C (= O) -OR5, -SO2-NY1Y2, -SO2-R7, -C (= O) R7, or R1 represents alkenyl, alkenyloxy, alkyl, alkynyl , aryl, heteroaryl, heterocycloalkyl, cycloalkyl or cycloalkylalkyl, each optionally substituted by one or more groups selected from aryl, cycloalkyl, cyano, halo, heteroaryl, heterocycloalkyl, -CHO, -C (= O) -NY1Y2, -C (= O ) -OR5, -NY1Y2, -N (R6) -C (= O) -R7, -N (R6) -C (= O) -NY3Y4, -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -OR7, -C (= O) -R7, hydroxy, alkoxy and carboxy; R2 represents one or more groups selected from hydrogen, acyl, alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halo, hydroxy , heteroaryl, heterocycloalkyl, nitro, R4, -C (= O) -NY1Y2, -C (= O) -OR5, -NY1Y2, -N (R6) -C (= O) -R7, N (R6) -C (= O) -NY3Y4, -N (R6) -C (= O) -OR7, -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -SO2-NY1Y2 and -ZR4; R3 represents H, cyano, halo, hydroxy, nitro, R4, NY1Y2, -ZR4, -C (= O) -OR5, C (= O) -R7, -C (= O) -NY1Y2, -N (R8) - C (= O) -R4, -N (R8) -C (= O) NY1Y2; -N (R8) -C (= O) -OR5, -SO2-NY3Y4 or -N (R8) -SO2-R7, or R3 represents aryl, heteroaryl, alkenyl or alkynyl, each optionally substituted by one or more groups selected from aryl , cyano, halo, hydroxy, heteroaryl, heterocycloalkyl, nitro, -C (= O) -NY1Y2, -C (= O) -OR5, -NY1Y2, -N (R6) -C (= O) -R7, -N (R6) -C (= O) -NY3Y4, -N (R6) -C (= O) -OR7, -N (R6) -SO2-R7, -N (R6) -SO2-NY3Y4, -SO2-NY1Y2 and -ZR4; R4 represents alkyl, cycloalkyl or cycloalkylalkyl each optionally substituted by one or more groups selected from aryl, cycloalkyl, cyano, halo, heteroaryl, heterocycloalkyl, hydroxy, -CHO, -C (= O) -NY1Y2, -C ( = O) -OR5, -NY1Y2, -N (R6) -C (= O) -R7, -N (R6) -C (= O) -NY3Y4, -N (R6) -SO2-R7, -N ( R6) -SO2-NY3Y4, -OR7 and -C (= O) -R7 wherein R4 is an optionally inserted group selected from O, S (O) n, and NR6R5 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R6 represents hydrogen or lower alkyl; R7 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R8 represents hydrogen or lower alkyl; Y1 and Y2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl or alkyl optionally substituted by one or more groups selected from aryl, halo, heteroaryl, hydroxy, -C (= O) - NY3Y4, -C (= O) -OR5, -NY3Y4, -N (R6) -C (= O) - R7, -N (R6) -C (= O) -NY3Y4, -N (R6) -SO2- R7, -N (R6) -SO2-NY3Y4 and -OR7; or the group - NY1Y2 may form a cyclic amine; Y3 and Y4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or a -NY3Y4 group may form a cyclic amine; Z represents O or S (O) n; n is zero or number 1 or 2; or N-oxide, an acid bioisoster, a pharmaceutically acceptable salt or solvate of a given compound; or N-oxide, or an acidic bioisomer of a given salt or solvate, wherein the alkenyl is an aliphatic hydrocarbon group containing a carbon-carbon double bond and a straight or branched chain of 2 to 15 carbon atoms, wherein
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MEP-193/08A MEP19308A (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115393.1A GB0115393D0 (en) | 2001-06-23 | 2001-06-23 | Chemical compounds |
US30167801P | 2001-06-28 | 2001-06-28 | |
PCT/GB2002/002835 WO2003000695A1 (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
RS99203A RS99203A (en) | 2006-12-15 |
RS51698B true RS51698B (en) | 2011-10-31 |
Family
ID=9917225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU99203A RS51698B (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1404676A1 (en) |
JP (1) | JP4344607B2 (en) |
CN (1) | CN1294135C (en) |
AU (1) | AU2002314325B8 (en) |
BR (1) | BR0210652A (en) |
CA (1) | CA2451932C (en) |
CZ (1) | CZ20033443A3 (en) |
EA (1) | EA007415B1 (en) |
EC (1) | ECSP034922A (en) |
EE (1) | EE05432B1 (en) |
GB (1) | GB0115393D0 (en) |
HU (1) | HUP0400300A3 (en) |
ME (1) | MEP19308A (en) |
NZ (1) | NZ529766A (en) |
OA (1) | OA12632A (en) |
PL (1) | PL374096A1 (en) |
RS (1) | RS51698B (en) |
SK (1) | SK15882003A3 (en) |
TN (1) | TNSN03144A1 (en) |
TR (1) | TR200302242T2 (en) |
UA (1) | UA76760C2 (en) |
WO (1) | WO2003000695A1 (en) |
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US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
AR114810A1 (en) | 2018-01-30 | 2020-10-21 | Incyte Corp | PROCESSES AND INTERMEDIATES TO DEVELOP A JAK INHIBITOR |
MX2022012285A (en) | 2018-03-30 | 2023-08-15 | Incyte Corp | Treatment of hidradenitis suppurativa using jak inhibitors. |
EA202190952A1 (en) | 2018-10-05 | 2021-12-22 | Аннапурна Байо, Инк. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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US6140317A (en) * | 1996-01-23 | 2000-10-31 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
IL129825A0 (en) * | 1996-11-27 | 2000-02-29 | Pfizer | Fused bicyclic pyrimidine derivatives |
ID26698A (en) * | 1998-06-19 | 2001-02-01 | Pfizer Prod Inc | PIROLO COMPOUNDS [2,3-d] PYRIMIDINE |
PA8474101A1 (en) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS |
KR20010085822A (en) * | 1998-09-18 | 2001-09-07 | 스타르크, 카르크 | 4-aminopyrrolopyrimidines as kinase inhibitors |
EP1382339B1 (en) * | 1999-12-10 | 2007-12-05 | Pfizer Products Inc. | Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives |
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- 2002-06-21 EP EP02740895A patent/EP1404676A1/en not_active Withdrawn
- 2002-06-21 CA CA002451932A patent/CA2451932C/en not_active Expired - Fee Related
- 2002-06-21 CZ CZ20033443A patent/CZ20033443A3/en unknown
- 2002-06-21 JP JP2003507098A patent/JP4344607B2/en not_active Expired - Fee Related
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- 2002-06-21 BR BR0210652-3A patent/BR0210652A/en not_active Application Discontinuation
- 2002-06-21 UA UA2004010502A patent/UA76760C2/en unknown
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- 2002-06-21 SK SK1588-2003A patent/SK15882003A3/en not_active Application Discontinuation
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JP4344607B2 (en) | 2009-10-14 |
ECSP034922A (en) | 2004-04-28 |
EP1404676A1 (en) | 2004-04-07 |
JP2005508300A (en) | 2005-03-31 |
CN1294135C (en) | 2007-01-10 |
HUP0400300A2 (en) | 2007-08-28 |
EA007415B1 (en) | 2006-10-27 |
EE200400003A (en) | 2004-02-16 |
SK15882003A3 (en) | 2004-07-07 |
WO2003000695A1 (en) | 2003-01-03 |
OA12632A (en) | 2006-06-14 |
CZ20033443A3 (en) | 2004-03-17 |
HUP0400300A3 (en) | 2010-12-28 |
GB0115393D0 (en) | 2001-08-15 |
EE05432B1 (en) | 2011-06-15 |
BR0210652A (en) | 2004-08-10 |
AU2002314325B8 (en) | 2009-01-29 |
UA76760C2 (en) | 2006-09-15 |
CA2451932C (en) | 2009-12-29 |
AU2002314325B2 (en) | 2009-01-08 |
NZ529766A (en) | 2008-11-28 |
PL374096A1 (en) | 2005-09-19 |
TR200302242T2 (en) | 2004-12-21 |
EA200400073A1 (en) | 2004-08-26 |
RS99203A (en) | 2006-12-15 |
MEP19308A (en) | 2010-06-10 |
TNSN03144A1 (en) | 2005-12-23 |
WO2003000695A8 (en) | 2004-03-11 |
CA2451932A1 (en) | 2003-01-03 |
CN1518552A (en) | 2004-08-04 |
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