ECSP034922A - PIRROLOPIRIMIDINES - Google Patents
PIRROLOPIRIMIDINESInfo
- Publication number
- ECSP034922A ECSP034922A EC2003004922A ECSP034922A ECSP034922A EC SP034922 A ECSP034922 A EC SP034922A EC 2003004922 A EC2003004922 A EC 2003004922A EC SP034922 A ECSP034922 A EC SP034922A EC SP034922 A ECSP034922 A EC SP034922A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- bioisoesters
- prodrugs
- solvates
- oxides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
A N-óxidos, profármacos, bioisoésteres ácidos, sales farmacéuticamente aceptables o solvatos de tales compuestos, ó N-óxidos, profármacos, ó bioisoésteres ácidos de tales sales ó solvatos; a composiciones que comprenden tales compuestos; y a métodos de tratamiento que comprenden administrar, a un paciente que lo necesite, tales compuestos y composicionesA N-oxides, prodrugs, acid bioisoesters, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs, or acid bioisoesters of such salts or solvates; to compositions comprising such compounds; and to treatment methods comprising administering such compounds and compositions to a patient in need.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115393.1A GB0115393D0 (en) | 2001-06-23 | 2001-06-23 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP034922A true ECSP034922A (en) | 2004-04-28 |
Family
ID=9917225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2003004922A ECSP034922A (en) | 2001-06-23 | 2003-12-23 | PIRROLOPIRIMIDINES |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1404676A1 (en) |
JP (1) | JP4344607B2 (en) |
CN (1) | CN1294135C (en) |
AU (1) | AU2002314325B8 (en) |
BR (1) | BR0210652A (en) |
CA (1) | CA2451932C (en) |
CZ (1) | CZ20033443A3 (en) |
EA (1) | EA007415B1 (en) |
EC (1) | ECSP034922A (en) |
EE (1) | EE05432B1 (en) |
GB (1) | GB0115393D0 (en) |
HU (1) | HUP0400300A3 (en) |
ME (1) | MEP19308A (en) |
NZ (1) | NZ529766A (en) |
OA (1) | OA12632A (en) |
PL (1) | PL374096A1 (en) |
RS (1) | RS51698B (en) |
SK (1) | SK15882003A3 (en) |
TN (1) | TNSN03144A1 (en) |
TR (1) | TR200302242T2 (en) |
UA (1) | UA76760C2 (en) |
WO (1) | WO2003000695A1 (en) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
IL166241A0 (en) | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
JP2007511596A (en) * | 2003-11-17 | 2007-05-10 | ファイザー・プロダクツ・インク | Pyrrolopyrimidine compounds useful in the treatment of cancer |
WO2005051393A1 (en) * | 2003-11-25 | 2005-06-09 | Pfizer Products Inc. | Method of treatment of atherosclerosis |
EP1763524A1 (en) * | 2004-04-23 | 2007-03-21 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
FR2876103B1 (en) * | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | NOVEL BIS-AZAINDOL DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS INHIBITORS OF KINASES |
DE602005023333D1 (en) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | KINASE INHIBITORS |
FR2878849B1 (en) | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
WO2006135915A2 (en) | 2005-06-13 | 2006-12-21 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
CN103214484B (en) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine |
SG175609A1 (en) | 2006-10-09 | 2011-11-28 | Takeda Pharmaceutical | Kinase inhibitors |
EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
CA2711777A1 (en) | 2008-01-11 | 2009-08-13 | Natco Pharma Limited | Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer drugs |
UA106045C2 (en) | 2008-06-10 | 2014-07-25 | Еббві Інк. | Tricyclic compounds |
HUE046493T2 (en) | 2009-05-22 | 2020-03-30 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
WO2011018894A1 (en) * | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
EP2485589A4 (en) | 2009-09-04 | 2013-02-06 | Biogen Idec Inc | Heteroaryl btk inhibitors |
CN102711476B (en) | 2009-12-01 | 2014-12-03 | Abbvie公司 | Novel tricyclic compounds |
MY175156A (en) | 2010-03-10 | 2020-06-11 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
TWI499421B (en) | 2010-05-21 | 2015-09-11 | Incyte Corp | Topical formulation for a jak inhibitor |
JP5917544B2 (en) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Heterocyclic substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
CN103415515B (en) | 2010-11-19 | 2015-08-26 | 因塞特公司 | The pyrrolopyridine replaced as the cyclobutyl of JAK inhibitor and Pyrrolopyrimidine derivatives |
CN103476776B (en) * | 2011-01-07 | 2016-09-28 | 北京赛林泰医药技术有限公司 | 2,4-diaminourea-6,7-dihydro-5H-pyrrolo-[2,3] pyrimidine derivatives as FAK/Pyk2 inhibitor |
CN102093364B (en) * | 2011-01-07 | 2015-01-28 | 北京赛林泰医药技术有限公司 | 2,4-diamido-6,7-dihydro-5H-pyrrolo [2,3] pyrimidine derivative as focal adhesion kinase/pyruvate kinase 2 (FAK/Pyk2) inhibitor |
AU2012273164B2 (en) | 2011-06-20 | 2015-05-28 | Incyte Holdings Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
TW201313721A (en) | 2011-08-18 | 2013-04-01 | Incyte Corp | Cyclohexyl azetidine derivatives as JAK inhibitors |
UA111854C2 (en) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS |
CA2869954C (en) | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
US9127003B2 (en) | 2012-07-26 | 2015-09-08 | Glaxo Group Limited | 2-(azaindol-2-yl)benzimidazoles as PAD4 inhibitors |
ES2889757T3 (en) * | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compounds and methods for the modulation of kinases and indications for these |
WO2014078486A1 (en) | 2012-11-15 | 2014-05-22 | Incyte Corporation | Sustained-release dosage forms of ruxolitinib |
ES2707355T3 (en) | 2013-03-06 | 2019-04-03 | Incyte Holdings Corp | Processes and intermediate products to elaborate a JAK inhibitor |
CA2901334A1 (en) | 2013-03-13 | 2014-10-02 | Abbvie Inc. | Pyridine cdk9 kinase inhibitors |
CA2901929A1 (en) | 2013-03-13 | 2014-10-02 | Abbvie Inc. | Cdk9 kinase inhibitors |
AU2014234077A1 (en) | 2013-03-14 | 2015-10-01 | Abbvie Inc. | Pyrrolo[2,3-b]pyridine CDK9 kinase inhibitors |
TW201444836A (en) | 2013-03-14 | 2014-12-01 | Abbvie Inc | Pyrrolo[2,3-B]pyridine CDK9 kinase inhibitors |
EP2970299A1 (en) * | 2013-03-14 | 2016-01-20 | Abbvie Inc. | Pyrrolopyrimindine cdk9 kinase inhibitors |
CA3155500A1 (en) | 2013-08-07 | 2015-02-12 | Incyte Corporation | Sustained release dosage forms for a jak1 inhibitor |
CN104804001B9 (en) * | 2014-01-24 | 2022-02-08 | 江苏柯菲平医药股份有限公司 | 4-substituted pyrrolo [2,3-d ] pyrimidine compounds and uses thereof |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
CN116270645A (en) | 2015-10-16 | 2023-06-23 | 艾伯维公司 | Process for preparing imidazo [1,2-a ] pyrrolo [2,3-e ] pyrazines and solid forms thereof |
US11564922B2 (en) | 2017-03-09 | 2023-01-31 | Abbvie Inc. | Methods of treating crohn's disease and ulcerative colitis |
JP2020510016A (en) | 2017-03-09 | 2020-04-02 | アッヴィ・インコーポレイテッド | Methods for treating Crohn's disease and ulcerative colitis |
AR113922A1 (en) | 2017-12-08 | 2020-07-01 | Incyte Corp | LOW DOSE COMBINATION THERAPY FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS |
MA51771B1 (en) | 2018-01-30 | 2022-03-31 | Incyte Corp | Processes for the preparation of (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidin-4-one) |
PE20210402A1 (en) | 2018-03-30 | 2021-03-02 | Incyte Corp | TREATMENT OF SUPURATIVE HYDRADENITIS USING JAK INHIBITORS |
JP2022508648A (en) | 2018-10-05 | 2022-01-19 | アンナプルナ バイオ インコーポレイテッド | Compounds and compositions for treating conditions associated with APJ receptor activity |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69712745T2 (en) * | 1996-01-23 | 2002-10-31 | Novartis Ag | PYRROLOPYRIMIDINES AND METHOD FOR THE PRODUCTION THEREOF |
US6413971B1 (en) * | 1996-11-27 | 2002-07-02 | Pfizer Inc | Fused bicyclic pyrimidine derivatives |
PA8474101A1 (en) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS |
PT1087970E (en) * | 1998-06-19 | 2004-06-30 | Pfizer Prod Inc | PYRIMIDINE COMPOUNDS 2,3-D | PYRIMIDINE |
NZ510587A (en) * | 1998-09-18 | 2003-11-28 | Abbott Gmbh & Co | 4-aminopyrrolopyrimidines as kinase inhibitors |
CZ303875B6 (en) * | 1999-12-10 | 2013-06-05 | Pfizer Products Inc. | Pyrrolo [2,3-d]pyrimidine compound and pharmaceutical composition in which the compound is comprised |
-
2001
- 2001-06-23 GB GBGB0115393.1A patent/GB0115393D0/en not_active Ceased
-
2002
- 2002-06-21 SK SK1588-2003A patent/SK15882003A3/en not_active Application Discontinuation
- 2002-06-21 EP EP02740895A patent/EP1404676A1/en not_active Withdrawn
- 2002-06-21 UA UA2004010502A patent/UA76760C2/en unknown
- 2002-06-21 EE EEP200400003A patent/EE05432B1/en not_active IP Right Cessation
- 2002-06-21 HU HU0400300A patent/HUP0400300A3/en unknown
- 2002-06-21 CZ CZ20033443A patent/CZ20033443A3/en unknown
- 2002-06-21 RS YU99203A patent/RS51698B/en unknown
- 2002-06-21 TR TR2003/02242T patent/TR200302242T2/en unknown
- 2002-06-21 OA OA1200300335A patent/OA12632A/en unknown
- 2002-06-21 PL PL02374096A patent/PL374096A1/en not_active Application Discontinuation
- 2002-06-21 CN CNB028119320A patent/CN1294135C/en not_active Expired - Fee Related
- 2002-06-21 ME MEP-193/08A patent/MEP19308A/en unknown
- 2002-06-21 AU AU2002314325A patent/AU2002314325B8/en not_active Ceased
- 2002-06-21 EA EA200400073A patent/EA007415B1/en not_active IP Right Cessation
- 2002-06-21 NZ NZ529766A patent/NZ529766A/en not_active IP Right Cessation
- 2002-06-21 TN TNPCT/GB2002/002835A patent/TNSN03144A1/en unknown
- 2002-06-21 WO PCT/GB2002/002835 patent/WO2003000695A1/en active Application Filing
- 2002-06-21 JP JP2003507098A patent/JP4344607B2/en not_active Expired - Fee Related
- 2002-06-21 CA CA002451932A patent/CA2451932C/en not_active Expired - Fee Related
- 2002-06-21 BR BR0210652-3A patent/BR0210652A/en not_active Application Discontinuation
-
2003
- 2003-12-23 EC EC2003004922A patent/ECSP034922A/en unknown
Also Published As
Publication number | Publication date |
---|---|
UA76760C2 (en) | 2006-09-15 |
CN1294135C (en) | 2007-01-10 |
CN1518552A (en) | 2004-08-04 |
EE200400003A (en) | 2004-02-16 |
RS51698B (en) | 2011-10-31 |
JP4344607B2 (en) | 2009-10-14 |
PL374096A1 (en) | 2005-09-19 |
EA200400073A1 (en) | 2004-08-26 |
NZ529766A (en) | 2008-11-28 |
RS99203A (en) | 2006-12-15 |
TR200302242T2 (en) | 2004-12-21 |
BR0210652A (en) | 2004-08-10 |
HUP0400300A2 (en) | 2007-08-28 |
EP1404676A1 (en) | 2004-04-07 |
GB0115393D0 (en) | 2001-08-15 |
EE05432B1 (en) | 2011-06-15 |
AU2002314325B2 (en) | 2009-01-08 |
TNSN03144A1 (en) | 2005-12-23 |
MEP19308A (en) | 2010-06-10 |
WO2003000695A1 (en) | 2003-01-03 |
HUP0400300A3 (en) | 2010-12-28 |
JP2005508300A (en) | 2005-03-31 |
SK15882003A3 (en) | 2004-07-07 |
CA2451932C (en) | 2009-12-29 |
OA12632A (en) | 2006-06-14 |
EA007415B1 (en) | 2006-10-27 |
AU2002314325B8 (en) | 2009-01-29 |
CA2451932A1 (en) | 2003-01-03 |
WO2003000695A8 (en) | 2004-03-11 |
CZ20033443A3 (en) | 2004-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP034922A (en) | PIRROLOPIRIMIDINES | |
DK1346041T3 (en) | Therapeutic agents and methods for their use in the treatment of an amyloidogenic disease | |
BG108269A (en) | Pyrazolopyrimidines as therapeutic agents | |
CR7193A (en) | PIRROLOPIRIMIDINAS AS INHIBITORS OF THE KINASA PROTENINE | |
BG108268A (en) | Pyrazolopyrimidines as therapeutic agents | |
SE0001899D0 (en) | New compounds | |
HK1062677A1 (en) | 17Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | |
TNSN06032A1 (en) | Pyridazine derivatives and their use as therapeutic agents | |
MXPA04004842A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1. | |
MXPA04004837A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1. | |
IL161154A0 (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
TNSN06034A1 (en) | Pyridazine derivatives and their use as therapeutic agents | |
HUP0202570A1 (en) | Compositions and therapeutic methods involving isoflavones and analogues thereof | |
EE05419B1 (en) | Substituted oxazolidinones for combination therapy | |
NO20050807L (en) | Pharmaceutical compositions including dextromethorphan and quinidine for the treatment of neurological disorders | |
TNSN05265A1 (en) | Composition comprising a pde4 inhibitor and a pde5 inhibitor | |
HK1086186A1 (en) | Use of spongosine (2-methoxyadenosein) for preparing pharmaceutical for the treatment of pain | |
GB0002336D0 (en) | Medicaments | |
GB0130677D0 (en) | Medicaments and novel compounds | |
RS44204A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
MXPA02010316A (en) | Compositions and therapies for hyperlipidaemia associated disorders. | |
MXPA04011835A (en) | Treatment for depression and anxiety by the combination of a pde iv inhibitor and an antidepressant or an anxiolytic agent. | |
NZ528164A (en) | Use of flumazenil to produce a medicament for the treatment of cocaine dependency | |
RS44304A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
MXPA06007007A (en) | Proline derivatives used as pharmaceutical active ingredients for the treatment of tumours. |