EA200400073A1 - Pyrrolipyrimins as inhibitors of protein kinases - Google Patents
Pyrrolipyrimins as inhibitors of protein kinasesInfo
- Publication number
- EA200400073A1 EA200400073A1 EA200400073A EA200400073A EA200400073A1 EA 200400073 A1 EA200400073 A1 EA 200400073A1 EA 200400073 A EA200400073 A EA 200400073A EA 200400073 A EA200400073 A EA 200400073A EA 200400073 A1 EA200400073 A1 EA 200400073A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- pyrrolipyrimins
- inhibitors
- protein kinases
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Данное изобретение предусматривает соединения формулы (I), N-оксиды, пролекарства, кислотные биоизостеры, фармацевтически приемлемые соли или сольваты таких соединений, либо N-оксиды, пролекарства или кислотные биоизостеры таких солей или сольватов; композиции, содержащие такие соединения, и способы лечения, включающие введение нуждающемуся в этом пациенту таких соединений и композиций.Международная заявка была опубликована вместе с отчетом о международном поиске.This invention provides compounds of formula (I), N-oxides, prodrugs, acid bioisosteres, pharmaceutically acceptable salts or solvates of such compounds, or N-oxides, prodrugs or acid bioisosteres of such salts or solvates; compositions containing such compounds and methods of treatment, including the administration to the patient in need of such compounds and compositions. The international application was published together with an international search report.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115393.1A GB0115393D0 (en) | 2001-06-23 | 2001-06-23 | Chemical compounds |
US30167801P | 2001-06-28 | 2001-06-28 | |
PCT/GB2002/002835 WO2003000695A1 (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400073A1 true EA200400073A1 (en) | 2004-08-26 |
EA007415B1 EA007415B1 (en) | 2006-10-27 |
Family
ID=9917225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400073A EA007415B1 (en) | 2001-06-23 | 2002-06-21 | Pyrrolopyrimidines as protein kinase inhibitors |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1404676A1 (en) |
JP (1) | JP4344607B2 (en) |
CN (1) | CN1294135C (en) |
AU (1) | AU2002314325B8 (en) |
BR (1) | BR0210652A (en) |
CA (1) | CA2451932C (en) |
CZ (1) | CZ20033443A3 (en) |
EA (1) | EA007415B1 (en) |
EC (1) | ECSP034922A (en) |
EE (1) | EE05432B1 (en) |
GB (1) | GB0115393D0 (en) |
HU (1) | HUP0400300A3 (en) |
ME (1) | MEP19308A (en) |
NZ (1) | NZ529766A (en) |
OA (1) | OA12632A (en) |
PL (1) | PL374096A1 (en) |
RS (1) | RS51698B (en) |
SK (1) | SK15882003A3 (en) |
TN (1) | TNSN03144A1 (en) |
TR (1) | TR200302242T2 (en) |
UA (1) | UA76760C2 (en) |
WO (1) | WO2003000695A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11564922B2 (en) | 2017-03-09 | 2023-01-31 | Abbvie Inc. | Methods of treating crohn's disease and ulcerative colitis |
US11607411B2 (en) | 2017-03-09 | 2023-03-21 | Abbvie Inc. | Methods of treating Crohn's disease and ulcerative colitis |
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US7517886B2 (en) | 2002-07-29 | 2009-04-14 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
EP1687309A1 (en) | 2003-11-17 | 2006-08-09 | Pfizer Products Inc. | Pyrrolopyrimidine compounds useful in treatment of cancer |
BRPI0416909A (en) * | 2003-11-25 | 2007-01-16 | Pfizer Prod Inc | atherosclerosis treatment method |
US20050250829A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Kinase inhibitors |
FR2876103B1 (en) * | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | NOVEL BIS-AZAINDOL DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS INHIBITORS OF KINASES |
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PE20140407A1 (en) | 2008-06-10 | 2014-04-25 | Abbott Lab | NEW TRICYCLIC COMPOUNDS |
MX2011012262A (en) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors. |
EA025520B1 (en) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
WO2011018894A1 (en) * | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
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US9029359B2 (en) | 2009-09-04 | 2015-05-12 | Biogen Idec Ma, Inc. | Heteroaryl Btk inhibitors |
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US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
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US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
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Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1441497A (en) * | 1996-01-23 | 1997-08-20 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
BR9713552A (en) * | 1996-11-27 | 2000-01-25 | Pfizer | Condensed bicyclic pyrimidine derivatives |
ID26698A (en) * | 1998-06-19 | 2001-02-01 | Pfizer Prod Inc | PIROLO COMPOUNDS [2,3-d] PYRIMIDINE |
PA8474101A1 (en) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS |
CZ2001959A3 (en) * | 1998-09-18 | 2001-12-12 | Basf Aktiengesellschaft | 4-Aminopyrrolopyrimidines functioning as kinase inhibitors |
DK1235830T3 (en) * | 1999-12-10 | 2004-03-29 | Pfizer Prod Inc | Pyrrolo [2,3-d] pyrimidine compounds as protein kinase inhibitors |
-
2001
- 2001-06-23 GB GBGB0115393.1A patent/GB0115393D0/en not_active Ceased
-
2002
- 2002-06-21 JP JP2003507098A patent/JP4344607B2/en not_active Expired - Fee Related
- 2002-06-21 NZ NZ529766A patent/NZ529766A/en not_active IP Right Cessation
- 2002-06-21 TR TR2003/02242T patent/TR200302242T2/en unknown
- 2002-06-21 PL PL02374096A patent/PL374096A1/en not_active Application Discontinuation
- 2002-06-21 EA EA200400073A patent/EA007415B1/en not_active IP Right Cessation
- 2002-06-21 UA UA2004010502A patent/UA76760C2/en unknown
- 2002-06-21 BR BR0210652-3A patent/BR0210652A/en not_active Application Discontinuation
- 2002-06-21 TN TNPCT/GB2002/002835A patent/TNSN03144A1/en unknown
- 2002-06-21 EP EP02740895A patent/EP1404676A1/en not_active Withdrawn
- 2002-06-21 OA OA1200300335A patent/OA12632A/en unknown
- 2002-06-21 RS YU99203A patent/RS51698B/en unknown
- 2002-06-21 SK SK1588-2003A patent/SK15882003A3/en not_active Application Discontinuation
- 2002-06-21 WO PCT/GB2002/002835 patent/WO2003000695A1/en active Application Filing
- 2002-06-21 CA CA002451932A patent/CA2451932C/en not_active Expired - Fee Related
- 2002-06-21 AU AU2002314325A patent/AU2002314325B8/en not_active Ceased
- 2002-06-21 HU HU0400300A patent/HUP0400300A3/en unknown
- 2002-06-21 ME MEP-193/08A patent/MEP19308A/en unknown
- 2002-06-21 CN CNB028119320A patent/CN1294135C/en not_active Expired - Fee Related
- 2002-06-21 EE EEP200400003A patent/EE05432B1/en not_active IP Right Cessation
- 2002-06-21 CZ CZ20033443A patent/CZ20033443A3/en unknown
-
2003
- 2003-12-23 EC EC2003004922A patent/ECSP034922A/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11564922B2 (en) | 2017-03-09 | 2023-01-31 | Abbvie Inc. | Methods of treating crohn's disease and ulcerative colitis |
US11607411B2 (en) | 2017-03-09 | 2023-03-21 | Abbvie Inc. | Methods of treating Crohn's disease and ulcerative colitis |
Also Published As
Publication number | Publication date |
---|---|
CN1518552A (en) | 2004-08-04 |
ECSP034922A (en) | 2004-04-28 |
JP2005508300A (en) | 2005-03-31 |
WO2003000695A1 (en) | 2003-01-03 |
RS99203A (en) | 2006-12-15 |
TR200302242T2 (en) | 2004-12-21 |
EA007415B1 (en) | 2006-10-27 |
NZ529766A (en) | 2008-11-28 |
MEP19308A (en) | 2010-06-10 |
JP4344607B2 (en) | 2009-10-14 |
CN1294135C (en) | 2007-01-10 |
SK15882003A3 (en) | 2004-07-07 |
HUP0400300A3 (en) | 2010-12-28 |
HUP0400300A2 (en) | 2007-08-28 |
AU2002314325B8 (en) | 2009-01-29 |
AU2002314325B2 (en) | 2009-01-08 |
RS51698B (en) | 2011-10-31 |
EE200400003A (en) | 2004-02-16 |
EP1404676A1 (en) | 2004-04-07 |
CA2451932A1 (en) | 2003-01-03 |
CA2451932C (en) | 2009-12-29 |
BR0210652A (en) | 2004-08-10 |
PL374096A1 (en) | 2005-09-19 |
GB0115393D0 (en) | 2001-08-15 |
UA76760C2 (en) | 2006-09-15 |
TNSN03144A1 (en) | 2005-12-23 |
EE05432B1 (en) | 2011-06-15 |
CZ20033443A3 (en) | 2004-03-17 |
WO2003000695A8 (en) | 2004-03-11 |
OA12632A (en) | 2006-06-14 |
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