EP1394256A3 - HCV genomic sequences for diagnostics and therapeutics - Google Patents

HCV genomic sequences for diagnostics and therapeutics Download PDF

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Publication number
EP1394256A3
EP1394256A3 EP03013389A EP03013389A EP1394256A3 EP 1394256 A3 EP1394256 A3 EP 1394256A3 EP 03013389 A EP03013389 A EP 03013389A EP 03013389 A EP03013389 A EP 03013389A EP 1394256 A3 EP1394256 A3 EP 1394256A3
Authority
EP
European Patent Office
Prior art keywords
therapeutics
diagnostics
genomic sequences
hcv genomic
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03013389A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1394256A2 (en
Inventor
Tai-An Cha
Eileen Beall
Bruce Irvine
Janice Kolberg
Michael S. Urdena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24800701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1394256(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of EP1394256A2 publication Critical patent/EP1394256A2/en
Publication of EP1394256A3 publication Critical patent/EP1394256A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
EP03013389A 1991-05-08 1992-05-08 HCV genomic sequences for diagnostics and therapeutics Withdrawn EP1394256A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69732691A 1991-05-08 1991-05-08
US697326 1991-05-08
EP92913881A EP0585398B1 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP92913881A Division EP0585398B1 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Publications (2)

Publication Number Publication Date
EP1394256A2 EP1394256A2 (en) 2004-03-03
EP1394256A3 true EP1394256A3 (en) 2008-03-12

Family

ID=24800701

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03013389A Withdrawn EP1394256A3 (en) 1991-05-08 1992-05-08 HCV genomic sequences for diagnostics and therapeutics
EP92913881A Revoked EP0585398B1 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP92913881A Revoked EP0585398B1 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Country Status (20)

Country Link
EP (2) EP1394256A3 (enExample)
JP (7) JPH06508026A (enExample)
KR (1) KR100193801B1 (enExample)
AT (1) ATE252154T1 (enExample)
BG (3) BG64627B1 (enExample)
CA (1) CA2108466C (enExample)
CZ (2) CZ288722B6 (enExample)
DE (1) DE69233234T2 (enExample)
DK (1) DK0585398T3 (enExample)
ES (1) ES2207633T3 (enExample)
FI (1) FI115725B (enExample)
HU (1) HU227548B1 (enExample)
IE (1) IE921482A1 (enExample)
NO (1) NO309532B1 (enExample)
PL (2) PL169880B1 (enExample)
PT (1) PT100472B (enExample)
RO (1) RO117267B1 (enExample)
RU (1) RU2155228C2 (enExample)
SK (1) SK284205B6 (enExample)
WO (1) WO1992019743A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0532167A3 (en) * 1991-08-09 1993-03-31 Immuno Japan Inc. Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
ATE231557T1 (de) * 1991-11-21 2003-02-15 Common Services Agency Detektion des hepatis-c virus.
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
EP0642592A4 (en) * 1992-05-29 1997-01-02 Abbott Lab LIGASE CHAIN REACTION STARTING WITH RNA SEQUENCES.
US6423489B1 (en) * 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
ATE202383T1 (de) * 1992-09-10 2001-07-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren für die behandlung von mit hepatitis c viren assoziierten krankheiten
JPH06153961A (ja) * 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
DE69334357D1 (de) 1992-11-27 2011-06-09 Innogenetics Nv Nachweis und Typisierung das Hepatitis C Virus (HCV) mittels 5'UTR und NS5 Nukleinsäuresequenzen
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US6762024B2 (en) 1993-04-27 2004-07-13 Innogenetics, S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
JPH0775585A (ja) * 1993-06-14 1995-03-20 Immuno Japan:Kk Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
US7070790B1 (en) 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
WO1995011918A1 (en) * 1993-10-29 1995-05-04 Srl, Inc. Antigen peptide compound and immunoassay method
JPH10503364A (ja) * 1994-05-10 1998-03-31 ザ ジェネラル ホスピタル コーポレーション Ｃ型肝炎ウイルスのアンチセンス阻害
DE69526973T3 (de) 1994-10-21 2010-01-07 Innogenetics N.V. Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel
US5851759A (en) * 1996-04-19 1998-12-22 Chiron Corporation Heteroduplex tracking assay (HTA) for genotyping HCV
IT1284847B1 (it) * 1996-06-07 1998-05-22 Sorin Biomedica Diagnostics Sp Procedimento per la rivelazione di acidi nucleici specifici di hcv
CA2308762A1 (en) * 1997-11-04 1999-05-14 Roche Diagnostics Gmbh Specific and sensitive nucleic acid detection method
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
CN100400101C (zh) 2000-08-17 2008-07-09 特里帕普股份公司 包含病毒唑的疫苗及其使用方法
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
JP5138230B2 (ja) 2004-01-07 2013-02-06 サード・ウェーブ・テクノロジーズ・インク Ｃ型肝炎ウイルスの遺伝子型の決定方法
KR100733186B1 (ko) * 2005-05-31 2007-06-27 재단법인 목암생명공학연구소 Ｈｃｖ 유전자에 특이적인 작은 간섭 ｒｎａ 및 그를유효성분으로 포함하는 ｃ형 간염 치료제
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510952A1 (en) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus

Family Cites Families (8)

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WO1989004669A1 (en) * 1987-11-18 1989-06-01 Chiron Corporation Nanbv diagnostics and vaccines
SU1645302A1 (ru) * 1989-01-05 1991-04-30 Московский Научно-Исследовательский Институт Педиатрии И Детской Хирургии Минздрава Рсфср Способ дифференциальной индикации вирусспецифических нуклеотидных последовательностей вируса герпеса простого типа 1 и 2.
HUT54896A (en) * 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
DE4040339C2 (de) * 1989-12-18 1999-07-08 Wellcome Found Virales Agens
WO1991014779A1 (fr) * 1990-03-28 1991-10-03 Mitsui Toatsu Chemicals, Incorporated Diagnostic du virus de l'hepatite
AU660925B2 (en) * 1990-04-06 1995-07-13 Genelabs Technologies, Inc. Hepatitis C virus epitopes
EP0933426A1 (en) * 1990-06-25 1999-08-04 The Research Foundation for Microbial Diseases of Osaka University Non-a, non-b hepatitis virus genomic cdna fragments and antigen polypeptides
FI913068A7 (fi) * 1990-06-25 1991-12-26 The Res Foundation For Microbial Ei-A-, ei-B-hepatiittiviruspartikkelit

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0510952A1 (en) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus

Non-Patent Citations (8)

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Title
CHOO Q-L ET AL: "GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 88, 1 March 1991 (1991-03-01), pages 2451 - 2455, XP000652139, ISSN: 0027-8424 *
ENOMOTO N ET AL: "THERE ARE TWO MAJOR TYPES OF HEPATITIS C VIRUS IN JAPAN", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 170, no. 3, 16 August 1990 (1990-08-16), pages 1021 - 1025, XP002047551, ISSN: 0006-291X *
HIROAKI OKAMOTO ET AL: "NUCLEOTIDE SEQUENCE OF THE GENOMIC RNA OF HEPATITIS C VIRUS ISOLATED FROM A HUMAN CARRIER: COMPARISON WITH REPORTED ISOLATES FOR CONSERVED AND DIVERGENT REGIONS", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 72, 1 November 1991 (1991-11-01), pages 2697 - 2704, XP000374155, ISSN: 0022-1317 *
KREMSDORF D ET AL: "PARTIAL NUCLEOTIDE SEQUENCE ANALYSIS OF A FRENCH HEPATITIS C VIRUS:IMPLICATIONS FOR HCV GENETIC VARIABILITY IN THE E2/NS1 PROTEIN", JOURNAL OF GENERAL VIROLOGY, READING, BERKS, GB, vol. 72, no. PART 10, January 1991 (1991-01-01), pages 2557 - 2561, XP000619231, ISSN: 0022-1317 *
NOBUYUKI KATO ET AL: "MOLECULAR CLONING OF THE HUMAN HEPATITIS C VIRUS GENOME FROM JAPANESE PATIENTS WITH NON-A, NON-B HEPATITIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 87, no. 24, 1 December 1990 (1990-12-01), pages 9524 - 9528, XP000168621, ISSN: 0027-8424 *
OGATA N ET AL: "NUCLEOTIDE SEQUENCE AND MUTATION RATE OF THE H STRAIN OF HEPATITIS C VIRUS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 88, no. 8, 15 April 1991 (1991-04-15), pages 3392 - 3396, XP001189373, ISSN: 0027-8424 *
OKAMOTO H ET AL: "FULL-LENGTH SEQUENCE OF A HEPATITIS C VIRUS GENOME HAVING POOR HOMOLOGY TO REPORTED ISOLATES: COMPARATIVE STUDY OF FOUR DISTINCT GENOTYPES", VIROLOGY, RAVEN PRESS, NEW YORK, NY, US, vol. 188, January 1992 (1992-01-01), pages 331 - 341, XP000351447, ISSN: 0042-6822 *
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Also Published As

Publication number Publication date
NO309532B1 (no) 2001-02-12
DE69233234D1 (de) 2003-12-04
PT100472B (pt) 1999-08-31
BG64627B1 (bg) 2005-09-30
JP2003024090A (ja) 2003-01-28
NO934019D0 (no) 1993-11-05
PL170151B1 (pl) 1996-10-31
JP2008178416A (ja) 2008-08-07
JP2003009893A (ja) 2003-01-14
JP2004290204A (ja) 2004-10-21
ATE252154T1 (de) 2003-11-15
SK284205B6 (sk) 2004-10-05
HU9303166D0 (en) 1994-03-28
KR100193801B1 (ko) 1999-06-15
EP0585398A1 (en) 1994-03-09
JP2003009892A (ja) 2003-01-14
JPH06508026A (ja) 1994-09-14
WO1992019743A3 (en) 1993-11-25
BG98200A (bg) 1995-01-31
HUT69609A (en) 1995-09-28
SK123293A3 (en) 1994-06-08
PL169880B1 (pl) 1996-09-30
CZ237793A3 (en) 1994-04-13
BG62142B1 (bg) 1999-03-31
DE69233234T2 (de) 2004-08-05
WO1992019743A2 (en) 1992-11-12
JP2003009891A (ja) 2003-01-14
HU227548B1 (en) 2011-08-29
FI934937A0 (fi) 1993-11-08
BG101876A (en) 1998-11-30
EP0585398B1 (en) 2003-10-15
RU2155228C2 (ru) 2000-08-27
CA2108466A1 (en) 1992-11-09
CZ288722B6 (cs) 2001-08-15
PT100472A (pt) 1993-08-31
ES2207633T3 (es) 2004-06-01
IE921482A1 (en) 1992-11-18
CZ288720B6 (cs) 2001-08-15
FI934937L (fi) 1994-01-05
FI115725B (fi) 2005-06-30
RO117267B1 (ro) 2001-12-28
AU2155892A (en) 1992-12-21
CA2108466C (en) 2007-07-10
EP1394256A2 (en) 2004-03-03
CZ121096A3 (en) 1996-08-14
DK0585398T3 (da) 2004-02-02
NO934019L (no) 1993-11-05
AU668355B2 (en) 1996-05-02

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