EP1115361B1 - Verbindungsvorrichtung zwischen behälter und inhalt und gebrauchsfertige anordungen die eine solche vorrichtung enthalten - Google Patents

Verbindungsvorrichtung zwischen behälter und inhalt und gebrauchsfertige anordungen die eine solche vorrichtung enthalten Download PDF

Info

Publication number
EP1115361B1
EP1115361B1 EP99946225A EP99946225A EP1115361B1 EP 1115361 B1 EP1115361 B1 EP 1115361B1 EP 99946225 A EP99946225 A EP 99946225A EP 99946225 A EP99946225 A EP 99946225A EP 1115361 B1 EP1115361 B1 EP 1115361B1
Authority
EP
European Patent Office
Prior art keywords
plunger
lip
piston
bore
face
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99946225A
Other languages
English (en)
French (fr)
Other versions
EP1115361A1 (de
Inventor
Antoine Aneas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biodome SAS
Original Assignee
Biodome SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodome SAS filed Critical Biodome SAS
Publication of EP1115361A1 publication Critical patent/EP1115361A1/de
Application granted granted Critical
Publication of EP1115361B1 publication Critical patent/EP1115361B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Definitions

  • the invention relates to a device for connecting a closed container and container.
  • the invention also relates to a ready-to-use set including, among other things, a closed container and a connection device of the aforementioned type.
  • a component of a drug preparation such as for example its active ingredient
  • a plug made of relatively soft material for example in elastomer.
  • Liquid can be introduced into this container after perforation of the cap to dissolve or put in suspends the component contained in the container, in order to obtain a drug preparation in liquid form ready to be administered to the patient.
  • a perforation of the cap at an angle means that the visible section of the orifice, created in the plug by the passage of the hollow needle, is greater than the diameter outside of this needle, to the point that leaks may occur produce through the plug, around the hollow needle.
  • the container and the container to which it is associated are placed in a gravity flow position of the reconstituted drug from the container to the container, i.e. when the container is placed above the containing, it is possible that the drug preparation flows from the container to the piston and flows over the hands of user, which can be dangerous for some drugs or unpleasant for less aggressive drugs.
  • the device of the invention is characterized in that it includes a sealing lip, provided on an inner surface of the bore opposite the piston or on a surface of the piston, this lip being shaped to be sealed against the piston or against an internal surface of the bore in the piston transfer position.
  • a confinement volume is created around the hollow needle, between the plunger and the surface internal bore, this containment volume allowing retain leaking liquid, possibly outside the container through the opening formed in the cap by the hollow needle.
  • the base comprises a support wall against a external part of the stopper, the lip being shaped on a face of this wall facing the piston.
  • the lip is shaped on a front face of the piston oriented towards the plug.
  • the lip is shaped on an internal radial surface of the flange or on an external radial surface of the piston.
  • the lip has, in cross section, an asymmetrical profile inducing a preferred direction of deformation.
  • This aspect of the invention guarantees an adequate positioning of the lip when the piston is in transfer position, this adequate positioning guaranteeing the required seal.
  • the flange carries, on its internal radial face, a circular rod able to cooperate with a corresponding shoulder of the external radial surface of the piston to lock this piston in the transfer position.
  • the purpose of the piston lock is effect of precisely fixing the position of the piston, and thereby even, crushing or deformation of the sealing lip, which ensures tight contact between the lip and the surface with which it must cooperate.
  • the rod has an asymmetrical cross-section, the face of the rod oriented towards the outlet of the bore being less inclined by compared to the internal radial surface of the flange that the face of the rod facing the cap.
  • the rod does not interfere or slightly interferes with the sliding movement of the piston towards the plug, from its released position towards its transfer position, when it can oppose effectively to a movement of the piston in opposite direction.
  • the rush is advantageously capable of sealingly separating a volume annular, defined in the bore around the front part of the piston in transfer position, from the ambient atmosphere.
  • the rod then fulfills a sealing function which is added to that of the lip previously mentioned.
  • the invention also relates to a ready-to-use assembly, comprising a closed container containing a product, this container with a neck, the opening of which is closed by a plug of relatively soft material, and a device for connection as previously described, mounted on the container.
  • a ready-to-use assembly comprising a closed container containing a product, this container with a neck, the opening of which is closed by a plug of relatively soft material, and a device for connection as previously described, mounted on the container.
  • the device 1 has a double function. On the one hand it ensures the inviolability of a container 2, for example a glass bottle, containing a non- shown and previously closed or blocked. It allows other part of ensuring or establishing a tight connection between inside container 2 and inside another container 2 ', shown in phantom in Figure 3, this container may be a flexible bag containing a liquid intended for dissolve or suspend the product contained in the container 2, for example the active principle of a medicament.
  • the container 2 comprises a neck 3, the opening 3 a of which is closed, in a leaktight manner, by a plug 4, made of a relatively soft material, for example of elastomer and in particular rubber.
  • the neck 3 includes an external annular bead 3 b used for mounting and fixing a base 5.
  • the plug 4 comprises a cylindrical central part 4 a , adapted to a flexible and tight fitting inside the opening 3 a of the neck 3, and a flattened external part 4 b supported on the bead 3 b .
  • the base 5 is made in one piece from a relatively hard plastic material compared to the material constituting the plug 4. It comprises several attachment teeth 6 provided to be arranged around the bead 3 b of the neck 3, in the manner shown in Figure 2 and in accordance with the technical teaching of WO-A-97/10 156.
  • the base 5 comprises a wall 8 bearing on the part 4 b of the plug 4, this wall being provided with a central recess 8 a whose function will be explained in the following.
  • the wall 8 also carries two circular ribs 8 b and 8 c oriented towards the plug 4 and designed to penetrate the external part 4 b of the plug 4, so that they create a tight barrier between the wall 8 and the plug 4
  • the base 5 is extended by a flange 9, oriented opposite the teeth 6 relative to the wall 8 and whose internal radial surface 9 a defines a bore A of substantially circular section.
  • a piston 10 is provided to slide, inside of bore A, in a direction defined by the axis of symmetry X-X 'of this bore, axis which is also the axis of symmetry of the base 5 around which the teeth 6 are distributed.
  • the piston 10 includes a section 10 is generally perpendicular to the axis XX 'and a skirt 10 b shaped cylindrical sleeve centered on the axis XX'.
  • a hollow needle 11 carried by the section 10a of the piston 10 is centered on the axis X-X '.
  • the skirt 10b of the piston 10 carries a shoulder 10c while the collar 9 is provided with a peripheral internal projection 9b at the outlet of the bore A.
  • the piston 10 can be inserted inside bore A, by elastic deformation of the flange 9, in a position such that the shoulder 10 c is in contact with the projection 9 b , the piston 10 then being locked inside of the bore A. In this position, the needle 11 is released relative to the plug 4, that is to say does not perforate this plug.
  • a cap 12 is provided to be arranged around the assembly formed by the base 5 and the piston 10 and comprises a lower ring 13, capable of locking the teeth 6 of the base 5 around the neck 3, and a breakable part 14 intended to protect the piston 10 in the position of FIG. 2, this part breakable being connected to the ring 13 by a breaking line 15.
  • the face 8 d of the wall 8 oriented towards the piston 10 carries a lip 22 directed towards the front face 10 d of the section 10 a of the piston 10.
  • the lip 22 is in one piece with the wall 8, it even in one piece with the rest of the base 5 which is made of plastic material harder than the plug 4, but having a flexibility allowing the deformation of the lip 22.
  • the lip 22 is circular, that is to say extends over a circumference centered on the axis XX ′, so that, when it is in contact with the front face 10 d of the piston 10, it closes a volume V for confinement of a possible leak of liquid through the orifice 20, this volume being shown in gray in FIG. 4.
  • the lip 22 has an asymmetrical cross section in the shape of an inclined tooth.
  • the angle of inclination ⁇ of its external face 22 a relative to a normal N to the face 8 d is greater than the angle ⁇ of its internal face 22 b relative to a normal N 'to the face 8 d .
  • the edge 22 c of the lip 22 projects inwardly relative to the foot 22 d of the internal face 22 b .
  • the lip 22 exerts on the piston 10 a reaction force which increases when liquid is present in the volume V, this liquid exerting a pressure on the internal face 22 b of the lip 22, a pressure which tends to bring the lip 22 back into its configuration of FIG. 4A.
  • a ring 24 is provided on the internal radial surface 9 a of the flange 9, at a height such as relative to the wall 8 that it cooperates with the shoulder 10 c of the skirt 10 b to lock the piston 10 in the position transfer of figures 3 and 4.
  • the rod 24 extends advantageously over the entire circumference of the surface 9 and has, in cross section and as shown in Figure 4B, a face 24 a facing the opening of the bore A and a face 24 b directed towards the bottom of this bore, that is to say towards the plug 4 and the wall 8.
  • the angle of inclination ⁇ of the surface 24 a relative to the surface 9 a is of the order of 30 °, while the angle of inclination ⁇ of the surface 24 b relative to this same surface is around 60 °.
  • This asymmetrical shape of the ring 24 allows it not to oppose too strongly the driving movement of the piston 10 inside the bore A, because the face 24 a is slightly inclined relative to the axis X- X ', while it effectively locks the shoulder 10 c thanks to the significant inclination of its face 24 b .
  • the rod locking function 24 guarantees that adequate pressure is exerted by the piston 10 on the lip 22 in order to obtain a satisfactory seal.
  • the rod 24 As the rod 24 extends over the entire periphery of the surface 9 a, it also contributes to the sealing of the entire device 1 to the extent that the liquid, which successfully outside the volume V because of 'a leak at the level of the lip 22, would remain confined in the volume V' defined between the front face 10 d and the wall 8 outside the lip 22 and by the annular clearance J between the skirt 10 b and the surface 9 a , at the front of the piston 10.
  • the ring 24 therefore has a double locking and sealing function.
  • the device of this embodiment differs from the previous essentially in that the sealing lip 72 is carried by the front face 60 d of the piston 60 and intended to come into contact with the upper face 58 d of the partition 58 of the base 55.
  • the lip 72 therefore makes it possible to define a volume of containment V of a possible leak of liquid.
  • a ring 74 is also provided on the inner radial surface 59a of the flange 59 to lock the piston 60 in position relative to the base 55 and to form a second sealing barrier of a second closed volume V ' .
  • the piston 60 carries a shoulder 60 c capable of cooperating with the rod 74.
  • the front face 60 d of the piston 60 carries a groove 76 inside which the lip 72 is immobilized, which can be made of a material separate from that of the piston 72 and, in particular, in a more flexible material allowing increased deformation when the piston 60 is pressed against the wall 58 in order to improve the seal.
  • the lip 72 is immobilized in the groove 76 by all appropriate means and, in particular, by cooperation of forms and / or bonding.
  • a sealing lip 122 is provided on the radial surface internal 109 a of the flange 109 facing the external radial surface 110 e of the skirt 110 b of the piston 110 to delimit a confinement volume V.
  • a ring 124 is provided on the surface 109 a for immobilizing d a shoulder 110 c of the piston 110 relative to the base 105 in the transfer position. It also acts as a sealing barrier for a second closed volume V '.
  • the sealing lip could be carried by the outer surface 110 e of the skirt 110.
  • the skirts 22 and 122 could be constituted by elements attached to the base, according to a technique analogous to that evoked with reference to the embodiment of FIG. 5.
  • the lip carried by the piston in the mode of embodiment of Figure 5 could also be in one piece with this piston.
  • lips 72 and 122 have an asymmetrical profile, just like lip 22, which gives them direction of privileged deformation.
  • the rod 24, 74 or 124 is formed of discrete angular sectors, i.e. not joined, in which case it effectively performs its function of locking but does not participate in sealing the volume V '.
  • the immobilization piston 10, 60 or 110 thanks to rod 24, 74 or 124 guarantees constant positioning of needle 11 or equivalent, relative to container 2, so that the dead volume of container 2, i.e. the quantity of product contained in the container which cannot be recovered from made of the distance between the end of the needle 11 and the container neck, is constant from one device to another.
  • the quantity of product introduced into container 2 or equivalent before being closed by the corresponding cap can therefore be determined with precision, taking into account what constant dead volume.
  • the invention is applicable independently of the method of fixing the base 5 to the container 2 and, so general, that it can be used in any device connection comprising a piston, movable inside a bore of a base mounted on a container.

Claims (10)

  1. Verbindungsvorrichtung zwischen einem geschlossenen Gefäß (2) und einem Behälter (2'), wobei das Gefäß einen Hals (3) umfasst, dessen Öffnung (3a) durch einen Stöpsel (4) verschlossen ist, wobei die Verbindungsvorrichtung eine Fußfläche (5) umfasst, die an dem Gefäß (2) angebracht ist und sich durch einen Flansch (9) verlängert, der eine Innenbohrung (A) bildet, einen Kolben (10), der dazu ausgelegt ist, in der Innenbohrung zwischen einer bezüglich des Stöpsels freigesetzten Position und einer Überführungsposition zu gleiten, in der eine Hohlnadel (11), die von dem Kolben getragen ist, den Stöpsel (4) durchquert, dadurch gekennzeichnet, dass sie eine Dichtungslippe (22; 72; 122) umfasst, die an einer Innenfläche (8d; 109a) der Bohrung (A) dem Kolben (10; 110) gegenüberstehend oder auf einer Oberfläche (60d) des Kolbens (60) vorgesehen ist, wobei die Lippe so angepasst ist, dass sie in der Überführungsposition des Kolbens in dichter Anlage am Kolben (10; 110) oder an einer Innenfläche (58d) der Bohrung sein kann.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Fußfläche (5) eine Wand (8) zum Abstützen an einem Außenteil (4b) des Stöpsels (4) umfasst, wobei die Lippe (22) an einer Seite (8d) der Wand (8) angepasst ist, die zum Kolben (10) hin ausgerichtet ist.
  3. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Lippe (72) an einer Seite (60d), nämlich der Vorderseite des Kolbens (60) angepasst ist, die zum Stöpsel (4) hin ausgerichtet ist.
  4. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Lippe (122) an einer radialen Innenfläche (109a) des Flansches (109) oder an einer radialen Außenfläche (110e) des Kolbens (110) angepasst ist.
  5. Vorrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die Lippe (22; 72; 122) im Querschnitt ein asymmetrisches Profil (α, β) aufweist, das eine bevorzugte Verformungsrichtung bewirkt.
  6. Vorrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass der Flansch (9; 59; 109) an einer radialen Innenseite (9a; 59a; 109a) einen Sprengring (24; 74; 124) trägt, der dazu ausgelegt ist, mit einer entsprechenden Schulter (10c; 60c; 110c) der radialen Außenfläche des Kolbens (10; 60; 110) zusammenzuwirken, um den Kolben in der Überführungsposition festzusetzen.
  7. Vorrichtung nach Anspruch 6, dadurch gekennzeichnet, dass der Sprengring (24; 74; 124) derart angeordnet ist, dass er den Kolben (10; 60; 110) in einer Position der dichten Anlage der Lippe (22; 72; 122) am Kolben (10; 110) oder an einer Innenfläche (58d) der Bohrung (A) festsetzt.
  8. Vorrichtung nach einem der Ansprüche 6 oder 7, dadurch gekennzeichnet, dass der Sprengring (24; 74; 124) einen asymmetrischen Querschnitt aufweist, wobei die Seite (24a) des Sprengrings, die zum Ausgang (9b) der Bohrung (A) hin weist, bezüglich der radialen Innenfläche (9a) des Flansches (9) weniger geneigt (γ, δ) ist als die Seite (24b) des Sprengrings, die zum Stöpsel hin weist.
  9. Vorrichtung nach einem der Ansprüche 6 bis 8, dadurch gekennzeichnet, dass der Sprengring (24; 74; 124) dazu ausgelegt ist, einen ringförmigen Hohlraum (V'), der in der Überführungsposition in der Bohrung (A) um den vorderen Teil des Kolbens (10; 60; 110) gebildet ist, bezüglich der Umgebungsatmosphäre auf dichte Weise abzutrennen.
  10. Gebrauchsfertige Einheit, die ein geschlossenes, ein Produkt enthaltendes Gefäß (2) umfasst, wobei das Gefäß einen Hals (3), dessen Öffnung (3a) durch einen Stöpsel (4) verschlossen ist, und eine am Gefäß angebrachte Verbindungsvorrichtung (5-24; 60-76; 109-124) nach einem der Ansprüche 1 bis 9 umfasst.
EP99946225A 1998-09-24 1999-09-23 Verbindungsvorrichtung zwischen behälter und inhalt und gebrauchsfertige anordungen die eine solche vorrichtung enthalten Expired - Lifetime EP1115361B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9812120 1998-09-24
FR9812120A FR2783808B1 (fr) 1998-09-24 1998-09-24 Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
PCT/FR1999/002268 WO2000016730A1 (fr) 1998-09-24 1999-09-23 Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif

Publications (2)

Publication Number Publication Date
EP1115361A1 EP1115361A1 (de) 2001-07-18
EP1115361B1 true EP1115361B1 (de) 2002-11-20

Family

ID=9530935

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99946225A Expired - Lifetime EP1115361B1 (de) 1998-09-24 1999-09-23 Verbindungsvorrichtung zwischen behälter und inhalt und gebrauchsfertige anordungen die eine solche vorrichtung enthalten

Country Status (18)

Country Link
US (1) US6537263B1 (de)
EP (1) EP1115361B1 (de)
JP (1) JP3983978B2 (de)
KR (1) KR100591213B1 (de)
CN (1) CN1178638C (de)
AT (1) ATE227966T1 (de)
AU (1) AU749364C (de)
BR (1) BR9913901A (de)
CA (1) CA2339897C (de)
DE (1) DE69904064T2 (de)
DK (1) DK1115361T3 (de)
ES (1) ES2188238T3 (de)
FR (1) FR2783808B1 (de)
HK (1) HK1039446A1 (de)
PT (1) PT1115361E (de)
RU (1) RU2214216C2 (de)
TR (1) TR200101557T2 (de)
WO (1) WO2000016730A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2815328B1 (fr) * 2000-10-17 2002-12-20 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
FR2819174B1 (fr) * 2001-01-08 2003-06-13 Pierre Frezza Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical dans un contenant
WO2003008021A1 (de) * 2001-07-17 2003-01-30 Bernd Hansen Vorrichtung zur abgabe von medien
DE10142450C1 (de) * 2001-08-31 2003-06-18 Aventis Behring Gmbh Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen
DE10203598A1 (de) * 2002-01-30 2003-08-07 Disetronic Licensing Ag Injektionsgerät mit steril montierter Injektionsnadel sowie Nadelträger und Ampulle für solch ein Injektionsgerät
FR2836129B1 (fr) * 2002-02-20 2004-04-02 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
US8562583B2 (en) 2002-03-26 2013-10-22 Carmel Pharma Ab Method and assembly for fluid transfer and drug containment in an infusion system
US7867215B2 (en) * 2002-04-17 2011-01-11 Carmel Pharma Ab Method and device for fluid transfer in an infusion system
SE523001C2 (sv) 2002-07-09 2004-03-23 Carmel Pharma Ab En kopplingsdel, en koppling, en infusionspåse, en infusionsanordning och ett förfarande för överföring av medicinska substanser
DE20210948U1 (de) * 2002-07-19 2002-11-21 Trw Airbag Sys Gmbh & Co Kg Transportbaugruppe
US7942861B2 (en) 2002-10-22 2011-05-17 Baxter International Inc. Fluid container with access port and safety cap
US7507226B2 (en) * 2002-10-22 2009-03-24 Baxter International Inc. Access port with safety tab and fluid container employing same
WO2004064903A1 (en) * 2003-01-21 2004-08-05 Carmel Pharma Ab A needle for penetrating a membrane
US7998106B2 (en) * 2004-05-03 2011-08-16 Thorne Jr Gale H Safety dispensing system for hazardous substances
US6997910B2 (en) * 2004-05-03 2006-02-14 Infusive Technologies, Llc Multi-chamber, sequential dose dispensing syringe
US7615041B2 (en) * 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
US20060184103A1 (en) * 2005-02-17 2006-08-17 West Pharmaceutical Services, Inc. Syringe safety device
US20070060904A1 (en) * 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
KR100745994B1 (ko) * 2005-08-17 2007-08-03 이용학 약액 주입 세트
ES2608284T3 (es) 2006-05-25 2017-04-07 Bayer Healthcare Llc Dispositivo de reconstitución
US7926856B2 (en) * 2007-03-02 2011-04-19 Smith & Nephew, Inc. Fluid conduit connection
US7942860B2 (en) 2007-03-16 2011-05-17 Carmel Pharma Ab Piercing member protection device
JP4903275B2 (ja) * 2007-03-16 2012-03-28 カルメル ファルマ アクチボラゲット 穿刺部材保護装置
US7975733B2 (en) * 2007-05-08 2011-07-12 Carmel Pharma Ab Fluid transfer device
US8029747B2 (en) 2007-06-13 2011-10-04 Carmel Pharma Ab Pressure equalizing device, receptacle and method
US8622985B2 (en) * 2007-06-13 2014-01-07 Carmel Pharma Ab Arrangement for use with a medical device
US8657803B2 (en) 2007-06-13 2014-02-25 Carmel Pharma Ab Device for providing fluid to a receptacle
US10398834B2 (en) 2007-08-30 2019-09-03 Carmel Pharma Ab Device, sealing member and fluid container
US8287513B2 (en) 2007-09-11 2012-10-16 Carmel Pharma Ab Piercing member protection device
DE102007046951B3 (de) * 2007-10-01 2009-02-26 B. Braun Melsungen Ag Vorrichtung zum Einführen eines Medikaments in einen Infusionsbehälter
GB0724827D0 (en) * 2007-12-20 2008-01-30 Smith & Nephew Connectors
DE102008020652A1 (de) * 2008-04-24 2009-12-31 Plümat Plate & Lübeck GmbH & Co. Durchstoßvorrichtung und Verfahren zum Entnehmen einer Flüssigkeit aus einem Beutel oder Zuführen einer Substanz in einen Beutel
US8075550B2 (en) * 2008-07-01 2011-12-13 Carmel Pharma Ab Piercing member protection device
US8523838B2 (en) * 2008-12-15 2013-09-03 Carmel Pharma Ab Connector device
US8790330B2 (en) * 2008-12-15 2014-07-29 Carmel Pharma Ab Connection arrangement and method for connecting a medical device to the improved connection arrangement
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
USD637713S1 (en) 2009-11-20 2011-05-10 Carmel Pharma Ab Medical device adaptor
US8480646B2 (en) * 2009-11-20 2013-07-09 Carmel Pharma Ab Medical device connector
US20130053814A1 (en) * 2010-01-15 2013-02-28 Bayer Healthcare Llc Device
US8753325B2 (en) 2010-02-24 2014-06-17 Medimop Medical Projects, Ltd. Liquid drug transfer device with vented vial adapter
US8684994B2 (en) 2010-02-24 2014-04-01 Medimop Medical Projects Ltd. Fluid transfer assembly with venting arrangement
US8162013B2 (en) 2010-05-21 2012-04-24 Tobias Rosenquist Connectors for fluid containers
US9168203B2 (en) 2010-05-21 2015-10-27 Carmel Pharma Ab Connectors for fluid containers
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
JP5868555B2 (ja) 2012-09-13 2016-02-24 メディモップ・メディカル・プロジェクツ・リミテッド 入れ子式雌薬瓶アダプタ
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
US20160000653A1 (en) * 2013-03-14 2016-01-07 Bayer Healthcare Llc Transfer set
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd A ready-to-use medicine vial device including a medicine vial closure, and a medicine vial closure for it
USD737960S1 (en) 2013-04-24 2015-09-01 BIOMéRIEUX, INC. Adapter cap with needle bore having flat internal surfaces
KR102155813B1 (ko) 2013-04-24 2020-09-14 바이오메리욱스, 인코포레이티드. 샘플 수집 용기용 어댑터 캡 및 코어 핀을 갖는 연관된 몰드 및 이와 관련된 방법
JP6199483B2 (ja) 2013-05-10 2017-09-20 メディモップ・メディカル・プロジェクツ・リミテッド インライン乾燥薬剤モジュールを有するバイアルアダプタを備える医療用デバイス
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
CN205626622U (zh) 2013-08-07 2016-10-12 麦迪麦珀医疗工程有限公司 与输液容器一起使用的液体转移装置
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
DE102014104281B3 (de) * 2014-03-27 2015-09-10 Medac Gesellschaft für klinische Spezialpräparate mbH Transfervorrichtung
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
WO2016087188A1 (en) * 2014-12-01 2016-06-09 Novo Nordisk A/S Needle assembly with needle hub shielding a needle cannula
EP3217944B1 (de) 2015-01-05 2019-04-10 West Pharma. Services IL, Ltd Dualphiolenadapteranordnungen mit schnell freisetzendem arzneimittelphiolenadapter zur korrekten verwendung
DE102015201288B4 (de) 2015-01-26 2017-01-05 Bayer Pharma AG Hohlnadel-Baugruppe
DE102015201275A1 (de) 2015-01-26 2016-07-28 Bayer Pharma AG Vorrichtung zum Überführen einer Flüssigkeit zwischen einem Lagerbehälter und mindestens einem weiteren Gebrauchsbehälter
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
BR112018010435B1 (pt) 2015-11-25 2022-06-28 West Pharma. Services IL, Ltd. Conjunto adaptador de ampola dupla para uso com uma seringa sem agulha com um conector macho, uma ampola de fármaco e uma ampola de líquido
WO2017112000A1 (en) * 2015-12-22 2017-06-29 Coopersurgical, Inc. Storing samples
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Devices with two vial adapters include an aerated drug vial adapter and an aerated liquid vial adapter
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd A device with two vial adapters includes two identical vial adapters
IL246073A0 (en) 2016-06-06 2016-08-31 West Pharma Services Il Ltd A fluid transport device for use with a slide-driven piston medicine pump cartridge
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Injector assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
JP6853275B2 (ja) * 2016-12-05 2021-03-31 微邦科技股▲ふん▼有限公司Ｍｉｃｒｏｂａｓｅ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． 切替え可能な部分を有するエアゾール発生装置
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd Liquid drug delivery devices are user-operated for use in pre-prepared liquid drug delivery assemblies (rtu)
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd A device with two vial adapters includes two identical perforated vial adapters
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
GB2575304B (en) * 2018-07-05 2022-05-18 Owen Mumford Ltd Medicament packaging arrangements
JP1630477S (de) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (de) 2019-01-17 2019-12-16
ES2946032T3 (es) 2019-01-31 2023-07-12 West Pharma Services Il Ltd Dispositivo de transferencia de líquido
JP7001838B2 (ja) 2019-04-30 2022-01-20 ウェスト ファーマ サービシーズ イスラエル リミテッド デュアルルーメンｉｖスパイク付き液体移送装置
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
RU208451U1 (ru) * 2021-11-03 2021-12-20 Общество С Ограниченной Ответственностью Химико Фармацевтический Концерн "Мир" Уплотняющий элемент крышки для укупоривания медицинских флаконов
GB2623306A (en) * 2022-10-10 2024-04-17 Owen Mumford Ltd Medicament delivery assembly

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847996A (en) 1953-08-13 1958-08-19 Miljam Instr Corp Hypodermic syringe
FR1423549A (fr) 1965-02-05 1966-01-03 Emballage de seringue
FR2227020B1 (de) 1973-04-27 1975-08-22 Radiologie Cie Gle
US3976073A (en) * 1974-05-01 1976-08-24 Baxter Laboratories, Inc. Vial and syringe connector assembly
US4195632A (en) 1978-05-03 1980-04-01 Cutter Laboratories, Inc. Fluid flow valve
US4296786A (en) * 1979-09-28 1981-10-27 The West Company Transfer device for use in mixing a primary solution and a secondary or additive substance
US4507113A (en) 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4589879A (en) 1983-11-04 1986-05-20 Baxter Travenol Laboratories, Inc. Cannula assembly having closed, pressure-removable piercing tip
IT1173370B (it) 1984-02-24 1987-06-24 Erba Farmitalia Dispositivo di sicurezza per collegare una siringa alla imboccatura di un flacone contenente un farmaco o di un tubicino per l'erogazione del farmaco della siringa
US4552277A (en) 1984-06-04 1985-11-12 Richardson Robert D Protective shield device for use with medicine vial and the like
US4607671A (en) * 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4675020A (en) * 1985-10-09 1987-06-23 Kendall Mcgaw Laboratories, Inc. Connector
US4662878A (en) 1985-11-13 1987-05-05 Patents Unlimited Ltd. Medicine vial adaptor for needleless injector
US4639250A (en) 1986-02-20 1987-01-27 Becton, Dickinson And Company Syringe barrel and hypodermic needle assembly
US4713060A (en) 1986-06-20 1987-12-15 Becton, Dickinson And Company Syringe assembly
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
US5152965A (en) 1989-06-02 1992-10-06 Abbott Laboratories Two-piece reagent container assembly
US5336180A (en) * 1990-04-24 1994-08-09 Science Incorporated Closed drug delivery system
US5060704A (en) 1990-05-25 1991-10-29 David Bull Laboratories Pty. Ltd. Suction transfer assembly
US5169388A (en) * 1990-06-07 1992-12-08 Gensia Pharmaceuticals, Inc. Pressure-activated medication dispenser
US5232029A (en) 1990-12-06 1993-08-03 Abbott Laboratories Additive device for vial
US5186323A (en) 1991-06-24 1993-02-16 Pfleger Frederick W Dual compartment mixing container
DE4122476A1 (de) 1991-07-06 1993-01-07 Leopold Pharma Gmbh Verfahren und vorrichtung zum ueberleiten von zwei oder mehr sterilen fluessigkeiten im geschlossenen system
JP3065735B2 (ja) 1991-08-29 2000-07-17 株式会社ニッショー 薬剤容器およびそれを用いた薬液注入装置
US5308347A (en) 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5352191A (en) 1991-10-25 1994-10-04 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5247972A (en) 1991-12-17 1993-09-28 Whittier Medical, Inc. Alignment guide for hypodermic syringe
US5224515A (en) 1992-01-30 1993-07-06 Porex Technologies Corp. Tube closure
US5423791A (en) 1992-03-31 1995-06-13 Bartlett; J. Mark Valve device for medical fluid transfer
CA2093560C (en) 1992-04-10 2005-06-07 Minoru Honda Fluid container
JP2605345Y2 (ja) 1992-05-01 2000-07-10 株式会社大塚製薬工場 薬剤容器
JPH05317383A (ja) 1992-05-19 1993-12-03 Nissho Corp 薬剤容器との連通手段を備えた溶解液容器
US5279576A (en) 1992-05-26 1994-01-18 George Loo Medication vial adapter
US5807323A (en) * 1992-08-13 1998-09-15 Science Incorporated Mixing and delivery syringe assembly
US5279583A (en) 1992-08-28 1994-01-18 Shober Jr Robert C Retractable injection needle assembly
US5344417A (en) 1992-09-11 1994-09-06 Becton, Dickinson And Company Universal fitting for inoculation receptacles
US5364386A (en) 1993-05-05 1994-11-15 Hikari Seiyaku Kabushiki Kaisha Infusion unit
US5429614A (en) 1993-06-30 1995-07-04 Baxter International Inc. Drug delivery system
WO1995001133A1 (en) 1993-06-30 1995-01-12 Baxter International Inc. Vial adapter
US5397303A (en) 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
CZ288168B6 (en) 1993-12-28 2001-05-16 Tetsuro Higashikawa Syringe
US5429256A (en) 1994-01-24 1995-07-04 Kestenbaum; Alan D. Drug withdrawal system for container
DE4414697C2 (de) 1994-04-27 1998-06-18 Caremed Vertriebsgesellschaft Vorrichtung zum Transferieren und Entnehmen von Flüssigkeiten aus Flaschen, Beuteln oder ähnlichen Behältnissen für medizinische Zwecke
EP1181921A3 (de) 1994-06-24 2002-03-06 ICU Medical, Inc. Vorrichtung zum Flüssigkeitstransfer sowie Anwendungsverfahren
US5526853A (en) 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US5653686A (en) * 1995-01-13 1997-08-05 Coulter Corporation Closed vial transfer method and system
US5613291A (en) 1995-01-25 1997-03-25 Becton, Dickinson And Company Method for providing a sterility seal in a medicinal storage bottle
JP2000515771A (ja) * 1995-04-13 2000-11-28 アドヴァンスド サイトメトリックス インコーポレイテッド 真空圧自蔵吸引針装置、方法およびこれと共に使用するアダプタ
FR2738550B1 (fr) * 1995-09-11 1997-11-07 Biodome Dispositif d'obturation d'un recipient lui-meme ferme, ensemble pour dispenser un produit comprenant un tel recipient et un tel dispositif d'obturation
DE29516650U1 (de) 1995-10-21 1995-12-14 Clinico Formtechnik Gmbh Einmalspritze zur Erzeugung variabler Medikamentenkonzentration durch Lösung oder Verdünnung.
CA2211629A1 (en) 1996-09-17 1998-03-17 Bernard Sams Vial connector assembly for a medicament container
US5873872A (en) * 1996-09-17 1999-02-23 Becton Dickinson And Company Multipositional resealable vial connector assembly for efficient transfer of liquid
FR2753624B1 (fr) 1996-09-25 1999-04-16 Biodome Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue
US5772652A (en) * 1997-05-14 1998-06-30 Comar, Inc. Stab cap for a vial having a puncturable seal
US5925029A (en) * 1997-09-25 1999-07-20 Becton, Dickinson And Company Method and apparatus for fixing a connector assembly onto a vial with a crimp cap
US6213994B1 (en) * 1997-09-25 2001-04-10 Becton Dickinson France, S.A. Method and apparatus for fixing a connector assembly onto a vial
US6019750A (en) * 1997-12-04 2000-02-01 Baxter International Inc. Sliding reconstitution device with seal
US6382442B1 (en) 1998-04-20 2002-05-07 Becton Dickinson And Company Plastic closure for vials and other medical containers
US6022339A (en) 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container

Also Published As

Publication number Publication date
CN1178638C (zh) 2004-12-08
US6537263B1 (en) 2003-03-25
AU749364C (en) 2003-01-23
EP1115361A1 (de) 2001-07-18
ES2188238T3 (es) 2003-06-16
HK1039446A1 (zh) 2002-08-02
DE69904064D1 (de) 2003-01-02
FR2783808A1 (fr) 2000-03-31
DK1115361T3 (da) 2003-03-10
WO2000016730A1 (fr) 2000-03-30
CA2339897A1 (fr) 2000-03-30
JP2002526202A (ja) 2002-08-20
JP3983978B2 (ja) 2007-09-26
PT1115361E (pt) 2003-02-28
FR2783808B1 (fr) 2000-12-08
CA2339897C (en) 2008-07-08
CN1314803A (zh) 2001-09-26
AU5867199A (en) 2000-04-10
KR100591213B1 (ko) 2006-06-22
BR9913901A (pt) 2001-07-03
RU2214216C2 (ru) 2003-10-20
DE69904064T2 (de) 2003-10-09
KR20010075324A (ko) 2001-08-09
AU749364B2 (en) 2002-06-27
ATE227966T1 (de) 2002-12-15
TR200101557T2 (tr) 2001-10-22

Similar Documents

Publication Publication Date Title
EP1115361B1 (de) Verbindungsvorrichtung zwischen behälter und inhalt und gebrauchsfertige anordungen die eine solche vorrichtung enthalten
EP1226077B1 (de) Einsatzbereite verbindungsvorrichtung
EP0453555B1 (de) Vorratsbehälter für einen bestandteil einer medikamentenlösung
EP0462255B1 (de) Aufbewahrungs- und umfüllflasche mit doppelter kammer
EP1881936B1 (de) Vorrichtung zum ausgeben und empfangen von flüssigprodukten
WO2002032372A1 (fr) Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
EP0295265B1 (de) Vorrichtung zum aufbewahren von flüssigen oder von flüssigen und festen substanzen
EP1216195B1 (de) Dichtung für dosierventil
FR2836129A1 (fr) Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
FR2858931A1 (fr) Dispositif d'administration orale d'un medicament
FR2789369A1 (fr) Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
FR2888822A1 (fr) Valve de distribution de produit fluide
WO1995019195A1 (fr) Dispositif a carpule pour la distribution d'un liquide
WO1998028090A1 (fr) Dispositif de distribution d'une matiere extrudable telle qu'une pate a usage dentaire
FR2537550A3 (fr) Recipient contenant des substances fluides, destine a etre utilise avec des petites pompes manuelles pour la distribution de ces substances
WO1998049994A1 (fr) Dispositif de mise en solution d'un produit lyophilise, contenu dans une cartouche a usage unique utilisee dans un dispositif d'injection sans aiguille
EP1124646B1 (de) Behälter mit verschluss- und füllvorrichtung und/oder sprühvorrichtung für flüssige produkte mit einem solchen behälter
EP0879191B1 (de) Vorrichtung zum dosieren eines fliessfähigen mediums in einem hermetisch geschlossenen behälter
FR2516899A1 (fr) Dispositif pour prelever des substances pateuses dans des recipients remplis avec un gaz propulseur
EP3069631B1 (de) Verbesserte roll-on-flasche
EP1103490B1 (de) Zerstäuber mit Treibgas
WO2003086646A1 (fr) Pompe de distribution de produit fluide
FR3066478A1 (fr) Ensemble destine au conditionnement d'un produit fluidique
FR2540467A1 (fr) Fermeture pour recipient a canule liberale

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010315

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 20020613

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

REF Corresponds to:

Ref document number: 227966

Country of ref document: AT

Date of ref document: 20021215

Kind code of ref document: T

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: FRENCH

REF Corresponds to:

Ref document number: 69904064

Country of ref document: DE

Date of ref document: 20030102

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20030127

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20030400380

Country of ref document: GR

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20021220

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2188238

Country of ref document: ES

Kind code of ref document: T3

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20030814

Year of fee payment: 5

Ref country code: AT

Payment date: 20030814

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: MC

Payment date: 20030818

Year of fee payment: 5

Ref country code: FI

Payment date: 20030818

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20030819

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20030821

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20030829

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030923

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20030821

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040923

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040923

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040923

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040923

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040930

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040930

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20041013

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20041208

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050405

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050930

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050930

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050930

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

BERE Be: lapsed

Owner name: *BIODOME

Effective date: 20050930

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20090907

Year of fee payment: 11

Ref country code: NL

Payment date: 20090924

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20100925

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20100929

Year of fee payment: 12

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20110401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110923

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20120927

Year of fee payment: 14

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110924

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69904064

Country of ref document: DE

Effective date: 20140401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140401

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20140926

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20170301

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150924

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20180820

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20180911

Year of fee payment: 20

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20190922

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20190922