EP0666085B1 - Powder medicament inhaler - Google Patents

Powder medicament inhaler Download PDF

Info

Publication number
EP0666085B1
EP0666085B1 EP95300378A EP95300378A EP0666085B1 EP 0666085 B1 EP0666085 B1 EP 0666085B1 EP 95300378 A EP95300378 A EP 95300378A EP 95300378 A EP95300378 A EP 95300378A EP 0666085 B1 EP0666085 B1 EP 0666085B1
Authority
EP
European Patent Office
Prior art keywords
air
capsule
holes
powder
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95300378A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0666085A1 (en
Inventor
Peter Villax
Rui Peres
William Richard Treneman
Iain Grierson Mcderment
Martin Bunce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Inter AG
Original Assignee
Plurichemie Anstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plurichemie Anstalt filed Critical Plurichemie Anstalt
Publication of EP0666085A1 publication Critical patent/EP0666085A1/en
Application granted granted Critical
Publication of EP0666085B1 publication Critical patent/EP0666085B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0038—Cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • This invention relates to a powered medicament inhaler, and to the use thereof to fluidise powdered medicament.
  • Pressurized inhalers for administering a metered dose of powdered medicament have long been known, but their use of chlorofluorocarbons as propellants is environmentally undesirable, and there is currently a renewed interest in breath-actuated powder inhalation devices.
  • a dispenser for powders comprising a tubular body having a downstream end for a person to draw air therethrough and an upstream end. Two diametrically opposed radial passages are provided in the tubular body for admitting a flow of air in response to the suction of a person inhaling through the downstream end of the tubular body.
  • a capsule containing a powdered medicament is fixedly disposed in the tubular body between the upstream and downstream ends.
  • the capsule includes at least one air entry hole and at least one air exit hole for drawing a second flow of air through the tubular body in response to the suction of a person inhaling through the downstream end of the tubular body.
  • Some capsule using devices have a low resistance to airflow and, as a result, during operation the powder tends to be administered too quickly and all at once. With the airflow saturated with powder, a considerable quantity of the powder can impinge in the mouth and throat, where it serves no beneficial therapeutic effect; indeed, the chief objective of the device, from the therapeutical aspect, is the maximization of the quantity of powder that reaches the lungs, a concern which until recently had remained secondary.
  • a powdered medicament inhaler comprising: an inhalation tube having a first, downstream end for a person to draw air therethrough and a second, upstream end; an air inlet in the inhalation tube for admitting a first flow of air in response to the suction of a person inhaling through the first end of the inhalation tube; a medicament chamber, for holding a quantity of medicament in the form of a powder, the medicament chamber being disposed in the inhalation tube upstream of the first end; wherein the medicament chamber includes at least one air entry hole and at least one air exit hole for drawing a second flow of air through said medicament chamber in response to the suction of a person inhaling through the first end of the inhalation tube, characterised in that: the area of the air inlet, the area of the air entry hole or holes and the area of the air exit hole or holes are configured such that, when air is drawn through the inhaler, the first flow of air is greater than the second flow of air; and the
  • this simple construction can give excellent fluidisation of powder inside the chamber and excellent flow of powder directly through the tube, mouth and throat into the lungs.
  • this fluidisation is important to provoke the dispersion of powder agglomerates into the desired fine particles.
  • the device can be tuned to suit different users and/or different medicaments.
  • the chamber for containing the powdered medicament can, for example, be constructed integrally with the tube, or it may be a separate unit receivable or connectable to the tube.
  • the chamber can include a dose providing means for supplying a unit dose of medicament to the chamber ready for inhalation.
  • the chamber comprises a capsule which may be conventional apart from the provision therein of holes for the air flow therethrough. The invention will hereafter be described mainly with reference to its use of a capsule chamber but it is to be understood that the invention is not limited to the use of a capsule.
  • air is drawn through the capsule or other chamber to fluidise ("aerosolise") the powder therein.
  • the air entry holes in the chamber should be of a size small enough to severely restrict the admission of air into the chamber, when compared to the main airflow created by the user inhaling through the device. This causes a low pressure area inside the chamber in front of the air entry holes, causing the powder to move at first toward that area, from which it is then fluidised and transported in the opposite direction, toward the air exit holes and into the tube.
  • the aerosol so generated is then diluted by admission of air into the inhalation tube, downstream of the chamber via one or more air inlets, so assisting the delivery of the powder to the lungs.
  • the inhalation tube comprises a simple tube one end of which is receivable in the user's mouth (or nostril) and the other end of which is sized to receive in friction fit a gelatin or plastic capsule containing the medicament.
  • the air inlet is disposed between the capsule and the mouth end of the tube.
  • the capsule has the air entry hole or holes at its outer end, and air exit hole or holes at its inner end to release the powder into the inhalation tube during use of the device.
  • the capsule can be visible during use of the device so that the user can see the aerosolisation of the powder therein and be assured as to its substantially complete emptying into the inhalation tube.
  • the capsule in the present invention is neither made to rotate, to vibrate or to be twisted open.
  • the only movement present is that of the powder within the capsule, which passes through the inhalation tube to the lungs.
  • the inhalation tube is provided with one or more air inlets to provide a supply of air into the tube downstream of the chamber.
  • air inlets We prefer to provide such inlets close to the end of the chamber.
  • the inlet(s) can be around the periphery of the chamber but more usually they will be slightly spaced downstream of the chamber. The size of the air inlet(s) will depend on the overall construction of the device as will be more fully described hereafter.
  • the inhalation tube itself can be, for example, a straw or the like, or it can be a flexible or rigid plastics or other tube. It can be disposable (for once-only use) or it can be made for continued use, the used capsule shell (or other chamber) being removed after each use.
  • the nature of the tube is not critical except for the provision of the air inlet(s) and for the provision of a structure capable of having the medicament chamber fixed thereto.
  • the inhalation tube is arranged so that, when a capsule is located therein, the through-bore of the inhalation tube is blocked by the capsule.
  • the seal need not be perfect and, indeed, in one arrangement described an air inlet passage is provided between the periphery of the capsule and the tube. However, generally the capsule will be a tight friction fit in the bore of the tube to substantially occlude it. In this way, during use of the device, most of the inhaled air is supplied by the air inlet(s) with only a small quantity being admitted through the capsule holes.
  • the medicament chamber may be received in an appropriately dimensioned inside end of the inhalation tube. In other more complex arrangements, the medicament chamber may be received in a separate unit attachable to the inhalation tube as desired.
  • the powdered medicament inhaler of the present invention is for use with standard (or specially made) conventional-type capsules containing unit doses of medicament, and the invention will hereafter be so described.
  • the invention will hereafter be so described.
  • the capsules for use in the inhalers of the invention must be punctured before use so as to allow an air flow therethrough.
  • one or more holes are formed in the capsules.
  • the holes are formed at each of the ends of the capsule, but other arrangements are possible.
  • the air exit hole or holes open into the inhalation tube and the air entry hole or holes open to an air supply.
  • small air entry holes of a diameter of less than 1 mm, provide for the best swirl of product inside the capsule. With less restricted air entry holes, the powder may exit the capsule in too short a time to be properly diluted by the air entering through the tube inlets, or may even fail completely to be suspended as an aerosol.
  • the exit and entry holes may be of the same or different sizes, and there may be the same or different numbers of each.
  • the optimum arrangement can be determined by routine trial and experiment. Instead of using capsules which have different puncture areas at each end, it is possible to use capsules equally punctured at each end, but to restrict air supply to the air entry holes of the capsule through the use of a similarly pierced cover or cap fitted over the air entry side of the capsule.
  • the passage of air through the punctured capsule fluidises the powder therein, and causes it to be finely suspended.
  • the turbulence is visible through the clear wall of the capsule, and the user simply inhales for as long as powder is visible in the capsule.
  • the delivery of powder from the capsule can be kept desirably slow.
  • the slowness of the emptying of the powder is a highly desirable feature of this device, as it permits to match the time it takes to empty the capsule with the time it takes to fill the user's lungs. This causes the powder to be finely dispersed and transported by air flow, reducing the quantity of powder becoming stuck in the user's mouth or throat, and increasing the proportion which reaches the lungs.
  • One feature which can be achieved in the devices of the invention is a level of resistance to air flow which makes the device comfortable for the user by reducing the effort required to empty the capsule.
  • the capsule holes are assumed to have all the same diameter, so that a variation in the number of holes results in a proportionate and measurable change in their total surface area.
  • air inlet(s) on the tube the total surface area of which can be, for example, 2 to 12 times that of the capsule air entry holes, it is possible to regulate the resistance of the device to the passage of air. All other things being equal, the greater the area of the air inlet(s) on the tube, the greater the quantity of air entering the tube and the greater its powder entrainment capability.
  • the existence of various inlets and holes provides for different conditions throughout the device.
  • the restricted admission of air causes a low pressure area and high air resistance, leading to a fluidisation of the powder, finely suspending it.
  • the low air resistance caused by more air being drawn through the air inlets results in a more comfortable use to the patient as well as a high powder entrainment capacity.
  • the embodiment of this invention combines the benefits of both low air resistance overall and high air resistance in the capsule, with none of their respective disadvantages.
  • holes in the capsules to enable the airflow therethrough can be effected in any suitable way.
  • needles can be used to form the holes, but we prefer to puncture the capsules with the cutting edge such as a knife blade.
  • the cutting edge such as a knife blade.
  • spillage of the powder contents from the capsule can be practically nil when the holes are formed by cutting whereas powder loss can sometimes occur when holes are formed using needles.
  • small entry holes of less than 1 mm. Holes produced by cutting are of an oblong shape, with the cut having a width at its widest point of typically 0.5 mm and a length of 3 to 5 mm.
  • the device of the invention can include a means for puncturing the pre-filled capsules, and this may form an integral part of the device or it may be a separate unit.
  • Known such devices normally comprise one or more needles arranged to pierce the capsule.
  • a preferred device for use in the present invention would provide a larger area of puncture in one region of the capsule than in another region.
  • the holes are formed by cutting, cutting blades can be provided to form cuts in, for example, each end of the capsule as desired.
  • the chamber is received in a barrel member including an elongate container for housing a single capsule, and knife members are provided to form cuts in each end of the capsule by relative movement between the capsule and the blades.
  • holes can be pre-formed in the capsules, the holes being temporarily covered to prevent premature loss of powder therefrom.
  • the temporary cover e.g. adhesive film
  • a capsule or capsule-like chamber
  • the outer holes of the capsule being temporarily covered with peelable film and the inner holes also temporarily covered. Then, immediately prior to use, the covers are removed.
  • the powder is removed by the unique air flow arrangements in the device.
  • the powder contents of a capsule form a "dancing cloud" as they are air-borne.
  • the capsule itself remains substantially motionless during inhalation.
  • an inhalation tube 1 having an end 2 to be received in the user's mouth, and a remote end 3.
  • a gelatin capsule 4 is snugly fitting and held in remote end 3 of tube 1. Near the inner end 5 of capsule 4 are two air-inlet orifices 6 in the tube 1.
  • Capsule 4 is a conventional capsule of two parts with rounded ends 5 and 5a. Outer end 5a has two holes 7 therein and inner end 5 has four holes 8 therein - (see also Figs. 4 and 5). The holes are the same size (although they need not be). For a standard no. 4 capsule (14 mm x 5mm), the hole size can be 0.65mm diameter for example.
  • the capsule 4 contains a dose (9) of medicament, either pure or mixed in a carrier powder. The powder should preferably not fill more than about 10%. of the volume of the capsule, to provide adequate space for aerosolisation of the powder during use.
  • Fig. 2 differs from Fig. 1 in that a cover 20 is provided over the outer end 5a of capsule 4, which end may have the same number of holes 10 therein as inner end 5.
  • Cover 20 has a restricted air orifice 21.
  • Fig. 3 differs from Fig. 1 in that air inlets 6 have been omitted and, instead, inner radial fins 30 are provided at end 3 of tube 1 to hold the capsule 4 spaced from the inner wall of the tube and so provide air inlet passages between the periphery of the capsule 4 and the tube 1.
  • Figs. 6 to 8 illustrate a fourth embodiment of inhaler of the invention.
  • like numerals indicate like parts.
  • Fig. 6 shows the inhaler 70 comprising a capsule reservoir cap 71, a rotatable barrel member 72 and mouthpiece member 73.
  • Mouthpiece member 73 includes a capsule ejection orifice 74 and an inhalation orifice 75.
  • Barrel member 72 includes a series of external ribs 76 for improved manual grip.
  • Fig. 7 is an "exploded" view of the inhaler of Fig. 6 showing its components.
  • Capsule reservoir cap 71 comprises a cylindrical cap member closed at one end 80, the other end 81 being open and containing internally thereof short screw-threads 82.
  • Reservoir support body 83 is of circular cross-section and includes a series of short screw-threads 84 on the periphery thereof for mating engagement with threads 82 on reservoir cap 71.
  • Support body 83 is formed on its forward face 89 with an axial hole 85 keyed to receive one end of axle 86. Offset from axial hole 85 is a through-bore 87 opening in an upstanding cylindrical sleeve on rear face 90.
  • Receivable in sleeve 88 is a cylinder 91 having a supply of capsules 92, stacked endwise.
  • Support member 83 also has two other upstanding cylindrical sleeves 93, 94 on its rear face 90, which receive and close the ends of spare capsule supply cylinders 95, 96.
  • a cutting blade 97 mounted on front face 89 of support 83 is a cutting blade 97 projecting perpendicular to the face 89.
  • an ejector ramp projection 150 is also mounted on face 89.
  • Barrel member 72 has an axial bore 100 in which is received axle 86 about which barrel member 72 is rotatable.
  • Barrel 72 has an offset through-bore 101 which constitutes a container for receiving a capsule in use of the device.
  • Around the periphery of cylindrical barrel 72 are external ribs 76.
  • Each end face 102, 103 of the barrel has a peripheral upstanding wall 104, 105 of a height slightly greater than the projecting length of blades 97, 110 so that the blades do not engage the respective end faces 102, 103 of the barrel member.
  • Blade support member 111 is of a circular shape and has an axial bore keyed to one end of the axle 86.
  • the member 111 has a first through bore 112 and a second through bore 113.
  • Projecting from member 111 towards barrel member 72 is a knife 110.
  • Member 111 has two air inlets (not shown in Fig. 7; see Fig. 8), which are straight bores perpendicular to the axis of first through bore 112.
  • Mouthpiece 73 is joined face to face to support member 111. Mouthpiece 73 has a first through bore 120 which constitutes an inhalation tube terminating at inhalation orifice 75 and a second through bore 121 which is a used capsule ejection bore, and terminates at capsule ejection orifice 74.
  • a cap 130 can be provided to cover the mouthpiece 73 when the device is not in use, the cap including a pocket clip 131.
  • Cylinder 91 containing a supply of powder containing capsules 92 is located in sleeve 88 and a capsule moves under gravity into bore 87 of body 83.
  • Barrel 72 is rotated with respect to supports 83 and 111, about axle 86, to bring bore 101 into line with bore 87.
  • the capsule enters and is fully received into the barrel member.
  • the capsule is slightly longer than the distance between the end faces 102, 103 of the barrel member, as a result of which the opposed ends of the capsule project beyond the said end faces 102, 103.
  • the barrel has a ratchet (or other device) associated therewith whereby it can be rotated about axle 86 in one direction only and in stepwise motion.
  • the ratchet is not shown.
  • the barrel is now rotated and this brings each projecting end of the capsule, in turn, into engagement with a respective knife member 97, 110.
  • the ends of the capsule are thus slit (see slits 140, 141 in Fig. 8).
  • the barrel is now advanced further, to bring the capsule into alignment with bore 112 of support 111.
  • the unit is now ready for inhalation.
  • the user inserts the end of the mouthpiece 73 into their mouth and inhales. Air is drawn through inhalation tube 120 and bore 112 and thus through bore 101 in barrel 72.
  • the suction draws the capsule forward to enter bore 112 and engage closely the end of bore 120 (see Fig. 8).
  • the end of the bore can be flared at 142 (Fig. 8).
  • the air flowing through the mouthpiece enters the device primarily through the path of least resistance, which is through air inlets 143 but also, in a smaller amount, through the slits in the capsule.
  • air is drawn through the capsule entering at slit 140 and exiting with the entrained powder at slit 141, for passage via bore 112, where a considerable amount of air is admitted through inlets 143.
  • the air flow entraining the powder now enters bore 120 of the mouthpiece for passage into the user's mouth.
  • barrel 72 is transparent, the user can repeat the inhalation operation for as long as powder remains visible inside the capsule.
  • the empty capsule falls away from the flared end of bore 120 into the barrel bore 101.
  • the barrel then continues to be rotated in the same direction as before to bring the capsule, still in bore 101 into line with the ejection bore 113.
  • the rearward end of the capsule is engaged by ejector ramp projection 150 which pushes the spent capsule out of ejection orifice 74.
  • Barrel 72 is now rotated to bring the empty bore 101 into registry with bore 87 to receive another capsule from reservoir cylinder 91.
  • cap 71 is removed and tube 91 is replaced by one of cylinders 95, 96.
  • the device in Fig. 7 relies on gravity for loading and ejecting capsules; therefore these operations have to be conducted with the device held close to the vertical.
  • the operations of cutting the capsule and inhaling it can be done with the device held in any position.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Manipulator (AREA)
EP95300378A 1994-02-02 1995-01-20 Powder medicament inhaler Expired - Lifetime EP0666085B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT10145094 1994-02-02
PT101450A PT101450B (pt) 1994-02-02 1994-02-02 Novo dispositivo para inalacao

Publications (2)

Publication Number Publication Date
EP0666085A1 EP0666085A1 (en) 1995-08-09
EP0666085B1 true EP0666085B1 (en) 2000-03-15

Family

ID=20085363

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95300378A Expired - Lifetime EP0666085B1 (en) 1994-02-02 1995-01-20 Powder medicament inhaler

Country Status (28)

Country Link
US (1) US5673686A (zh)
EP (1) EP0666085B1 (zh)
JP (1) JP3747076B2 (zh)
KR (1) KR100323942B1 (zh)
CN (2) CN100333807C (zh)
AT (1) ATE190511T1 (zh)
AU (1) AU698047B2 (zh)
BR (1) BR9500536A (zh)
CA (1) CA2141465C (zh)
CZ (1) CZ289964B6 (zh)
DE (1) DE69515536T2 (zh)
DK (1) DK0666085T3 (zh)
ES (1) ES2145212T3 (zh)
FI (1) FI117002B (zh)
GR (1) GR3032986T3 (zh)
HK (1) HK1003427A1 (zh)
HR (1) HRP950042B1 (zh)
HU (1) HU216961B (zh)
MY (1) MY112427A (zh)
NO (1) NO312748B1 (zh)
NZ (1) NZ270403A (zh)
PL (1) PL179714B1 (zh)
PT (1) PT101450B (zh)
RU (1) RU2150298C1 (zh)
SI (1) SI9500036A (zh)
SK (1) SK283691B6 (zh)
TW (1) TW353368U (zh)
ZA (1) ZA95356B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5694920A (en) * 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US6470884B2 (en) 1996-01-29 2002-10-29 Aventis Pharma Limited Capsule opening arrangement for use in a powder inhaler
DE19637125A1 (de) 1996-09-12 1998-03-19 Schuckmann Alfred Von Inhalier-Vorrichtung
SE9700423D0 (sv) * 1997-02-07 1997-02-07 Astra Ab Disposable inhaler
PT101988B (pt) 1997-04-04 2004-02-27 Hovione Farmaciencia Sa Sistema de orientacao e posicionamento de um objecto
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
US6234169B1 (en) * 1998-08-14 2001-05-22 Arthur Slutsky Inhaler
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1649886B1 (en) * 1999-07-23 2008-04-02 MannKind Corporation Unit dose capsules for a dry powder inhaler
ATE339981T1 (de) * 1999-07-23 2006-10-15 Mannkind Corp Trockenpulverinhalator
AU2005201843B2 (en) * 1999-07-23 2009-01-29 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20030003057A1 (en) * 2000-07-07 2003-01-02 Jeffry Weers Methods for administering leuprolide by inhalation
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
TWI290473B (en) 2000-05-10 2007-12-01 Alliance Pharma Phospholipid-based powders for drug delivery
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
DE60120105D1 (de) 2001-03-28 2006-07-06 Pera Ivo E Stiftförmige Inhalationsvorrichtung zur Abgabe von pulverförmigen Medikamenten in den Atmungstrakt
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
EP1446172B1 (en) * 2001-09-06 2010-04-14 MicroDose Therapeutx, Inc. Inhalation device type DPI
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
PT1458360E (pt) 2001-12-19 2011-07-13 Novartis Ag Derivados de indole como agonistas do recetor s1p1
DE60318938T2 (de) * 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US20040043064A1 (en) * 2002-08-29 2004-03-04 Iorio Theodore L. Dosage forms having reduced moisture transmission
ITMO20020297A1 (it) * 2002-10-16 2004-04-17 Roberto Oliva Inalatore per preparati monodose in capsule.
GB0227128D0 (en) * 2002-11-20 2002-12-24 Glaxo Group Ltd A capsule
CA2511555A1 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
ES2310722T3 (es) * 2003-03-20 2009-01-16 Galephar M/F Sistema inhalador de polvo seco mejorado.
SI1615689T1 (sl) 2003-04-09 2016-05-31 Novartis Ag Naprava za aerosolizacijo s poravnalnim vodilom za prebadanje kapsule
GB0308969D0 (en) 2003-04-17 2003-05-28 Glaxo Group Ltd Capsules
US20040235807A1 (en) * 2003-05-21 2004-11-25 Weinrich Karl P. Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea
GB0325628D0 (en) * 2003-11-03 2003-12-10 Glaxo Group Ltd A hand=-held capsule device
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
SE530149C2 (sv) * 2004-12-20 2008-03-11 Mederio Ag Knivanordning applicerad i en torrpulverinhalator samt ett förfarande för att öppna en dosbehållare
DE102005001332A1 (de) * 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren
KR101162913B1 (ko) 2005-05-03 2012-07-06 베링거 인겔하임 인터내셔날 게엠베하 분말 흡입기
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
DE102006009637A1 (de) 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion
DE102005054383B4 (de) 2005-11-15 2013-10-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nadel zum Lochen von Pulverkapseln für die Inhalation
US7832397B2 (en) * 2005-12-28 2010-11-16 Philip Morris Usa Inc. Aerosol powder delivery device
AU2007210177C1 (en) 2006-01-31 2012-11-01 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
DE102006006647B3 (de) * 2006-02-14 2007-01-18 Braunform Gmbh Vorrichtung zum Inhalieren eines in einer Kapsel sich befindenden Pulvers
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
DE102006010089A1 (de) * 2006-02-24 2007-10-18 Aha-Kunststofftechnik Gmbh Trockenpulver-Inhalator
US8360057B2 (en) * 2006-03-10 2013-01-29 Dose One, Llc Medication inhaler for dispensing multiple capsules
DE102006014434A1 (de) * 2006-03-27 2007-10-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Packmittel für Mehrdosispulverinhalatoren mit optimierten Entleerungseigenschaften
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102006016901A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mundstück für einen Inhalator
DE102006016903A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
EP1844805A1 (de) * 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co.KG Inhalator
WO2008156586A2 (en) * 2007-06-12 2008-12-24 Alkermes, Inc. Inhalation device for powdered substances
DE102007033860A1 (de) 2007-07-20 2009-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Prüfvorrichtung
DE102007052871A1 (de) 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen
PT2230934E (pt) 2007-12-14 2012-11-20 Aerodesigns Inc Distribuir produtos alimentares aerossolizáveis
ES2655921T3 (es) 2008-06-13 2018-02-22 Mannkind Corporation Un inhalador de polvo seco y sistema para administración de fármacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
DE202008015493U1 (de) 2008-11-21 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Faltschachtel
AT507631B1 (de) * 2008-11-26 2012-05-15 Haas Rouven Mag Vorrichtung zum ansaugen von pulver- oder granulat-material und kapsel hierfür
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
NZ595722A (en) * 2009-04-23 2014-02-28 Takeda Gmbh Improved apparatus for the aerosolization of large volumes of dry powder
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
DE102009037840B4 (de) 2009-08-18 2012-08-16 Gamptec Gmbh Inhalationsvorrichtung und Verfahren zur Inhalation eines Wirkstoffs aus einer Kapsel
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AU2010319328A1 (en) 2009-11-12 2012-05-31 Stc.Unm Dry powder inhaler with flutter dispersion member
PT105065B (pt) * 2010-04-26 2012-07-31 Hovione Farmaciencia S A Um inalador simples de cápsulas
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
FR2962342B1 (fr) * 2010-07-07 2013-02-15 Valois Sas Inhalateur de poudre seche.
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
ES2776003T3 (es) 2011-05-27 2020-07-28 Boehringer Ingelheim Int Inhalador y cápsula para un inhalador
US9877799B2 (en) * 2011-06-10 2018-01-30 Pharmaphd, Inc. Regulated periodontal dispensing apparatus and multiple dose applicator with a semilunar valve
CN102218182B (zh) * 2011-06-13 2015-02-18 上海秀新臣邦医药科技有限公司 一种干粉给药装置的振动给药装置
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013016784A1 (en) 2011-08-04 2013-02-07 Victor Esteve Dry powder inhaler
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2860119A1 (en) * 2011-12-23 2013-06-27 Koninklijke Philips N.V. Device for delivery of a tooth whitening agent
US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
JP6365848B2 (ja) * 2012-05-21 2018-08-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器及びカプセルで構成されたシステム
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US20140150787A1 (en) * 2012-12-04 2014-06-05 Civitas Therapeutics, Inc. Devices and methods for puncturing a capsule to release a powdered medicament therefrom
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
EP2991634A1 (en) 2013-04-30 2016-03-09 Otitopic Inc. Dry powder formulations and methods of use
WO2015006838A1 (en) 2013-07-16 2015-01-22 Victor Esteve Powder inhaler
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
ES2638972T3 (es) * 2013-08-08 2017-10-24 Med 2000 S.R.L. Vial de nebulizador para terapia de aerosol
US9272123B2 (en) * 2013-12-16 2016-03-01 Esther Gallant Device and method for inserting lubricating capsule
EP4119131A1 (en) 2014-02-20 2023-01-18 Otitopic Inc. Dry powder formulations for inhalation
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
MX2017009112A (es) 2015-01-14 2018-06-15 Respira Therapeutics Inc Metodos y dispositivos de dispersion de polvo.
PL228819B1 (pl) * 2015-04-16 2018-05-30 Zbigniew Chudy Inhalator pojedynczej dawki suchego proszku
AU2016376033A1 (en) * 2015-12-24 2018-06-28 Philip Morris Products S.A. Nicotine particle capsule
CN106237459A (zh) * 2016-07-26 2016-12-21 福建美菰林生物科技有限公司 一种鼻通器
JP7210476B2 (ja) 2017-05-22 2023-01-23 インスメッド インコーポレイテッド リポ‐グリコペプチド可切断性誘導体及びその使用
EP3630239A4 (en) * 2017-05-31 2021-05-19 Virginia Commonwealth University DEVICES, SYSTEMS AND METHODS FOR DRY POWDER TREATMENTS
JP7455144B2 (ja) 2019-04-29 2024-03-25 インスメッド インコーポレイテッド トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法
JP6983449B1 (ja) * 2021-07-09 2021-12-17 株式会社Green Rush By Weed 加熱式擬似喫煙具用カートリッジ
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1827463A (en) * 1930-04-21 1931-10-13 Lawrence Products Company Inc Medical powder applicator
US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2549303A (en) * 1949-04-20 1951-04-17 Bristol Lab Inc Inhaler for crystalline pencilllin or the like
GB705404A (en) * 1950-05-19 1954-03-10 A M Bickford & Sons Ltd An inhaler for medicinal substances
DE1047385B (de) * 1952-03-08 1958-12-24 Armour & Co Puderzerstaeuber mit einem auswechselbaren Puderbehaelter
US2992645A (en) * 1958-05-06 1961-07-18 Benger Lab Ltd Disperser for powders
GB1118341A (en) * 1965-04-20 1968-07-03 Fisons Pharmaceuticals Ltd Inhalation device
GB1182779A (en) * 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
US3949751A (en) * 1970-03-03 1976-04-13 Fisons Limited Method and device for dispensing medicament to the body
US3888253A (en) * 1972-08-04 1975-06-10 Beecham Group Ltd Device for administration of medicines
IT1016489B (it) * 1974-03-18 1977-05-30 Isf Spa Inalatore
IT1017153B (it) * 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
GB1521000A (en) * 1975-06-13 1978-08-09 Syntex Puerto Rico Inc Inhalation device
GB1562732A (en) * 1976-02-10 1980-03-12 Allen & Hanburys Ltd Device for dispensing medicaments
GB1561835A (en) * 1976-02-11 1980-03-05 Allen & Hanburys Ltd Devices for dispensing medicamtens
FR2352556A1 (fr) * 1976-05-26 1977-12-23 Pasteur Institut Inhalateur de poudre
US4105207A (en) * 1976-08-18 1978-08-08 Ideal Toy Corporation Pinball type baseball game
GB1598081A (en) * 1977-02-10 1981-09-16 Allen & Hanburys Ltd Inhaler device for dispensing medicaments
IE46865B1 (en) * 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
US4192309A (en) * 1978-09-05 1980-03-11 Syntex Puerto Rico, Inc. Inhalation device with capsule opener
IT1116047B (it) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma
US4265236A (en) * 1980-03-31 1981-05-05 Pacella Angelo M Portable inhalator device
DE3167567D1 (en) * 1980-06-06 1985-01-17 Fisons Plc Inhalation device for powdered medicaments
ES506585A0 (es) * 1980-10-30 1982-09-01 Riker Laboratories Inc Un dispositivo para facilitar la inhalacion oral de medica- mentos en forma de polvo
EP0069715B1 (en) * 1981-07-08 1986-11-05 Aktiebolaget Draco Powder inhalator
DE3345722A1 (de) * 1983-12-17 1985-06-27 Boehringer Ingelheim KG, 6507 Ingelheim Inhalator
CA1272917A (en) * 1985-07-30 1990-08-21 Paul Kenneth Rand Devices for administering medicaments to patients
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
JPS63143081A (ja) * 1986-12-05 1988-06-15 メクト株式会社 吸入器
IT1228459B (it) * 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
IT1228460B (it) * 1989-02-23 1991-06-19 Phidea S R L Inalatore monouso con capsula pre-forata
GB8914223D0 (en) * 1989-06-21 1989-08-09 Fisons Plc Medicament container
IT1230313B (it) * 1989-07-07 1991-10-18 Somova Spa Inalatore per medicamenti in capsule.
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
US5042472A (en) * 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
GB9026025D0 (en) * 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
GB9216038D0 (en) * 1992-07-28 1992-09-09 Bespak Plc Dispensing apparatus for powdered medicaments
US5239993A (en) * 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
US5372128A (en) * 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler

Also Published As

Publication number Publication date
AU698047B2 (en) 1998-10-22
JPH07222800A (ja) 1995-08-22
HUT71287A (en) 1995-11-28
BR9500536A (pt) 1997-03-25
PT101450A (pt) 1995-08-09
FI117002B (fi) 2006-05-15
HU9500286D0 (en) 1995-03-28
HRP950042B1 (en) 2000-12-31
FI950444A0 (fi) 1995-02-01
CA2141465A1 (en) 1995-08-03
CZ21095A3 (en) 1996-09-11
PL307011A1 (en) 1995-08-07
NO950368L (no) 1995-08-03
CN1524588A (zh) 2004-09-01
HU216961B (hu) 1999-10-28
GR3032986T3 (en) 2000-07-31
HK1003427A1 (en) 1998-10-30
SK283691B6 (sk) 2003-12-02
SK11995A3 (en) 1995-08-09
NO950368D0 (no) 1995-02-01
DE69515536D1 (de) 2000-04-20
SI9500036A (en) 1995-08-31
PL179714B1 (pl) 2000-10-31
NZ270403A (en) 1998-03-25
KR100323942B1 (ko) 2002-07-27
EP0666085A1 (en) 1995-08-09
DK0666085T3 (da) 2000-06-05
ZA95356B (en) 1995-12-14
TW353368U (en) 1999-02-21
MY112427A (en) 2001-06-30
RU2150298C1 (ru) 2000-06-10
CN1111160A (zh) 1995-11-08
JP3747076B2 (ja) 2006-02-22
CN100333807C (zh) 2007-08-29
DE69515536T2 (de) 2000-08-10
NO312748B1 (no) 2002-07-01
CZ289964B6 (cs) 2002-05-15
US5673686A (en) 1997-10-07
AU1140795A (en) 1995-08-10
FI950444A (fi) 1995-08-03
ES2145212T3 (es) 2000-07-01
CA2141465C (en) 2002-01-22
KR950031121A (ko) 1995-12-18
PT101450B (pt) 1999-11-30
HRP950042A2 (en) 1997-04-30
ATE190511T1 (de) 2000-04-15

Similar Documents

Publication Publication Date Title
EP0666085B1 (en) Powder medicament inhaler
RU2393883C1 (ru) Простой ингалятор
US5699789A (en) Dry powder inhaler
EP1061982B1 (en) Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6116239A (en) Inhalation device
EP2731571B1 (en) Improvements relating to delivery devices
US20040211419A1 (en) Inhalers
JP7189149B2 (ja) 乾燥粉末吸入器および乾燥粉末吸入器用スペーサ装置
KR20090074284A (ko) 단위 투약 카트리지 및 드라이파우더 흡입기
US20100154794A1 (en) Inhaler Flow Channel
HU209475B (en) Device for the administration of powdered medicinal substances
SE517229C2 (sv) Kontinuerlig inhalator för torrt pulver
CA2972826A1 (en) Powder dispersion methods and devices
US5988163A (en) Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
AU2002341219A1 (en) Inhalers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL SE

17P Request for examination filed

Effective date: 19951227

17Q First examination report despatched

Effective date: 19970925

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

RTI1 Title (correction)

Free format text: POWDER MEDICAMENT INHALER

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL SE

REF Corresponds to:

Ref document number: 190511

Country of ref document: AT

Date of ref document: 20000415

Kind code of ref document: T

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

ITF It: translation for a ep patent filed

Owner name: JACOBACCI & PERANI S.P.A.

REF Corresponds to:

Ref document number: 69515536

Country of ref document: DE

Date of ref document: 20000420

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: KIRKER & CIE SA

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2145212

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: HOVIONE INTER LIMITED

Free format text: PLURICHEMIE ANSTALT#P.O. BOX 34722#9490 VADUZ (LI) -TRANSFER TO- HOVIONE INTER LIMITED#BAHNHOFSTRASSE 21#6000 LUZERN 7 (CH)

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER & PEDRAZZINI AG

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: ISLER & PEDRAZZINI AG;POSTFACH 1772;8027 ZUERICH (CH)

NLS Nl: assignments of ep-patents

Owner name: HOVIONE INTER LIMITED

Effective date: 20070917

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20120112

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20130320

Year of fee payment: 19

Ref country code: GB

Payment date: 20130320

Year of fee payment: 19

Ref country code: DK

Payment date: 20130326

Year of fee payment: 19

Ref country code: SE

Payment date: 20130326

Year of fee payment: 19

Ref country code: CH

Payment date: 20130326

Year of fee payment: 19

Ref country code: IE

Payment date: 20130326

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20130329

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20130326

Year of fee payment: 19

Ref country code: ES

Payment date: 20120213

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20130325

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20130429

Year of fee payment: 19

Ref country code: NL

Payment date: 20130326

Year of fee payment: 19

BERE Be: lapsed

Owner name: HOVIONE INTER LTD

Effective date: 20140131

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69515536

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20140801

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20140131

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 190511

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140120

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20140120

REG Reference to a national code

Ref country code: GR

Ref legal event code: ML

Ref document number: 20000400686

Country of ref document: GR

Effective date: 20140801

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140801

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140801

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140131

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140131

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140801

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20140930

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69515536

Country of ref document: DE

Effective date: 20140801

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140120

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140131

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140120

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140121

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140131

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140120

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140131

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20150330

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140121

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140120