EP0191438A2 - Capsule double pour contenir des médicaments - Google Patents

Capsule double pour contenir des médicaments Download PDF

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Publication number
EP0191438A2
EP0191438A2 EP86101626A EP86101626A EP0191438A2 EP 0191438 A2 EP0191438 A2 EP 0191438A2 EP 86101626 A EP86101626 A EP 86101626A EP 86101626 A EP86101626 A EP 86101626A EP 0191438 A2 EP0191438 A2 EP 0191438A2
Authority
EP
European Patent Office
Prior art keywords
capsule
web
capsules
bodies
another
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86101626A
Other languages
German (de)
English (en)
Other versions
EP0191438A3 (fr
Inventor
Josef Hofer
Friedrich Stanislaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of EP0191438A2 publication Critical patent/EP0191438A2/fr
Publication of EP0191438A3 publication Critical patent/EP0191438A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Definitions

  • the invention relates to a capsule, in particular made of hard gelatin, for taking medication.
  • capsules allow an exact dosage of the drug. They are also preferably used to apply unpleasant tasting or smelling drugs orally.
  • additives are added to the capsule material, such as preservatives, plasticizers, flavors or colors.
  • Known capsules made of hard gelatin consist of two parts, namely a capsule body and a capsule cap, which are inserted into one another after filling.
  • the sizes of such hard gelatin capsules are standardized and have a capacity between 0.13 ml and about 1.4 ml.
  • the invention has for its object to provide a capsule arrangement with which the drug dosage can be varied in a simple manner.
  • this object is achieved in that two capsule bodies, each of which can be closed with a capsule cap, are connected to one another by a breakable web.
  • the separation according to the invention into two contiguous but separately ingestible capsules enables a larger amount of medicament to be distributed over two capsules which are taken one after the other. By connecting the capsules, the patient is reminded that two capsules - but no longer - should be taken.
  • the double capsule according to the invention also makes it possible to save dosage forms for certain medications, the dose of which is typically increased in the course of therapy. Instead of having to provide different capsule sizes and corresponding packs, the patient can be prescribed to take only one capsule at the start of therapy and to increase the dose to the entire double capsule at a certain time. Different filling quantities for the two capsule bodies connected to one another can further increase the variation possibilities with regard to the dosage.
  • the invention also enables the combination of two incompatible dosage forms, which can be taken by the patient with practically one grip, without confusion or mistakes being possible. The same applies to the combination of two different dosage forms.
  • chronobiologically constructed pharmaceutical forms can be simplified with the double capsule in a very sensible way, for example by taking the first partial capsule in the morning and the second partial capsule in the evening.
  • Retard and initial pellets can also be combined with one another without mixing problems according to the teaching of the invention.
  • the web connects opposite bottoms of two capsule bodies and is provided with a predetermined breaking point.
  • the web is preferably made of hard gelatin and integrally formed with both capsule bodies.
  • a plurality of capsule bodies in a row are each connected to one another by frangible webs.
  • the preferred embodiments of the webs described with the aid of the double capsule can also be transferred to the capsule series.
  • FIG. 1 schematically shows a double capsule 10, which is composed of two capsule bodies 12, 12 'and the associated capsule caps 14, 14'.
  • a web 16 connects coaxially the longitudinal axes of both capsule bodies 12, 12 'the bottoms 18, 18' of the capsule body.
  • a predetermined breaking point 20 is formed in the web 16 so that the two capsule bodies 12, 12 'can be separated from one another.
  • the double capsule 10 according to the invention can e.g. in a further development of the well-known immersion process for the production of individual capsules.
  • immersion sticks arranged in rows on metal slats are immersed in gelatin solution. So that a uniform gelatin layer forms, the slats are turned around after being pulled out of the solution.
  • This process can be modified in order to produce the double capsules according to the invention in such a way that the drop extension which is formed when the dip sticks are pulled out of the solution in the middle of the subsequent capsule base is used to form the web according to the invention.
  • two capsules can be joined together, depending on the dry state, if necessary with heating.
  • the capsules are also filled similarly to conventional capsules. After filling the upper capsule body and sealing it by means of the capsule cap, a rotation of 180 ° takes place and the process is repeated.
  • FIG. 2 shows two capsules 22, 22 'which are produced in a conventional manner by immersion and which are connected to one another in the area of the drop extension 24, 24' in such a way that a continuous, integral double capsule is formed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP86101626A 1985-02-11 1986-02-07 Capsule double pour contenir des médicaments Withdrawn EP0191438A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE8503747U 1985-02-11
DE19858503747 DE8503747U1 (de) 1985-02-11 1985-02-11 Doppel-Kapsel zur Aufnahme von Medikamenten

Publications (2)

Publication Number Publication Date
EP0191438A2 true EP0191438A2 (fr) 1986-08-20
EP0191438A3 EP0191438A3 (fr) 1987-09-23

Family

ID=6777300

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86101626A Withdrawn EP0191438A3 (fr) 1985-02-11 1986-02-07 Capsule double pour contenir des médicaments

Country Status (3)

Country Link
EP (1) EP0191438A3 (fr)
JP (1) JPS61217166A (fr)
DE (1) DE8503747U1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225565A2 (fr) * 1985-12-06 1987-06-16 Boehringer Ingelheim Kg Capsule divisible
EP0274345B1 (fr) * 1986-11-13 1991-08-07 Warner-Lambert Company Capsule divisible

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283566C (fr) *
DE1516488A1 (de) * 1964-10-16 1970-01-08 Lilly Co Eli Einsteckkapsel
DE2024841A1 (en) * 1969-06-18 1971-04-22 Scherer G C Ltd , Windsor, Ontario (Kanada) Capsule case for medications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283566C (fr) *
DE1516488A1 (de) * 1964-10-16 1970-01-08 Lilly Co Eli Einsteckkapsel
DE2024841A1 (en) * 1969-06-18 1971-04-22 Scherer G C Ltd , Windsor, Ontario (Kanada) Capsule case for medications

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225565A2 (fr) * 1985-12-06 1987-06-16 Boehringer Ingelheim Kg Capsule divisible
EP0225565A3 (en) * 1985-12-06 1988-06-15 Boehringer Ingelheim Kg Divisible capsule
EP0274345B1 (fr) * 1986-11-13 1991-08-07 Warner-Lambert Company Capsule divisible

Also Published As

Publication number Publication date
EP0191438A3 (fr) 1987-09-23
DE8503747U1 (de) 1985-05-09
JPS61217166A (ja) 1986-09-26

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