EP0005848B1 - Aminoalcools N-alcoylés et leurs sels, procédé pour leur préparation et compositions pharmaceutiques les contenant - Google Patents

Aminoalcools N-alcoylés et leurs sels, procédé pour leur préparation et compositions pharmaceutiques les contenant Download PDF

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EP0005848B1
EP0005848B1 EP79101724A EP79101724A EP0005848B1 EP 0005848 B1 EP0005848 B1 EP 0005848B1 EP 79101724 A EP79101724 A EP 79101724A EP 79101724 A EP79101724 A EP 79101724A EP 0005848 B1 EP0005848 B1 EP 0005848B1
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radical
formula
compound
alk
hydrogen
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EP0005848A1 (fr
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Franz Dr. Ostermayer
Markus Dr. Zimmermann
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Novartis AG
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Ciba Geigy AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Definitions

  • the present invention relates to new N-alkylated amino alcohols of the formula in which Ar is an unsubstituted or hydroxyl-substituted aromatic radical, n is zero or 1 and Alk is an alkylene radical having 2 to 5 carbon atoms, the nitrogen atom and the oxygen atom, or, if n is zero, the phenyl radical by at least two carbon atoms are separated from one another, and their salts, processes for their preparation and pharmaceutical preparations containing such compounds and their use.
  • a radical of aromatic character Ar is primarily a monocyclic carbo- or heterocyclic radical of aromatic character with 5 to 6 ring members and at most 3 heteroatoms, primarily nitrogen, oxygen and / or sulfur atoms, as ring members.
  • Ar is therefore in particular phenyl, furthermore pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, furyl, pyrryl, thienyl, oxazolyl, thiazolyl, pyrazolyl, imidazolyl or thiadiazolyl.
  • the group of the formula is attached to a carbon atom in an Ar radical and can take any of the possible positions.
  • a phenyl radical substituted by a hydroxyl group said group is preferably in the 4-position.
  • the rest of the formula can substitute the salicylamide ring in any of the possible positions.
  • Alkylene Alk can be straight-chain or branched and is. e.g. 1,2-ethylene, 1,2-, 2,3- or 1,3-propylene, 1,4- or 2,4-butylene or 2-methyl-2,4-butylene, preferably that associated with the nitrogen atom Carbon atom is branched.
  • Pyridyl is 2-, 3- or 4-pyridyl; Pyridazinyl is 3-or 4-pyridazinyl; Pyrimidinyl is 2-, 4- or 5-pyrimidinyl, while pyrazinyl is 2-pyrazinyl.
  • Furyl is 2- or 3-furyl; Pyrryl is 2- or 3-pyrryl; Thienyl is 2- or 3-thienyl, while oxazolyl is 2- or 4-oxazolyl, thiazolyl 2-, 4- or 5-thiazolyl, pyrazolyl 3- or 4-pyrazolyl, imidazolyl 2- or 4-imidazolyl and thiadiazolyl 1,2, 4-thiadiazol-3- or -5-yl, or 1,3,4-thiadiazol-2-yl.
  • Salts of compounds of formula 1 are primarily acid addition salts and in particular pharmaceutically acceptable, non-toxic acid addition salts with suitable inorganic acids, such as hydrochloric acid, hydrobromic acid, sulfuric acid or phosphoric acid, or with suitable organic aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic carbon Sulphonic acids, such as formic acid, acetic acid, propionic acid, succinic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, ascorbic acid, maleic acid, fumaric acid, pyruvic acid, benzoic acid, anthranilic acid, 4-hydroxybenzoic acid, salicyl acid, methanesulfonic acid, methanoic acid, phenyl acetic acid, phenyl acetic acid, phenyl acetic acid, phenyl acetic acid, methanoic acid, methanoic acid, phenolic acetic acid
  • suitable inorganic acids such
  • the free compounds and the salts are also to be understood as meaningful and appropriate, if appropriate, the corresponding salts or free compounds.
  • the new compounds have valuable pharmacological properties.
  • the main effect of the new compounds is to stimulate cardial ⁇ -receptors, which e.g. can be demonstrated in the heart as a positive inotropic or positive chronotropic effect.
  • concentrations above 0.3 ng / ml in the isolated guinea pig atrium an increase in frequency and concentration is achieved.
  • the positive isotropic and chronotropic effect can also be demonstrated in vivo (anesthetized cat) as an increase in the maximum rate of pressure increase in the left ventricle (dp / dt) and the heart rate from about 0.3 ⁇ g / kg iv.
  • Individual compounds show a clearly preferred inotropic effect.
  • the new compounds also block adrenergic ⁇ -receptors, which can be shown, for example, from about 100 ng / ml as an inhibition of noradrenaline contraction on the isolated vas deferens of the rat.
  • the new compounds also bring about a drop in blood pressure, which can be shown from around 0.003 mg / kg after iv application to the anesthetized cat.
  • Some of the new compounds show a clearly preferred stimulation of the ⁇ 1 -receptors of the heart over the ⁇ 2 -receptors in blood vessels and trachea and are therefore to be regarded as cardioselective ⁇ -stimulators.
  • the new compounds can thus be used as ⁇ -stimulators, in particular as positively inotropically active agents for the treatment of heart failure, alone or in combination with other preparations, such as e.g. Cardiac glycosides can be used.
  • Guinea pigs of both sexes weighing 250-450 g were anesthetized intraperitoreally with urethane (1.5 g / kg) and the atria were mounted in an organ bath.
  • the frequency of the right and the contraction force of the left atria were continuously recorded on the right, spontaneously beating and on the left, electrically stimulated with a constant frequency of 2.5 Hz (isometric contraction under 0.5 g diastolic preload).
  • the organ bath contained 50 ml of Krebs-Henseleit solution at 32 ° C, oxygenated with a mixture of 95% O 2 and 5% CO 2 . The substances were added cumulatively.
  • the inotropic effectiveness of the substance listed in Table 1, which can be prepared according to the present application, is about 200 times stronger than that of comparative substance II in accordance with the reciprocal ratio of the respective EC 50.
  • the extent of the inotropic stimulation of substance I is stronger than that of comparative substance II and corresponds essentially to that of full stimulation by isoproterenol.
  • the chronotropic activity of compound I is about 300 times stronger than that of control substance II, while the extent of the chronotropic stimulation is somewhat higher than that of control substance II.
  • the inotropic activity (increase in dP / dt max) of the substance I listed in Table 2 is about 30 times stronger, the chronotropic activity about 150 times stronger than that of the comparative compound II.
  • the extent of the effects on the heart is for the compounds I and II are the same and correspond to that of full stimulation by isoproterenol.
  • the doses required for a decrease in blood pressure for compound I are significantly higher than the doses effective at the heart, which shows that, in contrast to isoproterenol, this compound has a cardioselective effect.
  • a further expression of the cardioselective activity of the tested compounds is the fact that the extent of the decrease in blood pressure achieved with them is less than that caused by isoproterenol.
  • the invention relates in particular to compounds of the formula I in which Ar is in each case unsubstituted or substituted by 1 or 2-hydroxy groups phenyl or pyridyl, e.g. 2- or 3- or 4-pyridyl, or pyridazinyl e.g. 3- or 4- or 6-pyridazinyl, or pyrimidinyl e.g. 2- or 4- or 5-pyrimidinyl, or pyrazinyl, e.g. 2-pyrazinyl, or furyl, e.g. 2- or 3-furyl, or pyrryl, e.g. 2- or 3-pyrryl, or thienyl, e.g.
  • 2- or 3-thienyl or oxazolyl, e.g. 2- or 4-oxazolyl, or thiazolyl, e.g. 2- or 4-thiazolyl, or pyrazolyl, e.g. 3- or 5-pyrazolyl, or imidazolyl, e.g.
  • alk is an alkylene radical having 2 to 4 carbon atoms, where the nitrogen atom and the oxygen atom, or, if n is zero, the phenyl radical are separated from one another by 2 to 3 carbon atoms, and n is zero or 1, or their salts, in particular their pharmaceutically acceptable non-toxic acid addition salts.
  • the invention relates primarily to compounds of formula 1, in which Ar is in each case unsubstituted or substituted by 1 or 2 hydroxyl groups phenyl, 2- or 3-pyridyl, 2- or 3-furyl or 2- or 3-thienyl, and Alk has an alkylene radical Means 2 to 3 carbon atoms, the nitrogen atom and the oxygen atom, or, if n is zero, the phenyl radical are separated from one another by 2 to 3 carbon atoms, n is zero or 1, or their salts, in particular pharmaceutically acceptable non-toxic Acid addition salts.
  • the invention also relates in particular to the following compounds of the formula 1, in which Ar in each case denotes unsubstituted or substituted by 1 or 2 hydroxyl groups phenyl, 2- or 3-pyridyl, 2-furyl or 2-thienyl and alk an alkylene radical having 2 to 3 carbon atoms, and n stands for zero or 1, or their salts, in particular their pharmaceutically acceptable non-toxic acid addition salts.
  • the invention relates in particular to the compounds of the formula I or their salts mentioned in the examples, in particular their pharmaceutically acceptable, non-toxic acid addition salts.
  • the new compounds of formula I are prepared in a manner known per se. They can be obtained, for example, by using a compound of the formula with a compound of the formula wherein one of the groups Z 1 and Z 2 represents a reactive esterified hydroxy group and the other represents the primary amino group, and X represents hydroxy, or wherein X I and Z together represent the epoxy group and Z 2 represents the primary amino group, Ar , Alk and n have the above meaning, and / or, if desired, convert an obtained free compound into a salt or an obtained salt into a free compound, and / or, if desired, an obtained isomer mixture into the isomers or an obtained Racemat separates into the antipodes.
  • a reactive esterified hydroxyl group Z or Z 2 is a strong acid, in particular a strong inorganic acid, such as a hydrohalic acid, in particular hydrochloric, bromine or hydroiodic acid, or sulfuric acid, or a strong organic acid, in particular a strong organic acid Sulphonic acid, such as an aliphatic or aromatic sulphonic acid, for example methanesulphonic acid, 4-methylphenylsulphonic acid or 4-bromophenylsulphonic acid, esterified hydroxyl group, and primarily represents halogen, for example chlorine, bromine or iodine, or aliphatic or aromatically substituted sulphonyloxy, for example methylsulphonyloxy or 4-methylphenylsulphonyloxy represents.
  • a strong inorganic acid such as a hydrohalic acid, in particular hydrochloric, bromine or hydroiodic acid, or sulfuric acid
  • a strong organic acid in particular a strong organic acid Sulphonic acid, such
  • the above reaction is carried out in a manner known per se, particularly when using a starting material with a reactive esterified hydroxy group, advantageously in the presence of a basic agent such as an inorganic base, e.g. an alkali metal or alkaline earth metal carbonate or hydroxide, or an organic basic agent such as an alkali metal lower alkanolate and / or an excess of the basic reactant and usually in the presence of a solvent or mixture of solvents and, if necessary, with cooling or heating, e.g. in a temperature range from about -20 ° C to about + 150 ° C, in an open or closed vessel and / or in an inert gas atmosphere, e.g. in a nitrogen atmosphere.
  • a basic agent such as an inorganic base, e.g. an alkali metal or alkaline earth metal carbonate or hydroxide, or an organic basic agent such as an alkali metal lower alkanolate and / or an excess of the basic reactant and usually in the presence of a solvent
  • a compound of the formula Ar-H in which any hydroxyl groups which may be present can be protected by a protective group, for example one of those described below, with a haloacetyl halide, for example chloroacetyl chloride, in the presence of a suitable Lewis acid, for example aluminum chloride, according to Friedel-Crafts Method on a carbon atom of the radical Ar halogenoacetylieren and in the Ar-haloacetyl compound thus obtainable, for example by treatment with a suitable hydride reducing agent, reduce the carbonyl group to the carbinol group; if desired, a halogen Z can be obtained, for example by treating with ammonia or a suitable derivative thereof, such as hexamethylenetetramine and decomposing the compound obtained with dilute mineral acid, or by reacting it with an alkali metal salt of the phthalimide and cleaving the obtained
  • Starting materials of the formula II, in which X and Z 1 together are epoxy can, for example, by cyclization of a compound of the formula II, in which H, hydroxy and Z 1 represent a reactive esterified hydroxyl group, for example chlorine or methanesulfonyloxy, using alkaline reagents, for example a mixture of dilute sodium hydroxide solution and tetrabutyl ammonium chloride in a suitable solvent, for example methylene chloride.
  • alkaline reagents for example a mixture of dilute sodium hydroxide solution and tetrabutyl ammonium chloride in a suitable solvent, for example methylene chloride.
  • Starting materials of the formula III can be obtained, for example, by reacting a hydroxysalicylamide with a dihaloalkane corresponding to the meaning of alk, for example a chlorobromo or dibromoalkane in the presence of an alkaline condensing agent, such as an alkali metal carbonate. These reactions are carried out in a customary manner, protecting groups on the hydroxyl groups being split off simultaneously or, as described below.
  • the compounds of the formula can also be prepared by working in a compound of the formula wherein Ar 1 has the meaning of Ar or a radical Ar which is substituted by 1 to 2 groups which can be converted into hydroxyl, X 2 , X 3 and X 4 are each hydrogen or one by water Substitution-replaceable substituents and X 5 represents hydrogen, or X 2 and X 3 and / or X 4 and X 5 together represent a divalent radical which can be replaced by two hydrogen atoms, with the proviso that at least one of the radicals X 2 , X 3 and X 4 is different from hydrogen, or at least Ar means a radical Ar which is substituted by 1 to 2 groups which can be converted into hydroxyl, or at least X 2 and X 3 together or X 4 and X 5 together a divalent one which can be replaced by two hydrogen atoms Represent radical, or in a salt thereof, which replaces X 2 , X 3 , X 4 or X 4 and X 5 together with hydrogen together with
  • cleavage of the groups X 2 , X 3 or X 4 or in each case X 2 and X 3 or X 4 and X 5 together and the hydroxyl substituents present in a radical Ar 1 is carried out by means of solvolysis, such as hydrolysis, alcoholysis or acidolysis, or by means of Reduction including hydrogenolysis made.
  • a particularly suitable, removable group X 3 and X 4 and hydroxyl protective groups in an Ar 1 radical is primarily a hydrogenolytically removable a-aryl-lower alkyl group, such as an optionally substituted 1-polyphenyl or 1-phenyl-lower alkyl group, in which substituents, in particular of the phenyl part , for example lower alkyl, such as methyl, or lower alkoxy, such as methoxy, and primarily benzyl.
  • a group X 3 and in particular X 2 and X 4 and hydroxyl protective groups in an Ar 1 radical can also be a solvolytic, such as hydrolytic or acidolytic, furthermore a reductively, including hydrogenolytically, cleavable radical, in particular a corresponding acyl radical, such as the acyl radical of an organic Carboxylic acid, for example lower alkanoyl, such as acetyl, or aroyl, such as benzoyl, furthermore the acyl radical of a half ester of carbonic acid, such as lower alkoxycarbonyl, for example methoxycarbonyl, ethoxycarbonyl or tert.-butyloxycarbonyl, 2-halogeno lower alkoxycarbonyl, for example 2,2,2-trichloroethoxycarbonyl or 2- Iodoethoxycarbonyl, optionally substituted 1-phenyl-lower alkoxycarbonyl, for example benzyloxycarbonyl or dipheny
  • a cleavable radical formed by X 2 and X 3 and / or X 4 and X 5 is primarily a hydrogenolytically cleavable group, such as optionally substituted 1-phenyl-lower alkylidene, where substituents, in particular of the phenyl part, are, for example, lower alkyl or lower alkoxy can, and especially benzylidene, and solvolytically, in particular hydrolytically removable groups, such as lower alkylidene, for example methylene or isopropylidene, or 1-phenyl-lower alkylidene, the phenyl part of which is optionally substituted by lower alkyl, such as methyl or lower alkoxy, such as methoxy, in particular benzylidene or cycloalkylidene , for example cyclopentylidene or cyclohexylidene.
  • substituents, in particular of the phenyl part are, for example, lower alkyl or
  • Starting materials which can be used in the form of salts are primarily in the form of acid addition salts, e.g. with mineral acids, as well as with organic acids.
  • Hydrogenolytically removable radicals X 2 , X 3 and / or X 4 in particular optionally substituted 1-phenyl-lower alkyl groups, furthermore also suitable acyl groups, such as optionally substituted 1-phenyl-lower alkoxycarbonyl, and also formed by the groups X 2 and X 3 and X 4 and X 5 together , optionally substituted 1-phenyl-lower alkylidene groups, and hydroxyl protective groups of this type present in an Ar 1 radical can be split off by treatment with catalytically activated hydrogen, for example with hydrogen in the presence of a nickel catalyst, such as Raney nickel, or a suitable noble metal catalyst.
  • a nickel catalyst such as Raney nickel
  • Hydrolytically cleavable groups X 2 , X 3 and / or X 4 such as acyl residues of organic carboxylic acids, for example lower alkanoyl, and semi-esters of carbonic acid, for example lower alkoxycarbonyl, furthermore, for example, trityl residues, and by the residues X 2 and X 3 and / or X 4 and X s together formed lower alkylidene, 1-phenyl-lower alkylidene or cycloalkylidene groups and hydroxyl protective groups of this type present in an Ar 1 radical can, depending on the type of such radicals, be treated with water under acidic or basic conditions, for example in the presence of a mineral acid such as hydrogen chloride - or sulfuric acid, or an alkali metal or alkaline earth metal hydroxide or carbonate or an amine such as isopropylamine.
  • a mineral acid such as hydrogen chloride - or sulfuric acid
  • Acidolytically removable radicals X 2 , X 3 and / or X 4 and / or hydroxyl protective groups in an Ar 1 radical are in particular certain acyl radicals of half-esters of carbonic acid, such as, for example, tert.-lower alkoxycarbonyl or optionally substituted diphenylmethoxycarbonyl radicals, and also also tert.-lower alkyl radicals ; these can be eliminated by treatment with suitable strong organic carboxylic acids, such as optionally substituted by halogen, in particular fluorine, lower alkanecarboxylic acids, primarily with trifluoroacetic acid (if necessary in the presence of an activating agent such as anisole) and with formic acid.
  • suitable strong organic carboxylic acids such as optionally substituted by halogen, in particular fluorine, lower alkanecarboxylic acids, primarily with trifluoroacetic acid (if necessary in the presence of an activating agent such as anisole) and with formic acid.
  • Reductively cleavable radicals X 2 , X 3 and / or X 4 and / or hydroxyl protective groups in a radical Ar 1 are also understood to mean those groups which cleave off when treated with a chemical reducing agent (in particular with a reducing metal or a reducing metal compound) will.
  • Such residues are in particular 2-halogeno lower alkoxycarbonyl or arylmethoxycarbonyl, which, for example, when treated with a reducing heavy metal, such as zinc, or with a reducing heavy metal salt, such as Chromium (II) salt, for example chloride or acetate, usually in the presence of an organic carboxylic acid, such as formic acid or acetic acid, and can be split off from water.
  • Protecting groups which are present on hydroxy groups which may be present in a radical Ar 1 correspond to the groups mentioned above which can be split off and replaced by hydrogen using the methods described, such groups being split off simultaneously with other groups in the course of the process described or subsequently in a separate process measure .
  • suitable reactants may also function as such at the same time and, if necessary, with cooling or heating, e.g. in an open or closed vessel and / or in the atmosphere of an inert gas, e.g. Nitrogen.
  • an inert gas e.g. Nitrogen.
  • the starting materials of the formula IV can be obtained in a manner known per se by reacting a compound of the formula Ar 1 -H with a haloacetyl halide, for example chloroacetyl chloride, in the presence of a suitable Lewis acid, for example aluminum chloride, by the Friedel-Crafts method Carbonyl group in the Ar 1 -haloacetyl compound thus obtained or obtained in another, customary manner is reduced to the carbinol group, for example by means of sodium borohydride, and the compound obtained with an amine of the formula wherein X 3 has the meaning given, and X 4 or X 4 and X 5 together are different from hydrogen.
  • a haloacetyl halide for example chloroacetyl chloride
  • a suitable Lewis acid for example aluminum chloride
  • the reduction can also be carried out using activated hydrogen in the presence of a hydrogenation catalyst, for example a platinum-on-carbon catalyst.
  • Carbonyl compounds of formula (IVc) in turn can by reacting a compound of formula with a compound of the formula R-Hal (IVe), in which R has the above meaning, and a compound (IVe), for example a halogen ketone, for example chloroacetone, can be obtained in a conventional manner.
  • a group X 8 which can be split off by hydrogenolysis is primarily an a-aryl-lower alkyl group, such as an optionally substituted 1-phenyl-lower alkyl group, in which substituents, for example lower alkoxy, can be such as methoxy, and very particularly benzyl.
  • Protecting groups which are attached to the optionally substituted hydroxyl groups Ar 2 correspond to the groups previously mentioned for X 8 and can be split off by the methods described and replaced by hydrogen, such groups being used in the course of the process described simultaneously with other groups or subsequently in a separate group Procedural measure to be split off.
  • Starting materials of the formula V with a group X 6 of the formula Vb can also be in the isomeric form of ring tautomers of the formula where Alk 3 corresponds to the meaning of Alk, and the oxygen and nitrogen atoms are bonded to the same carbon atom.
  • alkyl-ylidene group Alk is, for example, methine or acethyl-ylidene, while an alkylidene group Alk 2 is, for example, methylene, ethylidene or 1-methyl-ethylidene.
  • the reduction of the nitrogen-carbon double bond in starting materials of the formula V which contain a group Va or Vb as X 6 , while Ar 2 , Y, X 8 and n have the meaning given under the formula V (or in the isomeric compounds of Formula Vg of the oxygen-carbon-nitrogen bond) for the nitrogen-carbon single bond can be carried out in a manner known per se, for example by treatment with catalytically activated hydrogen, such as hydrogen, in the presence of a suitable hydrogenation catalyst, for example a nickel, platinum or palladium catalyst, groups X 8 which can be split off by hydrogenolysis are simultaneously split off and replaced by hydrogen; or one works with a suitable hydride reducing agent, such as an alkali metal borohydride, for example sodium borohydride.
  • a suitable hydride reducing agent such as an alkali metal borohydride, for example sodium borohydride.
  • a carbonyl radical Y if present, is reduced to the hydroxymethylene radical at the same time as the group Va or Vb, and when using hydride reducing agents, acyl radicals of carboxylic acids such as acetic acid, such as acetic acid, may also be present as radicals X a and in the same operation be split off.
  • hydride reducing agents such as, for example, sodium borohydride or diborane.
  • the above reduction reactions are carried out in a manner known per se, usually in the presence of an inert solvent and, if necessary, with cooling or heating, for example in a temperature range from about -20 ° C. to about + 150 ° C., and / or in a closed one Vessel carried out under pressure and / or in an inert gas, for example nitrogen atmosphere.
  • a starting material of the formula V can be prepared in a manner known per se, if appropriate in situ, ie under the conditions of the process described.
  • a compound of the formula Ar 2 -H (Vi) can be acetylated with an acetic acid halide or anhydride in the presence of a Lewis acid and the acetyl group in the intermediate obtained can then be converted into the glyoxyloyl group, for example by treatment with a suitable oxidizing agent, such as selenium dioxide.
  • Such a glyoxyl compound, or, if desired, a suitable derivative thereof, such as an acetal, can then be reacted with an amine of the formula can be reacted to a starting product of the formula V with the group X6 of the formula Va, in which Y represents the carbonyl group.
  • halogenate a compound of the formula (Vi) with a haloacetyl halide for example chloroacetyl chloride
  • a suitable Lewis acid for example aluminum chloride
  • Friedel-Crafts method to give the corresponding Ar 2 -chloroacetyl compound
  • a suitable hydride reducing agent reduce the carbonyl to carbinol group, and convert the halogen atom into the primary amino group by treating with ammonia or a suitable derivative thereof, such as hexamethylenetetramine and decomposing the reaction product formed with dilute acid, such as aqueous hydrochloric acid.
  • the halogen atom is reacted with a 1-aryl-lower alkylamine, for example benzylamine or a di- (1- aryl-lower alkyl) -amine, for example dibenzylamine, is exchanged for the corresponding 1-aryl-lower alkylamino or di- (1-aryl-lower alkyl) -amino group and the compound obtained, for example the corresponding dibenzylamino compound, with the oxo compound of the formula (V1) under the reducing conditions of the process implements.
  • a 1-aryl-lower alkylamine for example benzylamine or a di- (1- aryl-lower alkyl) -amine, for example dibenzylamine
  • the reducing agent used here is primarily catalytically activated hydrogen, for example hydrogen in the presence of a heavy metal hydrogenation catalyst or a mixture thereof, such as a palladium and / or platinum catalyst.
  • groups X 8 which can be split off by hydrogenolysis for example benzyl groups, are split off, the carbonyl group which may be present is reduced to the carbinol group and at the same time the nitrogen-carbon double bond is reduced to the corresponding nitrogen-carbon single bond.
  • Oxo compounds of the formula (V1), in which n is 1, are, for example, by reacting a dihydroxy compound of the formula with a haloalkanone compound of the formula R - Hal (IVe), for example chloroacetone, in the presence of an alkaline condensing agent, for example potassium carbonate, or an organic base such as triethylamine.
  • an alkaline condensing agent for example potassium carbonate, or an organic base such as triethylamine.
  • Starting products of the formula V with a group X 6 of the formulas Vc or Vd can be prepared in a manner known per se, for example by reacting a formyl compound of the formula Ar 2 -CHO (Vn) with hydrogen cyanide and in the cyanohydrin intermediate thus obtainable the cyano- hydrolyzed to the carboxyl group, for example under acidic conditions.
  • the Ar 2 -2-hydroxyacetic acid obtained in this way or via the intermediate stages imidchloride, imido-lower alkyl ester and lower alkyl ester is then reacted with an amine of the formula (Vj) in the presence of a suitable condensing agent, for example a carbodiimide such as dicyclohexylcarbodiimide, after which a Starting material of the formula V with the group X 6 of the formula (Vc) is obtained.
  • a suitable condensing agent for example a carbodiimide such as dicyclohexylcarbodiimide
  • the carbonyl group can be converted to the carbinol group and the aliphatic carbamoyl group to the group of the formula reduce at the same time, for example by means of a hydride reducing agent, in particular diborane.
  • the new compounds of formula I can also be obtained by using a compound of formula wherein Ar 3 has the meaning of Ar, or represents a radical Ar which is substituted by 1 to 2 groups which can be converted into hydroxyl by means of ammonolysis, Xg is hydrogen or a group which can be split off by means of ammonolysis, or a reactive derivative of one of the carboxylic acids defined in formula VI , reacted with ammonia, and at the same time cleaves any Xg residues present and replaced them with hydrogen.
  • Ar 3 has the meaning of Ar, or represents a radical Ar which is substituted by 1 to 2 groups which can be converted into hydroxyl by means of ammonolysis
  • Xg is hydrogen or a group which can be split off by means of ammonolysis, or a reactive derivative of one of the carboxylic acids defined in formula VI , reacted with ammonia, and at the same time cleaves any Xg residues present and replaced them with hydrogen.
  • Residues Xg which can be split off hydrolytically and in particular ammonolytically are acyl residues of organic carboxylic acids, e.g. Aroyl such as benzoyl or lower alkanoyl such as acetyl.
  • Reactive derivatives of the carboxylic acids defined in formula VI are e.g. the halides, such as the chlorides or bromides, furthermore the azides, and acid anhydrides, in particular mixed acid anhydrides with e.g. Lower alkanecarboxylic acids, such as acetic acid or propionic acid, lower alkoxyalkanecarboxylic acids, such as 2-methoxyacetic acid.
  • Reactive derivatives of formula VI are especially esters, e.g. with lower alkanols, such as methanol, ethanol, isopropanol, tert-butanol, furthermore with aryl-lower alkanols, for example optionally through lower alkyl, e.g.
  • Methyl or lower alkoxy e.g. Methoxy, substituted benzyl alcohol, or phenols which are optionally activated by suitable substituents, e.g. by halogen, about 4-halogen, such as 4-chloro, lower alkoxy, about 4-lower alkoxy, such as 4-methoxy, 4-nitro or 2,4-dinitro, such as 4-chlorophenol, 4-methoxyphenol, 4-nitro- or 2, 4-Dinitrophenol, further with cycloalkanols, such as cyclopentanol or cyclohexanol, which may be substituted by lower alkyl, for example Methyl can be substituted.
  • the reaction is carried out in a manner known per se, usually in the presence of an inert solvent e.g. carried out in a temperature range of approximately -10 ° to + 50 ° C in a closed vessel.
  • the starting materials of formula VI may be obtained in known manner by reacting a compound of the formula Ar 3 - brominated COCH3, the carbonyl group in the thus obtained Ar 3 -Halogenacetyl connection to the carbinol group, for example using diborane, reduced and this with an amine of the formula wherein Xg has the meaning given, or a reactive derivative thereof.
  • the Ar 3 haloacetyl compound can also be reacted with the amine of the formula Vla and the carbonyl group subsequently converted into the carbinol group.
  • the reduction can also be carried out using activated hydrogen in the presence of a hydrogenation catalyst, for example a platinum-on-carbon catalyst.
  • Carbonyl compounds of the formula (VIc), in which n is 1, can in turn be obtained by reacting a compound of the formula with a compound of the formula R-Hal (IVe), in which Hal represents halogen, in particular chlorine, can be obtained in a manner known per se.
  • the new compounds are obtained in free form or in the form of their salts which are also encompassed by the invention, the new compounds or salts thereof also being able to be present as hemi-, mono-, sesqui or polyhydrates thereof.
  • Acid addition salts of the new compounds can be carried out in a manner known per se, e.g. by treatment with basic agents, such as alkali metal hydroxides, carbonates or bicarbonates or ion exchangers, are converted into the free compounds.
  • free bases obtained can be mixed with organic or inorganic acids, e.g. form with the acids mentioned, acid addition salts, the production of which in particular uses those acids which are suitable for the formation of pharmaceutically acceptable salts.
  • Oxalates or perchlorates can also be used to purify the free bases obtained by converting the free bases into salts, separating and cleaning them, and releasing the bases from the salts.
  • the new compounds can also be used as optical antipodes or racemates, or if they contain at least two asymmetric carbon atoms, as racemate mixtures lie.
  • the starting materials can also be used as optical antipodes.
  • Racemic mixtures obtained can, due to the physicochemical differences of the diastereoisomers, in a known manner, e.g. by chromatography and / or fractional crystallization into which the two stereoisomeric (diastereomeric) racemates are separated.
  • Racemates obtained can be broken down into the antipodes by methods known per se, e.g. by recrystallization from an optically active solvent, by treatment with suitable microorganisms or by reaction with an optically active substance, in particular acids, which forms salts with the racemic compound, and separation of the salt mixture obtained in this way, e.g. due to different solubilities, into the diastereomeric salts, from which the free antipodes can be released by the action of suitable agents.
  • optically active acids are e.g. the D and L forms of tartaric acid, di-o-toluene tartaric acid, malic acid, mandelic acid, camphorsulfonic acid, glutamic acid, aspartic acid or quinic acid. The more effective of the two antipodes is advantageously isolated.
  • the invention also relates to those embodiments of the process according to which one starts from a compound which is obtainable as an intermediate at any stage of the process and carries out the missing process steps, or terminates the process at any stage, or in which a starting material is formed under the reaction conditions, or in which a reaction component is optionally in the form of its salts.
  • the starting materials are known or, if new, can be used according to methods known per se, such as above, e.g. analogous to that described in the examples.
  • the new connections can e.g. find use in the form of pharmaceutical preparations which contain a pharmacologically effective amount of the active substance, optionally together with pharmaceutically usable excipients, which become enteral, e.g. oral, or parenteral administration, and can be inorganic or organic, solid or liquid.
  • tablets or gelatin capsules are used which contain the active ingredient together with diluents, e.g. Lactose, dextrose, sucrose, mannitol, sorbitol, cellulose and / or glycerin and / or lubricants, e.g.
  • Tablets can also contain binders, e.g. Magnesium aluminum silicate, starches such as corn, wheat, rice or arrowroot starch, gelatin, tragacanth, methyl cellulose, sodium carboxymethyl cellulose and / or polyvinyl pyrrolidone, and, if desired, disintegrants, e.g. Starches, agar, alginic acid or a salt thereof, such as sodium alginate, and / or effervescent mixtures, or adsorbents, colorants, flavors and sweeteners.
  • binders e.g. Magnesium aluminum silicate, starches such as corn, wheat, rice or arrowroot starch, gelatin, tragacanth, methyl cellulose, sodium carboxymethyl cellulose and / or polyvinyl pyrrolidone, and, if desired,
  • the new pharmacologically active compounds can also be used in the form of parenterally administrable preparations or infusion solutions.
  • solutions are preferably isotonic aqueous solutions or suspensions, these e.g. for lyophilized preparations which contain the active substance alone or together with a carrier material, e.g. Mannitol, can be prepared before use.
  • the pharmaceutical preparations can be sterilized and / or adjuvants, e.g. Preservatives, stabilizers, wetting agents and / or emulsifiers, solubilizers, salts for regulating the osmotic pressure and / or buffers.
  • the present pharmaceutical preparations which, if desired, can contain further pharmacologically active substances, are used in a manner known per se, e.g. produced by means of conventional mixing, granulating, coating, dissolving or lyophilizing processes and contain from about 0.1% to 100%, in particular from about 1% to about 50%, lyophilisates up to 100% of the active ingredient.
  • the dosage can depend on various factors, such as the mode of administration, species, age and / or individual condition.
  • the doses to be administered daily when administered orally to warm-blooded animals of approximately 70 kg are preferably between approximately 0.005 and 0.1 g.
  • the crystals formed are suction filtered after standing for several days, which also contain a mixture of the diastereoisomers of a- [N- [2- (3-carbamoyl-4-hydroxyphenoxy) -1-methy) -ethyi] -aminomethyi] -benzyi- alcohol represent a melting interval of approx. 120-150 °. Fractional recrystallization from isopropanol gives the pure enantiomer pairs, which melt at 166-168 ° or 152-154 °.
  • N- [2- (4-carbamoyl-3-hydroxyphenoxy) ethyl] benzylamine thus obtained forms an oil, the hydrochloride of which melts at 252-254 ° (from methanol).
  • the crystals obtained after standing for several days and having a melting point of 160-163 ° give, after further crystallization from methanol, a pure pair of enantiomers of melting point 166-168 °. After the solvent has been evaporated off by fractional crystallization using ethyl acetate or isopropanol, the lower melting enantomer pair of mp 152-154 ° is isolated from the first mother liquor.
  • a mixture of 2.7 g of a- [aminomethyl) -2-thiophenemethanol and 3.6 g of 2,3-dihydro-2,2-dimethyl-6- (2-bromoethoxy) -4H-1,3-benzoxazine -4-one is stirred together with 2 ml of triethylamine for 1 hour in a bath at 100-110 °.
  • the reaction mixture is between 100 ml of ethyl acetate and 10 ml of 2-n.
  • the starting material can be prepared analogously to Example 10a) using 7- (2-bromoethoxy) -2,3-dihydro-2,2-dimethyl-4H-1,3-benzoxazin-4-one.
  • the 4-benzyloxy-a- [N- [2- (4-carbamoyl-3-hydroxyphenoxy) ethyl] aminomethyl] benzyl alcohol thus obtained melts at 181-183 °.
  • a mixture of 13.7 g of a- (aminomethyl) benzyl alcohol and 9.4 g of 6- (3-bromopropoxy) -2,3-dihydro-2,2-dimethyl-4H-1,3-benzoxazin-4 -one is heated for 45 minutes with stirring in a bath at 120 °.
  • the reaction mixture is cooled, 250 ml of ethyl acetate are added and the solution is washed twice in succession with 50 ml of aqueous, saturated potassium bicarbonate solution, water and saturated sodium chloride solution, dried over magnesium sulfate and evaporated.
  • a suspension of 21.9 g of 5- (2-aminoethoxy) salicylamide, 36.0 a- (bromomethyl) benzyl alcohol and 30 g of potassium bicarbonate in 240 ml of ethanol is heated to reflux with stirring for 15 hours.
  • the reaction mixture is then cooled, filtered and evaporated.
  • the evaporation residue is between 300 ml and Distributed 100 ml of water, the organic phase separated, dried over magnesium sulfate and evaporated.
  • a- [N- [2- (3-carbamoyl-4-hydroxy-phenoxy) -1-methyl-ethyl] aminomethyl] benzyl alcohol of mp 152-154 ° is mixed with part of the wheat starch, lactose and colloidal silica and rubbed the mixture through a sieve. Another part of the wheat starch is gelatinized with 5 times the amount of water on the water bath and the powder mixture is kneaded with this paste until a weak plastic mass has formed.
  • the plastic mass is pressed through a sieve with a mesh size of approx. 3 mm, dried and the dry granules obtained are again passed through a sieve.
  • the remaining wheat starch, talc and magnesium stearate are then mixed in and the mixture is compressed into tablets of 145 mg in weight with a notch.
  • Capsules containing 20 mg of active substance are produced in the usual way as follows:
  • the active substance is mixed intimately with talc and colloidal silica, the mixture is passed through a sieve with a mesh size of 0.5 mm and this is filled into portions of 21 mg each in hard gelatin capsules of a suitable size.
  • the sugar, saccharin and glycerin are dissolved in 60 g of water.
  • the solution of the active ingredient and the flavor in ethanol is added with stirring. Then the mixture with dist. Make up water to 100 ml.

Claims (28)

1. Aminoalcools N-alcoylés de formule
Figure imgb0056
où Ar représente un radical non substitué ou substitué par hydroxy de caractère aromatique, n les nombres zéro ou 1 et Alc un radical alcoylène ayant de 2 à 5 atomes de carbone, où l'atome d'azote et l'atome d'oxygène ou, si n vaut zéro, le radical phényle sont séparés l'un de l'autre par au moins deux atomes de carbone sous forme de mélanges de racémates, de racémates stéréoisomères (diastéréoisomères) ou d'antipodes optiques.
2. Composés de formule I, où Ar représente un phényle non substitué ou substitué par un ou deux groupes hydroxy, un 2-, 3- ou 4-pyridyle, un 3-, 4- ou 6-pyridazinyle, un 2-, 4- ou 5-pyrimidi- nyle ou un 2-pyrazinyle, un 2-, ou 3-furyle, un 2-ou 3-pyrryle, un 2- ou 3-thiényle, un 2- ou 4-oxa- zolyle, un 2- ou 4-thiazolyle, un 3- ou 5-pyrazolyle, un 2- ou 4-imidazolyle, un 1,2,4-thiadiazol-3- ou 5-yle ou un 1,3,4-thiadiazol-2-yle et Alc un radical alcoylène ayant de 2 à 4 atomes de carbone, l'atome d'azote et l'atome d'oxygène ou, si n vaut zéro, le radical phényle, étant séparés l'un de l'autre par 2 à 3 atomes de carbone, et n vaut zéro ou 1.
3. Composés de formule I, où Ar représente un phényle non substitué ou substitué par un ou deux groupes hydroxy, un 2- ou 3-pyridyle, un 2-ou 3-furyle ou un 2- ou 3-thiényle et Alc un radical alcoyléne ayant de 2 à 3 atomes de carbone, où l'atome d'azote et l'atome d'oxygène ou, si n vaut zéro, le radical phényle, sont séparés l'un de l'autre par 2 à 3 atomes de carbone, et n vaut zéro ou 1.
4. Composés de formule I, où Ar représente un phényle non substitué ou substitué par un ou deux groupes hydroxy, un 2- ou 3-pyridyle, un 2-furyle ou un 2-thiényle et Alc un radical alcoylène ayant de 2 à 3 atomes de carbone, l'atome d'azote et l'atome oxygène ou, si n vaut zéro, le noyau phényle, étant séparés l'un de l'autre par 2 à 3 atomes de carbone, et n vaut zéro ou 1.
5. α-[N-[2-(3-carbamoyl-4-hydroxy-phé- noxy)-1-méthyl-éthyl]-aminométhyl]-benzylal- cool sous forme de paire d'énantiomères de Pt 166-168°.
6. a-[N-[2-(3-carbamoyl-4-hydroxy-phé- noxy)-1-méthyl-éthyl]-aminométhyl]-benzylal- cool sous forme de paire d'énantiomères de Pf 152-154°.
7. a-[N-[2-(3-carbamoyl-4-hydroxy-phé- noxy)-éthyl]-aminométhyll-benzylalcool.
8. a-[N-[2-(4-carbamoyl-3-hydroxy-phé- noxy)-éthyl]-aminométhyl]-4-hydroxy-benzylal- cool.
9. Les sels des composés des revendications 1 à 8.
10. Sels d'addition acides non toxiques pharmaceutiquement acceptables des composés des revendications 1 à 8.
11. Préparations pharmaceutiques contenant un composé des revendications 1 à 8 et 10 avec des additifs et supports inertes.
12. Composés de formule I comme médicaments.
13. Composés de formule I comme stimulateurs des β-récepteurs cardiaques.
14. Application des composés de formule 1 à la préparation de médicaments.
15. Composés de formule I aux fins d'application dans la lutte contre l'insuffisance cardiaque.
16. Procédé de préparation d'aminoalcools N-alcoylés de formule
Figure imgb0057
où Ar représente un radical non substitué ou substitué par hydroxy de caractère aromatique, n les nombres zéro ou 1 et Alc un radical alcoylène ayant de 2 à 5 atomes de carbone, où l'atome d'azote et l'atome d'oxygène ou, si n vaut zéro, le radical phényle sont séparés l'un de l'autre par au moins deux atomes de carbone et de leurs sels, caractérisé en ce qu'on procède
a) en faisant réagir un composé de formule
Figure imgb0058
avec un composé de formule
Figure imgb0059
où l'un des groupes Z1 et Z2 représente un groupe hydroxy estérifié réactif et l'autre le groupe amino primaire, et X1 représente un hydroxy, ou bien où X1 et Z1 représentent ensemble le groupe époxy et Z2 représente te groupe amino primaire, Ar, Alc et n ont la signification donnée ci-dessus, ou
b) dans un composé de formule
Figure imgb0060
où Ar1 a la signification d'Ar ou représente un radical Ar substitué par 1 à 2 groupes transformables en hydroxy, X2, X3 et X4 représentent chacun un hydrogène ou un substituant remplaçable par un hydrogène, et X5 représente un hydrogène, ou X2 et X3 et/ou X4 et X5 représentent ensemble un radical bivalent remplaçable par 2 atomes d'hydrogène, avec la précision qu'au moins l'un des radicaux X2, X3 et X4 est différent d'un hydrogène, ou bien où au moins Ar1 représente un radical Ar substitué par 1 à 2 groupes transformables en hydroxy, ou bien où au moins X2 et X3 ensemble ou X4 et X5 ensemble représentent un radical bivalent remplaçable par 2 atomes d'hydrogène, ou dans un de ses sels, au remplacement du X2, X3 ou X4 qui est différent d'un hydrogène, ou bien de X4 et X5 ensemble par un hydrogène, et/ou en transformant dans un radical Ar, l'hydroxy substitué présent en un hydroxy libre, ou
c) en réduisant dans un composé de formule
Figure imgb0061
où X6 est un groupe réductible de formules -CH = N - Alc- (Va), ou - CH2-N = Alc1 (Vb) ou -C (=X7)-N(X8)-Alc- (Vc) ou -CH2-N(X8)-C(=X7)-Alc2- (Vd) ou un groupe -CH2-N(X8)-Alc- (Ve), où Alc1 représente le radical alcoyl-ylidène correspondant à un radical Alc et où Alc2 correspond à un radical Alc raccourci d'un groupe méthylène lié sur l'atome d'azote, X7 représente le radical oxo ou thioxo et X8 un hydrogène ou un radical remplaçable par un hydrogène dans les conditions pour la réduction de X6 et/ou Y et Y représente un radical de formule -CO- (Vf) ou -CH(OX8)- (Vg) où X8 a la signification donnée ci-dessus, Ar2 correspond à un radical Ar, mais porte cependant éventuellement à la place d'un ou de deux hydroxy un ou deux groupes OX8, où X8 a la signification donnée ci-dessus, et n vaut zéro ou 1, où X6 est toujours un groupe Va à Vd réductible et/ou Y un groupe carbonyle Vf, en réduisant donc ce ou ces groupe(s) et dans le même mode opératoire en remplaçant les groupes X8 différents d'un hydrogène par un hydrogène,
ou
d) en faisant réagir avec de l'ammoniac un composé de formule
Figure imgb0062
où Ar3 a la signification de Ar, ou représente un radical Ar, qui est substitué par un à deux groupes transformables en hydroxy au moyen d'une ammonolyse, X9 représente un hydrogène ou un groupe séparable par ammonolyse, ou un dérivé réactif de l'un des acides carboxyliques définis dans la formule VI, et simultanément en séparant les radicaux X9 éventuellement présents et en les remplaçant par de l'hydrogène, et/ou, si on le désire, en dédoublant un mélange de racémates obtenu pour donner les deux racémates stéréoisomères (diastéréoisomères) ou un racé- mate obtenu pour donner les antipodes optiques.
17. Procédé selon la revendication 16 caractérisé en ce qu'on transforme un composé de formule I obtenu en un sel d'addition acide non toxique pharmaceutiquement acceptable.
EP79101724A 1978-06-05 1979-06-01 Aminoalcools N-alcoylés et leurs sels, procédé pour leur préparation et compositions pharmaceutiques les contenant Expired EP0005848B1 (fr)

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CA1124241A (fr) 1982-05-25
GB2026474B (en) 1982-07-14
ZA792748B (en) 1980-06-25
KR830000679A (ko) 1983-04-18
AU4773679A (en) 1979-12-13
FI791727A (fi) 1979-12-06
NO149034B (no) 1983-10-24
KR830000681A (ko) 1983-04-18
DE2961669D1 (en) 1982-02-18
MY8500690A (en) 1985-12-31
HU182019B (en) 1983-12-28
CY1256A (en) 1984-11-23
NO791841L (no) 1979-12-06
DK229879A (da) 1979-12-06
PL116529B1 (en) 1981-06-30
NO149034C (no) 1984-02-01
PL216090A1 (fr) 1980-03-24
GR74057B (fr) 1984-06-06
PT69723A (de) 1979-07-01
US4460580A (en) 1984-07-17
KR830000680A (ko) 1983-04-18
JPS54163543A (en) 1979-12-26
PL116612B1 (en) 1981-06-30
SG45884G (en) 1985-03-08
HK15585A (en) 1985-03-15
DD144050A5 (de) 1980-09-24
PL117158B1 (en) 1981-07-31
GB2026474A (en) 1980-02-06
NZ190632A (en) 1984-07-06
AR229951A1 (es) 1984-01-31
PL116597B1 (en) 1981-06-30
IL57471A (en) 1982-11-30
AU522483B2 (en) 1982-06-10
KR840000926B1 (ko) 1984-06-29
ATE511T1 (de) 1982-01-15
PL117155B1 (en) 1981-07-31
AR229022A1 (es) 1983-05-31
ES481238A1 (es) 1980-02-16
AR229581A1 (es) 1983-09-30
EP0005848A1 (fr) 1979-12-12

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